Ultrashort antibacterial and antifungal lipopeptides.

abstract：:Recessive N-ethyl-N-nitrosourea (ENU)-induced mutations recovered at the fitness-1 (fit1) locus in mouse chromosome 7 cause hematopoietic abnormalities, growth retardation, and shortened life span, with varying severity of the defects in different alleles. Abnormal iron distribution and metabolism and frequent scolios...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Klebig ML,Wall MD,Potter MD,Rowe EL,Carpenter DA,Rinchik EM

更新日期：2003-07-08 00:00:00

abstract：:An evolutionarily ancient plant hormone receptor complex comprising the α/β-fold hydrolase receptor KARRIKIN INSENSITIVE 2 (KAI2) and the F-box protein MORE AXILLARY GROWTH 2 (MAX2) mediates a range of developmental responses to smoke-derived butenolides called karrikins (KARs) and to yet elusive endogenous KAI2 ligan...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carbonnel S,Das D,Varshney K,Kolodziej MC,Villaécija-Aguilar JA,Gutjahr C

更新日期：2020-09-01 00:00:00

abstract：:Phylogenetic differences in acetylcholine receptors from skeletal neuromuscular synapses of various species of snakes and lizards have been investigated, using the snake venom alpha-neurotoxins alpha-atratoxin (cobrotoxin) and alpha-bungarotoxin. The acetylcholine receptors of the phylogenetically primitive lizards, l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burden SJ,Hartzell HC,Yoshikami D

更新日期：1975-08-01 00:00:00

abstract：:Adenosine deaminases that act on RNA (ADARs) constitute a family of RNA-editing enzymes that convert adenosine to inosine within double-stranded regions of RNA. We previously developed a method to identify inosine-containing RNAs and used it to identify five ADAR substrates in Caenorhabditis elegans. Here we use the s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morse DP,Aruscavage PJ,Bass BL

更新日期：2002-06-11 00:00:00

abstract：:Transport affects climate directly and indirectly through mechanisms that cause both warming and cooling of climate, and the effects operate on very different timescales. We calculate climate responses in terms of global mean temperature and find large differences between the transport sectors with respect to the size...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Berntsen T,Fuglestvedt J

更新日期：2008-12-09 00:00:00

abstract：:We noticed that disease-related amyloidogenic proteins and especially cellular prion proteins have the highest proportion of incompletely desolvated backbone H bonds among soluble proteins. Such bonds are vulnerable to water attack and thus represent structural weaknesses. We have measured the adsorption of proteins o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fernández A,Berry RS

更新日期：2003-03-04 00:00:00

abstract：:Mutations in genes that encode components of the phosphatidyl-inositol 3-kinase (PI3-kinase) signaling pathway are common in human cancer. The recent discovery of nonrandom somatic mutations in the PIK3CA gene of many human tumors suggests an oncogenic role for the mutated enzyme. We have determined the growth-regulat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kang S,Bader AG,Vogt PK

更新日期：2005-01-18 00:00:00

abstract：:A "projection function," P(x,z), is defined as the partial integral of the molecular electron density, rho(x,y,z), over the region -infinity < y < +infinity. The projection provides a three-dimensional representation of molecular electron distributions. Chemically useful information can be discerned from graphical dis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Streitwieser A,Collins JB,McKelvey JM,Grier D,Sender J,Toczko AG

更新日期：1979-06-01 00:00:00

abstract：:A human metallothionein (MT) gene was inserted into a bovine papillomavirus (BPV) vector. The chimeric vector (pMTII-BPV) transforms rodent fibroblasts to a cadmium-resistant phenotype. The resistance is due to the high level of expression of human MT-II in those cells. The vector is maintained in the cells as a free ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Karin M,Cathala G,Nguyen-Huu MC

更新日期：1983-07-01 00:00:00

abstract：:Scanning confocal fluorescence microscopy and multiphoton fluorescence microscopy were used to image the uptake of the protein lysozyme into individual ion exchange chromatography particles in a packed bed in real time. Self-sharpening concentration fronts penetrating into the particles were observed at low salt conce...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dziennik SR,Belcher EB,Barker GA,DeBergalis MJ,Fernandez SE,Lenhoff AM

