Abstract:
:Recommended infant vaccination in Korea includes DTaP-IPV and Hib vaccines administered as separate injections. In this randomized, open, controlled study we assessed the non-inferiority of immunogenicity of DTaP-IPV//Hib pentavalent combination vaccine (Pentaxim™) compared with licensed DTaP-IPV and Hib (PRP~T) vaccines. We enrolled 418 healthy Korean infants to receive either separate DTaP-IPV and Hib vaccines (n = 206) or the pentavalent DTaP-IPV//Hib (n = 208) vaccine at 2, 4, 6 months of age. Antibodies to all components were measured before the first vaccination and one month after the third, and safety was assessed after each vaccination including recording of reactions by parents. We confirmed the non-inferiority of DTaP-IPV//Hib compared with DTaP-IPV and Hib vaccines; 100% of both groups achieved seroprotection against D, T, IPV and PRP~T, and 97.5%-99.0% demonstrated seroresponses to pertussis antigens. Antibody levels were similar in both groups, except for those to the Hib component, PRP~T. In separate and combined groups geometric mean concentrations of anti-PRP~T antibodies were 23.9 and 11.0 μg/mL, respectively, but 98.3% and 97.4% had titers ≥ 1 μg/mL, indicative of long-term protection. All vaccines were well tolerated, with no vaccine-related serious adverse event. Both groups had similar safety profiles, but the combined vaccine group had fewer injection site reactions. The immunological non-inferiority and similar safety profile of DTaP-IPV//Hib vaccine to separate DTaP-IPV and Hib vaccines, with the advantage of fewer injections and injection site reactions, supports the licensure and incorporation of DTaP-IPV//Hib into the Korean national vaccination schedule (Clinical trial registry, NCT01214889).
journal_name
J Korean Med Scijournal_title
Journal of Korean medical scienceauthors
Kang JH,Lee HJ,Kim KH,Oh SH,Cha SH,Lee J,Kim NH,Eun BW,Kim CH,Hong YJ,Kim HH,Lee KY,Kim YJ,Cho EY,Kim HS,Guitton F,Ortiz Edoi
10.3346/jkms.2016.31.9.1383subject
Has Abstractpub_date
2016-09-01 00:00:00pages
1383-91issue
9eissn
1011-8934issn
1598-6357pii
31.1383journal_volume
31pub_type
临床试验,杂志文章,随机对照试验abstract::Allergen-specific immunotherapy (SIT) reduces allergen specific IgE (sIgE) levels and achieves clinical and immunological tolerance by modulating innate and adaptive immunological responses. Increased temperature and CO2 concentrations caused by climate changes contribute to an increase of pollen count and allergenici...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2014.29.7.1025
更新日期:2014-07-01 00:00:00
abstract::A collision tumor is defined by the presence of two separate masses in one organ, which are pathologically distinct. We described a 70-yr-old patient who complained of abnormal vaginal bleeding with a collision tumor of the uterine corpus. The patient received total hysterectomy, bilateral salphingo-oophorectomy, bila...
journal_title:Journal of Korean medical science
pub_type: 杂志文章,评审
doi:10.3346/jkms.2012.27.1.89
更新日期:2012-01-01 00:00:00
abstract::A case of aneurysmal ("angiomatoid") fibrous histiocytoma (AFH) in a 12-year-old girl is presented with its unusual clinicopathologic features. The lesion had the full microscopic characteristics of AFH described in prior reports, but it also had some features that differed from the original description of the disorde...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.1989.4.4.159
更新日期:1989-12-01 00:00:00
abstract::The incidence of lower gastrointestinal bleeding (LGIB) is increasing; however, predictors of outcomes for patients with LGIB are not as well defined as those for patients with upper gastrointestinal bleeding (UGIB). The aim of this study was to identify the clinical outcomes and the predictors of poor outcomes for pa...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2016.31.10.1611
更新日期:2016-10-01 00:00:00
abstract::Constructing a bone marrow chimera prior to graft transplantation can induce donor-specific immune tolerance. Mixed chimerism containing hematopoietic cells of both recipient- and donor-origin has advantages attributed from low dose of total body irradiation. In this study, we explored the mechanism of mixed chimerism...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2013.28.12.1723
更新日期:2013-12-01 00:00:00
abstract::Erysipelothrix rhusiopathiae is known as a pathogen of occupational diseases or a zoonosis. We report a case of E. rhusiopathiae peritonitis in a 50-yr-old male undergoing continuous ambulatory peritoneal dialysis (CAPD). He was suffered from mild abdominal pain with a distinctive erysipeloid skin lesion. E. rhusiopat...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2010.25.8.1234
