Abstract:
:Background and purpose - Hip resurfacing (HR) is a treatment option promoted for hip arthritis in young and active patients. However, adverse reactions to metal are a concern and the search for non-metallic bearing options proceeds. We present the first clinical study performed in patients using a newly developed hydrophilic polymer-on-polymer hip resurfacing device. Patients and methods - After performing extensive hip simulator tests, biocompatibility testing and animal tests (ISO 14242-1,3; 10993-3,4,5,10,11), approval was obtained from the IRB committee to enroll 15 patients in the first clinical study in humans using this experimental polymer-on-polymer hip resurfacing device. All surgeries were done by 2 experienced hip resurfacing surgeons. Clinical scores and standard radiographs as well as routine MRIs were obtained at regular intervals. Results - The surgical technique proved feasible with successful implantation of the new device using PMMA cement fixation on both sides without complications. Postoperative imaging revealed a well-positioned and well-fixed polymer resurfacing hip arthroplasty in all 4 initial cases. All 4 patients were free of pain and had good function for the first 2 months. However, in all 4 cases early cup loosening occurred between 8 and 11 weeks after surgery, necessitating immediate closure of the study. All 4 patients had a reoperation and were revised to a conventional THA. Retrieval analyses confirmed early cup loosening at the implant-cement interface in all 4 cases. The femoral components remained well attached to the cement. The periprosthetic tissues showed only small amounts of polymeric wear debris and there was only a very mild inflammatory reaction to this. Interpretation - Early cup loosening mandated a premature arrest of this study. After additional laboratory testing this failure mode was found to be the result of a small, yet measurable contraction in the cup size after exposing these implants to biological fluid divalent ion fluctuations in vivo. Currently used preclinical tests had failed to detect this failure mechanism. Modification of the polymer is essential to overcome these problems and before the potential of a polymer-on-polymer resurfacing arthroplasty may be further evaluated in patients.
journal_name
Acta Orthopjournal_title
Acta orthopaedicaauthors
Van Susante JLC,Verdonschot N,Bom LPA,Tomaszewski P,Campbell P,Ebramzadeh E,Schreurs BWdoi
10.1080/17453674.2017.1376526subject
Has Abstractpub_date
2018-02-01 00:00:00pages
59-65issue
1eissn
1745-3674issn
1745-3682journal_volume
89pub_type
杂志文章abstract:BACKGROUND:After total hip replacement, increased bone metabolism is seen. A local periprosthetic osteopenia can be measured by dual-energy X-ray absorptiometry (DXA), but it is still unkown whether biochemical markers can be used to monitor the local remodeling at an earlier stage. PATIENTS AND METHODS:In this prospe...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453670710013717
更新日期:2007-04-01 00:00:00
abstract:BACKGROUND:Laboratory tests and early clinical studies have shown that highly cross-linked polyethylene (PE) markedly improves wear resistance compared to conventional PE. We evaluated this type of PE in two randomized clinical studies using radiostereometric analysis (RSA). The 2- and 3-year follow-up of these studies...
journal_title:Acta orthopaedica
pub_type: 杂志文章,随机对照试验
doi:10.1080/17453670710014518
更新日期:2007-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Following transtibial amputation, a rigid dressing of plaster of Paris has been reported to have advantages over a soft dressing regarding wound healing and reduction of edema, but use of the former may be limited by difficulties in application and in gaining access to the wound. An easily applic...
