Abstract:
:Scleroderma (SSc) renal crisis has been reported to be associated with anti-RNA polymerase I and III (RNAP I/III) antibodies in Caucasians and the Japanese. However, no report is available for Korean SSc patients. Here, we describe the case of a 65-yr-old female SSc patient who developed renal crisis and whose serum contained anti-RNAP I/III antibodies. She was finally diagnosed as having diffuse cutaneous SSc based on skin thickening proximal to the elbows and knees. Sudden hypertension, oliguria, and pulmonary edema were features of her renal crisis. Despite the use of captopril and adequate blood pressure control, her renal function deteriorated. Subsequent renal biopsy findings showed severe fibrinoid necrosis with luminal obliteration in interlobar arteries and arterioles consistent with SSc renal crisis. Serum anti-RNAP I/III antibodies were detected by radioimmunoprecipitation. This is the first report of a renal crisis in a Korean SSc patient with RNAP I/III antibodies.
journal_name
J Korean Med Scijournal_title
Journal of Korean medical scienceauthors
Kang EH,Im CH,Kim SH,Chung JR,Lee EY,Kim DJ,Lee EB,Song YWdoi
10.3346/jkms.2006.21.6.1121subject
Has Abstractpub_date
2006-12-01 00:00:00pages
1121-3issue
6eissn
1011-8934issn
1598-6357pii
2006121121journal_volume
21pub_type
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