Alteration of the material properties of the normal supraspinatus tendon by nicotine treatment in a rat model.

Abstract:

BACKGROUND AND PURPOSE:Several studies have shown that nicotine has a detrimental effect on the development of rotator cuff tear. However, little is known about its mechanism. We evaluated the effect of nicotine on the maximum tensile load, the maximum tensile stress, and the elastic modulus of the supraspinatus tendon in a rat model. METHODS:27 rats were randomly assigned to 3 groups. Subcutaneously implanted osmotic pumps delivered two different concentrations of nicotine solution (high dose: 45 ng/mL; low dose: 22.5 ng/mL) or saline solution (controls) over a 12-week period. The level of serum cotinine, a breakdown product of nicotine, was evaluated. We performed tensile testing using the left supraspinatus tendon in each rat. The maximum load of the supraspinatus tendon was measured, and the maximum tensile stress and elastic modulus were calculated. RESULTS:Serum cotinine levels showed controlled systemic release of nicotine. The maximum tensile load and stress were similar in the three groups. The elastic modulus was, however, higher in the nicotine groups than in the control group. INTERPRETATION:In a rat model, nicotine caused a change in the material properties of the supraspinatus tendon. This change may predispose to a tear in the supraspinatus tendon.

journal_name

Acta Orthop

journal_title

Acta orthopaedica

authors

Ichinose R,Sano H,Kishimoto KN,Sakamoto N,Sato M,Itoi E

doi

10.3109/17453674.2010.524595

subject

Has Abstract

pub_date

2010-10-01 00:00:00

pages

634-8

issue

5

eissn

1745-3674

issn

1745-3682

journal_volume

81

pub_type

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