Phosphorylation of SNAP-23 at Ser95 causes a structural alteration and negatively regulates Fc receptor-mediated phagosome formation and maturation in macrophages.

abstract：:Vac8p is a vacuolar membrane protein that is required for efficient vacuole inheritance and fusion, cytosol-to-vacuole targeting, and sporulation. By analogy to other armadillo domain proteins, including beta-catenin and importin alpha, we hypothesize that Vac8p docks various factors at the vacuole membrane. Two-hybri...

journal_title：Molecular biology of the cell

authors： Pan X,Roberts P,Chen Y,Kvam E,Shulga N,Huang K,Lemmon S,Goldfarb DS

更新日期：2000-07-01 00:00:00

abstract：:Oncoprotein 18/stathmin (Op18) has been identified recently as a protein that destabilizes microtubules, but the mechanism of destabilization is currently controversial. Based on in vitro microtubule assembly assays, evidence has been presented supporting conflicting destabilization models of either tubulin sequestrat...

journal_title：Molecular biology of the cell

authors： Howell B,Larsson N,Gullberg M,Cassimeris L

更新日期：1999-01-01 00:00:00

abstract：:In cycling between the mammalian host and the tsetse fly vector, trypanosomes undergo major changes in energy metabolism and surface coat composition. Early procyclic (insect) forms in the tsetse fly midgut are coated by glycoproteins known as EP and GPEET procyclins. EP expression continues in late procyclic forms, w...

journal_title：Molecular biology of the cell

authors： Vassella E,Probst M,Schneider A,Studer E,Renggli CK,Roditi I

更新日期：2004-09-01 00:00:00

abstract：:Up-regulation of the cAMP pathway by forskolin or alpha-melanocyte stimulating hormone induces melanocyte and melanoma cell differentiation characterized by stimulation of melanin synthesis and dendrite development. Here we show that forskolin-induced dendricity is associated to a disassembly of actin stress fibers. S...

journal_title：Molecular biology of the cell

authors： Buscà R,Bertolotto C,Abbe P,Englaro W,Ishizaki T,Narumiya S,Boquet P,Ortonne JP,Ballotti R

更新日期：1998-06-01 00:00:00

abstract：:The skin's epidermis is a multilayered epithelial tissue and the first line of defense against mechanical stress. Its barrier function depends on an integrated assembly and reorganization of cell-matrix and cell-cell junctions in the basal layer and on different intercellular junctions in suprabasal layers. However, h...

journal_title：Molecular biology of the cell

authors： Noethel B,Ramms L,Dreissen G,Hoffmann M,Springer R,Rübsam M,Ziegler WH,Niessen CM,Merkel R,Hoffmann B

更新日期：2018-09-15 00:00:00

abstract：:Cyclin-dependent kinase (Cdk)2/cyclin E is imported into nuclei assembled in Xenopus egg extracts by a pathway that requires importin-alpha and -beta. Here, we identify a basic nuclear localization sequence (NLS) in the N-terminus of Xenopus cyclin E. Mutation of the NLS eliminated nuclear accumulation of both cyclin ...

journal_title：Molecular biology of the cell

authors： Moore JD,Kornbluth S,Hunt T

更新日期：2002-12-01 00:00:00

abstract：:Three mitochondrial DNA-encoded proteins, Cox1, Cox2, and Cox3, comprise the core of the cytochrome c oxidase complex. Gene-specific translational activators ensure that these respiratory chain subunits are synthesized at the correct location and in stoichiometric ratios to prevent unassembled protein products from ge...

journal_title：Molecular biology of the cell

authors： Roloff GA,Henry MF

更新日期：2015-08-15 00:00:00

abstract：:The membrane-trafficking pathway mediated by tetanus neurotoxin-insensitive vesicle-associated membrane protein (TI-VAMP) in neurons is still unknown. We show herein that TI-VAMP expression is necessary for neurite outgrowth in PC12 cells and hippocampal neurons in culture. TI-VAMP interacts with plasma membrane and e...

journal_title：Molecular biology of the cell

authors： Alberts P,Rudge R,Hinners I,Muzerelle A,Martinez-Arca S,Irinopoulou T,Marthiens V,Tooze S,Rathjen F,Gaspar P,Galli T

更新日期：2003-10-01 00:00:00

abstract：:The cation-dependent mannose 6-phosphate receptor (CD-MPR) mediates the transport of lysosomal enzymes from the trans-Golgi network to endosomes. Evasion of lysosomal degradation of the CD-MPR requires reversible palmitoylation of a cysteine residue in its cytoplasmic tail. Because palmitoylation is reversible and ess...

journal_title：Molecular biology of the cell

authors： Stöckli J,Rohrer J

更新日期：2004-06-01 00:00:00

abstract：:Mathematical modeling has been instrumental in identifying common principles of cell polarity across diverse systems. These principles include positive feedback loops that are required to destabilize a spatially uniform state of the cell. The conserved small G-protein Cdc42 is a master regulator of eukaryotic cellular...

