Necrotizing lymphadenitis--a clinico-pathologic study of 36 cases with immunohistochemical analysis.

Abstract:

:Thirty-six cases of necrotizing lymphadenitis--including 33 cases of unknown etiology, 1 typhoid lymphadenopathy, and 2 cases of suspicious lupus lymphadenopathy--were clinico-pathologically reviewed and analyzed with immunostaining for s-100 and lysozyme. All cases histologically showed architectural effacement by paracortical lesions composed of nuclear karyorrhexis and mononuclear cell proliferation. Immunohistochemical study revealed proliferation of lysozyme-positive macrophages in the necrotizing areas and an increase in the number of s-100-positive cells in the uninvolved paracortical areas. This observation suggests that necrotizing lymphadenitis may be a common morphologic expression of a T cell-mediated hyperimmune condition induced by diverse etiologies.

journal_name

J Korean Med Sci

authors

Cho KJ,Kim CW,Park SH,Lee SK

doi

10.3346/jkms.1991.6.1.55

subject

Has Abstract

pub_date

1991-03-01 00:00:00

pages

55-61

issue

1

eissn

1011-8934

issn

1598-6357

journal_volume

6

pub_type

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