Abstract:
BACKGROUND AND PURPOSE:The osteogenic potency of erythropoietin (EPO) has been documented. However, its efficacy in a large-animal model has not yet been investigated; nor has a clinically safe dosage. The purpose of this study was to overcome such limitations of previous studies and thereby pave the way for possible clinical application. Our hypothesis was that EPO increases calvarial bone healing compared to a saline control in the same subject. METHODS:We used a porcine calvarial defect model. In each of 18 pigs, 6 cylindrical defects (diameter: 1 cm; height: 1 cm) were drilled, allowing 3 pairwise comparisons. Treatment consisted of either 900 IU/mL EPO or an equal volume of saline in combination with either autograft, a collagen carrier, or a polycaprolactone (PCL) scaffold. After an observation time of 5 weeks, the primary outcome (bone volume fraction (BV/TV)) was assessed with high-resolution quantitative computed tomography. Secondary outcome measures were histomorphometry and blood samples. RESULTS:The median BV/TV ratio of the EPO-treated collagen group was 1.06 (CI: 1.02-1.11) relative to the saline-treated collagen group. Histomorphometry showed a similar median effect size, but it did not reach statistical significance. Autograft treatment had excellent healing potential and was able to completely regenerate the bone defect independently of EPO treatment. Bony ingrowth into the PCL scaffold was sparse, both with and without EPO. Neither a substantial systemic effect nor adverse events were observed. The number of blood vessels was similar in EPO-treated defects and saline-treated defects. INTERPRETATION:Topical administration of EPO on a collagen carrier moderately increased bone healing. The dosing regime was safe, and could have possible application in the clinical setting. However, in order to increase the clinical relevance, a more potent but still clinically safe dose should be investigated.
journal_name
Acta Orthopjournal_title
Acta orthopaedicaauthors
Rölfing JH,Jensen J,Jensen JN,Greve AS,Lysdahl H,Chen M,Rejnmark L,Bünger Cdoi
10.3109/17453674.2014.889981subject
Has Abstractpub_date
2014-04-01 00:00:00pages
201-9issue
2eissn
1745-3674issn
1745-3682journal_volume
85pub_type
杂志文章abstract:BACKGROUND AND PURPOSE:There is increasing awareness that non-steroidal anti-inflammatory drugs (NSAIDs), and especially the cyclooxygenase-2 (COX-2) selective ones, may retard bone healing. We have used NSAIDs (indomethacin for at least 7 days) to prevent heterotopic ossification after acetabular reconstructions using...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453670710015562
更新日期:2008-08-01 00:00:00
abstract:BACKGROUND:Laboratory tests and early clinical studies have shown that highly cross-linked polyethylene (PE) markedly improves wear resistance compared to conventional PE. We evaluated this type of PE in two randomized clinical studies using radiostereometric analysis (RSA). The 2- and 3-year follow-up of these studies...