journal_title：Molecular biology of the cell

authors： Goryachev AB,Leda M

更新日期：2017-02-01 00:00:00

abstract：:Tumor necrosis factor α (TNF-α) receptor-associated factor 2 (TRAF2) regulates activation of the c-Jun N-terminal kinase (JNK)/c-Jun and the inhibitor of κB kinase (IKK)/nuclear factor κB (NF-κB) signaling cascades in response to TNF-α stimulation. Gene knockout studies have revealed that TRAF2 inhibits TNF-α-induced ...

journal_title：Molecular biology of the cell

authors： Zhang L,Blackwell K,Altaeva A,Shi Z,Habelhah H

更新日期：2011-01-01 00:00:00

abstract：:Yeast cells, when exposed to stress, can enter a protective state in which cell division, growth, and metabolism are down-regulated. They remain viable in this state until nutrients become available again. How cells enter this protective survival state and what happens at a cellular and subcellular level are largely u...

journal_title：Molecular biology of the cell

authors： Marini G,Nüske E,Leng W,Alberti S,Pigino G

更新日期：2020-06-01 00:00:00

abstract：:Silica inhalation leads to the development of the chronic lung disease silicosis. Macrophages are killed by uptake of nonopsonized silica particles, and this is believed to play a critical role in the etiology of silicosis. However, the mechanism of nonopsonized-particle uptake is not well understood. We compared the ...

journal_title：Molecular biology of the cell

authors： Gilberti RM,Knecht DA

更新日期：2015-02-01 00:00:00

abstract：:Activation of the c-myc proto-oncogene by chromosomal translocation or proviral insertion frequently results in the separation of the c-myc coding region from its normal regulatory elements. Such rearrangements are often accompanied by loss or mutation of c-myc exon 1 sequences. These genetic alterations do not affect...

journal_title：Molecular biology of the cell

authors： Blackwood EM,Lugo TG,Kretzner L,King MW,Street AJ,Witte ON,Eisenman RN

更新日期：1994-05-01 00:00:00

abstract：:Thrombospondin (TSP) was demonstrated to inhibit the growth of bovine aortic endothelial cells, an activity that was not neutralized by antibodies to TSP or by other agents that block TSP-cell interactions but that partially was reversed by a neutralizing antibody to transforming growth factor-beta (TGF-beta). Similar...

journal_title：Molecular biology of the cell

authors： Murphy-Ullrich JE,Schultz-Cherry S,Höök M

更新日期：1992-02-01 00:00:00

abstract：:The gamma-tubulin ring complex (gammaTuRC), consisting of multiple protein subunits, can nucleate microtubule assembly. Although many subunits of the gammaTuRC have been identified, a complete set remains to be defined in any organism. In addition, how the subunits interact with each other to assemble into gammaTuRC r...

journal_title：Molecular biology of the cell

authors： Gunawardane RN,Martin OC,Zheng Y

更新日期：2003-03-01 00:00:00

abstract：:The Rab11 effector Rab11-family interacting protein 2 (Rab11-FIP2) regulates transcytosis through its interactions with Rab11a and myosin Vb. Previous studies implicated Rab11-FIP2 in the establishment of polarity in Madin-Darby canine kidney (MDCK) cells through phosphorylation of Ser-227 by MARK2. Here we examine th...

journal_title：Molecular biology of the cell

authors： Lapierre LA,Avant KM,Caldwell CM,Oztan A,Apodaca G,Knowles BC,Roland JT,Ducharme NA,Goldenring JR

更新日期：2012-06-01 00:00:00

abstract：:Mammalian mitochondrial ribosomes contain two prokaryotic-like rRNAs, 12S and 16S, both encoded by mitochondrial DNA. As opposed to cytosolic ribosomes, however, these ribosomes are not thought to contain 5S rRNA. For this reason, it has been unclear whether 5S rRNA, which can be detected in mitochondrial preparations...

journal_title：Molecular biology of the cell

authors： Magalhães PJ,Andreu AL,Schon EA

更新日期：1998-09-01 00:00:00

abstract：:Mechanical cues regulate the function of a broad range of stem cells in culture and in tissue. For example, soft substrates promote the neuronal differentiation of neural stem cells (NSCs) by suppressing cytoskeletal contractility. However, the mechanisms that link cytoskeletal signaling to the transcriptional regulat...

journal_title：Molecular biology of the cell

authors： Kang PH,Schaffer DV,Kumar S

更新日期：2020-03-01 00:00:00

abstract：:The split-ubiquitin technique was used to detect transient protein interactions in living cells. Nub, the N-terminal half of ubiquitin (Ub), was fused to Sec62p, a component of the protein translocation machinery in the endoplasmic reticulum of Saccharomyces cerevisiae. Cub, the C-terminal half of Ub, was fused to the...

