Abstract:
BACKGROUND AND PURPOSE:Optical coherence tomography (OCT) is a light-based imaging technique suitable for depiction of thin tissue layers such as articular cartilage. Quantification of results and direct comparison with a reference standard is needed to confirm the role of OCT in cartilage evaluation. MATERIALS AND METHODS:Goat talus articular cartilage repair was assessed quantitatively with OCT and compared with histopathology using semi-automated analysis software. Osteochondral defects were created centrally in goat tali with subsequent healing over 24 weeks. After sacrifice, the tali were analyzed using OCT and processed into histopathology slides. Cartilage thickness, repair tissue area, and surface roughness were measured. Also, light attenuation coefficient measurements were performed to assess differences in the properties of healthy tissue and repair tissue. RESULTS:Intra-class correlation coefficients for resemblance between the 2 techniques were 0.95 (p < 0.001) for thickness, 0.73 (p = 0.002) for repair tissue area, and 0.63 (p = 0.015) for surface roughness. Light attenuation differed significantly between healthy cartilage (8.2 (SD 3.9) mm(-1)) and repair tissue (2.8 (SD 1.5) mm(-1)) (p < 0.001). INTERPRETATION:Compared to histopathology as the standard reference method, OCT is a reproducible technique in quantitative analysis of goat talus articular cartilage, especially when assessing cartilage thickness and to a lesser extent when measuring repair tissue area and surface roughness. Moreover, differences in local light attenuation suggest measurable variation in tissue structure, enhancing the clinical applicability of quantitative measurements from cartilage OCT images.
journal_name
Acta Orthopjournal_title
Acta orthopaedicaauthors
Cernohorsky P,Kok AC,Bruin DM,Brandt MJ,Faber DJ,Tuijthof GJ,Kerkhoffs GM,Strackee SD,van Leeuwen TGdoi
10.3109/17453674.2014.979312subject
Has Abstractpub_date
2015-04-01 00:00:00pages
257-63issue
2eissn
1745-3674issn
1745-3682journal_volume
86pub_type
杂志文章abstract::Background and purpose - Although the use of patient-specific positioning guides (PSPGs) in total knee replacement (TKR) in theory is promising, the technique has not yet proven its superior- ity compared with the conventional method. We compared radio- logical alignment and clinical outcome between TKR performed with...
journal_title:Acta orthopaedica
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1080/17453674.2017.1393732
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:Hospital-specific variation in outcome is generally considered to be an important source of information for clinical improvement. We have measured the magnitude of this variation. METHODS:We determined the revision risk in 37,642 cemented primary total knee arthroplasties inserted as a result of osteoarthri...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453670610046442
更新日期:2006-06-01 00:00:00
abstract::Background and purpose - Patients having a total knee arthroplasty (TKA) after a previous high tibial osteotomy (HTO) constitute a minor group among those undergoing primary TKA for knee osteoarthritis (OA). There have been few reports on whether such patients differ pre- and postoperatively from those who undergo TKA...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453674.2016.1195663
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The risk of complications in cirrhosis patients after orthopedic surgery is unclear. We examined this risk after total hip arthroplasty (THA) or total knee arthroplasty (TKA). PATIENTS AND METHODS:Using Danish healthcare registries, we identified all Danish residents who underwent a THA or TKA f...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453674.2014.961397
更新日期:2015-02-01 00:00:00
abstract::Background and purpose - The annual number of total knee arthroplasties (TKAs) has increased worldwide in recent years. To make projections regarding future needs for primaries and revisions, additional knowledge is important. We analyzed and compared the incidences among 4 Nordic countries Patients and methods - Usin...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453674.2016.1275200
更新日期:2017-04-01 00:00:00
abstract::Background and purpose - The long-term outcome of pin-fixed supracondylar humerus fractures (SCHF) in children is not well known. We assessed the 7- to 12-year outcome in 168 children. Patients and methods - During 2002-2006, 210 domestic children (age 7 (1-14) years) with SCHF (Gartland III 79%, Gartland II 19%, and ...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453674.2018.1438765
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:This randomized study compared clinical results after surgery for posttraumatic shoulder instability with either an anatomical repair or an older, less anatomical but commonly used method. The less anatomical procedure has been considered quicker and less demanding, but it has been questioned reg...
