No effect of ketoprofen and meloxicam on bone graft ingrowth: a bone chamber study in goats.

Abstract:

BACKGROUND AND PURPOSE:There is increasing awareness that non-steroidal anti-inflammatory drugs (NSAIDs), and especially the cyclooxygenase-2 (COX-2) selective ones, may retard bone healing. We have used NSAIDs (indomethacin for at least 7 days) to prevent heterotopic ossification after acetabular reconstructions using impacted bone grafts. The long-term clinical results have been satisfying, making it difficult to believe that there is an important negative effect of NSAIDs on graft incorporation. We studied the effect of two different NSAIDs on bone and tissue ingrowth in a bone chamber model in goats, using autograft, rinsed allograft, and allograft that had been rinsed and subsequently irradiated. METHODS:9 goats received no NSAIDs, 9 received ketoprofen, and 9 received meloxicam--all for 6 weeks. In each goat 6 bone chambers were implanted: 2 filled with autograft, 2 with rinsed allograft, and 2 with allograft that had been rinsed and irradiated. The amount of bone ingrowth and total tissue ingrowth was compared between the groups. RESULTS:There were no statistically significant differences in bone ingrowth between the different groups. Also, no differences in bone ingrowth were found with respect to the type of graft used. Furthermore, there was no statistically significant difference in the total amount of ingrowth of fibrous tissue between the treatment groups. INTERPRETATION:No differences in bone ingrowth in titanium bone chambers could be detected with both ketoprofen and meloxicam compared to untreated control animals. This confirms our hypothesis that the effect of NSAIDs on the incorporation and ingrowth of bone graft is limited.

journal_name

Acta Orthop

journal_title

Acta orthopaedica

authors

van der Heide HJ,Hannink G,Buma P,Schreurs BW

doi

10.1080/17453670710015562

subject

Has Abstract

pub_date

2008-08-01 00:00:00

pages

548-54

issue

4

eissn

1745-3674

issn

1745-3682

pii

902115380

journal_volume

79

pub_type

杂志文章
  • Postoperative blood transfusion strategy in frail, anemic elderly patients with hip fracture: the TRIFE randomized controlled trial.

    abstract:BACKGROUND AND PURPOSE:Hip fracture (HF) in frail elderly patients is associated with poor physical recovery and death. There is often postoperative blood loss and the hemoglobin (Hb) threshold for red blood cell (RBC) transfusions in these patients is unknown. We investigated whether RBC transfusion strategies were as...

    journal_title:Acta orthopaedica

    pub_type: 杂志文章,随机对照试验

    doi:10.3109/17453674.2015.1006980

    authors: Gregersen M,Borris LC,Damsgaard EM

    更新日期:2015-06-01 00:00:00

  • Cyclooxygenase-2 inhibitor delays fracture healing in rats.

    abstract:BACKGROUND:Cyclooxigenase-2 (COX-2) inhibitors have been reported to delay fracture healing. To investigate the major inhibitory period of COX-2 inhibitors in fracture healing, we administrated etodolac, a COX-2-specific inhibitor, to a rat fracture model by altering the period of administration from early to late. ME...

    journal_title:Acta orthopaedica

    pub_type: 杂志文章

    doi:10.1080/17453670510041439

    authors: Endo K,Sairyo K,Komatsubara S,Sasa T,Egawa H,Ogawa T,Yonekura D,Murakami R,Yasui N

    更新日期:2005-08-01 00:00:00

  • 10-year results following impaction bone grafting of major bone defects in 29 rotational and hinged knee revision arthroplasties: a follow-up of a previous report.

    abstract:BACKGROUND AND PURPOSE:Substantial bone loss in revision total knee arthroplasty (TKA) is a challenging problem. We studied whether impaction bone grafting provides long-term restoration of bone stock in the treatment of major bone defects in revision surgery of rotational and hinged knee arthroplasties (LINK Endo-Mode...

    journal_title:Acta orthopaedica

    pub_type: 杂志文章

    doi:10.3109/17453674.2013.814012

    authors: Hilgen V,Citak M,Vettorazzi E,Haasper C,Day K,Amling M,Gehrke T,Gebauer M

    更新日期:2013-08-01 00:00:00

  • Locking plate osteosynthesis in displaced 4-part fractures of the proximal humerus.

    abstract:BACKGROUND AND PURPOSE:There is considerable uncertainty about the optimal treatment of displaced 4-part fractures of the proximal humerus. Within the last decade, locking plate technology has been considered a breakthrough in the treatment of these complex injuries. METHODS:We systematically identified and reviewed c...

