Donor specific response of estrogen and progesterone on cultured human melanocytes.

Abstract:

:The mechanisms of estrogen and progesterone in human cutaneous pigmentation are largely unknown. The molecular identification of estrogen receptor (ER) and progesterone receptor (PR) in the human melanocytes is of great importance to understand the mechanisms. We performed immunocytochemistry analysis and demonstrated that ER and PR were expressed in the cytoplasms and nuclei of human melanocytes. Reverse transcriptase-polymerase chain reaction (RT-PCR) and sequence analysis confirmed the expression of ER and PR at the transcriptional level. Despite of the presence of ER and PR, the physiological and pregnant levels of estrogen and progesterone showed inconsistent effects on the proliferation and tyrosinase activity of cultured human melanocytes. These results suggest that human melanocytes express ER and PR, which have a donor-specific action in human pigmentation. Further studies are needed to elucidate the induction mechanism and functions of these receptors, and the role of estrogen and progesterone in melanocytes.

journal_name

J Korean Med Sci

authors

Im S,Lee ES,Kim W,On W,Kim J,Lee M,Kang WH

doi

10.3346/jkms.2002.17.1.58

keywords:

subject

Has Abstract

pub_date

2002-02-01 00:00:00

pages

58-64

issue

1

eissn

1011-8934

issn

1598-6357

pii

200202058

journal_volume

17

pub_type

杂志文章
  • Expression and mutational analysis of c-kit in ovarian surface epithelial tumors.

    abstract::Coexpression of Kit ligand and c-kit has been reported in some gynecologic tumors. To determine whether imatinib mesylate is useful in ovarian epithelial tumors, we performed immunohistochemical and mutational analysis. The cases consisted of 33 cases, which included 13 serous cystadenocarcinomas, 1 borderline serous ...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2006.21.1.81

    authors: Kim DJ,Lee MH,Park TI,Bae HI

    更新日期:2006-02-01 00:00:00

  • Prevalence of otitis media and allied diseases in Korea--results of a nation-wide survey, 1991.

    abstract::A nation-wide survey was conducted to estimate the prevalence of otitis media and allied diseases through physical examination by otolaryngologic doctors from July to October, 1991. A sample study population was selected from a panel to be representative of the Korean population by multistage clustered and stratified ...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.1993.8.1.34

    authors: Kim CS,Jung HW,Yoo KY

    更新日期:1993-02-01 00:00:00

  • GAB2 Amplification in Squamous Cell Lung Cancer of Non-Smokers.

    abstract::Lung squamous cell cancer (SCC) is typically found in smokers and has a very low incidence in non-smokers, indicating differences in the tumor biology of lung SCC in smokers and non-smokers. However, the specific mutations that drive tumor growth in non-smokers have not been identified. To identify mutations in lung S...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2017.32.11.1784

    authors: Park YR,Bae SH,Ji W,Seo EJ,Lee JC,Kim HR,Jang SJ,Choi CM

    更新日期:2017-11-01 00:00:00

  • Comparison of M-serotypes of Streptococcus pyogenes isolated from healthy elementary school children in two rural areas.

    abstract::Serotypings have been used as markers for epidemiological surveys of Streptococcus pyogenes infections. Seventy-seven strains of S. pyogenes isolated from the throats of elementary school children in Kangwon Province in Korea in March and April 1992 were serotyped with M and/or opacity factor (OF) antisera. Sixty-eigh...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.1996.11.2.133

    authors: Kim SJ,Kim EC,Cha SH,Kaplan EL

    更新日期:1996-04-01 00:00:00

  • Metastatic involvement of the stomach secondary to lung carcinoma.

    abstract::Blood-borne metastatic involvement of the stomach by cancer is a rare entity. According to the number of reports in the literature, the most common tumors that spread to the stomach through the blood stream are malignant melanoma, breast carcinoma and lung carcinoma. Recently, two cases of metastatic involvement of th...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.1993.8.1.24

    authors: Kim HS,Jang WI,Hong HS,Lee CI,Lee DK,Yong SJ,Shin KC,Shim YH

    更新日期:1993-02-01 00:00:00

  • Information and Misinformation on COVID-19: a Cross-Sectional Survey Study.

    abstract:BACKGROUND:The coronavirus disease 2019 (COVID-19) pandemic has led to a large volume of publications, a barrage of non-reviewed preprints on various professional repositories and a slew of retractions in a short amount of time. METHODS:We conducted an e-survey using a cloud-based website to gauge the potential source...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2020.35.e256

    authors: Gupta L,Gasparyan AY,Misra DP,Agarwal V,Zimba O,Yessirkepov M

    更新日期:2020-07-13 00:00:00

  • Reliability and validity of the cognitive impairment diagnosing instrument (CIDI) in the elderly.