journal_title:Acta orthopaedica
pub_type: 杂志文章,随机对照试验
doi:10.3109/17453670902988345
更新日期:2009-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The most common surgical approaches in total hip arthroplasty in Sweden are the posterior and the anterolateral transgluteal approach. Currently, however, there is insufficient evidence to prefer one over the other regarding risk of subsequent surgery. PATIENTS AND METHODS:We searched the Swedis...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453674.2012.742394
更新日期:2012-12-01 00:00:00
abstract::Background and purpose - Total ankle replacement (TAR) is gaining popularity for treatment of end-stage ankle arthritis. Large patient-centered outcome studies are, however, few. Here, we report data from the Swedish Ankle Registry. Patients and methods - We examined outcomes after primary TAR in patients from the Swe...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453674.2017.1366405
更新日期:2017-12-01 00:00:00
abstract::Background and purpose - Unnecessary radiographic and clinical follow-ups are common in treatment of pediatric fractures. We hypothesized that follow-up radiographs are unnecessary to monitor union of physeal fractures of the distal tibia.Patients and methods - All 224 (147 boys) children under 16 years old treated fo...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453674.2019.1643632
更新日期:2019-12-01 00:00:00
abstract::Background and purpose - Hemiarthroplasty (HA) is the most common treatment for displaced femoral neck fractures in many countries. In Norway, there has been a tradition of using the direct lateral surgical approach, but worldwide a posterior approach is more often used. Based on data from the Norwegian Hip Fracture R...
journal_title:Acta orthopaedica
pub_type: 杂志文章,多中心研究
doi:10.1080/17453674.2016.1250480
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND:The etiology of osteoarthritis (OA) is multifactorial and current research attributes it to a complex network of biochemical factors. We attempted to identify important molecules in OA joint destruction. PATIENTS AND METHODS:Synovium was collected from 2 women with hip OA. Total RNA was extracted from the c...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453670710014400
更新日期:2007-10-01 00:00:00
abstract:BACKGROUND AND PURPOSES:The nervous system plays an important role in bone metabolism. However, the effect of denervation on bone formation during distraction osteogenesis (DO) remains unclear. We studied neural influence on bone regeneration during DO in a rabbit model. METHODS:24 New Zealand male white rabbits under...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453674.2012.702389
更新日期:2012-08-01 00:00:00
abstract::Background and purpose - Uncemented stems are increasingly used in revision hip arthroplasty, but only a few studies have analyzed the outcomes of uncemented and cemented revision stems in large cohorts of patients. We compared the results of uncemented and cemented revision stems. Patients and methods - 1,668 uncemen...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453674.2019.1624336
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Joint replacement with metal-on-metal (MOM) bearings have gained popularity in the last decades in young and active patients. However, the possible effects of MOM wear debris and its corrosion products are still the subject of debate. Alongside the potential disadvantages such as toxicity, the in...
journal_title:Acta orthopaedica
pub_type: 杂志文章,评审
doi:10.3109/17453674.2010.519169
更新日期:2010-10-01 00:00:00
abstract:BACKGROUND:The coronal alignment of the lower limb is important for knee reconstruction procedures. However, normal alignment is hard to define because of its wide variation among normal individuals. Our hypothesis was that the variation in the normal anatomy as assessed by radiography is greater than commonly accepted...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:
更新日期:2005-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We have previously shown that early fracture callus of rat rib has viscoelastic and contractile properties resembling those of smooth muscle. The cells responsible for this contractility have been hypothesized to be myofibroblast-like in nature. In soft-tissue healing, force generated by contract...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453674.2011.652891
更新日期:2012-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Most lung cancer patients with skeletal metastases have a short survival and it is difficult to identify those patients who will benefit from palliative surgery. We report complication and survival rates in a consecutive series of lung cancer patients who were operated for symptomatic skeletal me...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453674.2011.552779
更新日期:2011-02-01 00:00:00
abstract::- Knee pathologies including focal cartilage injuries, osteoarthritis (OA), and ligament injuries are common. The poor regeneration and healing potential of cartilage has led to the search for other treatment modalities with improved healing capacity. Furthermore, with an increasing elderly population that desires to ...