journal_title:Acta orthopaedica
pub_type: 杂志文章,随机对照试验
doi:10.1080/17453670710014518
更新日期:2007-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Monoblock acetabular cups represent a subtype of uncemented cups with the polyethylene liner molded into a metal shell, thus eliminating-or at least minimizing-potential backside wear. We hypothesized that the use of monoblock cups could reduce the incidence of osteolysis and aseptic loosening, a...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453674.2012.688726
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Recent literature suggests that the incidence and treatment modalities of distal radius fractures have been changing over the past 2 decades in the developed world. We examined the epidemiology of adult distal radius fractures in Iceland in 2004 and compared it with an Icelandic study from 1985 a...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453674.2011.606074
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Cementless total hip arthroplasty is currently favored by many orthopedic surgeons. The design of the porous surface is critically important for long-term fixation. We examined the clinical and radiographic outcome of the cementless titanium hip implant with a bottom coating of apatite-wollastoni...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453674.2012.736173
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:The advent of highly crosslinked polyethylene has allowed the re-evaluation of the use of femoral heads larger than 32 mm for metal-on-polyethylene total hip arthroplasties. However, the effect of larger heads on the frictional torque of highly crosslinked polyethylene is unknown. METHODS:We performed an in...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453670610012881
更新日期:2006-10-01 00:00:00
abstract:BACKGROUND:Instrumentation, particularly reaming, of the long bones carries the risk of embolic phenomenon. Emboli may result in pulmonary injury, which is usually manifested by desaturation. This pulmonary injury may be particularly relevant if there is diminished pulmonary reserve due to pre-existing lung disease suc...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453670710014202
更新日期:2007-08-01 00:00:00
abstract::Perspective Orthopaedic training in the United Kingdom has changed little from the Halstedian apprenticeship model of graduated responsibility, with the mantra "see one, do one, teach one". Whilst still relevant in surgical teaching, the current and ongoing disruption to surgical training secondary to the coronavirus ...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453674.2020.1845437
更新日期:2020-11-11 00:00:00
abstract:BACKGROUND:Cyclooxigenase-2 (COX-2) inhibitors have been reported to delay fracture healing. To investigate the major inhibitory period of COX-2 inhibitors in fracture healing, we administrated etodolac, a COX-2-specific inhibitor, to a rat fracture model by altering the period of administration from early to late. ME...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453670510041439
更新日期:2005-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Resurfacing total hip arthroplasty (RTHA) may preserve the femoral neck bone stock postoperatively. Bone mineral density (BMD) may be affected by the hip position, which might bias longitudinal studies. We investigated the dependency of BMD precision on type of ROI and hip position. METHOD:We DX...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453674.2010.480935
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:Arthroscopically-assisted reconstruction of the anterior cruciate ligament with hamstring tendons has achieved widespread acceptance; however, the anatomy of these tendons may cause technical problems at harvesting. METHODS:We studied the anatomy of the fascial band between semitendinosus and gastrocnemius ...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453670710013933
更新日期:2007-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Complications related to the fibula during distraction osteogenesis could cause malalignment. Most published studies have analyzed only migration of the fibula during lengthening, with few studies examining the effects of fibular complications. PATIENTS AND METHODS:We retrospectively reviewed 12...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453674.2012.665328
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:No prospective surveillance systems have been available for monitoring the outcome of cruciate ligament surgery in Scandinavia (Denmark, Norway, and Sweden). In the present paper we describe the Scandinavian ACL registries including their main function, similarities, and preliminary baseline resu...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453670903350107
更新日期:2009-10-01 00:00:00
abstract:BACKGROUND:The in vivo pharmacokinetics of gentamycin- loaded collagen fleeces in humans have not been described in the current literature. We therefore analyzed in vivo pharmacokinetics of these fleeces when used in the treatment of periprosthetic infections. PATIENTS AND METHODS:Gentamycin concentrations were measur...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453670810016650
更新日期:2008-10-01 00:00:00
abstract:BACKGROUND:It is well known that anterior cruciate ligament (ACL) injuries are commoner in female athletes. Accordingly, we hypothesized that serum estrogen may play some role in this sex difference. We evaluated the relationship between serum estrogen levels and the mechanical properties of the ACL in rabbits. ANIMAL...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453670610013312
更新日期:2006-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The first generations of total ankle replacements (TARs) showed a high rate of early failure. In the last decades, much progress has been made in the development of TARs, with the newer generation showing better results. We evaluated TARs implanted with rheumatoid arthritis (RA) or juvenile infla...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453670903153568
