Transcriptional repression of hypoxia-inducible factor-1 (HIF-1) by the protein arginine methyltransferase PRMT1.

abstract：:Natural killer cells are lymphocytes specialized to participate in host defense through their innate ability to mediate cytotoxicity by secreting the contents of preformed secretory lysosomes (lytic granules) directly onto a target cell. This form of directed secretion requires the formation of an immunological synaps...

journal_title：Molecular biology of the cell

authors： Mentlik AN,Sanborn KB,Holzbaur EL,Orange JS

更新日期：2010-07-01 00:00:00

abstract：:The c-myb proto-oncogene product (c-Myb) regulates proliferation and differentiation of hematopoietic cells. Recently we have shown that c-Myb is degraded in response to Wnt-1 stimulation via a pathway involving TAK1 (TGF-beta-activated kinase), HIPK2 (homeodomain-interacting protein kinase 2), and NLK (Nemo-like kina...

journal_title：Molecular biology of the cell

authors： Kurahashi T,Nomura T,Kanei-Ishii C,Shinkai Y,Ishii S

更新日期：2005-10-01 00:00:00

abstract：:Mechanical cues regulate the function of a broad range of stem cells in culture and in tissue. For example, soft substrates promote the neuronal differentiation of neural stem cells (NSCs) by suppressing cytoskeletal contractility. However, the mechanisms that link cytoskeletal signaling to the transcriptional regulat...

journal_title：Molecular biology of the cell

authors： Kang PH,Schaffer DV,Kumar S

更新日期：2020-03-01 00:00:00

abstract：:Members of the transforming acidic coiled coil (TACC) protein family are emerging as important mitotic spindle assembly proteins in a variety of organisms. The molecular details of how TACC proteins function are unknown, but TACC proteins have been proposed to recruit microtubule-stabilizing proteins of the tumor over...

journal_title：Molecular biology of the cell

authors： Albee AJ,Wiese C

更新日期：2008-08-01 00:00:00

abstract：:In view of the common regulatory mechanism that induces transcription of the mitotic phosphatase cdc25C and cyclin A at the beginning of S-phase, we investigated whether cdc25C was required for S-phase transit. Here, we show that in both nontransformed human fibroblasts and HeLa cells, cdc25C protein levels significan...

journal_title：Molecular biology of the cell

authors： Turowski P,Franckhauser C,Morris MC,Vaglio P,Fernandez A,Lamb NJ

更新日期：2003-07-01 00:00:00

abstract：:The zona pellucida (ZP) is a highly organized extracellular coat that surrounds all mammalian eggs. The mouse egg ZP is composed of three glycoproteins, called mZP1-3, that are synthesized, secreted, and assembled into a ZP exclusively by growing oocytes. Here, we microinjected epitope-tagged (Myc and Flag) cDNAs for ...

journal_title：Molecular biology of the cell

authors： Qi H,Williams Z,Wassarman PM

更新日期：2002-02-01 00:00:00

abstract：:A primary cilium is found on most mammalian cells, where it acts as a cellular antenna for the reception of both mechanical and chemical signals. A variety of diseases are associated with defective ciliogenesis, reflecting the ubiquity of the function of cilia and the number of proteins required for their assembly. Pr...

journal_title：Molecular biology of the cell

authors： Copeland SJ,McRae A,Guarguaglini G,Trinkle-Mulcahy L,Copeland JW

更新日期：2018-07-01 00:00:00

abstract：:In budding yeast, spindle polarity relies on a precise temporal program of cytoplasmic microtubule-cortex interactions throughout spindle assembly. Loss of Clb5-dependent kinase activity under conditions of attenuated Cdc28 function disrupts this program, resulting in diploid-specific lethality. Here we show that pola...

journal_title：Molecular biology of the cell

authors： Segal M,Bloom K,Reed SI

更新日期：2000-11-01 00:00:00

abstract：:We report a new nuclear gene, designated ATP25 (reading frame YMR098C on chromosome XIII), required for expression of Atp9p (subunit 9) of the Saccharomyces cerevisiae mitochondrial proton translocating ATPase. Mutations in ATP25 elicit a deficit of ATP9 mRNA and of its translation product, thereby preventing assembly...

journal_title：Molecular biology of the cell

authors： Zeng X,Barros MH,Shulman T,Tzagoloff A

更新日期：2008-04-01 00:00:00

abstract：:Human neutrophils generally function adherent to an extracellular matrix. We have previously reported that upon adhesion to laminin- or fibronectin-coated, but not uncoated, plastic there is a depolymerization of actin in neutrophils. This phenomenon was not affected by inhibitors of the more well-studied components o...

