Abstract:
BACKGROUND AND PURPOSE:Integration of repaired cartilage with surrounding native cartilage is a major challenge for successful tissue-engineering strategies of cartilage repair. We investigated whether incorporation of mesenchymal stem cells (MSCs) into the collagen scaffold improves integration and repair of cartilage defects in a cynomolgus macaque model. METHODS:Cynomolgus macaque bone marrow-derived MSCs were isolated and incorporated into type-I collagen gel. Full-thickness osteochondral defects (3 mm in diameter, 5 mm in depth) were created in the patellar groove of 36 knees of 18 macaques and were either left untreated (null group, n = 12), had collagen gel alone inserted (gel group, n = 12), or had collagen gel incorporating MSCs inserted (MSC group, n = 12). After 6, 12, and 24 weeks, the cartilage integration and tissue response were evaluated macroscopically and histologically (4 null, 4 gel, and 4 MSC knees at each time point). RESULTS:The gel group showed most cartilage-rich reparative tissue covering the defect, owing to formation of excessive cartilage extruding though the insufficient subchondral bone. Despite the fact that a lower amount of new cartilage was produced, the MSC group had better-quality cartilage with regular surface, seamless integration with neighboring naïve cartilage, and reconstruction of trabecular subchondral bone. INTERPRETATION:Even with intensive investigation, MSC-based cell therapy has not yet been established in experimental cartilage repair. Our model using cynomolgus macaques had optimized conditions, and the method using MSCs is superior to other experimental settings, allowing the possibility that the procedure might be introduced to future clinical practice.
journal_name
Acta Orthopjournal_title
Acta orthopaedicaauthors
Araki S,Imai S,Ishigaki H,Mimura T,Nishizawa K,Ueba H,Kumagai K,Kubo M,Mori K,Ogasawara K,Matsusue Ydoi
10.3109/17453674.2014.958807subject
Has Abstractpub_date
2015-02-01 00:00:00pages
119-26issue
1eissn
1745-3674issn
1745-3682journal_volume
86pub_type
杂志文章abstract:BACKGROUND:In some countries, commercially available antibiotic powder-loaded acrylic bone cement is routinely used in joint replacement, while, in others, "off-label" formulations are used in selected procedures (where the antibiotic powder is blended manually with the powder of a plain cement in the operating room/th...
journal_title:Acta orthopaedica
pub_type: 杂志文章
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pub_type: 杂志文章,随机对照试验
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章,随机对照试验
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更新日期:2009-08-01 00:00:00
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更新日期:2019-06-01 00:00:00
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pub_type: 杂志文章
doi:
更新日期:2005-06-01 00:00:00
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更新日期:2015-04-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2007-12-01 00:00:00
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更新日期:2017-10-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2012-06-01 00:00:00
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更新日期:2009-08-01 00:00:00
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