IL-28 and IL-29: newcomers to the interferon family.

abstract：:Evidence shows that oral glycerol supplementation during the early stages of rat liver cancer reduces the growth of preneoplastic lesions. Besides, human hepatocellular carcinoma (HCC) cells display decreased expression of glycerol channel aquaporin 9 (AQP9) and also diminished glycerol-3-phosphate (G3P) content. Acco...

journal_title：Biochimie

authors： Lorenzetti F,Capiglioni AM,Marinelli RA,Carrillo MC,Alvarez ML

更新日期：2020-03-01 00:00:00

abstract：:Nitroxyl (HNO) is a molecule of significant interest due to its unique pharmacological properties, particularly within the cardiovascular system. A large portion of HNO biological effects can be attributed to its reactivity with protein thiols, where it can generate disulfide bonds. Evidence from studies in erythrocyt...

journal_title：Biochimie

authors： Salie MJ,Oram DS,Kuipers DP,Scripture JP,Chenge J,MacDonald GJ,Louters LL

更新日期：2012-03-01 00:00:00

abstract：:The comparison of the amino acid sequences of 5 cysteine proteinases: papain, actinidin, rat cathepsins B and H and chicken cathepsin L, demonstrates a striking homology among their sequences. The N-terminal region (residues 1-70 in papain) and C-terminal region (residues 118-212 in papain) display the highest sequenc...

journal_title：Biochimie

authors： Dufour E

更新日期：1988-10-01 00:00:00

abstract：:Disintegrins are small non-enzymatic proteins common in the venoms of many viperid snakes. These proteins have received significant attention due to their ability to inhibit platelet aggregation and cell adhesion, making them model compounds in drug development and design investigations. The present study used a combi...

journal_title：Biochimie

authors： Saviola AJ,Modahl CM,Mackessy SP

更新日期：2015-09-01 00:00:00

abstract：:This review article outlines some potentials and limits of the recent application of high resolution Nuclear Magnetic Resonance technique--coupled to the Fourier transformation methods--to the study of biological membranes. Molecular arrangement and dynamical structure characters can be assessed at the level of indivi...

journal_title：Biochimie

authors： Podo F

更新日期：1975-01-01 00:00:00

abstract：:The cholesterol lowering drug lovastatin, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, blocks DNA synthesis and proliferation of thyrotropin (TSH) primed FRTL-5 rat thyroid cells. The blockade can be completely prevented and/or reversed by mevalonate and largely prevented and/o...

journal_title：Biochimie

authors： Bifulco M,Laezza C,Aloj SM

更新日期：1999-04-01 00:00:00

abstract：:Specific contacts between DNA phosphate groups and positively charged nucleophilic amino acids from the Escherichia coli Fpg protein play a significant role in DNA-Fpg protein interaction. In order to identify these phosphate groups the chemical crosslinking procedure was carried out. The probing of the Fpg protein ac...

journal_title：Biochimie

authors： Kuznetsova S,Rykhlevskaya A,Taranenko M,Sidorkina O,Oretskaya T,Laval J

更新日期：2003-05-01 00:00:00

abstract：:Bacillus subtilis strain SO113 secretes a pectate lyase which is produced during the exponential death phase of growth, just before sporulation. This extracellular pectate lyase, which produces unsaturated products from polygalacturonate, was purified 35-fold from the culture supernatant of Bacillus subtilis by a CM S...

journal_title：Biochimie

authors： Nasser W,Chalet F,Robert-Baudouy J

更新日期：1990-09-01 00:00:00

abstract：:NikR proteins are bacterial metallo-regulatory transcription factors that control the expression of the nickel uptake system and/or nickel containing enzymes such as urease, and are involved in the acid stress response. Here, a comparative study is reported on NikR from Helicobacter pylori (HpNikR) and Escherichia col...

journal_title：Biochimie

authors： Fauquant C,Diederix RE,Rodrigue A,Dian C,Kapp U,Terradot L,Mandrand-Berthelot MA,Michaud-Soret I

更新日期：2006-11-01 00:00:00

abstract：:Bothropstoxin-I (BthTx-I) is a homodimeric Lys49-PLA2 from the venom of the snake Bothrops jararacussu, which lacks hydrolytic activity against phospholipid substrates, yet permeabilizes membranes by a Ca2+-independent mechanism. The interaction of the BthTx-I with model membranes has been studied by intrinsic tryptop...