journal_title：Molecular biology of the cell

authors： Wang JS,Coburn JP,Tauber AI,Zaner KS

更新日期：1997-01-01 00:00:00

abstract：:Blebs are involved in various biological processes such as cell migration, cytokinesis, and apoptosis. While the expansion of blebs is largely an intracellular pressure-driven process, the retraction of blebs is believed to be driven by RhoA activation that leads to the reassembly of the actomyosin cortex at the bleb ...

journal_title：Molecular biology of the cell

authors： Jiao M,Wu D,Wei Q

更新日期：2018-03-01 00:00:00

abstract：:The proper execution of premeiotic S phase is essential to both the maintenance of genomic integrity and accurate chromosome segregation during the meiotic divisions. However, the regulation of premeiotic S phase remains poorly defined in metazoa. Here, we identify the p21(Cip1)/p27(Kip1)/p57(Kip2)-like cyclin-depende...

journal_title：Molecular biology of the cell

authors： Narbonne-Reveau K,Lilly M

更新日期：2009-04-01 00:00:00

abstract：:Although some of the principles of N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) function are well understood, remarkably little detail is known about sec1/munc18 (SM) protein function and its relationship to SNAREs. Popular models of SM protein function hold that these proteins promote or main...

journal_title：Molecular biology of the cell

authors： Williams AL,Ehm S,Jacobson NC,Xu D,Hay JC

更新日期：2004-01-01 00:00:00

abstract：:We report the identification of Cdc7/Dbf4 phosphorylation sites in human MCM2 and the determination of the role of Cdc7/Dbf4 phosphorylation of MCM2 in the initiation of DNA replication. Using immunoblotting, immunofluorescence, and high-speed automated cell-imaging analyses with antibodies specific against MCM2 and C...

journal_title：Molecular biology of the cell

authors： Tsuji T,Ficarro SB,Jiang W

更新日期：2006-10-01 00:00:00

abstract：:The extracellular signal-regulated kinase (ERK) pathway is generally mitogenic, but, upon strong activation, it causes cell cycle arrest by a not-yet fully understood mechanism. In response to genotoxic stress, Chk1 hyperphosphorylates Cdc25A, a positive cell cycle regulator, and targets it for Skp1/Cullin1/F-box prot...

journal_title：Molecular biology of the cell

authors： Isoda M,Kanemori Y,Nakajo N,Uchida S,Yamashita K,Ueno H,Sagata N

更新日期：2009-04-01 00:00:00

abstract：:To further elucidate the functions of actin in budding yeast and to relate actin structure to specific roles and interactions in vivo, we determined the phenotypes caused by 13 charged-to-alanine mutations isolated previously in the single Saccharomyces cerevisiae actin gene. Defects in actin organization, morphogenes...

journal_title：Molecular biology of the cell

authors： Drubin DG,Jones HD,Wertman KF

更新日期：1993-12-01 00:00:00

abstract：:Phosphoinositide 3-kinases (PI3K) are key molecular players in male fertility. However, the specific roles of different p110 PI3K catalytic subunits within the spermatogenic lineage have not been characterized so far. Herein, we report that male mice expressing a catalytically inactive p110beta develop testicular hypo...

journal_title：Molecular biology of the cell

authors： Ciraolo E,Morello F,Hobbs RM,Wolf F,Marone R,Iezzi M,Lu X,Mengozzi G,Altruda F,Sorba G,Guan K,Pandolfi PP,Wymann MP,Hirsch E

更新日期：2010-03-01 00:00:00

abstract：:The yeast Golgi membrane protein Rer1p is required for the retrieval of various endoplasmic reticulum (ER) membrane proteins such as Sec12p and Sec71p to the ER. We demonstrate here that the transmembrane domain (TMD) of Sec71p, a type-III membrane protein, contains an ER localization signal, which is required for phy...

journal_title：Molecular biology of the cell

authors： Sato K,Sato M,Nakano A

更新日期：2003-09-01 00:00:00

abstract：:Signals conveyed through the RAS-ERK pathway are essential for the determination of cell fate. It is well established that signal variability is achieved in the different microenvironments in which signals unfold. It is also known that signal duration is critical for decisions concerning cell commitment. However, it i...

journal_title：Molecular biology of the cell

authors： Herrero A,Casar B,Colón-Bolea P,Agudo-Ibáñez L,Crespo P

更新日期：2016-06-15 00:00:00

abstract：:Insulin and hypertonicity each increase the content of GLUT4 glucose transporters at the surface of muscle cells. Insulin enhances GLUT4 exocytosis without diminishing its endocytosis. The insulin but not the hypertonicity response is reduced by tetanus neurotoxin, which cleaves vesicle-associated membrane protein (VA...

journal_title：Molecular biology of the cell

authors： Randhawa VK,Thong FS,Lim DY,Li D,Garg RR,Rudge R,Galli T,Rudich A,Klip A

