Abstract:
BACKGROUND AND PURPOSE:There is increasing awareness that non-steroidal anti-inflammatory drugs (NSAIDs), and especially the cyclooxygenase-2 (COX-2) selective ones, may retard bone healing. We have used NSAIDs (indomethacin for at least 7 days) to prevent heterotopic ossification after acetabular reconstructions using impacted bone grafts. The long-term clinical results have been satisfying, making it difficult to believe that there is an important negative effect of NSAIDs on graft incorporation. We studied the effect of two different NSAIDs on bone and tissue ingrowth in a bone chamber model in goats, using autograft, rinsed allograft, and allograft that had been rinsed and subsequently irradiated. METHODS:9 goats received no NSAIDs, 9 received ketoprofen, and 9 received meloxicam--all for 6 weeks. In each goat 6 bone chambers were implanted: 2 filled with autograft, 2 with rinsed allograft, and 2 with allograft that had been rinsed and irradiated. The amount of bone ingrowth and total tissue ingrowth was compared between the groups. RESULTS:There were no statistically significant differences in bone ingrowth between the different groups. Also, no differences in bone ingrowth were found with respect to the type of graft used. Furthermore, there was no statistically significant difference in the total amount of ingrowth of fibrous tissue between the treatment groups. INTERPRETATION:No differences in bone ingrowth in titanium bone chambers could be detected with both ketoprofen and meloxicam compared to untreated control animals. This confirms our hypothesis that the effect of NSAIDs on the incorporation and ingrowth of bone graft is limited.
journal_name
Acta Orthopjournal_title
Acta orthopaedicaauthors
van der Heide HJ,Hannink G,Buma P,Schreurs BWdoi
10.1080/17453670710015562subject
Has Abstractpub_date
2008-08-01 00:00:00pages
548-54issue
4eissn
1745-3674issn
1745-3682pii
902115380journal_volume
79pub_type
杂志文章abstract:BACKGROUND AND PURPOSE:Hip fracture (HF) in frail elderly patients is associated with poor physical recovery and death. There is often postoperative blood loss and the hemoglobin (Hb) threshold for red blood cell (RBC) transfusions in these patients is unknown. We investigated whether RBC transfusion strategies were as...
journal_title:Acta orthopaedica
pub_type: 杂志文章,随机对照试验
doi:10.3109/17453674.2015.1006980
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:Cyclooxigenase-2 (COX-2) inhibitors have been reported to delay fracture healing. To investigate the major inhibitory period of COX-2 inhibitors in fracture healing, we administrated etodolac, a COX-2-specific inhibitor, to a rat fracture model by altering the period of administration from early to late. ME...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453670510041439
更新日期:2005-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Substantial bone loss in revision total knee arthroplasty (TKA) is a challenging problem. We studied whether impaction bone grafting provides long-term restoration of bone stock in the treatment of major bone defects in revision surgery of rotational and hinged knee arthroplasties (LINK Endo-Mode...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453674.2013.814012
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:There is considerable uncertainty about the optimal treatment of displaced 4-part fractures of the proximal humerus. Within the last decade, locking plate technology has been considered a breakthrough in the treatment of these complex injuries. METHODS:We systematically identified and reviewed c...
journal_title:Acta orthopaedica
pub_type: 杂志文章,评审
doi:10.3109/17453674.2011.588856
更新日期:2011-08-01 00:00:00
abstract::Background and purpose - Virtual reality simulation of hip fracture surgery is available for orthopedic residents nationwide in Denmark. Summative assessment of learning applying the learning curve cumulative summation test (LC-CUSUM) has not been utilized in orthopedic simulation training. The strength of the LC-CUSU...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453674.2020.1777511
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The first generations of total ankle replacements (TARs) showed a high rate of early failure. In the last decades, much progress has been made in the development of TARs, with the newer generation showing better results. We evaluated TARs implanted with rheumatoid arthritis (RA) or juvenile infla...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453670903153568
更新日期:2009-08-01 00:00:00
abstract::Background and purpose - Anterior knee pain is common after tibial nailing. Its origin is poorly understood. Injury of the infrapatellar nerve is a possible cause. In this randomized controlled trial we compared changes in knee pain after an infrapatellar nerve block with lidocaine or placebo in patients with persiste...
