Acute and chronic changes of vascular endothelial growth factor (VEGF) in induced sputum of toluene diisocyanate (TDI)-induced asthma patients.

Abstract:

:Vascular endothelial growth factor (VEGF) is a multi-functional cytokine involved in inflammation, repair and angiogenesis in asthmatic airway. This study aimed to evaluate the role of VEGF in immediate bronchoconstriction induced by TDI inhalation, and in chronic TDI-asthma patients. 11 newly diagnosed TDI-asthma patients (group I), 12 chronic TDI-asthma patients with persistent asthma symptoms followed for >4 yr and 15 unexposed healthy controls were enrolled. In group I, induced sputum and serum were collected before and 7 hr after placebo- and TDI-bronchoprovocation test (BPT). In group II, induced sputum and serum were collected every 2 yr. VEGF levels were measured by ELISA. There were no significant differences in sputum and serum VEGF levels between patients and controls. Before and after placebo and TDI-BPT, no significant changes were noted in sputum and serum VEGF levels of group I. In group II patients, sputum VEGF showed variable changes at 1-yr, then decreased significantly at 2-yr (p<0.05), while serum VEGF showed variable changes at 2-yr, which decreased significantly at 4-yr (p<0.05). These results suggest that VEGF may play a minor role in immediate bronchoconstriction after TDI-BPT. In chronic TDI-asthma, VEGF may be involved to 2 yr after the diagnosis and the contribution may decrease after then.

journal_name

J Korean Med Sci

authors

Choi JH,Suh YJ,Lee SK,Suh CH,Nahm DH,Park HS

doi

10.3346/jkms.2004.19.3.359

keywords:

subject

Has Abstract

pub_date

2004-06-01 00:00:00

pages

359-63

issue

3

eissn

1011-8934

issn

1598-6357

pii

200406359

journal_volume

19

pub_type

杂志文章
  • A Survey of Parental Perception and Pattern of Action in Response to Influenza-like Illness in Their Children: Including Healthcare Use and Vaccination in Korea.

    abstract::Seasonal influenza is a significant cause of morbidity and mortality of children in Korea. However, few data are available on parental perception and action toward childhood influenza. This study aimed to characterize parental perception and patterns of action in response to influenza and influenza-like illnesses (ILI...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2017.32.2.204

    authors: Hwang JH,Lim CH,Kim DH,Eun BW,Jo DS,Song YH,Kim YK

    更新日期:2017-02-01 00:00:00

  • Association of the GSTP1 and NQO1 polymorphisms and head and neck squamous cell carcinoma risk.

    abstract::The GSTP1 and NQO1 have been reported to be associated with an increased risk for smoking related head and neck squamous cell carcinoma (HNSCC). The purpose of this study was to determine the effect of these metabolic gene polymorphisms on the risk of HNSCC. The study population included 294 histologically confirmed H...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2006.21.6.1075

    authors: Cho CG,Lee SK,Nam SY,Lee MS,Lee SW,Choi EK,Park HJ,Kim SY

    更新日期:2006-12-01 00:00:00

  • 1,25-dihydroxy Vitamin D3 and Interleukin-6 Blockade Synergistically Regulate Rheumatoid Arthritis by Suppressing Interleukin-17 Production and Osteoclastogenesis.

    abstract:BACKGROUND:Immune cells express the vitamin (vit) D receptor, and vit D is a potent immune-modulator. A negative correlation between serum vit D levels and rheumatoid arthritis (RA) disease activity has been reported. Therefore, we aimed to investigate if the sufficient serum vit D level is helpful to control disease a...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2020.35.e40

    authors: Kim H,Baek S,Hong SM,Lee J,Jung SM,Lee J,Cho M,Kwok SK,Park SH

    更新日期:2020-02-17 00:00:00

  • Malignant gastrointestinal stromal tumor of the gallbladder.