更新日期:2010-08-01 00:00:00
abstract::Novel coronavirus (SARS-CoV-2) is found to cause a large outbreak started from Wuhan since December 2019 in China and SARS-CoV-2 infections have been reported with epidemiological linkage to China in 25 countries until now. We isolated SARS-CoV-2 from the oropharyngeal sample obtained from the patient with the first l...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2020.35.e84
更新日期:2020-02-24 00:00:00
abstract::A series of five endodermal sinus tumors was studied for their cytoskeletal and other phenotypic markers. They included 2 ovarian, 2 testicular, and 1 inguinal tumors. The cytoskeletal expression was also studied by gel electrophoresis and immunoblotting. Every tumor was diffusely and strongly immunostained for cytoke...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.1994.9.2.93
更新日期:1994-04-01 00:00:00
abstract::Lymphomatoid granulomatosis usually presents as a primary lung affliction with secondary metastatic spread to the central nervous system(CNS), and its initial manifestation purely as a CNS disease is rare. A 57-year-old man with histologically proven lymphomatoid granulomatosis of the brain as the sole manifestation o...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.1991.6.3.255
更新日期:1991-09-01 00:00:00
abstract::Because the spleen is likely to play a specific role in immunity, we have tried to observe the influence of the abdominal neoplasms on splenic lymphoid tissue as well as the distribution and localization of immunoregulatory cells with a special attention to the marginal zone, using splenectomy specimens in the various...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.1994.9.3.230
更新日期:1994-06-01 00:00:00
abstract::This study evaluated the value of procalcitonin (PCT) levels in pleural effusion to differentiate the etiology of parapneumonic effusion (PPE). Forty-one consecutive PPE patients were enrolled and were divided into bacterial and non-bacterial PPE. Blood and pleural effusion samples were collected for PCT measurement o...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2009.24.3.398
更新日期:2009-06-01 00:00:00
abstract:Background:To date, there have been few reports on the nationwide population-based epidemiology of Dupuytren's disease (DD). We investigated the prevalence and incidence of DD in Korea using the large dataset provided by the Korean Health Insurance Review and Assessment Service. This study is the second nationwide epid...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2018.33.e204
更新日期:2018-06-18 00:00:00
abstract::A button battery inserted in the nose of children is an unusual foreign body which is capable of causing extensive tissue damage, resulting from electrical and chemical burns. We report a case of button battery in the nose of a 4-year-old boy presenting with unilateral nasal discharge, and necrosis in the septum and t...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.1999.14.2.210
更新日期:1999-04-01 00:00:00
abstract::Hallervorden-Spatz syndrome (HSS) is a heredodegenerative disorder characterized by both progressive pyramidal and extrapyramidal signs, dysarthric speech, and mental deterioration. No diagnostic biochemical test is yet available, and diagnosis of HSS can be confirmed only at autopsy by the characteristic neuropatholo...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.1993.8.5.329
更新日期:1993-10-01 00:00:00
abstract:Background:We described a novel multi-step retinal fundus image reading system for providing high-quality large data for machine learning algorithms, and assessed the grader variability in the large-scale dataset generated with this system. Methods:A 5-step retinal fundus image reading tool was developed that rates im...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2018.33.e239
更新日期:2018-08-08 00:00:00
abstract::Situs inversus totalis is a rare anomaly in which the abdominal and thoracic cavity structures are opposite their usual positions. A 41-yr-old woman, who had an ulcerating cancer on the rectum, was found as a case of situs inversus totalis. We present an overview of the operative technique for the first documented lap...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2010.25.5.790
更新日期:2010-05-01 00:00:00
abstract::Vivax malaria was endemic on the Korean peninsula for many centuries until the late 1970's when the Republic of Korea (ROK) was declared "malaria free". Since its re-emergence in 1993, the number of malaria cases in the military increased exponentially through 2000 near the demilitarized zone. Chemoprophylaxis with ch...