    journal_title:Acta orthopaedica

    pub_type: 杂志文章,评审

    doi:10.3109/17453674.2011.588856

    authors: Brorson S,Frich LH,Winther A,Hróbjartsson A

    更新日期:2011-08-01 00:00:00

  • HipSim - hip fracture surgery simulation utilizing the Learning Curve-Cumulative Summation test (LC-CUSUM).

    abstract::Background and purpose - Virtual reality simulation of hip fracture surgery is available for orthopedic residents nationwide in Denmark. Summative assessment of learning applying the learning curve cumulative summation test (LC-CUSUM) has not been utilized in orthopedic simulation training. The strength of the LC-CUSU...

    journal_title:Acta orthopaedica

    pub_type: 杂志文章

    doi:10.1080/17453674.2020.1777511

    authors: Rölfing JD,Jensen RD,Paltved C

    更新日期:2020-12-01 00:00:00

  • Total ankle prostheses in rheumatoid arthropathy: Outcome in 52 patients followed for 1-9 years.

    abstract:BACKGROUND AND PURPOSE:The first generations of total ankle replacements (TARs) showed a high rate of early failure. In the last decades, much progress has been made in the development of TARs, with the newer generation showing better results. We evaluated TARs implanted with rheumatoid arthritis (RA) or juvenile infla...

    journal_title:Acta orthopaedica

    pub_type: 杂志文章

    doi:10.3109/17453670903153568

    authors: van der Heide HJ,Schutte B,Louwerens JW,van den Hoogen FH,Malefijt MC

    更新日期:2009-08-01 00:00:00

  • An infrapatellar nerve block reduces knee pain in patients with chronic anterior knee pain after tibial nailing: a randomized, placebo-controlled trial in 34 patients.

    abstract::Background and purpose - Anterior knee pain is common after tibial nailing. Its origin is poorly understood. Injury of the infrapatellar nerve is a possible cause. In this randomized controlled trial we compared changes in knee pain after an infrapatellar nerve block with lidocaine or placebo in patients with persiste...

    journal_title:Acta orthopaedica

    pub_type: 杂志文章,随机对照试验

    doi:10.1080/17453674.2019.1613808

    authors: Leliveld MS,Kamphuis SJM,Verhofstad MHJ

    更新日期:2019-08-01 00:00:00

  • Alteration of the material properties of the normal supraspinatus tendon by nicotine treatment in a rat model.

    abstract:BACKGROUND AND PURPOSE:Several studies have shown that nicotine has a detrimental effect on the development of rotator cuff tear. However, little is known about its mechanism. We evaluated the effect of nicotine on the maximum tensile load, the maximum tensile stress, and the elastic modulus of the supraspinatus tendon...

    journal_title:Acta orthopaedica

    pub_type: 杂志文章

    doi:10.3109/17453674.2010.524595

    authors: Ichinose R,Sano H,Kishimoto KN,Sakamoto N,Sato M,Itoi E

    更新日期:2010-10-01 00:00:00

  • Does estrogen alter the mechanical properties of the anterior cruciate ligament? An experimental study in rabbits.

    abstract:BACKGROUND:It is well known that anterior cruciate ligament (ACL) injuries are commoner in female athletes. Accordingly, we hypothesized that serum estrogen may play some role in this sex difference. We evaluated the relationship between serum estrogen levels and the mechanical properties of the ACL in rabbits. ANIMAL...

    journal_title:Acta orthopaedica

    pub_type: 杂志文章

    doi:10.1080/17453670610013312

    authors: Komatsuda T,Sugita T,Sano H,Kusakabe T,Watanuki M,Yoshizumi Y,Murakami T,Hashimoto M,Kokubun S

    更新日期:2006-12-01 00:00:00

  • The type of surgical approach influences the risk of revision in total hip arthroplasty: a study from the Swedish Hip Arthroplasty Register of 90,662 total hipreplacements with 3 different cemented prostheses.

    abstract:BACKGROUND AND PURPOSE:The most common surgical approaches in total hip arthroplasty in Sweden are the posterior and the anterolateral transgluteal approach. Currently, however, there is insufficient evidence to prefer one over the other regarding risk of subsequent surgery. PATIENTS AND METHODS:We searched the Swedis...

    journal_title:Acta orthopaedica

    pub_type: 杂志文章

    doi:10.3109/17453674.2012.742394

    authors: Lindgren V,Garellick G,Kärrholm J,Wretenberg P

    更新日期:2012-12-01 00:00:00

  • Detection of gene expression in synovium of patients with osteoarthritis using a random sequencing method.

