Induction of S. cerevisiae filamentous differentiation by slowed DNA synthesis involves Mec1, Rad53 and Swe1 checkpoint proteins.

abstract：:Recognition of surface-tethered antigens (Ags) by B-cells leads to the formation of an immune synapse that promotes Ag uptake for presentation onto MHC-II molecules. Extraction of immobilized Ags at the immune synapse of B-cells relies on the local secretion of lysosomes, which are recruited to the Ag contact site by ...

journal_title：Molecular biology of the cell

authors： Obino D,Diaz J,Sáez JJ,Ibañez-Vega J,Sáez PJ,Alamo M,Lankar D,Yuseff MI

更新日期：2017-04-01 00:00:00

abstract：:Sustained directional migration of epithelial cells is essential for regeneration of injured epithelia. Front-rear polarity of migrating cells is determined by local activation of a signaling network involving Cdc42 and other factors in response to spatial cues from the environment, the nature of which are obscure. We...

journal_title：Molecular biology of the cell

authors： Greciano PG,Moyano JV,Buschmann MM,Tang J,Lu Y,Rudnicki J,Manninen A,Matlin KS

更新日期：2012-01-01 00:00:00

abstract：:Discoidin I expression was used as a marker to screen for mutants affected in the growth-differentiation transition (GDT) of Dictyostelium. By REMI mutagenesis we have isolated mutant 2-9, an overexpressor of discoidin I. It displays normal morphogenesis but shows premature entry into the developmental cycle. The disr...

journal_title：Molecular biology of the cell

authors： Zeng C,Anjard C,Riemann K,Konzok A,Nellen W

更新日期：2000-05-01 00:00:00

abstract：:While lysosomes are degradative compartments and one of the defenses against invading pathogens, they are also hubs of metabolic activity. Late endocytic compartments accumulate around Plasmodium berghei liver-stage parasites during development, and whether this is a host defense strategy or active recruitment by the ...

journal_title：Molecular biology of the cell

authors： Petersen W,Stenzel W,Silvie O,Blanz J,Saftig P,Matuschewski K,Ingmundson A

更新日期：2017-03-15 00:00:00

abstract：:Vascular endothelial growth factor (VEGF, VEGF-A) is a major regulator of physiological and pathological angiogenesis. One feature of VEGF is the existence of multiple isoforms arising from alternative exon splicing. Our initial biochemical and biological studies indicated that such isoforms are uniquely suited to gen...

journal_title：Molecular biology of the cell

authors： Ferrara N

更新日期：2010-03-01 00:00:00

abstract：:Trafficking through the Golgi apparatus requires members of the Arf family of GTPases, whose activation is regulated by guanine nucleotide exchange factors (GEFs). Once activated, Arf-GTP recruits effectors such as coat complexes and lipid-modifying enzymes to specific membrane sites, creating a domain competent for c...

journal_title：Molecular biology of the cell

authors： Niu TK,Pfeifer AC,Lippincott-Schwartz J,Jackson CL

更新日期：2005-03-01 00:00:00

abstract：:Rapid alteration of gene expression in response to environmental changes is essential for normal development and behavior. The transcription factor hypoxia-inducible factor (HIF)-1 is well known to respond to alterations in oxygen availability. In nature, low oxygen environments are often found to contain high levels ...

journal_title：Molecular biology of the cell

authors： Budde MW,Roth MB

更新日期：2010-01-01 00:00:00

abstract：:Shroom (Shrm) proteins are essential regulators of cell shape and tissue morpho-logy during animal development that function by interacting directly with the coiled-coil region of Rho kinase (Rock). The Shrm-Rock interaction is sufficient to direct Rock subcellular localization and the subsequent assembly of contracti...

journal_title：Molecular biology of the cell

authors： Mohan S,Rizaldy R,Das D,Bauer RJ,Heroux A,Trakselis MA,Hildebrand JD,VanDemark AP

更新日期：2012-06-01 00:00:00

abstract：:Integrin alpha 3A cytoplasmic tail phosphorylation was mapped to amino acid S1042, as determined by mass spectrometry, and confirmed by mutagenesis. This residue occurs within a "QPSXXE" motif conserved in multiple alpha chains (alpha 3A, alpha 6A, alpha 7A), from multiple species. Phosphorylation of alpha 3A and alph...

journal_title：Molecular biology of the cell

authors： Zhang XA,Bontrager AL,Stipp CS,Kraeft SK,Bazzoni G,Chen LB,Hemler ME

更新日期：2001-02-01 00:00:00

abstract：:Microtubules are long, slender polymers of αβ-tubulin found in all eukaryotic cells. Tubulins associate longitudinally to form protofilaments, and adjacent protofilaments associate laterally to form the microtubule. In the textbook view, microtubules are 1) composed of 13 protofilaments, 2) arranged in a radial array ...