journal_title:Acta orthopaedica
pub_type: 杂志文章,随机对照试验
doi:10.1080/17453670710015265
更新日期:2008-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Intraoperative periprosthetic femoral fracture is a known complication of cementless total hip arthroplasty (THA). We determined the incidence of--and risk factors for--intraoperative calcar fracture, and assessed its influence on the risk of revision. PATIENTS AND METHODS:This retrospective ana...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453674.2015.1112712
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Aseptic loosening is the major cause of implant failure. In cemented hip arthroplasty, failure of the acetabular side is mainly due to lysis caused by wear particles. By using an implant with low wear characteristics and by enhancing acetabular fixation using an uncemented implant, we aimed to reduce acetabu...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453670710014103
更新日期:2007-08-01 00:00:00
abstract:BACKGROUND:By arthroscopy, we observed a phenomenon that, according to our knowledge not previously described, we call the "biceps tendon footprint" (BTF)--an area of chondromalacia beside the bicipital groove. PATIENTS AND METHODS:We studied 118 shoulder arthroscopies prospectively. We documented whether a BTF could ...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/00016470510030634
更新日期:2005-04-01 00:00:00
abstract:BACKGROUND:Periacetabular osteotomy improves radiographic predictors of osteoarthrosis and diminishes pain and functional impairment. No changes in function quantified by gait analysis have yet been documented. We evaluated the functional outcome of periacetabular osteotomy in relation to gait. METHODS:The gait patter...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453670610045920
更新日期:2006-04-01 00:00:00
abstract::Background and purpose - Impaction bone grafting (IBG) is an established method in hip revision surgery to reconstruct loss of bone stock. There is limited knowledge concerning the actual bone remodelling process within the allograft. We investigated with repeated bone mineral density (BMD) measurements the biological...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453674.2018.1460776
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The validity of various data sources for the assessment of the outcome quality of medical devices was investigated by comparative analysis of the published data sources available for a sample of implants. It was the aim of the study to determine the performance of this implant and to identify pot...
journal_title:Acta orthopaedica
pub_type: 杂志文章,评审
doi:10.3109/17453674.2011.570668
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:It is unclear whether osteoarthritis (OA) of the knee is seen better in standing flexion position radiographs than in the standing extended view. We assessed the value of standing flexion views. PATIENTS AND METHODS:We retrospectively evaluated 1,090 radiographs of 545 consecutive knees with non...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453674.2010.483989
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Several studies have shown that nicotine has a detrimental effect on the development of rotator cuff tear. However, little is known about its mechanism. We evaluated the effect of nicotine on the maximum tensile load, the maximum tensile stress, and the elastic modulus of the supraspinatus tendon...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453674.2010.524595
更新日期:2010-10-01 00:00:00
abstract::Background and purpose - Anterior knee pain is common after tibial nailing. Its origin is poorly understood. Injury of the infrapatellar nerve is a possible cause. In this randomized controlled trial we compared changes in knee pain after an infrapatellar nerve block with lidocaine or placebo in patients with persiste...
journal_title:Acta orthopaedica
pub_type: 杂志文章,随机对照试验
doi:10.1080/17453674.2019.1613808
更新日期:2019-08-01 00:00:00
abstract::Background and purpose - Patients having a total knee arthroplasty (TKA) after a previous high tibial osteotomy (HTO) constitute a minor group among those undergoing primary TKA for knee osteoarthritis (OA). There have been few reports on whether such patients differ pre- and postoperatively from those who undergo TKA...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453674.2016.1195663
更新日期:2016-08-01 00:00:00
abstract::- The International Society of Arthroplasty Registries (ISAR) Patient-Reported Outcome Measures (PROMs) Working Group have evaluated and recommended best practices in the selection, administration, and interpretation of PROMs for hip and knee arthroplasty registries. The 2 generic PROMs in common use are the Short For...
journal_title:Acta orthopaedica
pub_type: 评论,杂志文章
doi:10.1080/17453674.2016.1181816
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:In recent years several different plate designs for internal fixation of fractures of the distal radius have been developed. However, few biomechanical studies have been performed to compare these new implants. The purpose of this study was to compare the mechanical properties of 5 different comm...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453670902947440
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Bones used in mechanical studies are frequently harvested from human cadavers that have been embalmed in a buffered formaldehyde solution. It has been reported that formaldehyde fixation or freezing hardly affects the mechanical properties of bone after a storage period of several weeks. However,...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453670810016759
更新日期:2008-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Hydroxyapatite (HA) coating is believed to improve bone-implant ingrowth and long-term survival of prostheses. Recent studies, however, have challenged this view. Furthermore, HA particles may produce third-body wear and initiate aseptic loosening of implants. We report the performance of HA- and...