    abstract::The reliability and validity of the Cognitive Impairment Diagnosing Instrument (CIDI) were studied in 67 nursing home elderly subjects and 251 elderly psychiatric patients. Its possible highest score is 77 and covers 10 subscales: short-term memory, long-term memory, concentration/calculation, abstract thinking, judge...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.1995.10.4.287

    authors: Park JH,Ko HJ,Kim JB,Choi SY,Cho HC,Lee SK

    更新日期:1995-08-01 00:00:00

  • The clinical measures associated with C-peptide decline in patients with type 1 diabetes over 15 years.

    abstract::This study was done to characterize the natural course of C-peptide levels in patients with type 1 diabetes and identify distinguishing characters among patients with lower rates of C-peptide decline. A sample of 95 children with type 1 diabetes was analyzed to retrospectively track serum levels of C-peptide, HbA1c, w...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2013.28.9.1340

    authors: Lee TH,Kwon AR,Kim YJ,Chae HW,Kim HS,Kim DH

    更新日期:2013-09-01 00:00:00

  • Congenital insensitivity to pain with anhidrosis: a case report.

    abstract::Congenital insensitivity to pain with anhidrosis (CIPA) is a very rare genetic disorder of the peripheral nervous system characterized by recurrent episodes of unexplained fever, generalized anhidrosis, insensitivity to pain and temperature, and accompanied by self-mutilating behavior and mental retardation. We report...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.1999.14.4.460

    authors: Kim JS,Woo YJ,Kim GM,Kim CJ,Ma JS,Hwang TJ,Lee MC

    更新日期:1999-08-01 00:00:00

  • Usefulness of non-invasive markers for predicting significant fibrosis in patients with chronic liver disease.

    abstract::The purpose of this prospective study was to verify and compare the strengths of various blood markers and fibrosis models in predicting significant liver fibrosis. One hundred fifty-eight patients with chronic liver disease who underwent liver biopsy were enrolled. The mean age was 41 yr and male patients accounted f...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2010.25.1.67

    authors: Lee HH,Seo YS,Um SH,Won NH,Yoo H,Jung ES,Kwon YD,Park S,Keum B,Kim YS,Yim HJ,Jeen YT,Chun HJ,Kim CD,Ryu HS

    更新日期:2010-01-01 00:00:00

  • Pediatric Case Report on an Interstitial Lung Disease with a Novel Mutation of SFTPC Successfully Treated with Lung Transplantation.

    abstract::Mutations of the surfactant protein (SP)-C gene (SFTPC) have been associated with neonatal respiratory distress syndrome (RDS) and childhood interstitial lung disease (ILD). If accurate diagnosis and proper management are delayed, irreversible respiratory failure demanding lung transplantation may ensue. A girl was bo...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2018.33.e159

    authors: Park JS,Choi YJ,Kim YT,Park S,Chae JH,Park JD,Cho YJ,Kim WS,Seong MW,Park SH,Kwon D,Chung DH,Suh DI

    更新日期:2018-05-02 00:00:00

  • A nationwide epidemiological study of testicular torsion in Korea.

    abstract::Testicular torsion is a surgical emergency in the field of urology. Knowledge of the epidemiology and pathophysiology is significant to an urologist. However, the epidemiology of testicular torsion in Korea has not been studied. We performed a nationwide epidemiological study to improve knowledge of the epidemiology o...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2014.29.12.1684

    authors: Lee SM,Huh JS,Baek M,Yoo KH,Min GE,Lee HL,Lee DG

    更新日期:2014-12-01 00:00:00

  • The effect of probiotics for preventing radiation-induced morphological changes in intestinal mucosa of rats.

    abstract::Radiation therapy is an important treatment modality for abdominal or pelvic cancer, but there is a common and serious complication such as radiation-induced enteritis. Probiotics is reported to have positive effects against radiation-induced enteropathy. In this study, morphological changes of bowel mucosa were analy...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2014.29.10.1372

    authors: Ki Y,Kim W,Cho H,Ahn K,Choi Y,Kim D

    更新日期:2014-10-01 00:00:00

  • Association between Blood Pressure and Renal Progression in Korean Adults with Normal Renal Function.

    abstract:BACKGROUND:Although hypertension (HTN) is a well-established major risk factor for renal progression in patients with chronic kidney disease (CKD), few studies investigating its role in renal deterioration in the general population with normal renal function (NRF) have been published. Here, we analyzed the correlation ...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2020.35.e312

    authors: Lee KP,Kim YS,Yoon SA,Han K,Kim YO

    更新日期:2020-08-31 00:00:00

  • Intron 4 VNTR (4a/b) polymorphism of the endothelial nitric oxide synthase gene is associated with breast cancer in Mexican women.

