Abstract:
BACKGROUND:In 2002, a poster alerted the French health authorities to the possibility that the risk of childhood leukaemia might be increased by hepatitis B vaccination. Elucidating the role of vaccination in the aetiology of childhood acute leukaemia (AL) was therefore included in the objectives of an ongoing national study. METHODS:The ESCALE study was a French national population-based case-control study conducted in France in 2003 and 2004 in order to investigate the role of infectious, environmental and genetic factors in four childhood neoplastic diseases (leukaemia, lymphoma, neuroblastoma and brain tumour). The controls were randomly selected from the French population and age and gender frequency matched with the cases. A total of 776 cases of AL (91% of the eligible cases) and 1681 controls (71% of the eligible controls) were included. In a specific standardized telephone interview, which was the same for both the cases and controls, each mother was asked to read out her child's complete vaccination record. RESULTS:No association between vaccination and the risk of childhood AL: acute lymphoblastic leukaemia or acute myeloblastic leukaemia was observed. No relationship between the risk of leukaemia and the type of vaccine, number of doses of each vaccine, total number of injections, total number of vaccine doses or number of early vaccinations was evidenced. No confounding factor was observed. CONCLUSION:The study did not show any evidence of a role of vaccination in the aetiology of childhood leukaemia.
journal_name
Int J Epidemioljournal_title
International journal of epidemiologyauthors
Mallol-Mesnard N,Menegaux F,Auvrignon A,Auclerc MF,Bertrand Y,Nelken B,Robert A,Michel G,Margueritte G,Perel Y,Méchinaud F,Bordigoni P,Leverger G,Baruchel A,Hémon D,Clavel Jdoi
10.1093/ije/dyl270subject
Has Abstractpub_date
2007-02-01 00:00:00pages
110-6issue
1eissn
0300-5771issn
1464-3685pii
dyl270journal_volume
36pub_type
杂志文章abstract:BACKGROUND:Aetiological profiles of non-Hodgkin's lymphoma (NHL) may differ depending upon whether the disease is inheritance-related or sporadic. Because familial risk (a probable surrogate of inheritance-relatedness) of NHL is influenced by haematolymphoproliferative malignancies (HLPM), we evaluated whether non-fami...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/30.4.818
更新日期:2001-08-01 00:00:00
abstract:BACKGROUND:To describe the seroepidemiology of Helicobacter pylori infection in a population of Egyptian children under 3 years. METHODS:A cohort of children under 36 months, residing in Abu Homos, Egypt, were visited at home twice weekly. Information regarding the child's breastfeeding status was obtained, and period...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/29.5.928
更新日期:2000-10-01 00:00:00
abstract:BACKGROUND:A growing body of literature suggests that physical activity may be a protective factor against hip fracture. METHODS:To study the association between hip fracture risk and recreational physical activity at various ages, changes in activity during adult life, occupational physical activity and how risks var...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/29.2.308
更新日期:2000-04-01 00:00:00
abstract:BACKGROUND:Some, but not all, observational studies have suggested that taller stature is associated with a significant increased risk of glioma. In a pooled analysis of observational studies, we investigated the strength and consistency of this association, overall and for major sub-types, and investigated effect modi...