    abstract:BACKGROUND:The etiology of osteoarthritis (OA) is multifactorial and current research attributes it to a complex network of biochemical factors. We attempted to identify important molecules in OA joint destruction. PATIENTS AND METHODS:Synovium was collected from 2 women with hip OA. Total RNA was extracted from the c...

    journal_title:Acta orthopaedica

    pub_type: 杂志文章

    doi:10.1080/17453670710014400

    authors: Okabe T,Ohmori Y,Tanigami A,Hishigaki H,Suzuki Y,Sugano S,Kawaguchi A,Nakaya H,Wakitani S

    更新日期:2007-10-01 00:00:00

  • Health-related quality of life and self-reported ability concerning ADL and IADL after hip fracture: a randomized trial.

    abstract:BACKGROUND:It is not known whether postoperative occupational therapy is of value for hip fracture patients. In this randomized trial we evaluated the effects of an individualized, postoperative, occupational training (OT) program on the patient's self-reported health-related quality of life (HRQL) and self-reported ab...

    journal_title:Acta orthopaedica

    pub_type: 杂志文章,随机对照试验

    doi:10.1080/17453670610045786

    authors: Hagsten B,Svensson O,Gardulf A

    更新日期:2006-02-01 00:00:00

  • Limited range of motion of hip resurfacing arthroplasty due to unfavorable ratio of prosthetic head size and femoral neck diameter.

    abstract:BACKGROUND AND PURPOSE:Hip resurfacing arthroplasty is being used more and more frequently. The small ratio in size between the resurfaced femoral head and the relatively thick femoral neck raises the question of whether the range of motion is sufficient, particularly with regard to the high mobility required by younge...

    journal_title:Acta orthopaedica

    pub_type: 杂志文章

    doi:10.1080/17453670810016803

    authors: Kluess D,Zietz C,Lindner T,Mittelmeier W,Schmitz KP,Bader R

    更新日期:2008-12-01 00:00:00

  • Primary constrained and hinged total knee arthroplasty: 2- and 5-year revision risk compared with unconstrained total knee arthroplasty: a report on 401 cases from the Norwegian Arthroplasty Register 1994-2017.

    abstract::Background and purpose - The number of primary, highly constrained knee arthroplasty implants has increased with a theoretically increased risk of early failure. Therefore we analyzed the risk of all revision following total knee arthroplasty (TKA) in patients receiving a hinged or condylar constrained knee (CCK) comp...

    journal_title:Acta orthopaedica

    pub_type: 杂志文章

    doi:10.1080/17453674.2019.1627638

    authors: Badawy M,Fenstad AM,Furnes O

    更新日期:2019-10-01 00:00:00

  • The biceps tendon footprint.

    abstract:BACKGROUND:By arthroscopy, we observed a phenomenon that, according to our knowledge not previously described, we call the "biceps tendon footprint" (BTF)--an area of chondromalacia beside the bicipital groove. PATIENTS AND METHODS:We studied 118 shoulder arthroscopies prospectively. We documented whether a BTF could ...

    journal_title:Acta orthopaedica

    pub_type: 杂志文章

    doi:10.1080/00016470510030634

    authors: Sistermann R

    更新日期:2005-04-01 00:00:00

  • Lipid oxidation may reduce the quality of a fresh-frozen bone allograft. Is the approved storage temperature too high?

    abstract:BACKGROUND:International standards indicate that bone allografts for human use should be stored in a -40 degrees C or colder environment and the storage time should be up to 5 years. Bone allografts contain lipids which oxidate and become toxic with time. MATERIAL AND METHODS:We determined lipid oxidation in femoral h...

    journal_title:Acta orthopaedica

    pub_type: 杂志文章

    doi:10.1080/17453670610046343

    authors: Laitinen M,Kivikari R,Hirn M

    更新日期:2006-06-01 00:00:00

  • Gas chromatography-mass spectroscopy analysis of emissions from cement when using ultrasonically driven tools.

    abstract:BACKGROUND:Ultrasonically driven tools have been used to reduce the incidence of complications during cement removal at revision hip replacement operations. These have been shown to be safe and effective in various ways, but produce fumes. METHODS:Using gas chromatography-mass spectroscopy, we analyzed the fumes produ...

    journal_title:Acta orthopaedica

    pub_type: 杂志文章

    doi:10.1080/17453670510041718

    authors: Shewale SB,Briggs RD

    更新日期:2005-10-01 00:00:00

  • Outcome assessment of hemiarthroplasty of the shoulder: a 5-year follow-up with 4 evaluation tools.