    abstract::The endothelial nitric oxide synthase (eNOS) gene plays an important role in several biological functions. Polymorphisms of the eNOS gene have been associated with cancer. It has been suggested that the VNTR 4 a/b polymorphism may affect the expression of eNOS and contributes to tumor promotion in the mammary gland. W...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2013.28.11.1587

    authors: Ramírez-Patiño R,Figuera LE,Puebla-Pérez AM,Delgado-Saucedo JI,Legazpí-Macias MM,Mariaud-Schmidt RP,Ramos-Silva A,Gutiérrez-Hurtado IA,Gómez Flores-Ramos L,Zúñiga-González GM,Gallegos-Arreola MP

    更新日期:2013-11-01 00:00:00

  • Macrophage activation syndrome in a child with systemic juvenile rheumatoid arthritis.

    abstract::Macrophage activation syndrome (MAS) is a rare and potentially fatal complication of rheumatic disorders in children. We describe a 13-month-old boy in whom MAS developed as a complication of systemic juvenile rheumatoid arthritis (S-JRA). He suffered from fever and generalized rash followed by multiple joints swellin...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2005.20.4.695

    authors: Hur M,Kim YC,Lee KM,Kim KN

    更新日期:2005-08-01 00:00:00

  • Differentiated thyroid carcinoma of children and adolescents: 27-year experience in the yonsei university health system.

    abstract::Thyroid carcinomas are uncommon in childhood and adolescence. The aim of this study was to analyze clinical features and clinical outcomes of thyroid cancer in the pediatric population treated in the Yonsei University Health System. From September 1982 to June 2009, 90 patients (75 females, 15 males; female:male ratio...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2013.28.5.693

    authors: Park S,Jeong JS,Ryu HR,Lee CR,Park JH,Kang SW,Jeong JJ,Nam KH,Chung WY,Park CS

    更新日期:2013-05-01 00:00:00

  • Surgical treatment of primary malignant melanoma of the esophagus: a case report.

    abstract::Primary malignant melanoma of the esophagus (PMME) is an extremely rare tumor with only scattered cases reported. Although surgical resection has been considered as the best possible option, the prognosis has been nonetheless poor. We report a case of PMME which was treated by surgical resection and additionally follo...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2007.22.1.149

    authors: Lee SA,Hwang JJ,Choi YH

    更新日期:2007-02-01 00:00:00

  • Extrauterine incubation of fetal goats applying the extracorporeal membrane oxygenation via umbilical artery and vein.

    abstract::The fetus is an unstable subject for an isolated physiological and biochemical study. To study the fetus in a controlled and stable environment, a trial was done using 12 goat fetuses. Extrauterine incubation system was devised using an extracorporeal membrane oxygenation system. The system consisted of a venous reser...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2002.17.5.663

    authors: Pak SC,Song CH,So GY,Jang CH,Lee KH,Kim JY

    更新日期:2002-10-01 00:00:00

  • Relationship between the Clinical Characteristics and Intervention Scores of Infants with Apparent Life-threatening Events.

    abstract::We investigated the clinical presentations, diagnostic and therapeutic modalities, and prognosis from follow-up of infants with apparent life-threatening events (ALTE). In addition, the relationship between the clinical characteristics of patients and significant intervention scores was analyzed. We enrolled patients ...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2015.30.6.763

    authors: Choi HJ,Kim YH

    更新日期:2015-06-01 00:00:00

  • Application of Baveno Criteria and Modified Baveno Criteria with Shear-wave Elastography in Compensated Advanced Chronic Liver Disease.

    abstract:BACKGROUND:We aimed to validate Baveno VI and expanded Baveno VI criteria using two dimensional shear-wave elastography (2D-SWE) in compensated advanced chronic liver disease (cACLD) patients with alcohol as the main etiology. METHODS:Clinical data from 305 patients with cACLD who underwent a liver stiffness measureme...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2020.35.e249

    authors: Kang SH,Baik SK,Kim MY

    更新日期:2020-08-03 00:00:00

  • Metastatic glioblastoma in cervical lymph node after repeated craniotomies: report of a case with diagnosis by fine needle aspiration.

    abstract::Head and neck metastasis from glioblastoma is rare event usually seen in patients with previous and repeated surgery. We present the case of a 35 yr-old-female suffering from metastatic glioblastoma in cervical lymph node that was diagnosed by fine needle aspiration. During the last 4 yr, she had four separate craniot...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2004.19.6.911

    authors: Moon KS,Jung S,Lee MC,Kim IY,Kim HW,Lee JK,Kim TS

    更新日期:2004-12-01 00:00:00

  • Prevalence and risk factors of early-stage age-related macular degeneration in patients examined at a health promotion center in Korea.