journal_title：Molecular biology of the cell

authors： Chaaban S,Brouhard GJ

更新日期：2017-11-01 00:00:00

abstract：:In response to stress conditions (such as nutrient limitation or accumulation of damaged organelles) and certain pathological situations, eukaryotic cells use autophagy as a survival mechanism. During nutrient stress the main purpose of autophagy is to degrade cytoplasmic materials within the lysosome/vacuole lumen an...

journal_title：Molecular biology of the cell

authors： Yang Z,Huang J,Geng J,Nair U,Klionsky DJ

更新日期：2006-12-01 00:00:00

abstract：:In addition to their well-known role in microtubule organization, centrosomes function as signaling platforms and regulate cell cycle events. An important example of such a function is the spindle position checkpoint (SPOC) of budding yeast. SPOC is a surveillance mechanism that ensures alignment of the mitotic spindl...

journal_title：Molecular biology of the cell

authors： Caydasi AK,Micoogullari Y,Kurtulmus B,Palani S,Pereira G

更新日期：2014-07-15 00:00:00

abstract：:Glucose is a master regulator of cell behavior in the yeast Saccharomyces cerevisiae. It acts as both a metabolic substrate and a potent regulator of intracellular signaling cascades. Glucose starvation induces the transient delocalization and then partial relocalization of clathrin adaptors at the trans-Golgi network...

journal_title：Molecular biology of the cell

authors： Aoh QL,Hung CW,Duncan MC

更新日期：2013-03-01 00:00:00

abstract：:Supplying the appropriate amount of correctly folded α/β-tubulin heterodimers is critical for microtubule dynamics. Formation of assembly-competent heterodimers is remarkably elaborate at the molecular level, in which the α- and β-tubulins are separately processed in a chaperone-dependent manner. This sequential step ...

journal_title：Molecular biology of the cell

authors： Mori R,Toda T

更新日期：2013-06-01 00:00:00

abstract：:Damaged DNA-binding protein 2 (DDB2), a nuclear protein, participates in both nucleotide excision repair and mRNA transcription. The transcriptional regulatory function of DDB2 is significant in colon cancer, as it regulates metastasis. To characterize the mechanism by which DDB2 participates in transcription, we inve...

journal_title：Molecular biology of the cell

authors： Fantini D,Huang S,Asara JM,Bagchi S,Raychaudhuri P

更新日期：2017-01-01 00:00:00

abstract：:Small heat shock proteins (sHsps) bind destabilized proteins during cell stress and disease, but their physiological functions are less clear. We evaluated the impact of Hsp27, an sHsp expressed in airway epithelial cells, on the common protein misfolding mutant that is responsible for most cystic fibrosis. F508del cy...

journal_title：Molecular biology of the cell

authors： Ahner A,Gong X,Schmidt BZ,Peters KW,Rabeh WM,Thibodeau PH,Lukacs GL,Frizzell RA

更新日期：2013-01-01 00:00:00

abstract：:The inositol 1,4,5-trisphosphate receptor (IP3R) is an intracellular calcium channel involved in coupling cell membrane receptors to calcium signal transduction pathways within cells including endocrine cells. Several isoforms (I, II, and III) of IP3Rs have been identified, which are encoded by separate genes, and are...

journal_title：Molecular biology of the cell

authors： Nucifora FC Jr,Sharp AH,Milgram SL,Ross CA

更新日期：1996-06-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a leading cause of death worldwide. Using cDNA microarrays to characterize patterns of gene expression in HCC, we found consistent differences between the expression patterns in HCC compared with those seen in nontumor liver tissues. The expression patterns in HCC were also readily di...

journal_title：Molecular biology of the cell

authors： Chen X,Cheung ST,So S,Fan ST,Barry C,Higgins J,Lai KM,Ji J,Dudoit S,Ng IO,Van De Rijn M,Botstein D,Brown PO

更新日期：2002-06-01 00:00:00

abstract：:Treacher Collins syndrome (TCS) is an autosomal dominant disorder of craniofacial development caused by mutations in the gene TCOF1. Its gene product, treacle, consists mainly of a central repeat domain, which shows it to be structurally related to the nucleolar phosphoprotein Nopp140. Treacle remains mostly uncharact...

journal_title：Molecular biology of the cell

authors： Isaac C,Marsh KL,Paznekas WA,Dixon J,Dixon MJ,Jabs EW,Meier UT

更新日期：2000-09-01 00:00:00

abstract：:Precise chromosome transmission in cell division cycle is maintained by a number of genes. The attempt made in the present study was to isolate temperature-sensitive (ts) fission yeast mutants that display high loss rates of minichromosomes at permissive or semipermissive temperature (designated mis). By colony color ...

journal_title：Molecular biology of the cell

authors： Takahashi K,Yamada H,Yanagida M

更新日期：1994-10-01 00:00:00

abstract：:Clathrin-mediated endocytosis (CME) is the major mechanism for internalization in mammalian cells. CME initiates by recruitment of adaptors and clathrin to form clathrin-coated pits (CCPs). Nearly half of nascent CCPs abort, whereas others are stabilized by unknown mechanisms and undergo further maturation before pinc...

