Abstract:
:The GSTP1 and NQO1 have been reported to be associated with an increased risk for smoking related head and neck squamous cell carcinoma (HNSCC). The purpose of this study was to determine the effect of these metabolic gene polymorphisms on the risk of HNSCC. The study population included 294 histologically confirmed HNSCC cases and 333 controls without cancer. Genotyping analysis of the GSTP1 Ile105Val and NQO1 Trp139Arg genes was performed by polymerase chain reaction-based techniques on DNA prepared from peripheral blood. The Mantel-Haenszel chi2 test was used for statistical analysis. The allele frequencies of the GSTP1 and NQO1 polymorphisms were not statistically significant between cases and controls. In analyzing the association between smoking amounts and genetic polymorphisms, GSTP1 and NQO1 polymorphisms were associated with cigarette smoking amounts in cases. G allele containing genotypes in GSTP1 and T allele containing genotypes in NQO1 were associated with a tobacco dose-dependent increase in risk of HNSCC and these genotype distributions were statistically significant (p<0.05). We found that the GSTP1 105Val allele and NQO1 139Arg allele were associated with tobacco dose-dependent increase in risk of HNSCC. GSTP1 and NQO1 genotype polymorphisms may play an important role in the development of smoking related HNSCC.
journal_name
J Korean Med Scijournal_title
Journal of Korean medical scienceauthors
Cho CG,Lee SK,Nam SY,Lee MS,Lee SW,Choi EK,Park HJ,Kim SYdoi
10.3346/jkms.2006.21.6.1075subject
Has Abstractpub_date
2006-12-01 00:00:00pages
1075-9issue
6eissn
1011-8934issn
1598-6357pii
2006121075journal_volume
21pub_type
杂志文章abstract::Several factors can affect the perioperative immune function. We evaluated the effect of propofol and desflurane anesthesia on the surgery-induced immune perturbation in patients undergoing breast cancer surgery. The patients were randomly assigned to receive propofol (n = 20) or desflurane (n = 20) anesthesia. The to...
journal_title:Journal of Korean medical science
pub_type: 杂志文章,随机对照试验
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abstract::Vascular endothelial growth factor (VEGF) is a multi-functional cytokine involved in inflammation, repair and angiogenesis in asthmatic airway. This study aimed to evaluate the role of VEGF in immediate bronchoconstriction induced by TDI inhalation, and in chronic TDI-asthma patients. 11 newly diagnosed TDI-asthma pat...
journal_title:Journal of Korean medical science
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pub_type: 临床试验,杂志文章,多中心研究
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journal_title:Journal of Korean medical science
pub_type: 杂志文章
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journal_title:Journal of Korean medical science
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journal_title:Journal of Korean medical science
pub_type: 杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章,随机对照试验,收录出版
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journal_title:Journal of Korean medical science
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journal_title:Journal of Korean medical science
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journal_title:Journal of Korean medical science
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journal_title:Journal of Korean medical science
pub_type: 杂志文章
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journal_title:Journal of Korean medical science
pub_type: 杂志文章
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