journal_title:Acta orthopaedica
pub_type: 杂志文章,评审
doi:10.1080/17453674.2017.1368899
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:In recent years several different plate designs for internal fixation of fractures of the distal radius have been developed. However, few biomechanical studies have been performed to compare these new implants. The purpose of this study was to compare the mechanical properties of 5 different comm...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453670902947440
更新日期:2009-04-01 00:00:00
abstract::Background and purpose - Mobile-bearing total knee prostheses (TKPs) were developed in the 1970s in an attempt to increase function and improve implant longevity. However, modern fixed-bearing designs like the single-radius TKP may provide similar advantages. We compared tibial component migration measured with radios...
journal_title:Acta orthopaedica
pub_type: 杂志文章,随机对照试验
doi:10.1080/17453674.2018.1429108
更新日期:2018-04-01 00:00:00
abstract::Background and purpose - To date there is a lack of studies defining the anatomical position of the proximal fibula. This is especially relevant when planning surgical interventions affecting the knee joint such as permanent or temporary epiphysiodesis to correct leg length discrepancies or angular deformities in grow...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453674.2020.1769378
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:(18)F-FDG PET is a widely used tool for molecular imaging of oncological, cardiovascular, and neurological disorders. We evaluated (18)F-FDG microPET as an implant osteomyelitis imaging tool using a Staphylococcus aureus-induced peroperative implant infection in rabbits. METHODS:Intramedullary t...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453674.2014.900894
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:There is increasing awareness that non-steroidal anti-inflammatory drugs (NSAIDs), and especially the cyclooxygenase-2 (COX-2) selective ones, may retard bone healing. We have used NSAIDs (indomethacin for at least 7 days) to prevent heterotopic ossification after acetabular reconstructions using...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453670710015562
更新日期:2008-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:In recent years, intramedullary nails (INs) for the treatment of pertrochanteric hip fractures have gained prominence relative to conventional, sliding hip screws (SHSs). There is little empirical background for this development, however. A previous series of ours suggested that the use of SHS wa...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453674.2011.566143
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The first generations of total ankle replacements (TARs) showed a high rate of early failure. In the last decades, much progress has been made in the development of TARs, with the newer generation showing better results. We evaluated TARs implanted with rheumatoid arthritis (RA) or juvenile infla...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453670903153568
更新日期:2009-08-01 00:00:00
abstract:BACKGROUND:The use of impaction grafting in revisions with larger acetabular bone defects has mixed outcomes and sometimes high failures rates. PATIENTS AND METHODS:This prospective, single-center study involved a consecutive series of 24 patients who underwent complex reconstruction of the acetabulum using a trabecul...
journal_title:Acta orthopaedica
pub_type: 临床试验,杂志文章
doi:10.3109/17453674.2012.718518
更新日期:2012-08-01 00:00:00
abstract:UNLABELLED:BACKGROUND AND PURPOSE Corticosteroid treatment is associated with osteonecrosis of the femoral head (ON) in certain patients. The degree of drug sensitivity in general is governed by genetic variation between individuals. We investigated the relationship between ON and the presence of different alleles of t...
journal_title:Acta orthopaedica
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.3109/17453670903025378
更新日期:2009-06-01 00:00:00
abstract::Background and purpose - A lifetime perspective on revision risks is needed for optimal timing of arthroplasty in osteoarthritis (OA) patients, weighing the benefit of total hip arthroplasty/total knee arthroplasty (THA/TKA) against the risk of revision, after which outcomes are less favorable. Therefore, we provide p...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.1080/17453674.2021.1876998
更新日期:2021-01-22 00:00:00
abstract:BACKGROUND AND PURPOSE:Although total ankle replacement (TAR) is a recognized procedure for treatment of the painful arthritic ankle, the best choice of implant and the long-term results are still unknown. We evaluated the survival of two TAR designs and factors associated with survival using data from the nationwide a...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453671003685459
更新日期:2010-02-01 00:00:00