更新日期：2003-01-21 00:00:00

abstract：:A genomic clone of one member of the Arabidopsis thaliana (L.) Heynh. 1-aminocyclopropane-1-carboxylate (ACC) synthase (S-adenosyl-L-methionine methylthioadenosine-lyase, EC 4.4.1.14) gene family (AT-ACC1) was isolated and sequenced. A region of homology was found in the 5'-untranslated region with the promoter of a z...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Van der Straeten D,Rodrigues-Pousada RA,Villarroel R,Hanley S,Goodman HM,Van Montagu M

更新日期：1992-10-15 00:00:00

abstract：:Experimental work in animals has shown that memory formation depends on a cascade of molecular events. Here we show that variability of human memory performance is related to variability in genes encoding proteins of this signaling cascade, including the NMDA and metabotrobic glutamate receptors, adenylyl cyclase, CAM...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： de Quervain DJ,Papassotiropoulos A

更新日期：2006-03-14 00:00:00

abstract：:High-resolution magnetic resonance microscopy (MRM) was used to determine regional brain volumetric changes in a mouse model of Alzheimer's disease. These transgenic (Tg) mice overexpress human mutant amyloid precursor protein (APP) V717F under control of platelet-derived growth factor promoter (PDAPP mice), and corti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Redwine JM,Kosofsky B,Jacobs RE,Games D,Reilly JF,Morrison JH,Young WG,Bloom FE

更新日期：2003-02-04 00:00:00

abstract：:The photosystem II (PSII) subunit S (PsbS) plays a key role in nonphotochemical quenching, a photoprotective mechanism for dissipation of excess excitation energy in plants. The precise function of PsbS in nonphotochemical quenching is unknown. By reconstituting PsbS together with the major light-harvesting complex of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wilk L,Grunwald M,Liao PN,Walla PJ,Kühlbrandt W

更新日期：2013-04-02 00:00:00

abstract：:Colocalization of proteins that are part of the same signal transduction pathway via compartmentalization, scaffold, or anchor proteins is an essential aspect of the signal transduction system in eukaryotic cells. If interaction must occur via free diffusion, then the spatial separation between the sources of the two ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Batada NN,Shepp LA,Siegmund DO

更新日期：2004-04-27 00:00:00

abstract：:Clones of Friend erythroleukemia cells, characterized by the presence of 40-70% benzidine-positive cells synthesizing hemoglobin in the absence of inducing drugs, were treated with several phorbol diesters with a known range of tumor-promoting activity on mouse skin. Good correlation was found between the reported tum...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rovera G,O'Brien TG,Diamond L

更新日期：1977-07-01 00:00:00

abstract：:The primary obstacle to producing renewable fuels from lignocellulosic biomass is a plant's recalcitrance to releasing sugars bound in the cell wall. From a sample set of wood cores representing 1,100 individual undomesticated Populus trichocarpa trees, 47 extreme phenotypes were selected across measured lignin conten...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Studer MH,DeMartini JD,Davis MF,Sykes RW,Davison B,Keller M,Tuskan GA,Wyman CE

更新日期：2011-04-12 00:00:00

abstract：:The adaptations in the freshwater turtle that permit survival despite prolonged loss of mitochondrial ATP generation were investigated by comparing the bioenergetics of turtle brain slices with rat brain slices. Aerobic turtle brain shows no significant difference in basal levels of total ATP generation compared to ra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Robin ED,Lewiston N,Newman A,Simon LM,Theodore J

更新日期：1979-08-01 00:00:00

abstract：:The hepatic pigment accumulated in 3,5-diethoxycarbonyl-1,4-dihydrocollidine-treated rats, which has been reported to inhibit ferrochelatase, has been isolated and purified. The pigment has been resolved into one major, one minor, and two trace components, all of which appear to be isomeric porphyrins. The major fract...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ortiz de Montellano PR,Beilan HS,Kunze KL

更新日期：1981-03-01 00:00:00

abstract：:Plants can recognize and resist invading pathogens by signaling the induction of rapid defense responses. Often these responses are mediated by single dominant resistance genes (R genes). The products of R genes have been postulated to recognize the pathogen and trigger rapid host defense responses. Here we describe i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dinesh-Kumar SP,Whitham S,Choi D,Hehl R,Corr C,Baker B

