Incidence of genetic polymorphisms involved in lipid metabolism among Chinese patients with osteonecrosis of the femoral head.

Abstract:

UNLABELLED:BACKGROUND AND PURPOSE Corticosteroid treatment is associated with osteonecrosis of the femoral head (ON) in certain patients. The degree of drug sensitivity in general is governed by genetic variation between individuals. We investigated the relationship between ON and the presence of different alleles of the cytochrome P450 gene (CYP3A4), the product of which metabolizes corticosteroids, and of the P-glycoprotein (P-gp) gene (ABCBI), the product of which modulates cellular uptake of corticosteroids, to determine whether patients with certain alleles may be at higher risk of ON after corticosteroid treatment. METHODS:We studied 31 patients from Guangdong, China who were both treated with corticosteroid therapy and developed ON, and 17 corticosteroid-therapy patients without ON. Patient DNA was screened for known polymorphisms in the CYP3A4 gene (CYP3A4*4, CYP3A4*5, CYP3A4*6) and the P-gp gene ABCB1 (mutations C3435T, G2677T/A). RESULTS:The majority (20/31) of the corticosteroid-treated patients who developed ON were heterozygous for ABCB1, whereas only 3/17 without ON were heterozygous. Statistical significance was observed between the ON and the control groups for the ABCB1 G2677T/A polymorphism. Analysis of haplotypic frequencies indicated significant linkage disequilibrium between the two ABCB1 polymorphisms, C3435T and G2677T/A (D' = 0.034). No CYP3A4 polymorphisms were detected in any of the patients. INTERPRETATION:Patients carrying an ABCB1 polymorphism had a higher risk of having corticosteroid-associated ON than those with wild-type genotypes. This statistically significant association conflicts with previous studies, possibly due to different sampling methods. Knowing which genetic backgrounds are most strongly associated with corticosteroid-associated ON provides a method of screening for patients who are most at risk of developing ON.

journal_name

Acta Orthop

journal_title

Acta orthopaedica

authors

He W,Li K

doi

10.3109/17453670903025378

subject

Has Abstract

pub_date

2009-06-01 00:00:00

pages

325-9

issue

3

eissn

1745-3674

issn

1745-3682

pii

913235412

journal_volume

80

pub_type

杂志文章,多中心研究,随机对照试验
  • Registration rate in the Norwegian Cruciate Ligament Register: large-volume hospitals perform better.

    abstract:BACKGROUND AND PURPOSE:The Norwegian Cruciate Ligament Register (NCLR) was founded in 2004. The purpose of the NCLR is to provide representative and reliable data for future research. In this study we evaluated the development of the registration rate in the NCLR. METHODS:The Norwegian Patient Register (NPR) and the e...

    journal_title:Acta orthopaedica

    pub_type: 杂志文章

    doi:10.3109/17453674.2012.678800

    authors: Ytterstad K,Granan LP,Ytterstad B,Steindal K,Fjeldsgaard KA,Furnes O,Engebretsen L

    更新日期:2012-04-01 00:00:00

  • Continuous adductor canal block added to local infiltration analgesia (LIA) after total knee arthroplasty has no additional benefits on pain and ambulation on postoperative day 1 and 2 compared with LIA alone.

    abstract::Background and purpose - The additional effects of a continuous adductor canal block (ACB) compared with a single-dose local infiltration anesthesia (LIA) after total knee arthroplasty (TKA) has not been widely researched. Both methods have good effect individually. We hypothesized that a continuous ACB added to a sin...

    journal_title:Acta orthopaedica

    pub_type: 杂志文章,随机对照试验

    doi:10.1080/17453674.2017.1342184

    authors: Gudmundsdottir S,Franklin JL

    更新日期:2017-10-01 00:00:00

  • Poor patient-reported outcome after shoulder replacement in young patients with cuff-tear arthropathy: a matched-pair analysis from the Danish Shoulder Arthroplasty Registry.

