Abstract:
:The [URE3] and [PSI(+)] prions are infectious amyloid forms of Ure2p and Sup35p. Several chaperones influence prion propagation: Hsp104p overproduction destabilizes [PSI(+)], whereas [URE3] is sensitive to excess of Ssa1p or Ydj1p. Here, we show that overproduction of the chaperone, Sse1p, can efficiently cure [URE3]. Sse1p and Fes1p are nucleotide exchange factors for Ssa1p. Interestingly, deletion of either SSE1 or FES1 completely blocked [URE3] propagation. In addition, deletion of SSE1 also interfered with [PSI(+)] propagation.
journal_name
Mol Biol Celljournal_title
Molecular biology of the cellauthors
Kryndushkin D,Wickner RBdoi
10.1091/mbc.e07-02-0128subject
Has Abstractpub_date
2007-06-01 00:00:00pages
2149-54issue
6eissn
1059-1524issn
1939-4586pii
E07-02-0128journal_volume
18pub_type
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