journal_title：Biochimie

authors： Ferreira TL,Ruller R,Chioato L,Ward RJ

更新日期：2008-09-01 00:00:00

abstract：:Insect prophenoloxidase (PPO) is an essential innate immunity protein to induce pathogen into melanization. In Bombyx mori, pro-phenoloxidase-activating enzyme (PPAE) can directly cleave and activate PPO. However, PPO in Manduca sexta cannot be cleaved into active phenoloxidase (PO) by serine proteases unless cofactor...

journal_title：Biochimie

authors： Lu A,Li X,Hillyer JF,Beerntsen BT,Söderhäll K,Ling E

更新日期：2014-07-01 00:00:00

abstract：:An alkaline aminopeptidase was isolated from the culture medium of Penicillium roqueforti. The enzyme was purified by ammonium sulfate precipitation, filtration on Bio-Gel P-100, chromatography on D.E.A.E.-cellulose and hydroxylapatite, filtration on Bio-Gel P-150 and electrofusing. The purified preparation was homoge...

journal_title：Biochimie

authors： Gripon JC

更新日期：1977-01-01 00:00:00

abstract：:In search for yet uncharacterized proteins involved in lipid metabolism of the chicken, we have isolated a hitherto unknown protein from the serum lipoprotein fraction with a buoyant density of ≤1.063 g/ml. Data obtained by protein microsequencing and molecular cloning of cDNA defined a 537 bp cDNA encoding a precurso...

journal_title：Biochimie

authors： Nikolay B,Plieschnig JA,Subik D,Schneider JD,Schneider WJ,Hermann M

更新日期：2013-12-01 00:00:00

abstract：:DNA mismatch repair (MMR) is an important replication error avoidance mechanism that prevents mutation. The association of defective MMR with familial and sporadic gastrointestinal and endometrial cancer has been acknowledged for some years. More recently, it has become apparent that MMR defects are common in acute my...

journal_title：Biochimie

authors： Karran P,Offman J,Bignami M

更新日期：2003-11-01 00:00:00

abstract：:The incubation of polyphosphates with the ribosomal fraction of Sulfolobus acidocaldarius leads to the covalent attachment of phosphate to threonine residue(s) of a single 40,000 Mr protein. The hydrolysis kinetics of this protein showed that polyphosphate might be the modifying group. The reaction requires 2 mM Mn2+ ...

journal_title：Biochimie

authors： Skorko R

更新日期：1989-09-01 00:00:00

abstract：:Calcineurin (CN) is a unique calcium/calmodulin (CaM)-activated serine/threonine phosphatase. To perform its diverse biological functions, CN communicates with many substrates and other proteins. In the physiological activation of T cells, CN acts through transcriptional factors belonging to the NFAT family and other ...

journal_title：Biochimie

authors： Zhao Y,Zhang J,Shi X,Li J,Wang R,Song R,Wei Q,Cai H,Luo J

更新日期：2016-08-01 00:00:00

abstract：:The 11 kb las locus, present on the 50 kb plasmid pCIM1, specifies the production of the lantibiotic lactocin S in Lactobacillus sakei L45. The gene cluster is organized into two oppositely orientated operons, lasAMNTUVPJW (lasA-W) and lasXY, the former of which contains the biosynthetic, immunity and transport genes....

journal_title：Biochimie

authors： Rawlinson EL,Nes IF,Skaugen M

更新日期：2002-05-01 00:00:00

abstract：:Reuber H 35 hepatoma cells were synchronized by transfer in a serum free medium. Growth was re-initiated by addition of serum. Under these conditions DNA synthesis exhibited a maximum after 24 hours. Chromatin non-histone proteins prepared from cells at various phases of the cell cycle were incubated with [gamma-32P] ...

journal_title：Biochimie

authors： Defer N,Tichonicky L,Kruh J,Zoutewelle G,Van Wijk R

更新日期：1979-01-01 00:00:00

abstract：:Theoretic and experimental arguments are surveyed which justify the setting up, within the family of pyridoxal-P-dependent lyases, of a special subgroup that comprizes several enzymes catalyzing exclusively beta-replacement reactions of alpha-aminoacids with electronegative substituents in the beta-position. The autho...

journal_title：Biochimie

authors： Braunstein AE,Goryachenkova EV

更新日期：1976-01-01 00:00:00

abstract：:Coumarins are a group of natural compounds widely distributed in plants. Of late, coumarins and their derivatives have grabbed much attention from the pharmacological and pharmaceutical arena due to their broad range of therapeutical qualities. A coumarin derivative 4-methylesculetin (4-ME) has known to possess effect...

journal_title：Biochimie

authors： Hemshekhar M,Sunitha K,Thushara RM,Sebastin Santhosh M,Shanmuga Sundaram M,Kemparaju K,Girish KS

