Abstract:
:The combined use of a drug-eluting balloon (DEB) and a bare metal stent (BMS) for the treatment of de novo non-small vessel coronary artery diseases (CAD) remains to be evaluated. We investigated the efficacy of a sequential treatment using a DEB together with a BMS implantation in comparison to a zotarolimus-eluting stent (ZES). This study was a prospective, randomized, open-label study. We designed it to demonstrate the non-inferiority of a sequential treatment using a DEB first followed by a BMS (DEB + BMS) compared with the use of a ZES. The primary endpoint was in-segment late loss (LL) at 9 months measured by quantitative coronary angiography (QCA). A total of 180 patients were enrolled in the study. The 9-month follow-up angiography was performed in 72 patients with DEB + BMS and 74 patients with ZES. When comparing the DEB + BMS results with the ZES ones, LL was 0.50 ± 0.46 mm in DEB + BMS patients vs. 0.21 ± 0.44 mm in ZES patients (P < 0.001). The mean difference of the LL was 0.31 mm, which was larger than the prespecified non-inferiority margin of 0.19 mm, and the 2-sided 95% confidence interval was 0.15-0.48. The clinical outcomes were not significantly different. In conclusion, the DEB + BMS strategy is inferior to the ZES one in terms of the LL result at 9 months. The DEB strategy for de novo coronary artery lesions needs to be improved for it to become an alternative treatment option.
journal_name
J Korean Med Scijournal_title
Journal of Korean medical scienceauthors
Chae IH,Yoon CH,Park JJ,Oh IY,Suh JW,Cho YS,Youn TJ,Choi DJdoi
10.3346/jkms.2017.32.6.933subject
Has Abstractpub_date
2017-06-01 00:00:00pages
933-941issue
6eissn
1011-8934issn
1598-6357pii
32.933journal_volume
32pub_type
杂志文章,随机对照试验abstract::Placenta increta is an uncommon and life-threatening complication of pregnancy characterized by complete or partial absence of the decidua basalis. Placenta increta usually presents with vaginal bleeding during difficult placental removal in the third-trimester. Although placenta increta may complicate first and early...
journal_title:Journal of Korean medical science
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journal_title:Journal of Korean medical science
pub_type: 临床试验,杂志文章
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abstract::To compare the mediator releasability between atopic and nonatopic asthmatics, we measured basophil histamine releasability (BaHR) using a calcium-ionophore A23187 and anti-IgE in 137 subjects who were treated at Seoul National University Hospital. Subjects were categorized into atopic (group AA, n=77) or nonatopic as...
journal_title:Journal of Korean medical science
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journal_title:Journal of Korean medical science
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journal_title:Journal of Korean medical science
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doi:10.3346/jkms.2020.35.e407
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pub_type: 杂志文章
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journal_title:Journal of Korean medical science
pub_type: 杂志文章
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journal_title:Journal of Korean medical science
pub_type: 杂志文章
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更新日期:2006-10-01 00:00:00
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journal_title:Journal of Korean medical science
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journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.1998.13.6.676
更新日期:1998-12-01 00:00:00
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journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2006.21.3.577
更新日期:2006-06-01 00:00:00
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journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.1995.10.3.155
更新日期:1995-06-01 00:00:00
abstract::Vascular endothelial growth factor (VEGF) is a multi-functional cytokine involved in inflammation, repair and angiogenesis in asthmatic airway. This study aimed to evaluate the role of VEGF in immediate bronchoconstriction induced by TDI inhalation, and in chronic TDI-asthma patients. 11 newly diagnosed TDI-asthma pat...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
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journal_title:Journal of Korean medical science
pub_type: 杂志文章
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journal_title:Journal of Korean medical science
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journal_title:Journal of Korean medical science
pub_type: 杂志文章
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journal_title:Journal of Korean medical science
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pub_type: 杂志文章,评审
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journal_title:Journal of Korean medical science
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journal_title:Journal of Korean medical science
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abstract::This study investigated the patterns of alcohol disorder comorbidity with other psychiatric disorders, using Korean nationwide epidemiological data. By two-stage cluster sampling, 5,176 adult household residents of Korea were interviewed using the Korean version of the Diagnostic Interview Schedule. Psychiatric disord...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
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journal_title:Journal of Korean medical science
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journal_title:Journal of Korean medical science
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abstract::Aim of this study was to compare the outcomes of transplantation by donor source and to help select the best alternative donor in children with leukemia. Donor sources included matched related donor (MRD, n = 35), allele-matched unrelated donor (M-UD, n = 10) or -mismatched (MM)-UD (n = 13) or unrelated umbilical cord...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
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journal_title:Journal of Korean medical science
pub_type: 杂志文章
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