Abstract:
:Telomere dysfunction results in fertility defects in a number of organisms. Although data from fission yeast and Caenorhabditis elegans suggests that telomere dysfunction manifests itself primarily as defects in proper meiotic chromosome segregation, it is unclear how mammalian telomere dysfunction results in germ cell death. To investigate the specific effects of telomere dysfunction on mammalian germ cell development, we examined the meiotic progression and germ cell apoptosis in late generation telomerase null mice. Our results indicate that chromosome asynapsis and missegregation are not the cause of infertility in mice with shortened telomeres. Rather, telomere dysfunction is recognized at the onset of meiosis, and cells with telomeric defects are removed from the germ cell precursor pool. This germ cell telomere surveillance may be an important mechanism to protect against the transmission of dysfunctional telomeres and chromosomal abnormalities.
journal_name
Mol Biol Celljournal_title
Molecular biology of the cellauthors
Hemann MT,Rudolph KL,Strong MA,DePinho RA,Chin L,Greider CWdoi
10.1091/mbc.12.7.2023keywords:
subject
Has Abstractpub_date
2001-07-01 00:00:00pages
2023-30issue
7eissn
1059-1524issn
1939-4586journal_volume
12pub_type
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journal_title:Molecular biology of the cell
pub_type: 杂志文章
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journal_title:Molecular biology of the cell
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journal_title:Molecular biology of the cell
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journal_title:Molecular biology of the cell
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journal_title:Molecular biology of the cell
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journal_title:Molecular biology of the cell
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doi:10.1091/mbc.E17-07-0446
更新日期:2018-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2002-02-01 00:00:00
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journal_title:Molecular biology of the cell
pub_type: 杂志文章
doi:10.1091/mbc.E17-03-0195
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abstract::Mutations in the cytolinker protein plectin lead to grossly distorted morphology of neuromuscular junctions (NMJs) in patients suffering from epidermolysis bullosa simplex (EBS)-muscular dystrophy (MS) with myasthenic syndrome (MyS). Here we investigated whether plectin contributes to the structural integrity of NMJs ...
journal_title:Molecular biology of the cell
pub_type: 杂志文章
doi:10.1091/mbc.E14-06-1174
更新日期:2014-12-15 00:00:00
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journal_title:Molecular biology of the cell
pub_type: 杂志文章
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journal_title:Molecular biology of the cell
pub_type: 杂志文章
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journal_title:Molecular biology of the cell
pub_type: 杂志文章
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journal_title:Molecular biology of the cell
pub_type: 杂志文章
doi:10.1091/mbc.e04-04-0350
更新日期:2004-12-01 00:00:00
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journal_title:Molecular biology of the cell
pub_type: 杂志文章
doi:10.1091/mbc.8.6.1117
更新日期:1997-06-01 00:00:00
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journal_title:Molecular biology of the cell
pub_type: 杂志文章
doi:10.1091/mbc.e03-06-0371
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pub_type: 杂志文章
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journal_title:Molecular biology of the cell
pub_type: 杂志文章
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journal_title:Molecular biology of the cell
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pub_type: 杂志文章
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journal_title:Molecular biology of the cell
pub_type: 杂志文章
doi:10.1091/mbc.E14-11-1552
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pub_type: 杂志文章
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journal_title:Molecular biology of the cell
pub_type: 杂志文章
doi:10.1091/mbc.E11-11-0927
更新日期:2012-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1091/mbc.3.11.1259
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journal_title:Molecular biology of the cell
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pub_type: 杂志文章
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journal_title:Molecular biology of the cell
pub_type: 杂志文章
doi:10.1091/mbc.e05-04-0272
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pub_type: 杂志文章
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