    abstract::Gastrointestinal stromal tumors (GISTs) of the gallbladder are representative of an extremely rare group of tumors. We have encountered a patient with a malignant GIST of the gallbladder and presented it with a review of some articles. A 72-yr-old woman initially presented with right upper quadrant abdominal pain, fev...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章,评审

    doi:10.3346/jkms.2004.19.5.763

    authors: Park JK,Choi SH,Lee S,Min KO,Yun SS,Jeon HM

    更新日期:2004-10-01 00:00:00

  • Takayasu's arteritis treated by percutaneous transluminal angioplasty with stenting in the descending aorta.

    abstract::A 17-yr-old young woman was referred to our hospital with a 2-yr history of claudication of the lower extremities and severe arterial hypertension. Physical examination revealed significantly different blood pressures between both arms (160/92 and 180/95 mmHg) and legs (92/61 and 82/57 mmHg). The hematological and bio...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2008.23.3.551

    authors: Shim BJ,Youn HJ,Kim YC,Kim WT,Choi YS,Lee DH,Park C,Oh YS,Chung WS,Kim JH,Choi KB,Hong SJ,Jung SE,Hahn ST

    更新日期:2008-06-01 00:00:00

  • The Natural Course of Biopsy-Proven Isolated Microscopic Hematuria: a Single Center Experience of 350 Patients.

    abstract::The increasing interest in healthcare and health screening events is revealing additional cases of asymptomatic isolated microscopic hematuria (IMH). However, a consensus of the evaluation and explanation of the IMH prognosis is controversial among physicians. Here, we present the natural course of IMH together with t...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2016.31.6.909

    authors: Lee HM,Hyun JI,Min JW,Lee K,Kim YK,Choi EJ,Song HC

    更新日期:2016-06-01 00:00:00

  • Effects of hepatocyte growth factor on collagen synthesis and matrix metalloproteinase production in keloids.

    abstract::Keloids are pathologic proliferations of the dermal layer of the skin resulting from excessive collagen production and deposition. Hepatocyte growth factor (HGF) increases the expression of matrix metalloproteinase (MMP)-1 and suppresses collagen synthesis to modulate extracellular matrix turnover. To investigate the ...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2011.26.8.1081

    authors: Lee WJ,Park SE,Rah DK

    更新日期:2011-08-01 00:00:00

  • Interleukin-10 promoter polymorphism is associated with the predisposition to the development of IgA nephropathy and focal segmental glomerulosclerosis in Korea.

    abstract::The roles of interleukin-10 (IL-10) have been emphasized in several models of glomerulonephritis (GN). Three biallelic polymorphisms within the IL-10 promoter region, at positions -1,082, -819, and -592 from the transcription initiation site, were shown to affect the level of IL-10 production. To investigate the effec...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2005.20.6.989

    authors: Chin HJ,Na KY,Kim SJ,Oh KH,Kim YS,Lim CS,Kim S,Chae DW

    更新日期:2005-12-01 00:00:00

  • Evaluation of anti-malarial effects of mass chemoprophylaxis in the Republic of Korea army.

    abstract::Vivax malaria was endemic on the Korean peninsula for many centuries until the late 1970's when the Republic of Korea (ROK) was declared "malaria free". Since its re-emergence in 1993, the number of malaria cases in the military increased exponentially through 2000 near the demilitarized zone. Chemoprophylaxis with ch...

    journal_title:Journal of Korean medical science

    pub_type: 临床试验,杂志文章

    doi:10.3346/jkms.2005.20.5.707

    authors: Yeom JS,Ryu SH,Oh S,Choi DH,Song KJ,Oh YH,Lee JH,Kim YA,Ahn SY,Yang HY,Cha JE,Park JW

    更新日期:2005-10-01 00:00:00

  • Legislative Issues in Disclosing Financial Conflicts of Interest to Participants in Biomedical Research: Effectiveness and Methodology.

    abstract::This research focuses on the analysis regarding disclosure of financial conflicts of interest (FCOI) after Gelsinger v. University of Pennsylvania (Penn). The main legal issue was that the participants did not have enough opportunity to make an autonomous decision about participating in the research because he was not...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章,评审

    doi:10.3346/jkms.2017.32.12.1910

    authors: Kim JS

    更新日期:2017-12-01 00:00:00

  • Corporeal blood gas changes according to duration of drug-induced prolonged erection.