journal_title：Molecular biology of the cell

authors： Antonescu CN,Aguet F,Danuser G,Schmid SL

更新日期：2011-07-15 00:00:00

abstract：:WDR92 is a highly conserved WD-repeat protein that has been proposed to be involved in apoptosis and also to be part of a prefoldin-like cochaperone complex. We found that WDR92 has a phylogenetic signature that is generally compatible with it playing a role in the assembly or function of specifically motile cilia. To...

journal_title：Molecular biology of the cell

authors： Patel-King RS,King SM

更新日期：2016-04-15 00:00:00

abstract：:Repellents evoke growth cone turning by eliciting asymmetric, localized loss of actin cytoskeleton together with changes in substratum attachment. We have demonstrated that semaphorin-3A (Sema3A)-induced growth cone detachment and collapse require eicosanoid-mediated activation of protein kinase C epsilon (PKC epsilon...

journal_title：Molecular biology of the cell

authors： Gatlin JC,Estrada-Bernal A,Sanford SD,Pfenninger KH

更新日期：2006-12-01 00:00:00

abstract：:The fission yeast Mcs6-Mcs2-Pmh1 complex, homologous to metazoan Cdk7-cyclin H-Mat1, has dual functions in cell division and transcription: as a partially redundant cyclin-dependent kinase (CDK)-activating kinase (CAK) that phosphorylates the major cell cycle CDK, Cdc2, on Thr-167; and as the RNA polymerase (Pol) II c...

journal_title：Molecular biology of the cell

authors： Lee KM,Miklos I,Du H,Watt S,Szilagyi Z,Saiz JE,Madabhushi R,Penkett CJ,Sipiczki M,Bähler J,Fisher RP

更新日期：2005-06-01 00:00:00

abstract：:RIO proteins form a conserved family of atypical protein kinases. Humans possess three distinct RIO kinases-hRio1, hRio2, and hRio3, of which only hRio2 has been characterized with respect to its role in ribosomal biogenesis. Here we show that both hRio1 and hRio3, like hRio2, are associated with precursors of 40S rib...

journal_title：Molecular biology of the cell

authors： Widmann B,Wandrey F,Badertscher L,Wyler E,Pfannstiel J,Zemp I,Kutay U

更新日期：2012-01-01 00:00:00

abstract：:Clathrin-mediated endocytosis and phagocytosis are both selective surface internalization processes but have little known mechanistic similarity or interdependence. Here we show that the phosphotyrosine-binding (PTB) domain protein Ced-6, a well-established phagocytosis component that operates as a transducer of so-ca...

journal_title：Molecular biology of the cell

authors： Jha A,Watkins SC,Traub LM

更新日期：2012-05-01 00:00:00

abstract：:During their migration to the periphery, cranial neural crest cells (NCCs) are repulsed by an ErbB4-dependent cue(s) in the mesenchyme adjoining rhombomeres (r) 3 and 5, which are segmented hindbrain neuromeres. ErbB4 has many ligands, but which ligand functions in the above system has not yet been clearly determined....

journal_title：Molecular biology of the cell

authors： Hoshino H,Uchida T,Otsuki T,Kawamoto S,Okubo K,Takeichi M,Chisaka O

更新日期：2007-04-01 00:00:00

abstract：:Wnt signaling plays key roles in embryonic development and adult stem cell homeostasis and is altered in human cancer. Signaling is turned on and off by regulating stability of the effector β-catenin (β-cat). The multiprotein destruction complex binds and phosphorylates β-cat and transfers it to the SCF-TrCP E3-ubiqui...

journal_title：Molecular biology of the cell

authors： Schaefer KN,Pronobis MI,Williams CE,Zhang S,Bauer L,Goldfarb D,Yan F,Major MB,Peifer M

更新日期：2020-05-01 00:00:00

abstract：:Epidermolysis bullosa simplex associated with late-onset muscular dystrophy (EBS-MD) is an autosomal recessive disorder resulting from mutations in the plectin gene. The majority of these mutations occur within the large exon 31 encoding the central rod domain and leave the production of a low-level rodless plectin sp...

journal_title：Molecular biology of the cell

authors： Ketema M,Secades P,Kreft M,Nahidiazar L,Janssen H,Jalink K,de Pereda JM,Sonnenberg A

更新日期：2015-07-01 00:00:00

abstract：:Two cDNAs encoding casein kinase-1 have been isolated from a yeast cDNA library and termed CKI1 and CKI2. Each clone encodes a protein of approximately 62,000 Da containing a highly conserved protein kinase domain surrounded by variable amino- and carboxy-terminal domains. The proteins also contain two conserved carbo...

journal_title：Molecular biology of the cell

authors： Wang PC,Vancura A,Mitcheson TG,Kuret J

更新日期：1992-03-01 00:00:00