Deformity of the femoral head following vascular infarct in piglets.

Abstract:

BACKGROUND:In Legg-Calvé-Perthes disease (LCPD), 4 major patterns (coxa plana, coxa magna, coxa vara, subluxation) of the femoral head are commonly observed. However, direct observation of pathological specimens is rarely possible. An animal model of LCPD may clarify the pathogenesis of femoral head deformity. ANIMALS AND METHODS:In 26 piglets, we interrupted the vascular supply to the capital femoral epiphysis by cutting the ligamentum teres and ligating the femoral neck containing the epiphyseal artery. 6-7 piglets in each experimental group were killed at early (2 and 4 weeks: P2 and P4), intermediate (12 weeks: P12), and late (20 weeks: P20) periods. We examined the extracted femoral heads macroscopically and radiographically. RESULTS:The mean decrease in epiphyseal height was 1.5 mm, 4.1 mm, 5.0 mm, and 7.5 mm in P2, P4, P12 and P20, respectively (rs = 0.76, p = 0.002). The mean increase of diameter was 4.1 mm, 6.9 mm, and 6.8 mm in P4, P12 and P20, respectively. Decrease of the articulotrochanteric distance was mild in P2 and P4, and severe in P12 and P20. Subluxation of the femoral head was observed only in P12 and P20 piglets. INTERPRETATION:The piglet model of LCPD was useful in the early stage of devascularization for investigation of the developmental pattern of femoral head deformity. However, when the piglets had grown to 20 weeks old or more--that is, to full skeletal maturity--the femoral head and acetabulum showed severe deformities that were most likely caused by heavy body weight.

journal_name

Acta Orthop

journal_title

Acta orthopaedica

authors

Rowe SM,Lee JJ,Chung JY,Moon ES,Song EK,Seo HY

doi

10.1080/17453670610045678

keywords:

subject

Has Abstract

pub_date

2006-02-01 00:00:00

pages

33-8

issue

1

eissn

1745-3674

issn

1745-3682

pii

738520545

journal_volume

77

pub_type

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