The role of the coagulation cascade in the continuum of sepsis and acute lung injury and acute respiratory distress syndrome.

abstract：:Achieving hemostasis, preventing and treating thrombosis, and laboratory measurement of the hemostatic pathways constitute the core elements of managing the critically ill patient with liver failure. Uncontrolled bleeding in acutely decompensated cirrhosis and acute-on-chronic liver failure is probably the most famili...

journal_title：Seminars in respiratory and critical care medicine

authors： Intagliata NM,Davis JPE,Caldwell SH

更新日期：2018-10-01 00:00:00

abstract：:Antibiotic resistance has emerged as a key determinant of outcome in patients with serious infections along with the virulence of the underlying pathogen. Within the intensive care unit (ICU) setting, ventilator-associated pneumonia (VAP) is a common nosocomial infection that is frequently caused by multidrug-resistan...

journal_title：Seminars in respiratory and critical care medicine

authors： Kollef MH,Burnham CD

更新日期：2017-06-01 00:00:00

abstract：:Cardiopulmonary resuscitation (CPR) is performed frequently by paramedics, emergency department personnel, and inpatient physicians. Unfortunately, after more than 40 years of practice and study, there are still many controversies and unresolved treatment issues. This article focuses on four current controversies in C...

journal_title：Seminars in respiratory and critical care medicine

authors： White SJ,Himes D,Rouhani M,Slovis CM

更新日期：2001-01-01 00:00:00

abstract：:Lung cancer in never smokers (LCINS) has lately been recognized as a unique disease based on rapidly gained knowledge from genomic changes to treatment responses. The focus of this article is on current knowledge and challenges with regard to LCINS expanded from recent reviews highlighting five areas: (1) distribution...

journal_title：Seminars in respiratory and critical care medicine

authors： Yang P

更新日期：2011-02-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a systemic disease, characterized by symmetric joint involvement, but it can also affect other organ systems, including the lungs. The better-known pulmonary manifestations of RA are interstitial lung disease, rheumatoid nodules, and pleural effusions. Less common manifestations include br...

journal_title：Seminars in respiratory and critical care medicine

authors： Gauhar UA,Gaffo AL,Alarcón GS

更新日期：2007-08-01 00:00:00

abstract：:Hematologic factors, in particular platelets and the coagulation system, play an important role in the pathogenesis of organ failure in the intensive care unit. Failure of these hematologic systems is common in intensive care patients and may range from isolated thrombocytopenia or prolonged global clotting tests to c...

journal_title：Seminars in respiratory and critical care medicine

authors： Levi M,Schultz M

更新日期：2011-10-01 00:00:00

abstract：:Evaluation of a patient with hypoventilation requires a combination of clinical history, physical examination, pulmonary function testing, and chest radiography to help determine the cause. Specialized testing such as measurement of respiratory muscle strength and assessment of ventilatory control may also be needed. ...

journal_title：Seminars in respiratory and critical care medicine

authors： Berry RB,Sriram P

更新日期：2009-06-01 00:00:00

abstract：:Usual interstitial pneumonia (UIP) is a distinct histological lesion observed in idiopathic pulmonary fibrosis (IPF) but can be found in other etiologies. The diagnosis of UIP can be established by surgical lung biopsy or by high-resolution thin-section computed tomographic (CT) scans (provided the radiographic featur...

journal_title：Seminars in respiratory and critical care medicine

authors： Lynch JP 3rd,Saggar R,Weigt SS,Zisman DA,White ES

更新日期：2006-12-01 00:00:00

abstract：:Healthcare-associated pneumonia (HCAP) represents one of the largest subsets of patients with pneumonia. Based on epidemiological projections for the aging U.S. population, the number of hospitalizations for HCAP is expected to increase exponentially for the next several decades. The unique risk factors for colonizati...

journal_title：Seminars in respiratory and critical care medicine

authors： Morrow LE

更新日期：2009-02-01 00:00:00

abstract：:The diaphragm is the most important muscle of ventilation. Its contraction is key to the development of intrathoracic pressures. Diseases that affect diaphragmatic function result in decreased pressure-generating capacity by the respiratory muscles. If the involvement is severe or if there is underlying respiratory pa...