    abstract::Background and purpose - Reverse shoulder arthroplasty (RSA) has become the treatment of choice for cuff-tear arthropathy. There are, however, concerns about the longevity and the outcome of an eventual revision procedure. Thus, resurfacing hemiarthroplasty (RHA) with extended articular surface has been suggested for ...

    journal_title:Acta orthopaedica

    pub_type: 杂志文章

    doi:10.1080/17453674.2018.1563855

    authors: Ammitzboell M,Baram A,Brorson S,Olsen BS,Rasmussen JV

    更新日期:2019-04-01 00:00:00

  • Younger age increases the risk of early prosthesis failure following primary total knee replacement for osteoarthritis. A follow-up study of 32,019 total knee replacements in the Finnish Arthroplasty Register.

    abstract:BACKGROUND AND PURPOSE:Total knee replacements (TKRs) are being increasingly performed in patients aged < or = 65 years who often have high physical demands. We investigated the relation between age of the patient and prosthesis survival following primary TKR using nationwide data collected from the Finnish Arthroplast...

    journal_title:Acta orthopaedica

    pub_type: 杂志文章

    doi:10.3109/17453674.2010.501747

    authors: Julin J,Jämsen E,Puolakka T,Konttinen YT,Moilanen T

    更新日期:2010-08-01 00:00:00

  • Limited range of motion of hip resurfacing arthroplasty due to unfavorable ratio of prosthetic head size and femoral neck diameter.

    abstract:BACKGROUND AND PURPOSE:Hip resurfacing arthroplasty is being used more and more frequently. The small ratio in size between the resurfaced femoral head and the relatively thick femoral neck raises the question of whether the range of motion is sufficient, particularly with regard to the high mobility required by younge...

    journal_title:Acta orthopaedica

    pub_type: 杂志文章

    doi:10.1080/17453670810016803

    authors: Kluess D,Zietz C,Lindner T,Mittelmeier W,Schmitz KP,Bader R

    更新日期:2008-12-01 00:00:00

  • Inferior stabilization of cementless compared with cemented dual-mobility cups in elderly osteoarthrosis patients: a randomized controlled radiostereometry study on 60 patients with 2 years' follow-up.

    abstract::Background and purpose - Elderly patients may benefit from a dislocation low-risk dual-mobility (DM) articulation in total hip arthroplasty, but the best cup fixation method is unknown. We compared cup migration for cemented and cementless DM cups using radiostereometry.Patients and methods - In a patient-blinded rand...

    journal_title:Acta orthopaedica

    pub_type: 杂志文章,随机对照试验

    doi:10.1080/17453674.2020.1720978

    authors: Tabori-Jensen S,Mosegaard SB,Hansen TB,Stilling M

    更新日期:2020-06-01 00:00:00

  • Lessons learnt from early failure of a patient trial with a polymer-on-polymer resurfacing hip arthroplasty.

    abstract::Background and purpose - Hip resurfacing (HR) is a treatment option promoted for hip arthritis in young and active patients. However, adverse reactions to metal are a concern and the search for non-metallic bearing options proceeds. We present the first clinical study performed in patients using a newly developed hydr...

    journal_title:Acta orthopaedica

    pub_type: 杂志文章

    doi:10.1080/17453674.2017.1376526

    authors: Van Susante JLC,Verdonschot N,Bom LPA,Tomaszewski P,Campbell P,Ebramzadeh E,Schreurs BW

    更新日期:2018-02-01 00:00:00

  • Unexpected varus deformity and concomitant metal ion release and MRI findings of modular-neck hip stems: descriptive RSA study in 75 hips with 8 years' follow-up.

    abstract::Background and purpose - Modular-neck hip stems have been identified with corrosion-related problems from the neck-stem junction. We report an ongoing varus deformity of modular-neck hip stems with simultaneous metal ion release observed during a study comparing the migration of modular vs. standard hip stems. Patient...