更新日期：2013-06-01 00:00:00

abstract：:An efficient phosphotriester methodology based on the use of condensing agents in the presence of several O-nucleophilic catalysts has been developed. ...

journal_title：Biochimie

authors： Efimov VA,Chakhmakhcheva OG

更新日期：1985-07-01 00:00:00

abstract：:The central glycolytic and oxidative pathways and the ATP-producing mechanisms differ in sane and malignant cells by their regulation and dynamics. Fast-growing, poorly-differentiated cancer cells characteristically show high aerobic glycolysis. In the same way, cholesterol biosynthesis, which occurs by normal pathway...

journal_title：Biochimie

authors： Baggetto LG

更新日期：1992-11-01 00:00:00

abstract：:The metabolism of the phospholipids of the submaxillary gland are studied after intraperitoneal injections of [32P]-orthophosphate in several groups of rats. The gland contains mainly phosphatidylcholines and phosphatidylethanolamines and in smaller quantities phosphatidylinositols, phosphatidylserines, sphingomyelins...

journal_title：Biochimie

authors： Leclercq C,Di Costanzo G

更新日期：1976-01-01 00:00:00

abstract：:Clustered apurinic/apyrimidinic (AP) sites are more cytotoxic than isolated AP lesions because double strand breaks (DSB) can be formed during repair of closely positioned bistranded AP sites. Formation of DSB due to simultaneous cleavage of bistranded AP sites may be regulated by proteins specifically interacting wit...

journal_title：Biochimie

authors： Ilina ES,Khodyreva SN,Lavrik OI

更新日期：2018-07-01 00:00:00

abstract：:Porcine pancreatic extracts (PPE), also named pancreatin, are commonly used as a global source of pancreatic enzymes for enzyme replacement therapy in patients with exocrine pancreatic insufficiency. They are considered as a good substitute of human pancreatic enzymes and they have become a material of choice for in v...

journal_title：Biochimie

authors： Salhi A,Amara S,Mansuelle P,Puppo R,Lebrun R,Gontero B,Aloulou A,Carrière F

更新日期：2020-02-01 00:00:00

abstract：:Triiodothyronine (T3), injected daily into rats, induces heart hypertrophy. In a recent work we have shown that a single T3 injection stimulates RNA synthesis and modifies the translational products of myocardial mRNAs in reticulocyte lysates, quantitatively and qualitatively. In this work we show that T3 induces smal...

journal_title：Biochimie

authors： Raymondjean M,Leibovitch SA,Leibovitch MP,Harel J,Kruh J

更新日期：1984-09-01 00:00:00

abstract：:The poisonous bite by Hippasa partita, a funnel web spider from the Indian subcontinent has been demonstrated to give rise to severe dermo- and myonecrosis. In this work a hemorrhagic metalloprotease, Partitagin was purified from H. partita venom by successive chromatography on Sephadex G-100, DEAE Sephadex A-50 and B...

journal_title：Biochimie

authors： Nagaraju S,Girish KS,Fox JW,Kemparaju K

更新日期：2007-11-01 00:00:00

abstract：:A variety of species of GPDH undergo acylation at two of the four active cystein sites per mole of tetrameric enzyme. This reaction requires tightly bound NAD+, a situation restricted to two of the four NAD sites per tetramer. S leads to N acyl transfer from cysteins to lysine in the diacyl enzyme yields an inactive e...

journal_title：Biochimie

authors： Malhotra OP,Bernhard SA,Seydoux F

更新日期：1981-02-01 00:00:00

abstract：:We are here reporting that calpain-1 is a constitutive component of a distinct lipid raft/caveolin-1 microdomain isolated from bEnd5 cells in association with endothelial nitric oxide synthase (eNOS) and heat shock protein 90 (HSP90). Perturbations in intracellular calcium concentration by Ca2+-ionophore A23187 or pro...

journal_title：Biochimie

authors： Martines A,Stifanese R,Faelli EL,Perasso L,Melloni I,Ruggeri P,Averna M

更新日期：2017-02-01 00:00:00

abstract：:Apoptosis is the physiological process by which unwanted cells in an organism are killed. Bcl-2, a membrane-bound cytoplasmic protein, and its close relative Bcl-xL, are both effective inhibitors of apoptosis induced by a wide variety of stimuli in many different cell types. In a previous study, we reported that suppr...

journal_title：Biochimie

authors： Cherbonnel-Lasserre C,Dosanjh MK

更新日期：1997-10-01 00:00:00