journal_title:Acta orthopaedica
pub_type: 杂志文章,随机对照试验
doi:10.1080/17453674.2019.1613808
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Several studies have shown that nicotine has a detrimental effect on the development of rotator cuff tear. However, little is known about its mechanism. We evaluated the effect of nicotine on the maximum tensile load, the maximum tensile stress, and the elastic modulus of the supraspinatus tendon...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453674.2010.524595
更新日期:2010-10-01 00:00:00
abstract:BACKGROUND:It is well known that anterior cruciate ligament (ACL) injuries are commoner in female athletes. Accordingly, we hypothesized that serum estrogen may play some role in this sex difference. We evaluated the relationship between serum estrogen levels and the mechanical properties of the ACL in rabbits. ANIMAL...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453670610013312
更新日期:2006-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The most common surgical approaches in total hip arthroplasty in Sweden are the posterior and the anterolateral transgluteal approach. Currently, however, there is insufficient evidence to prefer one over the other regarding risk of subsequent surgery. PATIENTS AND METHODS:We searched the Swedis...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453674.2012.742394
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:The etiology of osteoarthritis (OA) is multifactorial and current research attributes it to a complex network of biochemical factors. We attempted to identify important molecules in OA joint destruction. PATIENTS AND METHODS:Synovium was collected from 2 women with hip OA. Total RNA was extracted from the c...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453670710014400
更新日期:2007-10-01 00:00:00
abstract:BACKGROUND:It is not known whether postoperative occupational therapy is of value for hip fracture patients. In this randomized trial we evaluated the effects of an individualized, postoperative, occupational training (OT) program on the patient's self-reported health-related quality of life (HRQL) and self-reported ab...
journal_title:Acta orthopaedica
pub_type: 杂志文章,随机对照试验
doi:10.1080/17453670610045786
更新日期:2006-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Hip resurfacing arthroplasty is being used more and more frequently. The small ratio in size between the resurfaced femoral head and the relatively thick femoral neck raises the question of whether the range of motion is sufficient, particularly with regard to the high mobility required by younge...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453670810016803
更新日期:2008-12-01 00:00:00
abstract::Background and purpose - The number of primary, highly constrained knee arthroplasty implants has increased with a theoretically increased risk of early failure. Therefore we analyzed the risk of all revision following total knee arthroplasty (TKA) in patients receiving a hinged or condylar constrained knee (CCK) comp...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453674.2019.1627638
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:By arthroscopy, we observed a phenomenon that, according to our knowledge not previously described, we call the "biceps tendon footprint" (BTF)--an area of chondromalacia beside the bicipital groove. PATIENTS AND METHODS:We studied 118 shoulder arthroscopies prospectively. We documented whether a BTF could ...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/00016470510030634
更新日期:2005-04-01 00:00:00
abstract:BACKGROUND:International standards indicate that bone allografts for human use should be stored in a -40 degrees C or colder environment and the storage time should be up to 5 years. Bone allografts contain lipids which oxidate and become toxic with time. MATERIAL AND METHODS:We determined lipid oxidation in femoral h...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453670610046343
更新日期:2006-06-01 00:00:00
abstract:BACKGROUND:Ultrasonically driven tools have been used to reduce the incidence of complications during cement removal at revision hip replacement operations. These have been shown to be safe and effective in various ways, but produce fumes. METHODS:Using gas chromatography-mass spectroscopy, we analyzed the fumes produ...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453670510041718
更新日期:2005-10-01 00:00:00
abstract:BACKGROUND:Outcome measurement of shoulder arthroplasty is not standardized. We compared 3 scores and 1 evaluation form. PATIENTS AND METHODS:We report on 35 hemiarthroplasties of the shoulder (32 cementless). Mean age of the patients was 62 (29-87) years. After a mean follow-up of 6 years (range 2-18 years) patients ...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453670610012980
更新日期:2006-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Surgical treatment of chronic acromioclavicular joint dislocations is challenging, and no single procedure can be considered to be the gold standard. In 2010, the GraftRope method (Arthrex Inc., Naples, FL) was introduced in a case series of 10 patients, showing good clinical results and no compl...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453674.2014.976806
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:Degree of satisfaction with a knee arthroplasty is said to be correlated to reduced pain and better function. During a validation of the Swedish Knee Arthroplasty Register in 1997, previously operated patients were asked how satisfied they were with their knee. A subgroup of "satisfied" patients was identifi...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453670510045372
更新日期:2005-12-01 00:00:00
abstract::Background and purpose - Although the use of patient-specific positioning guides (PSPGs) in total knee replacement (TKR) in theory is promising, the technique has not yet proven its superior- ity compared with the conventional method. We compared radio- logical alignment and clinical outcome between TKR performed with...