    abstract::The corporeal blood gas changes in accordance with the duration of the prolonged erection which developed after intracorporeal pharmacotherapy with papaverine and phentolamine were investigated in 62 impotence patients. The picture of the corporeal blood taken from 15 psychogenic impotence patients (a control group) a...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.1993.8.3.202

    authors: Kim SC,Seo KK,Oh CH

    更新日期:1993-06-01 00:00:00

  • Effect of bilirubin on triglyceride synthesis in streptozotocin-induced diabetic nephropathy.

    abstract::We aimed to elucidate the effect of bilirubin on dyslipidemia and nephropathy in a diabetes mellitus (DM) type I animal model. Sprague-Dawley rats were separated into control, DM, and bilirubin-treated DM (Bil) groups. The Bil group was injected intraperitoneally with 60 mg/kg bilirubin 3 times per week and hepatoma c...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2014.29.S2.S155

    authors: Xu J,Lee ES,Baek SH,Ahn SY,Kim S,Na KY,Chae DW,Chin HJ

    更新日期:2014-09-01 00:00:00

  • Association of Fatty Acid Ethyl Esters in Meconium of Neonates with Growth Deficits at Birth: a Prospective, Single-Centre Cohort Study.

    abstract:Background:In this prospective cohort study, we investigated the association between fatty acid ethyl esters (FAEEs) in meconium as biomarkers of prenatal ethanol exposure and growth deficits, as birth outcomes, that constitute several of the key cardinal features of fetal alcohol syndrome. Methods:A total of 157 meco...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2018.33.e318

    authors: Lee HS,Kim YH,Kwak HS,Han JY,Jo SJ,Lee HK

    更新日期:2018-11-15 00:00:00

  • Cancer in patients on chronic dialysis in Korea.

    abstract::The study of cancer in patients treated with dialysis in Korea has not been reported. The aim of this study was to investigate the incidence and mortality of cancer among patients on dialysis in Korea. The study subjects were 106 cancer patients (2.3%) out of 4,562 end-stage renal disease (ESRD) patients maintained on...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2009.24.S1.S95

    authors: Lee JE,Han SH,Cho BC,Park JT,Yoo TH,Kim BS,Park HC,Kang SW,Lee HY,Han DS,Ha SK,Choi KH

    更新日期:2009-01-01 00:00:00

  • Process of Obtaining Social Consensus and 3-Year Functional Outcomes of the First Hand Allotransplantation in Korea.

    abstract:BACKGROUND:On February 2, 2017, the surgical team of ten board-certified hand specialists of W Hospital in Korea successfully performed the nation's first hand transplantation at Yeungnam University Medical Center (YUMC). This paper reports on the legal, financial, and cultural hurdles that were overcome to open the wa...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2021.36.e6

    authors: Woo SH,Kim YW,Cheon HJ,Jang S,Do JY,Choi JH,Kang DH,Nam HJ,Yoo MJ,Lee YS,Choi JH

    更新日期:2021-01-11 00:00:00

  • Antiviral Efficacy of Tenofovir Monotherapy in Children with Nucleos(t)ide-naive Chronic Hepatitis B.

    abstract:BACKGROUND:The purpose was to compare the efficacy between tenofovir disoproxil fumarate (TDF) and lamivudine (LMV) in children with nucleos(t)ide-naive chronic hepatitis B (CHB) infection. Patients with CHB were treated with TDF in the immune-reactive phase and compared with a historical control group of patients trea...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2018.33.e11

    authors: Choe JY,Ko JS,Choe BH,Kim JE,Kang B,Lee KJ,Yang HR

    更新日期:2018-01-08 00:00:00

  • Patterns of neutropenia and risk factors for febrile neutropenia of diffuse large B-cell lymphoma patients treated with rituximab-CHOP.

    abstract::Febrile neutropenia (FN) is the major toxicity of rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) regimen in the treatment of diffuse large B-cell lymphoma (DLBCL). The prediction of neutropenia and FN is mandatory to continue the planned R-CHOP therapy resulting in successful anti-c...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2014.29.11.1493

    authors: Choi YW,Jeong SH,Ahn MS,Lee HW,Kang SY,Choi JH,Jin UR,Park JS

    更新日期:2014-11-01 00:00:00

  • p53 protein expression and its prognostic importance in patients with nodal non-Hodgkin's lymphoma.