    abstract:BACKGROUND:Outcome measurement of shoulder arthroplasty is not standardized. We compared 3 scores and 1 evaluation form. PATIENTS AND METHODS:We report on 35 hemiarthroplasties of the shoulder (32 cementless). Mean age of the patients was 62 (29-87) years. After a mean follow-up of 6 years (range 2-18 years) patients ...

    journal_title:Acta orthopaedica

    pub_type: 杂志文章

    doi:10.1080/17453670610012980

    authors: Krepler P,Wanivenhaus AH,Wurnig C

    更新日期:2006-10-01 00:00:00

  • Chronic acromioclavicular joint dislocations treated by the GraftRope device.

    abstract:BACKGROUND AND PURPOSE:Surgical treatment of chronic acromioclavicular joint dislocations is challenging, and no single procedure can be considered to be the gold standard. In 2010, the GraftRope method (Arthrex Inc., Naples, FL) was introduced in a case series of 10 patients, showing good clinical results and no compl...

    journal_title:Acta orthopaedica

    pub_type: 杂志文章

    doi:10.3109/17453674.2014.976806

    authors: Nordin JS,Aagaard KE,Lunsjö K

    更新日期:2015-04-01 00:00:00

  • Revision in previously satisfied knee arthroplasty patients is the result of their call on the physician, not on pre-planned follow-up: a retrospective study of 181 patients who underwent revision within 2 years.

    abstract:BACKGROUND:Degree of satisfaction with a knee arthroplasty is said to be correlated to reduced pain and better function. During a validation of the Swedish Knee Arthroplasty Register in 1997, previously operated patients were asked how satisfied they were with their knee. A subgroup of "satisfied" patients was identifi...

    journal_title:Acta orthopaedica

    pub_type: 杂志文章

    doi:10.1080/17453670510045372

    authors: Bremander AB,Dunbar M,Knutson K,Petersson IF,Robertsson O

    更新日期:2005-12-01 00:00:00

  • No radiological and clinical advantages with patient-specific positioning guides in total knee replacement.

    abstract::Background and purpose - Although the use of patient-specific positioning guides (PSPGs) in total knee replacement (TKR) in theory is promising, the technique has not yet proven its superior- ity compared with the conventional method. We compared radio- logical alignment and clinical outcome between TKR performed with...

    journal_title:Acta orthopaedica

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1080/17453674.2017.1393732

    authors: Van Leeuwen JAMJ,Snorrason F,Röhrl SM

    更新日期:2018-02-01 00:00:00

  • Factors that can predict pain with walking, 12 months after total knee arthroplasty.

    abstract::Background and purpose - Functional limitations after total knee arthroplasty (TKA) are common. In this longitudinal study, we wanted to identify subgroups of patients with distinct trajectories of pain-related interference with walking during the first year after TKA and to determine which demographic, clinical, symp...

    journal_title:Acta orthopaedica

    pub_type: 杂志文章

    doi:10.1080/17453674.2016.1237440

    authors: Lindberg MF,Miaskowski C,RustøEn T,Rosseland LA,Cooper BA,Lerdal A

    更新日期:2016-12-01 00:00:00

  • In vitro comparison of frictional torque and torsional resistance of aged conventional gamma-in-nitrogen sterilized polyethylene versus aged highly crosslinked polyethylene articulating against head sizes larger than 32 mm.

    abstract:BACKGROUND:The advent of highly crosslinked polyethylene has allowed the re-evaluation of the use of femoral heads larger than 32 mm for metal-on-polyethylene total hip arthroplasties. However, the effect of larger heads on the frictional torque of highly crosslinked polyethylene is unknown. METHODS:We performed an in...

    journal_title:Acta orthopaedica

    pub_type: 杂志文章

    doi:10.1080/17453670610012881

    authors: Burroughs BR,Muratoglu OK,Bragdon CR,Wannomae KK,Christensen S,Lozynsky AJ,Harris WH

    更新日期:2006-10-01 00:00:00

  • Increased use of total shoulder arthroplasty for osteoarthritis and improved patient-reported outcome in Denmark, 2006-2015: a nationwide cohort study from the Danish Shoulder Arthroplasty Registry.

    abstract::Background and purpose - Osteoarthritis has become the most common indication for shoulder arthroplasty in Denmark, and the treatment strategies have changed towards the use of anatomical total shoulder arthroplasty and reverse shoulder arthroplasty. We investigated whether changes in the use of arthroplasty types hav...

