Abstract:
:- Knee pathologies including focal cartilage injuries, osteoarthritis (OA), and ligament injuries are common. The poor regeneration and healing potential of cartilage has led to the search for other treatment modalities with improved healing capacity. Furthermore, with an increasing elderly population that desires to remain active, the burden of knee pathologies is expected to increase. Increased sports participation and the desire to return to activities faster is also demanding more effective and minimally invasive treatment options. Thus, the use of biologic agents in the treatment of knee pathologies has emerged as a potential option. Despite the increasing use of biologic agents for knee pathology, there are conflicting results on the efficacy of these products. Furthermore, strong data supporting the optimal preparation methods and composition for widely used biologic agents, such as platelet-rich plasma (PRP) and bone marrow aspirate concentrate (BMAC), largely remain absent from the literature. This review presents the literature on the most commonly employed biologic agents for the different knee pathologies.
journal_name
Acta Orthopjournal_title
Acta orthopaedicaauthors
Moatshe G,Morris ER,Cinque ME,Pascual-Garrido C,Chahla J,Engebretsen L,Laprade RFdoi
10.1080/17453674.2017.1368899subject
Has Abstractpub_date
2017-12-01 00:00:00pages
670-674issue
6eissn
1745-3674issn
1745-3682journal_volume
88pub_type
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journal_title:Acta orthopaedica
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doi:10.3109/17453670903448257
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abstract:BACKGROUND:No data exist regarding mortality rate in young patients with a first-time anterior shoulder dislocation. A cohort of 255 patients aged 12-40 years had a primary anterior shoulder dislocation during the years 1978 and 1979. After 10 years, 9 of the patients had died--which is a high figure for this cohort of...
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abstract:BACKGROUND AND PURPOSE:Surgical correction of foot deformities as part of single-event multilevel surgery (SEMLS) to optimize postoperative training is sometimes indicated in ambulatory children with cerebral palsy. We have, however, experienced excessive postoperative pain and rehabilitation problems in a number of th...
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doi:10.3109/17453674.2014.960141
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abstract::Background and purpose - There is a lack of information on any associations between the functional outcome and age and diagnosis in patients who have undergone shoulder arthroplasty. We therefore evaluated the functional outcome in "young" and "old" patients treated with either hemiarthroplasty (HA) or total shoulder ...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453674.2017.1280656
更新日期:2017-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Loss of bone stock remains a challenge in revision hip surgery. Grafting with allograft is well established, but there are problems with availability, cost, infection, antigenicity, reproducibility, and stability of the created construct. BoneSave is a biphasic porous ceramic consisting of sinter...
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更新日期:2013-08-01 00:00:00
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journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453674.2019.1605669
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We have previously shown that during the first 2 years after total hip arthroplasty (THA), periprosthetic bone resorption can be prevented by 6 months of risedronate therapy. This follow-up study investigated this effect at 4 years. PATIENTS AND METHODS:A single-center, double-blind, randomized ...
journal_title:Acta orthopaedica
pub_type: 杂志文章,随机对照试验
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更新日期:2015-01-01 00:00:00
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journal_title:Acta orthopaedica
pub_type: 杂志文章,评审
doi:10.3109/17453674.2011.566134
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND:Hospital-specific variation in outcome is generally considered to be an important source of information for clinical improvement. We have measured the magnitude of this variation. METHODS:We determined the revision risk in 37,642 cemented primary total knee arthroplasties inserted as a result of osteoarthri...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453670610046442
更新日期:2006-06-01 00:00:00
abstract::Background and purpose - Smoking is a modifiable risk factor that may adversely affect postoperative outcomes. Healthcare providers are increasingly denying smokers access to total hip and knee arthroplasty (THA and TKA) until they stop smoking. Evidence supporting this is unclear. We assessed the effect of smoking on...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453674.2019.1649510
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Postoperative muscle strength and component alignment are important factors affecting functional results after total knee arthroplasty (TKA). We are not aware of any studies that have investigated the relationship between them. We therefore investigated whether coronal malalignment of the mechani...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453674.2015.1059689
更新日期:2015-01-01 00:00:00
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journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453674.2018.1501974
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The number of periprosthetic fractures following total hip arthroplasty (THA) is increasing. There is, however, limited data on the functional outcome following these injuries. We analyzed functional outcome for revision THA following periprosthetic fracture, and compared this to the outcome of e...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453670710015463
更新日期:2008-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The most common surgical approaches in total hip arthroplasty in Sweden are the posterior and the anterolateral transgluteal approach. Currently, however, there is insufficient evidence to prefer one over the other regarding risk of subsequent surgery. PATIENTS AND METHODS:We searched the Swedis...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453674.2012.742394
更新日期:2012-12-01 00:00:00
abstract::Background and purpose - Hemiarthroplasty (HA) is the most common treatment for displaced femoral neck fractures in many countries. In Norway, there has been a tradition of using the direct lateral surgical approach, but worldwide a posterior approach is more often used. Based on data from the Norwegian Hip Fracture R...
