Abstract:
:This study addressed the anticonvulsant effects of repeated administration of phenytoin, carbamazepine, phenobarbital, valproate, and ethosuximide in kindled guinea-pigs in order to further substantiate this novel model of partial seizures for the screening of future anticonvulsant drugs. Behavioral toxic effects were assessed at 30 min following drug administration using scores on a sedation/muscle relaxation rating index. In response to suprathreshold stimulation, the anticonvulsant efficacy of the drugs were evaluated from measurements of afterdischarge duration (ADD) and behavioral seizure severity (SS) during a repeated drug treatment schedule in kindled guinea-pigs. All drugs exerted slight to moderate sedative effects in guinea-pigs on our rating index. We found that phenytoin, carbamazepine, and phenobarbital exhibited effective anticonvulsant properties in kindled guinea-pigs by reducing both ADD and SS. We found that valproate consistently reduced ADD throughout the treatment schedule but failed to significantly reduce SS. Lastly, ethosuximide failed to exhibit effective anticonvulsant properties. Our results indicate that the guinea-pig kindling model correctly predicted the actions of these common anticonvulsant drugs in the treatment of partial seizures. Guinea-pig amygdala kindling appears to serve as a useful and valid model for partial epilepsy.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Gilbert TH,Teskey GCdoi
10.1007/s00221-006-0716-zsubject
Has Abstractpub_date
2007-03-01 00:00:00pages
115-25issue
1eissn
0014-4819issn
1432-1106journal_volume
178pub_type
杂志文章abstract::Flexible and stable postural control requires adaptation to changing environmental conditions, a process which requires re-weighting of multisensory stimuli. Recent studies, as well as predictions from a computational model, have indicated a reciprocal re-weighting relationship between modalities when a sensory stimul...
journal_title:Experimental brain research
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abstract::The electrophysiological properties of neurons of the medial septal nucleus and the nucleus of the diagnonal band of Broca (MS/DB) were studied using intracellular methods in urethane-anesthetized rats. Three types of rhythmically bursting neurons were identified in vivo on the basis of their action potential shapes a...
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abstract::We determined whether uncertainty about the location of one's hand in virtual environments limits the efficacy of online control processes. In the Non-aligned and Aligned conditions, the participant's hand was represented by a cursor on a vertical or horizontal display, respectively. In the Natural condition, particip...
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pub_type: 杂志文章
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abstract::In this study, we investigated the neural basis of virtual time to contact (VTC) and the hypothesis that VTC provides predictive information for future postural instability. A novel approach to differentiate stable pre-falling and transition-to-instability stages within a single postural trial while a subject was perf...
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doi:10.1007/s00221-010-2174-x
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00250598
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journal_title:Experimental brain research
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210050301
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abstract::Stimulation of the parietal association cortex as well as the frontal motor cortex elicited clearly extracellular unitary activities or field potentials in the ipsilateral inferior olive in the cat. The parietal-induced responses came out generally at a longer and more variable latency than the frontal-induced ones. T...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF01474258
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journal_title:Experimental brain research
pub_type: 杂志文章
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journal_title:Experimental brain research
pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1007/s00221-007-1264-x
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-001-0948-x
更新日期:2002-02-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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