journal_title：Seminars in respiratory and critical care medicine

authors： Celli BR

更新日期：2002-06-01 00:00:00

abstract：:Legionella pneumophila has been found to be a common cause of community-acquired pneumonia in patients who required intensive care unit (ICU) admission. In many studies, the clinical manifestations for Legionnaires' disease were more severe and the mortality was higher when compared with pneumonias of other etiology. ...

journal_title：Seminars in respiratory and critical care medicine

authors： Vergis EN,Akbas E,Yu VL

更新日期：2000-01-01 00:00:00

abstract：:Shock is a broad category of injury to the human body caused by a variety of insults. Fluid resuscitation is the cornerstone of initial therapy for nearly all forms of shock. This article reviews the basic physiology determining body fluid composition, the goals of fluid resuscitation in shock, the types of fluids ava...

journal_title：Seminars in respiratory and critical care medicine

authors： Martin GS,Lewis CA

更新日期：2004-12-01 00:00:00

abstract：:Identifying genetic determinants of pulmonary fibrosis is at an early stage of evolution. It is now well recognized that "pulmonary fibrosis" covers a broad range of lung diseases including most topically the idiopathic interstitial pneumonias that have been classified recently. Additionally, it is recognized that the...

journal_title：Seminars in respiratory and critical care medicine

authors： du Bois RM,Kangesan I,Veeraraghavan S

更新日期：2003-04-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is defined as a mean pulmonary artery pressure greater then 25 mm Hg at rest and greater then 30 mm Hg with exercise in association with normal left heart filling pressures. However, many patients with PAH have much higher pulmonary artery pressures, which, untreated, can rapidly ...

journal_title：Seminars in respiratory and critical care medicine

authors： Bull TM

更新日期：2005-08-01 00:00:00

abstract：:Cystic fibrosis (CF) is a multisystem disease. Some of this is accounted for by CF transmembrane regulator (CFTR) dysfunction in individual organs but in some cases this is compounded by the effects of systemic inflammation. The inflammation is in response to the chronic infection in the airways and is particularly im...

journal_title：Seminars in respiratory and critical care medicine

authors： Elborn JS

更新日期：2007-06-01 00:00:00

abstract：:Despite significant progress in the field of transplant immunology, acute cellular rejection (ACR) remains a very frequent complication after lung transplantation (LTx), with almost 30% of LTx recipients experiencing at least one episode of treated ACR during the first year of follow-up. Most episodes respond to the f...

journal_title：Seminars in respiratory and critical care medicine

authors： Koutsokera A,Levy L,Pal P,Orchanian-Cheff A,Martinu T

更新日期：2018-04-01 00:00:00

abstract：:Venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), is the third most common cardiovascular pathology after coronary disease and cerebrovascular diseases and is responsible for significant morbidity and mortality in the general population. Full-dose anticoagulation is the st...

journal_title：Seminars in respiratory and critical care medicine

authors： Imberti D,Maraldi C,Gallerani M

更新日期：2012-04-01 00:00:00

abstract：:Nonspecific interstitial pneumonia (NSIP) is a complex disorder commonly associated with other conditions such as connective tissue diseases (CTDs) and environmental exposures. Although idiopathic NSIP has been recognized as a separate clinical entity, recent studies have suggested that a proportion of these cases hav...

journal_title：Seminars in respiratory and critical care medicine

authors： Teoh AKY,Corte TJ

更新日期：2020-04-01 00:00:00

abstract：:Pseudomonas aeruginosa is a formidable pathogen in the infection arena. It is able to easily adapt to the environment which it inhabits and can also colonize and invade the human host to cause serious infections. In 2011, it was responsible for 7.1% of all health care-associated infection in the United States. The mor...

journal_title：Seminars in respiratory and critical care medicine

authors： McCarthy K

更新日期：2015-02-01 00:00:00

abstract：:Hepatic sarcoidosis is a relatively common manifestation of extrapulmonary sarcoidosis. It occurs in 20 to 30% of cases and is rarely severe. However, a cluster of patients may develop severe complications such as cirrhosis and portal hypertension. In this review, we describe the current knowledge of clinical, biologi...

journal_title：Seminars in respiratory and critical care medicine

authors： Rossi G,Ziol M,Roulot D,Valeyre D,Mahévas M

更新日期：2020-10-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease of unknown cause, occurring in adults, limited to the lungs and associated with the pathologic and radiologic pattern of usual interstitial pneumonia. Prognosis is poor, and most patients die of respiratory failure within 3 to 6 years from the o...