    abstract::To determine whether the p53 expression might be a predictor for treatment response and overall survival in nodal non-Hodgkin's lymphoma (NHL), we analyzed the expression of p53 in 69 NHL patients. p53 protein expression was analyzed by immunohistochemistry with long-term follow up (1-148 months: median 12.2). p53 exp...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2000.15.1.59

    authors: Ahn MJ,Kim H,Kim IS,Park JK,Ki MR,Park CK

    更新日期:2000-02-01 00:00:00

  • Recent Trend and Associated Factors of Harmful Alcohol Use Based on Age and Gender in Korea.

    abstract:BACKGROUND:Previous studies suggest that the impact of social factors on harmful alcohol use between men and women may be different. We aimed to explore the gender-based difference in temporal trend and social risk factors associated with harmful alcohol use. METHODS:The Korea National Health and Nutrition Examination...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2018.33.e23

    authors: Choe SA,Yoo S,JeKarl J,Kim KK

    更新日期:2018-01-22 00:00:00

  • Hepatitis A in Korea from 2011 to 2013: Current Epidemiologic Status and Regional Distribution.

    abstract::The hepatitis A virus (HAV) has been the leading cause of viral hepatitis in Korea since the 2000s. We aimed to describe the current status and regional differences in hepatitis A incidence. We studied the total number of hepatitis A cases reported to the Korea Centers for Disease Control and Prevention through the Na...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2016.31.1.67

    authors: Moon S,Han JH,Bae GR,Cho E,Kim B

    更新日期:2016-01-01 00:00:00

  • Comparison of ertapenem and ceftriaxone therapy for acute pyelonephritis and other complicated urinary tract infections in Korean adults: a randomized, double-blind, multicenter trial.

    abstract::The efficacy and safety of ertapenem, 1 g once daily, were compared with that of ceftriaxone, 2 g once daily, for the treatment of adults with acute pyelonephritis (APN) and complicated urinary tract infections (cUTIs) in a prospective, multicenter, double-blinded, randomized study. After ≥ 3 days of parenteral study ...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.3346/jkms.2012.27.5.476

    authors: Park DW,Peck KR,Chung MH,Lee JS,Park YS,Kim HY,Lee MS,Kim JY,Yeom JS,Kim MJ

    更新日期:2012-05-01 00:00:00

  • Prevalences and Management of Diabetes and Pre-diabetes among Korean Teenagers and Young Adults: Results from the Korea National Health and Nutrition Examination Survey 2005-2014.

    abstract::The rapid increases in childhood obesity and physical inactivity are linked to the incidence of diabetes among young individuals. However, few studies have evaluated the prevalence of diabetes among this population. Therefore, we used Korea National Health and Nutrition Examination Survey (KNHANES) data to evaluate th...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2017.32.12.1984

    authors: Cho EH,Shin D,Cho KH,Hur J

    更新日期:2017-12-01 00:00:00

  • Microarray analysis of thyroid stimulating hormone, insulin-like growth factor-1, and insulin-induced gene expression in FRTL-5 thyroid cells.

    abstract::To determine which genes are regulated by thyroid stimulating hormone (thyrotropin, TSH), insulin and insulin-like growth factor-1 (IGF-1) in the rat thyroid, we used the microarray technology and observed the changes in gene expression. The expressions of genes for bone morphogenetic protein 6, the glucagon receptor,...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2007.22.5.883

    authors: Lee YJ,Park DJ,Shin CS,Park KS,Kim SY,Lee HK,Park YJ,Cho BY

    更新日期:2007-10-01 00:00:00

  • The role of keratinocyte-derived chemokine in hemorrhage-induced acute lung injury in mice.