    journal_title:Acta orthopaedica

    pub_type: 杂志文章

    doi:10.1080/17453674.2020.1853387

    authors: Kiernan S,Kaptein B,Flivik C,Sundberg M,Flivik G

    更新日期:2020-12-10 00:00:00

  • Dislocation of total hip replacement in patients with fractures of the femoral neck.

    abstract:BACKGROUND:Total hip replacement is increasingly used in active, relatively healthy elderly patients with fractures of the femoral neck. Dislocation of the prosthesis is a severe complication, and there is still controversy regarding the optimal surgical approach and its influence on stability. We analyzed factors infl...

    journal_title:Acta orthopaedica

    pub_type: 杂志文章

    doi:10.3109/17453670902930024

    authors: Enocson A,Hedbeck CJ,Tidermark J,Pettersson H,Ponzer S,Lapidus LJ

    更新日期:2009-04-01 00:00:00

  • 10-year results following impaction bone grafting of major bone defects in 29 rotational and hinged knee revision arthroplasties: a follow-up of a previous report.

    abstract:BACKGROUND AND PURPOSE:Substantial bone loss in revision total knee arthroplasty (TKA) is a challenging problem. We studied whether impaction bone grafting provides long-term restoration of bone stock in the treatment of major bone defects in revision surgery of rotational and hinged knee arthroplasties (LINK Endo-Mode...

    journal_title:Acta orthopaedica

    pub_type: 杂志文章

    doi:10.3109/17453674.2013.814012

    authors: Hilgen V,Citak M,Vettorazzi E,Haasper C,Day K,Amling M,Gehrke T,Gebauer M

    更新日期:2013-08-01 00:00:00

  • Effects of metal-on-metal wear on the host immune system and infection in hip arthroplasty.

    abstract:BACKGROUND AND PURPOSE:Joint replacement with metal-on-metal (MOM) bearings have gained popularity in the last decades in young and active patients. However, the possible effects of MOM wear debris and its corrosion products are still the subject of debate. Alongside the potential disadvantages such as toxicity, the in...

    journal_title:Acta orthopaedica

    pub_type: 杂志文章,评审

    doi:10.3109/17453674.2010.519169

    authors: Hosman AH,van der Mei HC,Bulstra SK,Busscher HJ,Neut D

    更新日期:2010-10-01 00:00:00

  • No effect of risedronate on femoral periprosthetic bone loss following total hip arthroplasty. A 4-year follow-up of 61 patients in a double-blind, randomized placebo-controlled trial.

    abstract:BACKGROUND AND PURPOSE:We have previously shown that during the first 2 years after total hip arthroplasty (THA), periprosthetic bone resorption can be prevented by 6 months of risedronate therapy. This follow-up study investigated this effect at 4 years. PATIENTS AND METHODS:A single-center, double-blind, randomized ...

    journal_title:Acta orthopaedica

    pub_type: 杂志文章,随机对照试验

    doi:10.3109/17453674.2015.1041846

    authors: Muren O,Akbarian E,Salemyr M,Bodén H,Eisler T,Stark A,Sköldenberg O

    更新日期:2015-01-01 00:00:00

  • Sequence of the Essex-Lopresti lesion--a high-speed video documentation and kinematic analysis.

    abstract:BACKGROUND AND PURPOSE:The pathomechanics of the Essex-Lopresti lesion are not fully understood. We used human cadavers and documented the genesis of the injury with high-speed cameras. METHODS:4 formalin-fixed cadaveric specimens of human upper extremities were tested in a prototype, custom-made, drop-weight test ben...

    journal_title:Acta orthopaedica

    pub_type: 杂志文章

    doi:10.3109/17453674.2014.887952

    authors: Wegmann K,Engel K,Burkhart KJ,Ebinger M,Holz R,Brüggemann GP,Müller LP

    更新日期:2014-04-01 00:00:00

  • Survival and revision causes of hip resurfacing arthroplasty and the Mitch proximal epiphyseal replacement: results from the Danish Hip Arthroplasty Register.