更新日期:2009-08-01 00:00:00
abstract::Background and purpose - Survivorship of total hip arthroplasty (THA) with the ultra-high molecular weight polyethylene (UHMWPE) monoblock cup has been limited due to periprosthetic osteolysis and aseptic loosening, secondary to wear of the UHMWPE. In response, a vitamin E blended highly cross-linked polyethylene (HXL...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453674.2020.1807220
更新日期:2020-12-01 00:00:00
abstract::Background and purpose - Larger prospective studies investigating periacetabular osteotomy (PAO) with patient-reported outcome measures developed for young patients are lacking. We investigated changes in patient-reported outcome (PRO), changes in muscle-tendon pain, and any associations between them from before to 1 ...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453674.2018.1555637
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:No data exist regarding mortality rate in young patients with a first-time anterior shoulder dislocation. A cohort of 255 patients aged 12-40 years had a primary anterior shoulder dislocation during the years 1978 and 1979. After 10 years, 9 of the patients had died--which is a high figure for this cohort of...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453670710014617
更新日期:2007-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:There is continuing confusion among practitioners with regard to the optimal choice of anesthetic type for repair of hip fractures. We investigated whether type of anesthetic was associated with short-term mortality after hip fracture surgery. PATIENTS AND METHODS:We conducted a retrospective co...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453674.2015.1128781
更新日期:2016-01-01 00:00:00
abstract::Background and purpose - Alternative bearing surfaces such as ceramics and highly crosslinked polyethylene (HXLPE) were developed in order to further improve implant performance of total hip arthroplasties (THAs). Whether these alternative bearing surfaces result in increased longevity is subject to debate. Patients a...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453674.2017.1405669
更新日期:2018-04-01 00:00:00
abstract::Background and purpose - Hemiarthroplasty (HA) is the most common treatment for displaced femoral neck fractures in many countries. In Norway, there has been a tradition of using the direct lateral surgical approach, but worldwide a posterior approach is more often used. Based on data from the Norwegian Hip Fracture R...
journal_title:Acta orthopaedica
pub_type: 杂志文章,多中心研究
doi:10.1080/17453674.2016.1250480
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:It is unclear whether osteoarthritis (OA) of the knee is seen better in standing flexion position radiographs than in the standing extended view. We assessed the value of standing flexion views. PATIENTS AND METHODS:We retrospectively evaluated 1,090 radiographs of 545 consecutive knees with non...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453674.2010.483989
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:Overweight and a high level of physical activity are known risk factors for loosening of a total hip arthroplasty (THA) due to primary osteoarthritis. We wanted to investigate how these factors, together with age and sex, affect the risk of revision surgery. PATIENTS AND METHODS:We matched data from the Nor...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453670610013493
更新日期:2007-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Commercial gentamicin-loaded bone cement beads (Septopal) constitute an effective delivery system for local antibiotic therapy. These beads are not available in all parts of the world, and are too expensive for frequent use in others. Thus, orthopedic surgeons worldwide make antibiotic-loaded bea...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453670903389782
更新日期:2009-10-01 00:00:00
abstract::Background and purpose - Femoral neck fractures are commonly treated with cemented or uncemented hemiarthroplasties (HA). We evaluated differences in mortality and revision rates in this fragile patient group.Patients and methods - From January 1, 2007 until December 31, 2016, 22,356 HA procedures from the Dutch Arthr...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453674.2020.1752522
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The pathomechanics of the Essex-Lopresti lesion are not fully understood. We used human cadavers and documented the genesis of the injury with high-speed cameras. METHODS:4 formalin-fixed cadaveric specimens of human upper extremities were tested in a prototype, custom-made, drop-weight test ben...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453674.2014.887952
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:The mechanism of failure of metal-on-metal (MoM) total hip arthroplasty (THA) has been related to a high rate of metal wear debris, which is partly generated from the head-trunnion interface. However, it is not known whether implant fixation is affected by metal wear debris. PATIENTS AND METHODS:49 cases of...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453674.2014.922731
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Several studies have shown that nicotine has a detrimental effect on the development of rotator cuff tear. However, little is known about its mechanism. We evaluated the effect of nicotine on the maximum tensile load, the maximum tensile stress, and the elastic modulus of the supraspinatus tendon...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453674.2010.524595
更新日期:2010-10-01 00:00:00
abstract::Background and purpose - Discharge on the day of surgery (DOS) in selected patients operated with total hip arthroplasty (THA) or total knee arthroplasty (TKA) has been shown to be feasible, but different factors may determine whether patients are discharged on the DOS or not and setting may be one of them. We investi...
journal_title:Acta orthopaedica
pub_type: 杂志文章,随机对照试验
doi:10.1080/17453674.2019.1686205
更新日期:2020-02-01 00:00:00