Vaccination and the risk of childhood acute leukaemia: the ESCALE study (SFCE).

Abstract:

BACKGROUND:In 2002, a poster alerted the French health authorities to the possibility that the risk of childhood leukaemia might be increased by hepatitis B vaccination. Elucidating the role of vaccination in the aetiology of childhood acute leukaemia (AL) was therefore included in the objectives of an ongoing national study. METHODS:The ESCALE study was a French national population-based case-control study conducted in France in 2003 and 2004 in order to investigate the role of infectious, environmental and genetic factors in four childhood neoplastic diseases (leukaemia, lymphoma, neuroblastoma and brain tumour). The controls were randomly selected from the French population and age and gender frequency matched with the cases. A total of 776 cases of AL (91% of the eligible cases) and 1681 controls (71% of the eligible controls) were included. In a specific standardized telephone interview, which was the same for both the cases and controls, each mother was asked to read out her child's complete vaccination record. RESULTS:No association between vaccination and the risk of childhood AL: acute lymphoblastic leukaemia or acute myeloblastic leukaemia was observed. No relationship between the risk of leukaemia and the type of vaccine, number of doses of each vaccine, total number of injections, total number of vaccine doses or number of early vaccinations was evidenced. No confounding factor was observed. CONCLUSION:The study did not show any evidence of a role of vaccination in the aetiology of childhood leukaemia.

journal_name

Int J Epidemiol

authors

Mallol-Mesnard N,Menegaux F,Auvrignon A,Auclerc MF,Bertrand Y,Nelken B,Robert A,Michel G,Margueritte G,Perel Y,Méchinaud F,Bordigoni P,Leverger G,Baruchel A,Hémon D,Clavel J

doi

10.1093/ije/dyl270

subject

Has Abstract

pub_date

2007-02-01 00:00:00

pages

110-6

issue

1

eissn

0300-5771

issn

1464-3685

pii

dyl270

journal_volume

36

pub_type

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