journal_title:Journal of Korean medical science
pub_type: 临床试验,杂志文章
doi:10.3346/jkms.2005.20.5.707
更新日期:2005-10-01 00:00:00
abstract::Seasonal influenza is a significant cause of morbidity and mortality of children in Korea. However, few data are available on parental perception and action toward childhood influenza. This study aimed to characterize parental perception and patterns of action in response to influenza and influenza-like illnesses (ILI...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2017.32.2.204
更新日期:2017-02-01 00:00:00
abstract::We determined the relationship between the progression of immunoglobulin A nephropathy (IgAN) and the A1818T polymorphism in intron 2 of Angiotensin II type 2 receptor (AT2R) gene, which might play protective roles in the pathogenesis of IgAN. Patients with biopsy-proven IgAN were recruited from the registry of the Pr...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2009.24.S1.S38
更新日期:2009-01-01 00:00:00
abstract::The objective of this study was to develop a Korean version of the Assessment of Spondyloarthritis International Society-Health Index/Environmental Factor (ASAS HI/EF) and to evaluate its reliability and validity in Korean patients with axial spondyloarthritis (SpA). A total of 43 patients participated. Translation an...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2014.29.3.334
更新日期:2014-03-01 00:00:00
abstract::We reviewed dinical, histological and ultrastructural findings of 124 cases of sural nerve biopsy specimens to delineate the trends of peripheral nerve diseases in our institute. Eighty-one were men and 43 were women. We categorized them into five groups: specific diagnosis (66 cases, 53.2%), axonal degeneration type ...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2000.15.2.211
更新日期:2000-04-01 00:00:00
abstract::We evaluated the prevalence and risk factors for early age-related macular degeneration (AMD) in Koreans 50 yr of age or older who were examined at a single health promotion center. We retrospectively reviewed the records of 10,449 subjects who visited the center over a 6-month period. Fundus photography was performed...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2012.27.5.537
更新日期:2012-05-01 00:00:00
abstract::This is the first case of human cyclosporiasis reported in Korea. We detected the oocyst of Cyclospora cayetanensis from a 14-yr old girl who complained of persistent diarrhea after traveling to Indonesia. Round oocysts sized about 8 to 9 m with wrinkle on the wall were found in modified acid fast stained stool specim...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2003.18.5.738
更新日期:2003-10-01 00:00:00
abstract:BACKGROUND:Invasive Streptococcus agalactiae (group B streptococcus, GBS) infection most commonly occurs in infants; however, cases of GBS infection in adults, particularly in the elderly with significant underlying diseases, are being increasingly reported. We analyzed the serotype specific opsonophagocytic antibodies...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2018.33.e127
更新日期:2018-04-16 00:00:00
abstract::Placenta increta is an uncommon and life-threatening complication of pregnancy characterized by complete or partial absence of the decidua basalis. Placenta increta usually presents with vaginal bleeding during difficult placental removal in the third-trimester. Although placenta increta may complicate first and early...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2007.22.5.932
更新日期:2007-10-01 00:00:00
abstract::Bronchiolitis obliterans organizing pneumonia (BOOP) is a clinicopathological syndrome associated with a variety of disease entities. The aim of this study was to review cases with initial diagnosis of BOOP applying uniform histopathologic criteria, and analyze the clinical characteristics of proven cases of BOOP incl...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2002.17.2.179
更新日期:2002-04-01 00:00:00
abstract::Miyoshi myopathy (MM) is an autosomal recessive distal muscular dystrophy caused by mutations in the dysferlin gene (DYSF) on chromosome 2p13. Although MM patients and their mutations in the DYSF gene have been found from all over the world, there is only one report of genetically confirmed case of MM in Korea. Recent...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2006.21.4.724
更新日期:2006-08-01 00:00:00
abstract::Tumor necrosis factor-Related Apoptosis-Inducing Ligand (TRAIL) has been reported to specifically kill malignant cells but to be relatively nontoxic to normal cells. One of disadvantages to previous in vivo protocols was the need for large quantities of TRAIL recombinant protein to suppress tumor growth. To evaluate t...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2005.20.6.1046
更新日期:2005-12-01 00:00:00
abstract::This study aimed to evaluate the clinical profiles, antibiotic susceptibility, risk factors of multi-drug resistance (MDR) and outcomes of P. aeruginosa bacteremia in children by retrospective methods at a tertiary teaching children's hospital in Seoul, Korea during 2000-2009. A total of 62 episodes were evaluated and...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2011.26.5.612
更新日期:2011-05-01 00:00:00
abstract::A patient with renal cell carcinoma (RCC) developed synchronous bone metastasis with metachronous relapses to the bone and renal fossa. The primary lesion was initially removed surgically, and the metastatic bone lesions and locally recurrent tumours were treated by a high-fractional dose and high-total-dose intensity...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2008.23.4.740
更新日期:2008-08-01 00:00:00