Abstract:
BACKGROUND:Cancellous bone can act as a delivery vehicle for vancomycin without impairment of graft incorporation. However, local and systemic antibiotic levels, biological activity of vancomycin, interaction with antibiotic-loaded cement, and also nephrotoxicity of these composites have not yet been studied clinically. MATERIAL AND METHODS:Blood, drainage and urine samples of 20 consecutive patients undergoing revision total hip arthroplasties with impaction grafting technique utilizing 1 g of vancomycin per femoral head were studied. Plain PMMA cement was used in 10 cases, while PMMA with gentamycin was used in 5 cases and tobramycin was used in the remaining 5 cases. Biological activity of vancomycin was studied using kinetic killing curves in three ATCC organisms (methicillin-sensitive Staphylococcus aureus, methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosas). Quantification was done with fluorescent polarized immunoassay. Renal function was evaluated with preoperative and postoperative urea and creatinine. RESULTS:Local active bactericidal levels of vancomycin reached 1400 microg/mL (average 5-point level = 367 microg/mL) without nephrotoxicity. Vancomycin was present in urine until the fifteenth day. Both aminoglycosides in the cement had activity against Pseudomonas aeruginosas. INTERPRETATION:Local levels of vancomycin were 35 times greater than the highest levels reported with vancomycin-loaded PMMA. A synergistic effect was observed between vancomycin released from impacted allografts and aminoglycoside-loaded PMMA.
journal_name
Acta Orthopjournal_title
Acta orthopaedicaauthors
Buttaro MA,Gimenez MI,Greco G,Barcan L,Piccaluga Fkeywords:
subject
Has Abstractpub_date
2005-06-01 00:00:00pages
336-40issue
3eissn
1745-3674issn
1745-3682journal_volume
76pub_type
杂志文章abstract:BACKGROUND AND PURPOSES:The nervous system plays an important role in bone metabolism. However, the effect of denervation on bone formation during distraction osteogenesis (DO) remains unclear. We studied neural influence on bone regeneration during DO in a rabbit model. METHODS:24 New Zealand male white rabbits under...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453674.2012.702389
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The risk of complications in cirrhosis patients after orthopedic surgery is unclear. We examined this risk after total hip arthroplasty (THA) or total knee arthroplasty (TKA). PATIENTS AND METHODS:Using Danish healthcare registries, we identified all Danish residents who underwent a THA or TKA f...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453674.2014.961397
更新日期:2015-02-01 00:00:00
abstract::Background and purpose - To date there is a lack of studies defining the anatomical position of the proximal fibula. This is especially relevant when planning surgical interventions affecting the knee joint such as permanent or temporary epiphysiodesis to correct leg length discrepancies or angular deformities in grow...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453674.2020.1769378
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The Norwegian Cruciate Ligament Register (NCLR) was founded in 2004. The purpose of the NCLR is to provide representative and reliable data for future research. In this study we evaluated the development of the registration rate in the NCLR. METHODS:The Norwegian Patient Register (NPR) and the e...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453674.2012.678800
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Several mechanisms are responsible for patellar dislocation. We investigated how the primary pathomechanism relates to patient characteristics and the outcome. METHODS:126 patients (81 females) with primary patellar dislocation reported the knee position before the episode, the movement during i...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453670903110634
更新日期:2009-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Ultrasound is used for imaging of pseudotumors associated with metal-on-metal (MoM) hips. Ultrasound has been compared with magnetic resonance imaging, but to date there have been no studies comparing ultrasound findings and revision findings. METHODS:We evaluated the sensitivity and specificity...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453674.2014.1001970
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:The etiology of osteoarthritis (OA) is multifactorial and current research attributes it to a complex network of biochemical factors. We attempted to identify important molecules in OA joint destruction. PATIENTS AND METHODS:Synovium was collected from 2 women with hip OA. Total RNA was extracted from the c...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453670710014400
更新日期:2007-10-01 00:00:00
abstract::Background and purpose - Larger prospective studies investigating periacetabular osteotomy (PAO) with patient-reported outcome measures developed for young patients are lacking. We investigated changes in patient-reported outcome (PRO), changes in muscle-tendon pain, and any associations between them from before to 1 ...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453674.2018.1555637
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:The coronal alignment of the lower limb is important for knee reconstruction procedures. However, normal alignment is hard to define because of its wide variation among normal individuals. Our hypothesis was that the variation in the normal anatomy as assessed by radiography is greater than commonly accepted...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:
更新日期:2005-06-01 00:00:00
abstract:BACKGROUND:The frontal pelvic plane has traditionally served as the reference plane for implantation of the acetabular cup during total hip arthroplasty, with referencing performed with the patient supine on the operating table. During daily activities in an upright position, the frontal pelvic plane changes from a hor...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453670510045471
更新日期:2005-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Although a tourniquet may reduce bleeding during total knee replacement (TKA), and thereby possibly improve fixation, it might also cause complications. Migration as measured by radiostereometric analysis (RSA) can predict future loosening. We investigated whether the use of a tourniquet influenc...