    abstract::Background and purpose - The Mitch proximal epiphyseal replacement (PER) was developed to preserve proximal femoral bone and minimize femoral neck fracture associated with hip resurfacing arthroplasty (HRA). We studied the survival and risk of revision of HRA compared with cementless metal-on-polyethylene (MoP) total ...

    journal_title:Acta orthopaedica

    pub_type: 杂志文章

    doi:10.1080/17453674.2019.1646201

    authors: Tang-Jensen M,Kjærsgaard-Andersen P,Poulsen TK,Overgaard S,Varnum C

    更新日期:2019-12-01 00:00:00

  • In vitro comparison of frictional torque and torsional resistance of aged conventional gamma-in-nitrogen sterilized polyethylene versus aged highly crosslinked polyethylene articulating against head sizes larger than 32 mm.

    abstract:BACKGROUND:The advent of highly crosslinked polyethylene has allowed the re-evaluation of the use of femoral heads larger than 32 mm for metal-on-polyethylene total hip arthroplasties. However, the effect of larger heads on the frictional torque of highly crosslinked polyethylene is unknown. METHODS:We performed an in...

    journal_title:Acta orthopaedica

    pub_type: 杂志文章

    doi:10.1080/17453670610012881

    authors: Burroughs BR,Muratoglu OK,Bragdon CR,Wannomae KK,Christensen S,Lozynsky AJ,Harris WH

    更新日期:2006-10-01 00:00:00

  • Low risk of cardiac events during intramedullary instrumentation of lung cancer metastases.

    abstract:BACKGROUND:Instrumentation, particularly reaming, of the long bones carries the risk of embolic phenomenon. Emboli may result in pulmonary injury, which is usually manifested by desaturation. This pulmonary injury may be particularly relevant if there is diminished pulmonary reserve due to pre-existing lung disease suc...

    journal_title:Acta orthopaedica

    pub_type: 杂志文章

    doi:10.1080/17453670710014202

    authors: Clayer MT,Tang X

    更新日期:2007-08-01 00:00:00

  • Similar mortality with general or regional anesthesia in elderly hip fracture patients.

    abstract:BACKGROUND AND PURPOSE:There is continuing confusion among practitioners with regard to the optimal choice of anesthetic type for repair of hip fractures. We investigated whether type of anesthetic was associated with short-term mortality after hip fracture surgery. PATIENTS AND METHODS:We conducted a retrospective co...

    journal_title:Acta orthopaedica

    pub_type: 杂志文章

    doi:10.3109/17453674.2015.1128781

    authors: Brox WT,Chan PH,Cafri G,Inacio MC

    更新日期:2016-01-01 00:00:00

  • Gait improvement surgery in ambulatory children with diplegic cerebral palsy.

    abstract:BACKGROUND AND PURPOSE:Instrumented 3-D gait analyses (GA) in children with cerebral palsy (CP) have shown improved gait function 1 year postoperatively. Using GA, we assessed the outcome after 5 years and evaluated parental satisfaction with the surgery and the need for additional surgery. PATIENTS AND METHODS:34 amb...

    journal_title:Acta orthopaedica

    pub_type: 杂志文章

    doi:10.3109/17453674.2015.1011927

    authors: Terjesen T,Lofterød B,Skaaret I

    更新日期:2015-01-01 00:00:00

  • Detection of gene expression in synovium of patients with osteoarthritis using a random sequencing method.

    abstract:BACKGROUND:The etiology of osteoarthritis (OA) is multifactorial and current research attributes it to a complex network of biochemical factors. We attempted to identify important molecules in OA joint destruction. PATIENTS AND METHODS:Synovium was collected from 2 women with hip OA. Total RNA was extracted from the c...