更新日期：1995-05-09 00:00:00

abstract：:The visual (retinoid) cycle, the enzymatic pathway that regenerates chromophore after light absorption, is located primarily in the retinal pigment epithelium (RPE) and is essential for rod photoreceptor survival. Whether this pathway also is essential for cone photoreceptor survival is unknown, and there are no data ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jacobson SG,Aleman TS,Cideciyan AV,Heon E,Golczak M,Beltran WA,Sumaroka A,Schwartz SB,Roman AJ,Windsor EA,Wilson JM,Aguirre GD,Stone EM,Palczewski K

更新日期：2007-09-18 00:00:00

abstract：:Cancer vaccines genetically engineered to produce interleukin 2 have been investigated intensively in a series of animal models and are at the point of entering into clinical trials. In this study we demonstrate a strong correlation between the rate of interleukin 2 production and the protection efficiency of murine S...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schmidt W,Schweighoffer T,Herbst E,Maass G,Berger M,Schilcher F,Schaffner G,Birnstiel ML

更新日期：1995-05-09 00:00:00

abstract：:The neurotrophin (NT) brain-derived neurotrophic factor (BDNF) plays an essential role in the formation of long-term potentiation (LTP). Here, we address whether this modulation by BDNF requires its continuous presence, or whether a local increase in BDNF is necessary during a specific time period of LTP initiation. U...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gärtner A,Staiger V

更新日期：2002-04-30 00:00:00

abstract：:Focal electric stimulation of the auditory cortex is well suited for exploration of the function of the corticofugal (descending) system and the neural mechanism of plasticity in the central auditory system, because it evokes changes in frequency-tuning, called best frequency (BF) shifts, as does auditory fear conditi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xiao Z,Suga N

更新日期：2005-12-27 00:00:00

abstract：:A conformational isoform of the mammalian prion protein (PrP(Sc)) is the sole component of the infectious pathogen that causes the prion diseases. We have obtained X-ray fiber diffraction patterns from infectious prions that show cross-beta diffraction: meridional intensity at 4.8 A resolution, indicating the presence...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wille H,Bian W,McDonald M,Kendall A,Colby DW,Bloch L,Ollesch J,Borovinskiy AL,Cohen FE,Prusiner SB,Stubbs G

更新日期：2009-10-06 00:00:00

abstract：:The complete amino acid sequence for human erythrocyte band 4.2 has been derived from the nucleotide sequence of a full-length 2.35-kilobase (kb) cDNA. The 2.35-kb cDNA was isolated from a human reticulocyte cDNA library made in the expression vector lambda gt11. Of the 2348 base pairs (bp), 2073 bp encode 691 amino a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Korsgren C,Lawler J,Lambert S,Speicher D,Cohen CM

更新日期：1990-01-01 00:00:00

abstract：:Uncoupling protein 1 (UCP1) catalyzes fatty acid-activated, purine nucleotide-sensitive proton leak across the mitochondrial inner membrane of brown adipose tissue to produce heat, and could help combat obesity and metabolic disease in humans. Studies over the last 30 years conclude that the protein is a dimer, bindin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee Y,Willers C,Kunji ER,Crichton PG

更新日期：2015-06-02 00:00:00

abstract：:The interaction of carboxylate ions (acetate, butyrate) with nucleic aicd bases and nucleosides has been investigated by proton magnetic resonance in dimethyl sulfoxide (d6)/H2O mixtures. Carboxylate ions interacted only with guanine derivatives and led to a large downfield shift of the NH2 resonance. A 1:1 stoichiome...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lancelot G,Hélène C

更新日期：1977-11-01 00:00:00

abstract：:The goal of the current study was to investigate the role of exogenous and endogenous hydrogen sulfide (H(2)S) on neovascularization and wound healing in vitro and in vivo. Incubation of endothelial cells (ECs) with H(2)S enhanced their angiogenic potential, evidenced by accelerated cell growth, migration, and capilla...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Papapetropoulos A,Pyriochou A,Altaany Z,Yang G,Marazioti A,Zhou Z,Jeschke MG,Branski LK,Herndon DN,Wang R,Szabó C

更新日期：2009-12-22 00:00:00

abstract：:Cellular morphogenesis relies partly on cell polarization by the cytoskeleton. In the fission yeast Schizosaccharomyces pombe, it is well established that microtubules (MTs) deliver the spatial cue Tea1, a kelch repeat protein, to the tip regions to direct the growth machinery at the cell tips driving the linear exten...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scheffler K,Recouvreux P,Paoletti A,Tran PT

更新日期：2014-12-16 00:00:00