journal_title:Acta orthopaedica
pub_type: 杂志文章,多中心研究
doi:10.1080/17453674.2016.1250480
更新日期:2017-02-01 00:00:00
abstract::Background and purpose - Femoral neck preserving hip replacement has been suggested to improve clinical results and facilitate late revision. We compared the 2-year outcome and radiostereometric pattern of femoral head migration between the Collum Femoris Preserving (CFP) stem and the Corail stem. Patients and methods...
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pub_type: 杂志文章,随机对照试验
doi:10.1080/17453674.2019.1577344
更新日期:2019-06-01 00:00:00
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journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453674.2014.961397
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pub_type: 杂志文章
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更新日期:2005-12-01 00:00:00
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journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453671003685459
更新日期:2010-02-01 00:00:00
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journal_title:Acta orthopaedica
pub_type: 杂志文章,评审
doi:10.1080/17453674.2016.1193799
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Surgical treatment of chronic acromioclavicular joint dislocations is challenging, and no single procedure can be considered to be the gold standard. In 2010, the GraftRope method (Arthrex Inc., Naples, FL) was introduced in a case series of 10 patients, showing good clinical results and no compl...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453674.2014.976806
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:Since the osteogenic potential of bone marrow derived mesenchymal stem cells (BMSCs) becomes reduced with passage, establishment of culture condition that permit the rapid expansion of BMSCs while retaining their potential for differentiation is needed for clinical application. Bone morphogenetic proteins st...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453670710013816
更新日期:2007-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Intraoperative periprosthetic femoral fracture is a known complication of cementless total hip arthroplasty (THA). We determined the incidence of--and risk factors for--intraoperative calcar fracture, and assessed its influence on the risk of revision. PATIENTS AND METHODS:This retrospective ana...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453674.2015.1112712
更新日期:2016-01-01 00:00:00
abstract:UNLABELLED:BACKGROUND AND PURPOSE Over the last 5 years, there has been increasing interest in reducing length of hospitalization (LOS) through accelerated programs. We examined the clinical outcome of patients undergoing a unicompartmental knee replacement (UKR) in an accelerated care program (A group) compared to a c...
journal_title:Acta orthopaedica
pub_type: 杂志文章,随机对照试验
doi:10.3109/17453670903035559
更新日期:2009-06-01 00:00:00
abstract:BACKGROUND:The advent of highly crosslinked polyethylene has allowed the re-evaluation of the use of femoral heads larger than 32 mm for metal-on-polyethylene total hip arthroplasties. However, the effect of larger heads on the frictional torque of highly crosslinked polyethylene is unknown. METHODS:We performed an in...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453670610012881
更新日期:2006-10-01 00:00:00
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journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453670903389782
更新日期:2009-10-01 00:00:00
abstract::Background and purpose - When nonoperative treatment of proximal humerus fracture (PHF) fails, shoulder arthroplasty may be indicated. We investigated risk factors for revision and evaluated patient-reported outcome 1 year after treatment with either stemmed hemiarthroplasty (SHA) or reverse total shoulder arthroplast...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453674.2020.1730660
更新日期:2020-06-01 00:00:00
abstract::Background and purpose - The uncemented Symax hip stem has shown early proximal ingrowth as result of the BONIT-hydroxyapatite (HA) coating and the distal DOTIZE surface treatment. We evaluated 2-year postoperative radiostereometric analysis (RSA) migration of the Symax hip stem in THA patients. We also investigated t...
journal_title:Acta orthopaedica
pub_type: 杂志文章,随机对照试验
doi:10.1080/17453674.2019.1709956
更新日期:2020-04-01 00:00:00