    abstract::We evaluated the prevalence and risk factors for early age-related macular degeneration (AMD) in Koreans 50 yr of age or older who were examined at a single health promotion center. We retrospectively reviewed the records of 10,449 subjects who visited the center over a 6-month period. Fundus photography was performed...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2012.27.5.537

    authors: Moon BG,Joe SG,Hwang JU,Kim HK,Choe J,Yoon YH

    更新日期:2012-05-01 00:00:00

  • Chylothorax in Gorham's disease.

    abstract::A 25-yr-old woman presented with a right pleural effusion. Destruction of 9th through 12th ribs, adjacent vertebral bodies, and transverse processes was noted on plain radiograph and a large low-attenuated, irregular shaped mass lesion with peripheral rim enhancement, destroying vertebral body and transverse process, ...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2002.17.6.826

    authors: Lee WS,Kim SH,Kim I,Kim HK,Lee KS,Lee SY,Heo DS,Jang BS,Bang YJ,Kim NK

    更新日期:2002-12-01 00:00:00

  • Pertussis seroprevalence in korean adolescents and adults using anti-pertussis toxin immunoglobulin G.

    abstract::This study was conducted to evaluate age-specific seroprevalence of pertussis in Korea and to formulate a strategy to prevent and reduce the incidence of pertussis. Residual serum samples of healthy adolescents and adults 11 yr of age or older were collected between July 2012 and December 2012, and anti-pertussis toxi...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2014.29.5.652

    authors: Lee SY,Han SB,Bae EY,Kim JH,Kang JH,Park YJ,Ma SH

    更新日期:2014-05-01 00:00:00

  • Epidemiological and clinical characteristics of community-acquired severe sepsis and septic shock: a prospective observational study in 12 university hospitals in Korea.

    abstract::A prospective multicenter observational study was performed to investigate the epidemiology and outcomes of community-acquired severe sepsis and septic shock. Subjects included 1,192 adult patients admitted to the 22 participating intensive care units (ICUs) of 12 university hospitals in the Korean Sepsis Registry Sys...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章,多中心研究

    doi:10.3346/jkms.2012.27.11.1308

    authors: Park DW,Chun BC,Kim JM,Sohn JW,Peck KR,Kim YS,Choi YH,Choi JY,Kim SI,Eom JS,Kim HY,Song JY,Song YG,Choi HJ,Kim MJ

    更新日期:2012-11-01 00:00:00

  • Analysis of the immunologic mechanism of intravesical bacillus Calmette-Guerin therapy for superficial bladder tumors: distribution and function of immune cells.

    abstract::Intravesical bacillus Calmette-Guerin (BCG) administration has been used as an adjuvant therapy after transurethral resection for superficial bladder cancer, but the exact mechanisms of its antitumor activity are not yet known. The aim of this study was to characterize the immunologic aspects of antitumor activity of ...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.1993.8.2.135

    authors: Chung JY,Lee ES,Lee WJ,Kim HH,Min KJ,Lee C

    更新日期:1993-04-01 00:00:00

  • Purulent pericarditis caused by group G streptococcus as an initial presentation of colon cancer.

    abstract::Bacterial pericarditis has been recognized as a rare disease since the development of antibiotics. Usually, the disease is associated with underlying conditions or a seeding of infection elsewhere to the pericardium. Here we describe a case of group G streptococcal pericarditis as an initial presentation of colon canc...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2002.17.4.571

    authors: Kim NH,Park JP,Jeon SH,Lee YJ,Choi HJ,Jeong KM,Lee JG,Choi SP,Lim JH,Kim YH,Kim YS,Kim YM,Hwang MH,Cho JW,Moon Y,Oh SK,Jeong JW

    更新日期:2002-08-01 00:00:00

  • Heterogeneity of invasive ductal carcinoma: proposal for a hypothetical classification.

    abstract::To investigate what heterogeneity exists in breast cancer, 228 consecutive patients with operable invasive duetal carcinoma (IDC), not otherwise specified, were categorized on the basis of the horizontal progression model of carcinogenesis. Using the reversed Black's nuclear grade (RBNG) in the IDC component and the a...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2006.21.3.460

    authors: Jo BH,Chun YK

    更新日期:2006-06-01 00:00:00

  • Prevalence of treated epilepsy in Korea based on national health insurance data.

    abstract::The Korean national health security system covers the entire population and all medical facilities. We aimed to estimate epilepsy prevalence, anticonvulsant utilization pattern and the cost. We identified prevalent epilepsy patients by the prescription of anticonvulsants under the diagnostic codes suggesting seizure o...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2012.27.3.285

    authors: Lee SY,Jung KY,Lee IK,Yi SD,Cho YW,Kim DW,Hwang SS,Kim S,Korean Epilepsy Society.

    更新日期:2012-03-01 00:00:00