journal_title:Acta orthopaedica
pub_type: 杂志文章,随机对照试验
doi:10.3109/17453674.2012.727078
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:International standards indicate that bone allografts for human use should be stored in a -40 degrees C or colder environment and the storage time should be up to 5 years. Bone allografts contain lipids which oxidate and become toxic with time. MATERIAL AND METHODS:We determined lipid oxidation in femoral h...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453670610046343
更新日期:2006-06-01 00:00:00
abstract::Background and purpose - Hip resurfacing (HR) is a treatment option promoted for hip arthritis in young and active patients. However, adverse reactions to metal are a concern and the search for non-metallic bearing options proceeds. We present the first clinical study performed in patients using a newly developed hydr...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453674.2017.1376526
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:The in vivo pharmacokinetics of gentamycin- loaded collagen fleeces in humans have not been described in the current literature. We therefore analyzed in vivo pharmacokinetics of these fleeces when used in the treatment of periprosthetic infections. PATIENTS AND METHODS:Gentamycin concentrations were measur...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453670810016650
更新日期:2008-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Intraoperative periprosthetic femoral fracture is a known complication of cementless total hip arthroplasty (THA). We determined the incidence of--and risk factors for--intraoperative calcar fracture, and assessed its influence on the risk of revision. PATIENTS AND METHODS:This retrospective ana...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453674.2015.1112712
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:There are no reports in the literature on the influence of learning on the pedicle screw insertion. We studied the effect of learning on the rate of screw misplacement in patients with adolescent idiopathic scoliosis treated with segmental pedicle screw fixation. METHOD:We retrospectively evalua...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453674.2010.548032
更新日期:2011-02-01 00:00:00
abstract::Background and purpose - There is a general call for phased introduction of new implants, and one step in the introduction is an early evaluation of micromotion. We compared the micromotion in the Triathlon and its predecessor, the Duracon total knee prosthesis, concentrating especially on continuous migration over 5 ...
journal_title:Acta orthopaedica
pub_type: 评论,杂志文章
doi:10.3109/17453674.2016.1166876
更新日期:2016-06-01 00:00:00
abstract::- Knee pathologies including focal cartilage injuries, osteoarthritis (OA), and ligament injuries are common. The poor regeneration and healing potential of cartilage has led to the search for other treatment modalities with improved healing capacity. Furthermore, with an increasing elderly population that desires to ...
journal_title:Acta orthopaedica
pub_type: 杂志文章,评审
doi:10.1080/17453674.2017.1368899
更新日期:2017-12-01 00:00:00
abstract::Background and purpose - Elderly patients may benefit from a dislocation low-risk dual-mobility (DM) articulation in total hip arthroplasty, but the best cup fixation method is unknown. We compared cup migration for cemented and cementless DM cups using radiostereometry.Patients and methods - In a patient-blinded rand...
journal_title:Acta orthopaedica
pub_type: 杂志文章,随机对照试验
doi:10.1080/17453674.2020.1720978
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:It is not known whether postoperative occupational therapy is of value for hip fracture patients. In this randomized trial we evaluated the effects of an individualized, postoperative, occupational training (OT) program on the patient's self-reported health-related quality of life (HRQL) and self-reported ab...
journal_title:Acta orthopaedica
pub_type: 杂志文章,随机对照试验
doi:10.1080/17453670610045786
更新日期:2006-02-01 00:00:00
abstract:BACKGROUND:To overcome the mismatch between a stiff stem and the more elastic bone, the concept of isoelasticity was introduced in the 1970s. This concept was based on the assumption that the implant and the bone should deform as one unit to avoid stress shielding. The Robert Mathys (RM) cementless total hip replacemen...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/00016470510030535
更新日期:2005-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Operative findings during revision of metal-on-metal hip arthroplasty (MOMHA) vary widely and can involve massive soft tissue and bone disruption. As a result, planning of theater time and resources is difficult, surgery is challenging, and outcomes are often poor. We describe our experience with...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453674.2013.797313
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Resurfacing total hip arthroplasty (RTHA) may preserve the femoral neck bone stock postoperatively. Bone mineral density (BMD) may be affected by the hip position, which might bias longitudinal studies. We investigated the dependency of BMD precision on type of ROI and hip position. METHOD:We DX...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453674.2010.480935
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Multimodal techniques can aid early rehabilitation and discharge of patients following primary joint replacement. We hypothesized that this not only reduces the economic burden of joint replacement by reducing length of stay, but also helps in reduction of early complications. PATIENTS AND METHO...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453674.2011.618911
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Hydroxyapatite (HA) coating is believed to improve bone-implant ingrowth and long-term survival of prostheses. Recent studies, however, have challenged this view. Furthermore, HA particles may produce third-body wear and initiate aseptic loosening of implants. We report the performance of HA- and...
journal_title:Acta orthopaedica
pub_type: 杂志文章,随机对照试验
doi:10.3109/17453674.2013.854665
更新日期:2013-12-01 00:00:00
abstract::Background and purpose - Virtual reality simulation of hip fracture surgery is available for orthopedic residents nationwide in Denmark. Summative assessment of learning applying the learning curve cumulative summation test (LC-CUSUM) has not been utilized in orthopedic simulation training. The strength of the LC-CUSU...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453674.2020.1777511
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The number of periprosthetic fractures following total hip arthroplasty (THA) is increasing. There is, however, limited data on the functional outcome following these injuries. We analyzed functional outcome for revision THA following periprosthetic fracture, and compared this to the outcome of e...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453670710015463
更新日期:2008-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Hip resurfacing arthroplasty is being used more and more frequently. The small ratio in size between the resurfaced femoral head and the relatively thick femoral neck raises the question of whether the range of motion is sufficient, particularly with regard to the high mobility required by younge...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453670810016803
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Problems during knee extension, due to kinematic alterations, are not uncommon after total knee arthroplasty. Hinged prostheses provide higher stability than non-hinged designs and may minimize these alterations. Thus, in this in vitro study we investigated the quadriceps force required to extend...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453670710014734
更新日期:2008-02-01 00:00:00
abstract::Background and purpose - Hindfoot arthrodesis using retrograde intramedullary nailing assumes a critical role in limb salvage for patients with diabetic Charcot neuro-arthropathy (CN). However, this procedure is compelling and fraught with complications in diabetic patients. We report the mid-term clinical and radiolo...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453674.2020.1746605
更新日期:2020-06-01 00:00:00