    abstract::Dominant inflammatory cytokines might be different depending on the underlying causes of acute lung injury (ALI). The role of kertinocyte-derived chemokine (KC), a potent chemoattractant for neutrophils, has not been clearly established in hemorrhage-induced ALI. In this study, lung injury and cytokine expression were...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2009.24.5.775

    authors: Lee BH,Lee TJ,Jung JW,Oh DJ,Choi JC,Shin JW,Park IW,Choi BW,Kim JY

    更新日期:2009-10-01 00:00:00

  • Serologically diagnosed Lyme disease manifesting erythema migrans in Korea.

    abstract::Lyme disease is a vector-borne infection, primarily transmitted by Ixodes ticks, and caused by Borrelia burgdorferi. It has a wide distribution in the northern hemisphere. In Korea, however, only one human case has been reported, although B. burgdorferi was isolated from the vector tick I. persulcatus in the region. A...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.1999.14.1.85

    authors: Kim TH,Choi EH,Lee MG,Ahn SK

    更新日期:1999-02-01 00:00:00

  • Clinical Perspectives of Parkinson's Disease for Ophthalmologists, Otorhinolaryngologists, Cardiologists, Dentists, Gastroenterologists, Urologists, Physiatrists, and Psychiatrists.

    abstract::Parkinson's disease (PD) is a multisystemic disorder characterized by various non-motor symptoms (NMS) in addition to motor dysfunction. NMS include sleep, ocular, olfactory, throat, cardiovascular, gastrointestinal, genitourinary, or musculoskeletal disorders. A range of NMS, particularly hyposmia, sleep disturbances...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章,评审

    doi:10.3346/jkms.2020.35.e230

    authors: Choi JH,Kim JM,Yang HK,Lee HJ,Shin CM,Jeong SJ,Kim WS,Han JW,Yoon IY,Song YS,Bae YJ

    更新日期:2020-07-20 00:00:00

  • A case of adult-onset Still's disease complicated with diffuse alveolar hemorrhage.

    abstract::Adult-onset Still's disease (AOSD) is an inflammatory disease that presents with a variety of clinical symptoms. Pulmonary involvement is well-known in AOSD and is seen in up to 53% of AOSD cases, with the most common pulmonary diseases being pleural effusion and transient pulmonary infiltrates. We present the first c...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2009.24.1.155

    authors: Sari I,Birlik M,Binicier O,Akar S,Yilmaz E,Onen F,Akkoc N

    更新日期:2009-02-01 00:00:00

  • Asymptomatic infection by Streptococcus pyogenes in schoolchildren and diagnostic usefulness of antideoxyribonuclease B.

    abstract::This study is designed to evaluate the immune status of schoolchildren with respect to Streptococcus pyogenes, and to ascertain the usefulness of antideoxyribonuclease B (ADNase B). Antistreptolysin O (ASO) and ADNase B concentrations were measured quantitatively in 266 serum samples from healthy elementary school chi...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2005.20.6.938

    authors: Kim S,Lee NY

    更新日期:2005-12-01 00:00:00

  • Time to Disease Recurrence Is a Predictor of Metastasis and Mortality in Patients with High-risk Prostate Cancer Who Achieved Undetectable Prostate-specific Antigen Following Robot-assisted Radical Prostatectomy.

    abstract:Background:Robot-assisted radical prostatectomy (RARP) is a feasible treatment option for high-risk prostate cancer (PCa). While patients may achieve undetectable prostate-specific antigen (PSA) levels after RARP, the risk of disease progression is relatively high. We investigated metastasis-free survival, cancer-speci...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2018.33.e285

    authors: Kim DK,Koo KC,Lee KS,Hah YS,Rha KH,Hong SJ,Chung BH

    更新日期:2018-10-16 00:00:00

  • Erratum: correction of prevalence of falls by sex in article 'risk factors for falls in older korean adults: the 2011 community health survey'.

    abstract::[This corrects the article on p. 1482 in vol. 29, PMID: 25408578.]. ...

    journal_title:Journal of Korean medical science

    pub_type: 已发布勘误

    doi:10.3346/jkms.2015.30.1.117

    authors: Choi EJ,Kim SA,Kim NR,Rhee JA,Yun YW,Shin MH

    更新日期:2015-01-01 00:00:00