    journal_title:Acta orthopaedica

    pub_type: 杂志文章

    doi:10.1080/17453670710014400

    authors: Okabe T,Ohmori Y,Tanigami A,Hishigaki H,Suzuki Y,Sugano S,Kawaguchi A,Nakaya H,Wakitani S

    更新日期:2007-10-01 00:00:00

  • Health-related quality of life and self-reported ability concerning ADL and IADL after hip fracture: a randomized trial.

    abstract:BACKGROUND:It is not known whether postoperative occupational therapy is of value for hip fracture patients. In this randomized trial we evaluated the effects of an individualized, postoperative, occupational training (OT) program on the patient's self-reported health-related quality of life (HRQL) and self-reported ab...

    journal_title:Acta orthopaedica

    pub_type: 杂志文章,随机对照试验

    doi:10.1080/17453670610045786

    authors: Hagsten B,Svensson O,Gardulf A

    更新日期:2006-02-01 00:00:00

  • Direct superior approach versus posterolateral approach in total hip arthroplasty: a randomized controlled trial on early outcomes on gait, risk of fall, clinical and self-reported measurements.

    abstract::Background and purpose - Several surgical approaches are used in primary total hip arthroplasty (THA). In this randomized controlled trial we compared gait, risk of fall, self-reported and clinical measurements between subjects after direct superior approach (DSA) versus posterolateral approach (PL) for THA. Patients ...

    journal_title:Acta orthopaedica

    pub_type: 杂志文章

    doi:10.1080/17453674.2020.1865633

    authors: Ulivi M,Orlandini L,Vitale JA,Meroni V,Prandoni L,Mangiavini L,Rossi N,Peretti GM

    更新日期:2021-01-07 00:00:00

  • The effect of bearing type on the outcome of total hip arthroplasty.

    abstract::Background and purpose - Alternative bearing surfaces such as ceramics and highly crosslinked polyethylene (HXLPE) were developed in order to further improve implant performance of total hip arthroplasties (THAs). Whether these alternative bearing surfaces result in increased longevity is subject to debate. Patients a...

    journal_title:Acta orthopaedica

    pub_type: 杂志文章

    doi:10.1080/17453674.2017.1405669

    authors: Peters RM,Van Steenbergen LN,Stevens M,Rijk PC,Bulstra SK,Zijlstra WP

    更新日期:2018-04-01 00:00:00

  • Similar clinical outcome after unicompartmental knee arthroplasty using a conventional or accelerated care program: a randomized, controlled study of 40 patients.

    abstract:UNLABELLED:BACKGROUND AND PURPOSE Over the last 5 years, there has been increasing interest in reducing length of hospitalization (LOS) through accelerated programs. We examined the clinical outcome of patients undergoing a unicompartmental knee replacement (UKR) in an accelerated care program (A group) compared to a c...

    journal_title:Acta orthopaedica

    pub_type: 杂志文章,随机对照试验

    doi:10.3109/17453670903035559

    authors: Borgwardt L,Zerahn B,Bliddal H,Christiansen C,Sylvest J,Borgwardt A

    更新日期:2009-06-01 00:00:00

  • Moderate varus/valgus malalignment after total knee arthroplasty has little effect on knee function or muscle strength.

    abstract:BACKGROUND AND PURPOSE:Postoperative muscle strength and component alignment are important factors affecting functional results after total knee arthroplasty (TKA). We are not aware of any studies that have investigated the relationship between them. We therefore investigated whether coronal malalignment of the mechani...

    journal_title:Acta orthopaedica

    pub_type: 杂志文章

    doi:10.3109/17453674.2015.1059689

    authors: Stucinskas J,Robertsson O,Sirka A,Lebedev A,Wingstrand H,Tarasevicius S

    更新日期:2015-01-01 00:00:00

  • Similar outcome for total knee arthroplasty after previous high tibial osteotomy and for total knee arthroplasty as the first measure.