journal_title:International journal of epidemiology
pub_type: 杂志文章,多中心研究
doi:10.1093/ije/dys114
更新日期:2012-08-01 00:00:00
abstract::The association between breast cancer risk and oral contraceptive use was examined in 401 breast cancer patients and 519 hospital controls interviewed in New York City during 1979-1981. Control subjects were ascertained utilizing variable ratio matching to the cases (2:1 or 1:1) by sex, age, hospital, and time of diag...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/19.2.240
更新日期:1990-06-01 00:00:00
abstract::Computer stimulations have been used to estimate the efficiency, as measured by the statistical power, of various combinations of design and analysis strategies for case-control studies. Conditions under which the various forms of analysis yield consistent relative risk estimators are derived for the general model. Th...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/12.2.238
更新日期:1983-06-01 00:00:00
abstract:BACKGROUND:The Italian Longitudinal Study on Aging (ILSA) evaluates the rates of diabetes, cardiovascular and neurological disorders in a random sample of 5632 Italians aged 65-84 years. METHODS:The ILSA has two components: a first screening phase administered to all participants, that includes a personal interview, p...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/26.5.995
更新日期:1997-10-01 00:00:00
abstract:Background:Interventions to mitigate fuel poverty and particularly energy efficiency façade retrofitting (EEFR) have demonstrated positive impacts on health but the impacts of EEFR interventions on cold-related mortality have not been studied in depth. We evaluated the impact of EEFR interventions in Barcelona on the a...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyw335
更新日期:2017-08-01 00:00:00
abstract::Data from the Seven Countries Study are analysed to examine the relationship between the observed incidence of Coronary Heart Disease in the second 5-year period of follow-up and the major entry risk factors and their changes over the first 5 years. The analysis, using the Multiple Logistic Function model, shows that ...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/10.1.31
更新日期:1981-03-01 00:00:00
abstract:BACKGROUND:Debates exist over whether health inequities are bound to rise as population health improves, due to health improving more quickly among the better off, with most analyses focused on mortality data. METHODS:We analysed 50 years of socioeconomic inequities in measured health status among US-born Black and Wh...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyu047
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:We examined secular changes in resting heart rate (RHR) and their relationship with changes in other cardiovascular risk factors in adult men and women over a 22-year period. METHODS:A single-centre population-based longitudinal study comprised 30,699 men and women aged 30-89 years who participated in at le...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyv061
更新日期:2015-06-01 00:00:00
abstract::This discussion of sexually transmitted diseases (STDs) in less developed countries covers incidence/prevalence, antimicrobial resistance, sequelae, future trends, and new opportunities for STD control -- technological changes, health service changes, and social and political changes. For most countries, current, pop...
journal_title:International journal of epidemiology
pub_type: 杂志文章,评审
doi:10.1093/ije/14.4.505
更新日期:1985-12-01 00:00:00
abstract:BACKGROUND:We analyse the NHANES III sample to assess the suitability of measured stature and sitting height to estimate leg length (tibia + femur) and predict fatness. High rates of overweight in the United States population may lead to greater gluteo-femoral fat mass which will increase sitting height and artificiall...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dym254
更新日期:2008-02-01 00:00:00
abstract:BACKGROUND:The tuberculin skin test (TST) is the most commonly used tool to detect infection with Mycobacterium tuberculosis. We sought to determine whether tuberculin skin testing is useful to detect latent infection by M. tuberculosis in a population that was vaccinated with the Bacille Calmette Guérin (BCG) vaccine....
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyl213
更新日期:2006-12-01 00:00:00
abstract:OBJECTIVE:To examine the effects, by income group, of targeted food taxes and subsidies on nutrition, health and expenditure in the UK. METHODS:A model based on consumption data and demand elasticity was constructed to predict the effects of four food taxation-subsidy regimens. Resulting changes in demand, expenditure...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyp214
更新日期:2009-10-01 00:00:00
abstract:BACKGROUND:International rankings of infant mortality rates have been consistently lower for the US than other industrialized countries, and this ranking has been falling. This study examines the influence of birth registrations among very low birthweight infants on these international rankings. METHODS:Birth rates of...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/24.3.583
更新日期:1995-06-01 00:00:00
abstract:BACKGROUND:Most HIV infections originate from individuals who are undiagnosed and unaware of their infection. Estimation of this quantity from surveillance data is hard because there is incomplete knowledge about (i) the time between infection and diagnosis (TI) for the general population, and (ii) the time between imm...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyz100