更新日期：2004-12-01 00:00:00

abstract：:Mitochondrial dysfunction and altered transmembrane potential initiate a mitochondrial respiratory stress response, also known as mitochondrial retrograde response, in a wide spectrum of cells. The mitochondrial stress response activates calcineurin, which regulates transcription factors, including a new nuclear facto...

journal_title：Molecular biology of the cell

authors： Guha M,Pan H,Fang JK,Avadhani NG

更新日期：2009-09-01 00:00:00

abstract：:The cdc25 tyrosine phosphatase is known to activate cdc2 kinase in the G2/M transition by dephosphorylation of tyrosine 15. To determine how entry into M-phase in eukaryotic cells is controlled, we have investigated the regulation of the cdc25 protein in Xenopus eggs and oocytes. Two closely related Xenopus cdc25 gene...

journal_title：Molecular biology of the cell

authors： Izumi T,Walker DH,Maller JL

更新日期：1992-08-01 00:00:00

abstract：:Although chromosome condensation in the yeast Saccharomyces cerevisiae has been widely studied, visualization of this process in vivo has not been achieved. Using Lac operator sequences integrated at two loci on the right arm of chromosome IV and a Lac repressor-GFP fusion protein, we were able to visualize linear con...

journal_title：Molecular biology of the cell

authors： Vas AC,Andrews CA,Kirkland Matesky K,Clarke DJ

更新日期：2007-02-01 00:00:00

abstract：:Repellents evoke growth cone turning by eliciting asymmetric, localized loss of actin cytoskeleton together with changes in substratum attachment. We have demonstrated that semaphorin-3A (Sema3A)-induced growth cone detachment and collapse require eicosanoid-mediated activation of protein kinase C epsilon (PKC epsilon...

journal_title：Molecular biology of the cell

authors： Gatlin JC,Estrada-Bernal A,Sanford SD,Pfenninger KH

更新日期：2006-12-01 00:00:00

abstract：:Cdk5, a cyclin-dependent kinase, is critical for neuronal development, neuronal migration, cortical lamination, and survival. Its survival role is based, in part, on "cross-talk" interactions with apoptotic and survival signaling pathways. Previously, we showed that Cdk5 phosphorylation of mitogen-activated protein ki...

journal_title：Molecular biology of the cell

authors： Zheng YL,Li BS,Kanungo J,Kesavapany S,Amin N,Grant P,Pant HC

更新日期：2007-02-01 00:00:00

abstract：:The human fungal pathogen Candida albicans can switch between yeast, pseudohyphal, and hyphal morphologies. To investigate whether the distinctive characteristics of hyphae are due to increased activity of the Cdc42 GTPase, strains lacking negative regulators of Cdc42 were constructed. Unexpectedly, the deletion of th...

journal_title：Molecular biology of the cell

authors： Court H,Sudbery P

更新日期：2007-01-01 00:00:00

abstract：:Nuclear factor kappa B (NF-kappa B) modulates the expression of numerous genes via interaction with a specific DNA sequence termed the kappa B site. Its activity is modulated by a cytosolic inhibitor protein termed I kappa B, and its activation occurs in response to a variety of agents in a variety of cell types, most...

journal_title：Molecular biology of the cell

authors： Olashaw NE,Kowalik TF,Huang ES,Pledger WJ

更新日期：1992-10-01 00:00:00

abstract：:Astrocytes in neuron-free cultures typically lack processes, although they are highly process-bearing in vivo. We show that basic fibroblast growth factor (bFGF) induces cultured astrocytes to grow processes and that Ras family GTPases mediate these morphological changes. Activated alleles of rac1 and rhoA blocked and...

journal_title：Molecular biology of the cell

authors： Kalman D,Gomperts SN,Hardy S,Kitamura M,Bishop JM

更新日期：1999-05-01 00:00:00

abstract：:Alzheimer's β-amyloid precursor protein (APP) associates with kinesin-1 via JNK-interacting protein 1 (JIP1); however, the role of JIP1 in APP transport by kinesin-1 in neurons remains unclear. We performed a quantitative analysis to understand the role of JIP1 in APP axonal transport. In JIP1-deficient neurons, we fi...

journal_title：Molecular biology of the cell

authors： Chiba K,Araseki M,Nozawa K,Furukori K,Araki Y,Matsushima T,Nakaya T,Hata S,Saito Y,Uchida S,Okada Y,Nairn AC,Davis RJ,Yamamoto T,Kinjo M,Taru H,Suzuki T

更新日期：2014-11-05 00:00:00

abstract：:Large cargoes require multiple receptors for efficient transport through the nuclear pore complex. The 60S ribosomal subunit is one of the bulkiest transport cargoes, and in yeast three different receptors, Crm1, Mex67/Mtr2, and Arx1, collaborate in its export. However, only Crm1, recruited by the adapter Nmd3, appear...

journal_title：Molecular biology of the cell

authors： Lo KY,Johnson AW

更新日期：2009-03-01 00:00:00