journal_title:Acta orthopaedica
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1080/17453674.2017.1393732
更新日期:2018-02-01 00:00:00
abstract::Background and purpose - Functional limitations after total knee arthroplasty (TKA) are common. In this longitudinal study, we wanted to identify subgroups of patients with distinct trajectories of pain-related interference with walking during the first year after TKA and to determine which demographic, clinical, symp...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453674.2016.1237440
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:The advent of highly crosslinked polyethylene has allowed the re-evaluation of the use of femoral heads larger than 32 mm for metal-on-polyethylene total hip arthroplasties. However, the effect of larger heads on the frictional torque of highly crosslinked polyethylene is unknown. METHODS:We performed an in...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453670610012881
更新日期:2006-10-01 00:00:00
abstract::Background and purpose - Osteoarthritis has become the most common indication for shoulder arthroplasty in Denmark, and the treatment strategies have changed towards the use of anatomical total shoulder arthroplasty and reverse shoulder arthroplasty. We investigated whether changes in the use of arthroplasty types hav...
journal_title:Acta orthopaedica
pub_type: 杂志文章,多中心研究
doi:10.1080/17453674.2019.1633759
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:Total hip replacement is increasingly used in active, relatively healthy elderly patients with fractures of the femoral neck. Dislocation of the prosthesis is a severe complication, and there is still controversy regarding the optimal surgical approach and its influence on stability. We analyzed factors infl...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453670902930024
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Commercial gentamicin-loaded bone cement beads (Septopal) constitute an effective delivery system for local antibiotic therapy. These beads are not available in all parts of the world, and are too expensive for frequent use in others. Thus, orthopedic surgeons worldwide make antibiotic-loaded bea...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453670903389782
更新日期:2009-10-01 00:00:00
abstract:BACKGROUND:The occurrence of club foot (CF) varies between countries and populations, and may be related to endogenous and exogenous factors. We analyzed the occurrence of CF in a whole country over a long period of time (16 years). METHODS:Patients born in Denmark with a foot deformity 1978-93 were identified from th...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453670610013114
更新日期:2006-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Following transtibial amputation, a rigid dressing of plaster of Paris has been reported to have advantages over a soft dressing regarding wound healing and reduction of edema, but use of the former may be limited by difficulties in application and in gaining access to the wound. An easily applic...
journal_title:Acta orthopaedica
pub_type: 杂志文章,随机对照试验
doi:10.1080/17453670710015265
更新日期:2008-06-01 00:00:00
abstract:BACKGROUND:In Legg-Calvé-Perthes disease (LCPD), 4 major patterns (coxa plana, coxa magna, coxa vara, subluxation) of the femoral head are commonly observed. However, direct observation of pathological specimens is rarely possible. An animal model of LCPD may clarify the pathogenesis of femoral head deformity. ANIMALS...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453670610045678
更新日期:2006-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Joint replacement with metal-on-metal (MOM) bearings have gained popularity in the last decades in young and active patients. However, the possible effects of MOM wear debris and its corrosion products are still the subject of debate. Alongside the potential disadvantages such as toxicity, the in...
journal_title:Acta orthopaedica
pub_type: 杂志文章,评审
doi:10.3109/17453674.2010.519169
更新日期:2010-10-01 00:00:00