journal_title：Molecular biology of the cell

authors： Dünnwald M,Varshavsky A,Johnsson N

更新日期：1999-02-01 00:00:00

abstract：:During their migration to the periphery, cranial neural crest cells (NCCs) are repulsed by an ErbB4-dependent cue(s) in the mesenchyme adjoining rhombomeres (r) 3 and 5, which are segmented hindbrain neuromeres. ErbB4 has many ligands, but which ligand functions in the above system has not yet been clearly determined....

journal_title：Molecular biology of the cell

authors： Hoshino H,Uchida T,Otsuki T,Kawamoto S,Okubo K,Takeichi M,Chisaka O

更新日期：2007-04-01 00:00:00

abstract：:The last steps of multivesicular body (MVB) formation, human immunodeficiency virus (HIV)-1 budding and cytokinesis require a functional endosomal sorting complex required for transport (ESCRT) machinery to facilitate topologically equivalent membrane fission events. Increased sodium tolerance (IST) 1, a new positive ...

journal_title：Molecular biology of the cell

authors： Agromayor M,Carlton JG,Phelan JP,Matthews DR,Carlin LM,Ameer-Beg S,Bowers K,Martin-Serrano J

更新日期：2009-03-01 00:00:00

abstract：:Vascular endothelial (VE)-cadherin, the major adherens junction adhesion molecule in endothelial cells, interacts with p120-catenin and β-catenin through its cytoplasmic tail. However, the specific functional contributions of the catenins to the establishment of strong adhesion are not fully understood. Here we use bi...

journal_title：Molecular biology of the cell

authors： Oas RG,Nanes BA,Esimai CC,Vincent PA,García AJ,Kowalczyk AP

更新日期：2013-03-01 00:00:00

abstract：:Members of the adenine nucleotide translocase (ANT) family exchange ADP for ATP across the mitochondrial inner membrane, an activity that is essential for oxidative phosphorylation (OXPHOS). Mutations in or dysregulation of ANTs is associated with progressive external ophthalmoplegia, cardiomyopathy, nonsyndromic inte...

journal_title：Molecular biology of the cell

authors： Lu YW,Acoba MG,Selvaraju K,Huang TC,Nirujogi RS,Sathe G,Pandey A,Claypool SM

更新日期：2017-06-01 00:00:00

abstract：:Lumen establishment and maintenance are fundamental for tubular organs physiological functions. Most of the studies investigating the mechanisms regulating this process have been carried out in cell cultures or in smaller organisms, whereas little has been done in mammalian model systems in vivo. Here we used the sali...

journal_title：Molecular biology of the cell

authors： Shitara A,Malec L,Ebrahim S,Chen D,Bleck C,Hoffman MP,Weigert R

更新日期：2019-02-01 00:00:00

abstract：:Laminin (LM)-332 is an extracellular matrix protein that plays a structural role in normal tissues and is also important in facilitating recovery of epithelia from injury. We have shown that expression of LM-332 is up-regulated during renal epithelial regeneration after ischemic injury, but the molecular signals that ...

journal_title：Molecular biology of the cell

authors： Moyano JV,Greciano PG,Buschmann MM,Koch M,Matlin KS

更新日期：2010-11-01 00:00:00

abstract：:The subcellular distribution of kinases and other signaling proteins is regulated in response to cellular cues; however, the extent of this regulation has not been investigated for any gene set in any organism. Here, we present a systematic analysis of protein kinases in the budding yeast, screening for differential l...

journal_title：Molecular biology of the cell

authors： Bharucha N,Ma J,Dobry CJ,Lawson SK,Yang Z,Kumar A

更新日期：2008-07-01 00:00:00

abstract：:Caenorhabditis elegans is a powerful model to study the molecular basis of autosomal dominant polycystic kidney disease (ADPKD). ADPKD is caused by mutations in the polycystic kidney disease (PKD)1 or PKD2 gene, encoding polycystin (PC)-1 or PC-2, respectively. The C. elegans polycystins LOV-1 and PKD-2 are required f...

journal_title：Molecular biology of the cell

authors： Hu J,Barr MM

更新日期：2005-02-01 00:00:00

abstract：:B cell antigen receptor (BCR) association with lipid rafts, the actin cytoskeleton, and clathrin-coated pits influences B cell signaling and antigen presentation. Although all three cellular structures have been separately implicated in BCR internalization, the relationship between them has not been clearly defined. I...

journal_title：Molecular biology of the cell

authors： Stoddart A,Jackson AP,Brodsky FM

更新日期：2005-05-01 00:00:00

abstract：:Tubulogenesis by epithelial cells regulates kidney, lung, and mammary development, whereas that by endothelial cells regulates vascular development. Although functionally dissimilar, the processes necessary for tubulation by epithelial and endothelial cells are very similar. We performed microarray analysis to further...

journal_title：Molecular biology of the cell

authors： Albig AR,Schiemann WP

更新日期：2005-02-01 00:00:00