journal_title:Acta orthopaedica
pub_type: 杂志文章,随机对照试验
doi:10.3109/17453674.2013.854665
更新日期:2013-12-01 00:00:00
abstract::Background and purpose - Radiostereometric analysis (RSA) is the gold standard to study micromotion of joint replacements. RSA requires the acquisition of additional radiographs increasing the radiation dose of patients included in RSA studies. It is important to keep this dose as low as possible. Effective radiation ...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453674.2020.1767443
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We have previously reported that the first 10 years of hip arthroplasty in Lithuania resulted in a higher cumulative revision rate than that observed in Sweden. We thus compared the corresponding results after introduaction of total knee replacement in Lithuania. METHODS:The 10-year revision rat...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453670902804984
更新日期:2009-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The Knee Injury and Osteoarthritis Outcome Score (KOOS) is distinguished from other knee-specific measures by the inclusion of separate scales for evaluation of activities of daily living, sports and recreation function, and knee-related quality of life, with presentation of separate subscale sco...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453674.2012.747921
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:The use of impaction grafting in revisions with larger acetabular bone defects has mixed outcomes and sometimes high failures rates. PATIENTS AND METHODS:This prospective, single-center study involved a consecutive series of 24 patients who underwent complex reconstruction of the acetabulum using a trabecul...
journal_title:Acta orthopaedica
pub_type: 临床试验,杂志文章
doi:10.3109/17453674.2012.718518
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Operative findings during revision of metal-on-metal hip arthroplasty (MOMHA) vary widely and can involve massive soft tissue and bone disruption. As a result, planning of theater time and resources is difficult, surgery is challenging, and outcomes are often poor. We describe our experience with...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453674.2013.797313
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND:Since the osteogenic potential of bone marrow derived mesenchymal stem cells (BMSCs) becomes reduced with passage, establishment of culture condition that permit the rapid expansion of BMSCs while retaining their potential for differentiation is needed for clinical application. Bone morphogenetic proteins st...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453670710013816
更新日期:2007-04-01 00:00:00
abstract::Background and purpose - Mobile-bearing total knee prostheses (TKPs) were developed in the 1970s in an attempt to increase function and improve implant longevity. However, modern fixed-bearing designs like the single-radius TKP may provide similar advantages. We compared tibial component migration measured with radios...
journal_title:Acta orthopaedica
pub_type: 杂志文章,随机对照试验
doi:10.1080/17453674.2018.1429108
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The most common surgical approaches in total hip arthroplasty in Sweden are the posterior and the anterolateral transgluteal approach. Currently, however, there is insufficient evidence to prefer one over the other regarding risk of subsequent surgery. PATIENTS AND METHODS:We searched the Swedis...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453674.2012.742394
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:Outcome measurement of shoulder arthroplasty is not standardized. We compared 3 scores and 1 evaluation form. PATIENTS AND METHODS:We report on 35 hemiarthroplasties of the shoulder (32 cementless). Mean age of the patients was 62 (29-87) years. After a mean follow-up of 6 years (range 2-18 years) patients ...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453670610012980
更新日期:2006-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Extracorporeal shock wave treatment has been used successfully for the treatment of avascular necrosis of the femoral head. The pathway of biological events by which this is accomplished has not been fully elucidated. BMP-2 is a key mediator of bone development and repair, and is uniquely require...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453670710014833
更新日期:2008-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The osteogenic potency of erythropoietin (EPO) has been documented. However, its efficacy in a large-animal model has not yet been investigated; nor has a clinically safe dosage. The purpose of this study was to overcome such limitations of previous studies and thereby pave the way for possible c...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453674.2014.889981
更新日期:2014-04-01 00:00:00
abstract::Background and purpose - Functional limitations after total knee arthroplasty (TKA) are common. In this longitudinal study, we wanted to identify subgroups of patients with distinct trajectories of pain-related interference with walking during the first year after TKA and to determine which demographic, clinical, symp...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453674.2016.1237440
更新日期:2016-12-01 00:00:00
abstract::Background and purpose - Alternative bearing surfaces such as ceramics and highly crosslinked polyethylene (HXLPE) were developed in order to further improve implant performance of total hip arthroplasties (THAs). Whether these alternative bearing surfaces result in increased longevity is subject to debate. Patients a...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453674.2017.1405669
更新日期:2018-04-01 00:00:00