Abstract:
BACKGROUND:It is well known that anterior cruciate ligament (ACL) injuries are commoner in female athletes. Accordingly, we hypothesized that serum estrogen may play some role in this sex difference. We evaluated the relationship between serum estrogen levels and the mechanical properties of the ACL in rabbits. ANIMALS AND METHODS:In 40 ovariectomized rabbits, the serum estrogen levels (SEL) were controlled by intramuscular injection of 17beta-estradiol. The mean SEL in each rabbit was defined as the average of 5 determinations done at 1, 2, 3, 4 and 5 weeks after ovariectomy. The animals were divided into 4 groups according to the dose of estradiol administered (low, medium, high and control: L, M, H and C, respectively) and into 2 groups according to the mean SEL (high-SEL group and low-SEL group). The medial portions of ACL attached to both femur and tibia harvested at 5 weeks after ovariectomy were examined mechanically. RESULTS:The mean serum estrogen levels in groups C, L, M and H were 37, 50, 60 and 231 pg/mL. Statistically significant differences in the mean serum estrogen levels were seen among the 4 groups, except between groups L and M. Statistically significant differences were found between groups M and H in both the ultimate tensile stress and linear stiffness. In the comparison between 2 groups using the mean SEL value, both ultimate tensile stress and linear stiffness were lower in the high-SEL group. In all animals, a positive correlation was found between ultimate tensile stress and linear stiffness. INTERPRETATION:Our findings suggest that high SEL might be one of the factors in the multifactorial pathogenesis of ACL rupture.
journal_name
Acta Orthopjournal_title
Acta orthopaedicaauthors
Komatsuda T,Sugita T,Sano H,Kusakabe T,Watanuki M,Yoshizumi Y,Murakami T,Hashimoto M,Kokubun Sdoi
10.1080/17453670610013312subject
Has Abstractpub_date
2006-12-01 00:00:00pages
973-80issue
6eissn
1745-3674issn
1745-3682pii
770235903journal_volume
77pub_type
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journal_title:Acta orthopaedica
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pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章,随机对照试验
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更新日期:2011-02-01 00:00:00
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pub_type: 评论,杂志文章
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更新日期:2016-07-01 00:00:00
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