Acute kidney injury after using contrast during cardiac catheterization in children with heart disease.

Abstract:

:Acute kidney injury (AKI) is closely associated with the mortality of hospitalized patients and long-term development of chronic kidney disease, especially in children. The purpose of our study was to assess the evidence of contrast-induced AKI after cardiac catheterization in children with heart disease and evaluate the clinical usefulness of candidate biomarkers in AKI. A total of 26 children undergoing cardiac catheterization due to various heart diseases were selected and urine and blood samples were taken at 0 hr, 6 hr, 24 hr, and 48 hr after cardiac catheterization. Until 48 hr after cardiac catheterization, there was no significant increase in serum creatinine level in all patients. Unlike urine kidney injury molecule-1, IL-18 and neutrophil gelatinase-associated lipocalin, urine liver-type fatty acid-binding protein (L-FABP) level showed biphasic pattern and the significant difference in the levels of urine L-FABP between 24 and 48 hr. We suggest that urine L-FABP can be one of the useful biomarkers to detect subclinical AKI developed by the contrast before cardiac surgery.

journal_name

J Korean Med Sci

authors

Hwang YJ,Hyun MC,Choi BS,Chun SY,Cho MH

doi

10.3346/jkms.2014.29.8.1102

subject

Has Abstract

pub_date

2014-08-01 00:00:00

pages

1102-7

issue

8

eissn

1011-8934

issn

1598-6357

journal_volume

29

pub_type

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