journal_title：Seminars in respiratory and critical care medicine

authors： Puglisi S,Torrisi SE,Giuliano R,Vindigni V,Vancheri C

更新日期：2016-06-01 00:00:00

abstract：:Pandemics of influenza have been reported since the early sixteenth century. Recent pandemics include the Spanish flu (H1N1) from 1918 to 1920 (resulting in approximately 50 million deaths worldwide); the Asian flu (H2N2) from 1957 to 1958 (resulting in more than 1 million deaths); the Hong Kong flu (H3N2) from 1968 t...

journal_title：Seminars in respiratory and critical care medicine

authors： Rajagopal S,Treanor J

更新日期：2007-04-01 00:00:00

abstract：:This review summarizes the effects of beta2-agonists on asthma severity. There has been a controversy as to whether the regularly scheduled use of beta2-adrenergic agonists increases the risk of adverse outcomes in asthma. A number of epidemiological and clinical studies have found an association between the regularly...

journal_title：Seminars in respiratory and critical care medicine

authors： Ford JG,Iqbal J,Sunmonu Y

更新日期：2002-08-01 00:00:00

abstract：:Cystic fibrosis (CF) is now more common in adults than children in countries with well-developed health care systems. The number of adults continues to increase and will further increase if the new cystic fibrosis transmembrane conductance regulator (CFTR) modulators are disease modifying. Most of the complex morbidit...

journal_title：Seminars in respiratory and critical care medicine

authors： Elborn JS

更新日期：2019-12-01 00:00:00

abstract：:Patients with cystic fibrosis (CF) exhibit significant variability in the course and severity of the disease, and this variability is best interpreted in the context of an interaction between genetic and nongenetic determinants. While a small number of patients with "mild" mutations in the CF transmembrane conductance...

journal_title：Seminars in respiratory and critical care medicine

authors： Schechter MS

更新日期：2003-12-01 00:00:00

abstract：:Treatment strategies for anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) are evolving. Cyclophosphamide (CYC) plus corticosteroids (CSs) is the mainstay of therapy for generalized, multisystemic AAV. Historically, the combination of CYC plus CS was used for a minimum of 12 months, but concern a...

journal_title：Seminars in respiratory and critical care medicine

authors： Wang T,Weigt SS,Belperio JA,Lynch JP 3rd

更新日期：2011-06-01 00:00:00

abstract：:Pulmonary immunity to fungal pathogens requires both innate and adaptive immune responses. Alveolar macrophages, dendritic cells, and neutrophils are the phagocytic cells of the lung innate system. These cells produce early inflammatory mediators (i.e., reactive oxygen species, cytokines, and chemokines) in response t...

journal_title：Seminars in respiratory and critical care medicine

authors： Hernández Y,Herring AC,Huffnagle GB

更新日期：2004-02-01 00:00:00

abstract：:Intensive care unit (ICU) acquired pneumonia is one of the most common and morbid health care-associated infections. Despite decades of work developing and testing prevention strategies, ICU-acquired pneumonia remains stubbornly pervasive. Pneumonia prevention studies are difficult to interpret because all are at risk...

journal_title：Seminars in respiratory and critical care medicine

authors： Klompas M

更新日期：2019-08-01 00:00:00

abstract：:The overarching goals of early sepsis management include early recognition, appropriate antibiotic therapy and source control, maintenance of hemodynamic stability, and supportive care of organ dysfunction. Despite increasing awareness of the global burden of sepsis, and general agreement on the goals of management, t...

journal_title：Seminars in respiratory and critical care medicine

authors： Moss SR,Prescott HC

更新日期：2019-10-01 00:00:00

abstract：:Nonspecific interstitial pneumonia (NSIP) represents one histologic subtype of idiopathic interstitial pneumonia (IIP). NSIP is typified by temporal homogeneity and less profusion of fibroblastic foci than is seen with usual interstitial pneumonia (UIP), the most common IIP. Clinically patients with NSIP present with ...

journal_title：Seminars in respiratory and critical care medicine

authors： Flaherty KR,Martinez FJ,Travis W,Lynch JP 3rd

更新日期：2001-08-01 00:00:00