更新日期:2019-12-01 00:00:00
abstract::The Rochester Epidemiology Project (REP) medical records-linkage system was established in 1966 to capture health care information for the entire population of Olmsted County, MN, USA. The REP includes a dynamic cohort of 502 820 unique individuals who resided in Olmsted County at some point between 1966 and 2010, and...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dys195
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:Meta-analysis of randomized controlled trials (RCTs) is usually based on trials where patients are randomized individually into two different, parallel, treatment groups. This paper concentrates on RCTs of a different design-two-period, two-treatment cross-over trials. METHODS:The characteristics of these t...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/31.1.140
更新日期:2002-02-01 00:00:00
abstract:BACKGROUND:Birthweight distributions among second-born infants depend on the birthweights of older siblings, with implications for weight-specific perinatal mortality. We wanted to study whether these relations were explained by socioeconomic levels, and to study time trends in a situation with decreasing perinatal mor...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyg163
更新日期:2003-08-01 00:00:00
abstract:BACKGROUND:There is evidence that occupational factors that cause psychological strain can affect physical and mental health, but findings are not consistent. METHODS:Work satisfaction was used as a convenient global index of job-related psychological strain. Relationships with general, physical and emotional health, ...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/23.1.98
更新日期:1994-02-01 00:00:00
abstract:BACKGROUND:Under-5 mortality is unacceptably high in many countries, the burden of which is mainly borne by the poor. Whereas country characteristics are known to influence under-5 mortality, it is unknown whether these have a different impact on the poor and the rich. We aimed to describe how the association between u...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyi190
更新日期:2005-12-01 00:00:00
abstract:Background:Pancreatic cancer is one of the most lethal. Most countries have exhibited a stable or decreasing incidence over time. The aim of this study was to provide updated French temporal trends in pancreatic cancer incidence and mortality over the past three decades. Methods:Incidence was estimated using the Frenc...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyx088
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:Present understanding of increased risk of Epstein-Barr virus (EBV)-related infectious mononucleosis among children of low birth order or small sibships is mainly based on old and indirect evidence. Societal changes and methodological limitations of previous studies call for new data. METHODS:We used data f...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyu118
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:Small body size at birth, as a marker of an adverse intrauterine environment, has recently emerged as an important risk factor for death from cardiovascular disease. Our aim was to study the relationship between small size at birth and all-cause and non-cardiovascular mortality, which has been poorly documen...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyi048
更新日期:2005-06-01 00:00:00
abstract:BACKGROUND:Several studies have shown that inactivated, whole-cell oral cholera vaccines (OCVs) confer both direct protection on vaccinees and herd protection on populations. Because our earlier cluster-randomized effectiveness trial (CRT) in urban Bangladesh failed to detect OCV herd protection, we reanalysed the tria...
journal_title:International journal of epidemiology
pub_type: 杂志文章,随机对照试验
doi:10.1093/ije/dyz060
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:Lower maternal serum vitamin B12 (B12) and folate levels have been associated with lower offspring birthweight, in observational studies. The aim of this study was to investigate whether this relationship is causal. METHODS:We performed two-sample Mendelian randomization (MR) using summary data on associati...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyaa256
更新日期:2020-12-21 00:00:00
abstract:Background:Mendelian randomization (MR) is being increasingly used to strengthen causal inference in observational studies. Availability of summary data of genetic associations for a variety of phenotypes from large genome-wide association studies (GWAS) allows straightforward application of MR using summary data metho...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyx102
更新日期:2017-12-01 00:00:00
abstract::A 10-year prospective study of Hawaii Japanese males with partial gastrectomy shows that the age-adjusted mortality rates in men with partial gastrectomy were slightly higher than in those with an intact stomach, but the difference failed to achieve statistical significance. This excess of mortality is due, in part, t...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/13.3.299
更新日期:1984-09-01 00:00:00
abstract::A comparative study of the effects of combined oral contraceptives (OC) on coagulation and fibrinolytic variables using standardized laboratory technique and methodology has been performed in Dublin (Ireland), Salvador (Brazil), Santiago (Chile) and Singapore. Of 777 entrants to the study, 622 were randomly allocated ...
journal_title:International journal of epidemiology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1093/ije/20.4.913
更新日期:1991-12-01 00:00:00