Abstract:
UNLABELLED:BACKGROUND AND PURPOSE Corticosteroid treatment is associated with osteonecrosis of the femoral head (ON) in certain patients. The degree of drug sensitivity in general is governed by genetic variation between individuals. We investigated the relationship between ON and the presence of different alleles of the cytochrome P450 gene (CYP3A4), the product of which metabolizes corticosteroids, and of the P-glycoprotein (P-gp) gene (ABCBI), the product of which modulates cellular uptake of corticosteroids, to determine whether patients with certain alleles may be at higher risk of ON after corticosteroid treatment. METHODS:We studied 31 patients from Guangdong, China who were both treated with corticosteroid therapy and developed ON, and 17 corticosteroid-therapy patients without ON. Patient DNA was screened for known polymorphisms in the CYP3A4 gene (CYP3A4*4, CYP3A4*5, CYP3A4*6) and the P-gp gene ABCB1 (mutations C3435T, G2677T/A). RESULTS:The majority (20/31) of the corticosteroid-treated patients who developed ON were heterozygous for ABCB1, whereas only 3/17 without ON were heterozygous. Statistical significance was observed between the ON and the control groups for the ABCB1 G2677T/A polymorphism. Analysis of haplotypic frequencies indicated significant linkage disequilibrium between the two ABCB1 polymorphisms, C3435T and G2677T/A (D' = 0.034). No CYP3A4 polymorphisms were detected in any of the patients. INTERPRETATION:Patients carrying an ABCB1 polymorphism had a higher risk of having corticosteroid-associated ON than those with wild-type genotypes. This statistically significant association conflicts with previous studies, possibly due to different sampling methods. Knowing which genetic backgrounds are most strongly associated with corticosteroid-associated ON provides a method of screening for patients who are most at risk of developing ON.
journal_name
Acta Orthopjournal_title
Acta orthopaedicaauthors
He W,Li Kdoi
10.3109/17453670903025378subject
Has Abstractpub_date
2009-06-01 00:00:00pages
325-9issue
3eissn
1745-3674issn
1745-3682pii
913235412journal_volume
80pub_type
杂志文章,多中心研究,随机对照试验abstract:BACKGROUND AND PURPOSE:The Norwegian Cruciate Ligament Register (NCLR) was founded in 2004. The purpose of the NCLR is to provide representative and reliable data for future research. In this study we evaluated the development of the registration rate in the NCLR. METHODS:The Norwegian Patient Register (NPR) and the e...
journal_title:Acta orthopaedica
pub_type: 杂志文章
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更新日期:2012-04-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2017-10-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2020-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-12-10 00:00:00
abstract:BACKGROUND:Total hip replacement is increasingly used in active, relatively healthy elderly patients with fractures of the femoral neck. Dislocation of the prosthesis is a severe complication, and there is still controversy regarding the optimal surgical approach and its influence on stability. We analyzed factors infl...
journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453670902930024
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journal_title:Acta orthopaedica
pub_type: 杂志文章
doi:10.3109/17453674.2013.814012
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pub_type: 杂志文章,评审
doi:10.3109/17453674.2010.519169
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abstract:BACKGROUND AND PURPOSE:We have previously shown that during the first 2 years after total hip arthroplasty (THA), periprosthetic bone resorption can be prevented by 6 months of risedronate therapy. This follow-up study investigated this effect at 4 years. PATIENTS AND METHODS:A single-center, double-blind, randomized ...
journal_title:Acta orthopaedica
pub_type: 杂志文章,随机对照试验
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更新日期:2015-01-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2019-12-01 00:00:00
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更新日期:2006-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1080/17453670710014202
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pub_type: 杂志文章
doi:10.3109/17453674.2015.1128781
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Instrumented 3-D gait analyses (GA) in children with cerebral palsy (CP) have shown improved gait function 1 year postoperatively. Using GA, we assessed the outcome after 5 years and evaluated parental satisfaction with the surgery and the need for additional surgery. PATIENTS AND METHODS:34 amb...
journal_title:Acta orthopaedica
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doi:10.3109/17453674.2015.1011927
更新日期:2015-01-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2021-01-07 00:00:00
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pub_type: 杂志文章
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更新日期:2018-04-01 00:00:00
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journal_title:Acta orthopaedica
pub_type: 杂志文章,随机对照试验
doi:10.3109/17453670903035559
更新日期:2009-06-01 00:00:00
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更新日期:2015-01-01 00:00:00
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更新日期:2019-02-01 00:00:00
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更新日期:2014-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:2009-08-01 00:00:00