    abstract::Background and purpose - Patients having a total knee arthroplasty (TKA) after a previous high tibial osteotomy (HTO) constitute a minor group among those undergoing primary TKA for knee osteoarthritis (OA). There have been few reports on whether such patients differ pre- and postoperatively from those who undergo TKA...

    journal_title:Acta orthopaedica

    pub_type: 杂志文章

    doi:10.1080/17453674.2016.1195663

    authors: W-Dahl A,Robertsson O

    更新日期:2016-08-01 00:00:00

  • Patient-reported outcome and muscle-tendon pain after periacetabular osteotomy are related: 1-year follow-up in 82 patients with hip dysplasia.

    abstract::Background and purpose - Larger prospective studies investigating periacetabular osteotomy (PAO) with patient-reported outcome measures developed for young patients are lacking. We investigated changes in patient-reported outcome (PRO), changes in muscle-tendon pain, and any associations between them from before to 1 ...

    journal_title:Acta orthopaedica

    pub_type: 杂志文章

    doi:10.1080/17453674.2018.1555637

    authors: Jacobsen JS,Søballe K,Thorborg K,Bolvig L,Storgaard Jakobsen S,Hölmich P,Mechlenburg I

    更新日期:2019-02-01 00:00:00

  • Alteration of the material properties of the normal supraspinatus tendon by nicotine treatment in a rat model.

    abstract:BACKGROUND AND PURPOSE:Several studies have shown that nicotine has a detrimental effect on the development of rotator cuff tear. However, little is known about its mechanism. We evaluated the effect of nicotine on the maximum tensile load, the maximum tensile stress, and the elastic modulus of the supraspinatus tendon...

    journal_title:Acta orthopaedica

    pub_type: 杂志文章

    doi:10.3109/17453674.2010.524595

    authors: Ichinose R,Sano H,Kishimoto KN,Sakamoto N,Sato M,Itoi E

    更新日期:2010-10-01 00:00:00

  • How precise is the PRECICE compared to the ISKD in intramedullary limb lengthening? Reliability and safety in 26 procedures.

    abstract:BACKGROUND AND PURPOSE:The PRECICE intramedullary limb lengthening system uses a new technique with a magnetic rod and a motorized external remote controller (ERC) with rotational magnetic field. We evaluated the reliability and safety of the PRECICE system. METHODS:We compared our preliminary results with PRECICE in ...

    journal_title:Acta orthopaedica

    pub_type: 杂志文章

    doi:10.3109/17453674.2014.913955

    authors: Schiedel FM,Vogt B,Tretow HL,Schuhknecht B,Gosheger G,Horter MJ,Rödl R

    更新日期:2014-06-01 00:00:00

  • Total ankle replacement: a population-based study of 515 cases from the Finnish Arthroplasty Register.

    abstract:BACKGROUND AND PURPOSE:Although total ankle replacement (TAR) is a recognized procedure for treatment of the painful arthritic ankle, the best choice of implant and the long-term results are still unknown. We evaluated the survival of two TAR designs and factors associated with survival using data from the nationwide a...

    journal_title:Acta orthopaedica

    pub_type: 杂志文章

    doi:10.3109/17453671003685459

    authors: Skyttä ET,Koivu H,Eskelinen A,Ikävalko M,Paavolainen P,Remes V

    更新日期:2010-02-01 00:00:00

  • Total ankle prostheses in rheumatoid arthropathy: Outcome in 52 patients followed for 1-9 years.

    abstract:BACKGROUND AND PURPOSE:The first generations of total ankle replacements (TARs) showed a high rate of early failure. In the last decades, much progress has been made in the development of TARs, with the newer generation showing better results. We evaluated TARs implanted with rheumatoid arthritis (RA) or juvenile infla...

    journal_title:Acta orthopaedica

    pub_type: 杂志文章

    doi:10.3109/17453670903153568

    authors: van der Heide HJ,Schutte B,Louwerens JW,van den Hoogen FH,Malefijt MC

    更新日期:2009-08-01 00:00:00