    journal_title:Acta orthopaedica

    pub_type: 杂志文章,多中心研究

    doi:10.1080/17453674.2019.1633759

    authors: Rasmussen JV,Amundsen A,Sørensen AKB,Klausen TW,Jakobsen J,Jensen SL,Olsen BS

    更新日期:2019-10-01 00:00:00

  • Dislocation of total hip replacement in patients with fractures of the femoral neck.

    abstract:BACKGROUND:Total hip replacement is increasingly used in active, relatively healthy elderly patients with fractures of the femoral neck. Dislocation of the prosthesis is a severe complication, and there is still controversy regarding the optimal surgical approach and its influence on stability. We analyzed factors infl...

    journal_title:Acta orthopaedica

    pub_type: 杂志文章

    doi:10.3109/17453670902930024

    authors: Enocson A,Hedbeck CJ,Tidermark J,Pettersson H,Ponzer S,Lapidus LJ

    更新日期:2009-04-01 00:00:00

  • Concepts for increasing gentamicin release from handmade bone cement beads.

    abstract:BACKGROUND AND PURPOSE:Commercial gentamicin-loaded bone cement beads (Septopal) constitute an effective delivery system for local antibiotic therapy. These beads are not available in all parts of the world, and are too expensive for frequent use in others. Thus, orthopedic surgeons worldwide make antibiotic-loaded bea...

    journal_title:Acta orthopaedica

    pub_type: 杂志文章

    doi:10.3109/17453670903389782

    authors: Rasyid HN,van der Mei HC,Frijlink HW,Soegijoko S,van Horn JR,Busscher HJ,Neut D

    更新日期:2009-10-01 00:00:00

  • Increasing incidence of club foot with higher population density: incidence and geographical variation in Denmark over a 16-year period--an epidemiological study of 936,525 births.

    abstract:BACKGROUND:The occurrence of club foot (CF) varies between countries and populations, and may be related to endogenous and exogenous factors. We analyzed the occurrence of CF in a whole country over a long period of time (16 years). METHODS:Patients born in Denmark with a foot deformity 1978-93 were identified from th...

    journal_title:Acta orthopaedica

    pub_type: 杂志文章

    doi:10.1080/17453670610013114

    authors: Krogsgaard MR,Jensen PK,Kjaer I,Husted H,Lorentzen J,Hvass-Christensen B,Christensen SB,Larsen K,Sonne-Holm S

    更新日期:2006-12-01 00:00:00

  • Comparison of vacuum-formed removable rigid dressing with conventional rigid dressing after transtibial amputation: similar outcome in a randomized controlled trial involving 27 patients.

    abstract:BACKGROUND AND PURPOSE:Following transtibial amputation, a rigid dressing of plaster of Paris has been reported to have advantages over a soft dressing regarding wound healing and reduction of edema, but use of the former may be limited by difficulties in application and in gaining access to the wound. An easily applic...

    journal_title:Acta orthopaedica

    pub_type: 杂志文章,随机对照试验

    doi:10.1080/17453670710015265

    authors: Johannesson A,Larsson GU,Oberg T,Atroshi I

    更新日期:2008-06-01 00:00:00

  • Deformity of the femoral head following vascular infarct in piglets.

    abstract:BACKGROUND:In Legg-Calvé-Perthes disease (LCPD), 4 major patterns (coxa plana, coxa magna, coxa vara, subluxation) of the femoral head are commonly observed. However, direct observation of pathological specimens is rarely possible. An animal model of LCPD may clarify the pathogenesis of femoral head deformity. ANIMALS...

    journal_title:Acta orthopaedica

    pub_type: 杂志文章

    doi:10.1080/17453670610045678

    authors: Rowe SM,Lee JJ,Chung JY,Moon ES,Song EK,Seo HY

    更新日期:2006-02-01 00:00:00

  • Effects of metal-on-metal wear on the host immune system and infection in hip arthroplasty.

    abstract:BACKGROUND AND PURPOSE:Joint replacement with metal-on-metal (MOM) bearings have gained popularity in the last decades in young and active patients. However, the possible effects of MOM wear debris and its corrosion products are still the subject of debate. Alongside the potential disadvantages such as toxicity, the in...

    journal_title:Acta orthopaedica

    pub_type: 杂志文章,评审

    doi:10.3109/17453674.2010.519169

    authors: Hosman AH,van der Mei HC,Bulstra SK,Busscher HJ,Neut D

    更新日期:2010-10-01 00:00:00