Pseudomonas aeruginosa: evolution of antimicrobial resistance and implications for therapy.

abstract：:The vasculitides affecting large and medium-sized vessels are heterogeneous. This group includes such disorders as giant cell arteritis, Takayasu's disease, and sarcoidosis. There are several challenges that may arise in the care of patients with these disorders. Diagnosis may be elusive when initially evaluating pati...

journal_title：Seminars in respiratory and critical care medicine

authors： Maksimowicz-McKinnon K,Hoffman GS

更新日期：2004-10-01 00:00:00

abstract：:Invasive candidiasis (IC) is the most frequent health care associated invasive fungal infection. It is also associated with high morbidity, mortality, and cost. The most frequent etiologic agent is Candida albicans, but non-albicans species are increasing and associated with reduced antifungal susceptibility and outbr...

journal_title：Seminars in respiratory and critical care medicine

authors： Gonzalez-Lara MF,Ostrosky-Zeichner L

更新日期：2020-02-01 00:00:00

abstract：:Over the past 3 decades, antimicrobial resistance among Streptococcus pneumoniae, the most common cause of community-acquired pneumonia (CAP), has escalated dramatically worldwide. In the late 1970s, strains of pneumococci displaying resistance to penicillin were described in South Africa and Spain. By the early 1990s...

journal_title：Seminars in respiratory and critical care medicine

authors： Lynch JP 3rd,Zhanel GG

更新日期：2009-04-01 00:00:00

abstract：:Severe chronic obstructive pulmonary disease (COPD) exacerbations requiring hospitalization are a major cause of morbidity and mortality. Recognition of the importance of COPD exacerbations has led to the knowledge that prevention of exacerbations and early treatment are important goals of COPD therapy. Preventive man...

journal_title：Seminars in respiratory and critical care medicine

authors： Bourbeau J

更新日期：2010-06-01 00:00:00

abstract：:Malignant pleural mesothelioma is a rare cancer associated with asbestos exposure and portends a dismal prognosis. Its worldwide incidence has been increasing, and treatment options are currently suboptimal and noncurative. However, since the turn of the century, several encouraging steps have been made toward improvi...

journal_title：Seminars in respiratory and critical care medicine

authors： Kim RY,Sterman DH,Haas AR

更新日期：2019-06-01 00:00:00

abstract：:Despite advances in positive pressure therapy for obstructive sleep apnea, compliance continues to be a problem for many patients. Sleep apnea surgery is a viable option for patients who are intolerant of positive pressure therapy. This review presents the current state of the art in sleep apnea surgery, including air...

journal_title：Seminars in respiratory and critical care medicine

authors： Li KK

更新日期：2005-02-01 00:00:00

abstract：:The elderly are especially prone to the adverse health effects of chronic obstructive pulmonary disease (COPD), which is a common disorder in that population. While the prevalence and morbidity of COPD in the elderly are high, it is often undiagnosed and thus undertreated. The diagnosis of COPD is primarily based on t...

journal_title：Seminars in respiratory and critical care medicine

authors： Hanania NA,Sharma G,Sharafkhaneh A

更新日期：2010-10-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) in the pediatric population is associated with a variety of underlying diseases and causes, significantly morbidity and mortality. In the majority of patients, PAH in children is idiopathic or associated with congenital heart disease (CHD), with pulmonary hypertension (PH) associa...

journal_title：Seminars in respiratory and critical care medicine

authors： Takatsuki S,Ivy DD

更新日期：2013-10-01 00:00:00

abstract：:Asthma is a heterogeneous disorder with a complex etiology. Prevalence rates for asthma have been increasing in many countries over the past few decades. While it is unclear why this increase is occurring, the variation reported in asthma prevalence and severity associated with ethnicity offers some insight into the d...

journal_title：Seminars in respiratory and critical care medicine

authors： Moraes TJ,Sears MR,Subbarao P

更新日期：2018-02-01 00:00:00

abstract：:The human Herpesviridae family consists of eight members: cytomegalovirus (CMV), Epstein-Barr virus (EBV), herpes simplex virus 1 and 2 (HSV-1, -2), varicella-zoster virus (VZV), and human herpesvirus 6, 7, and 8 (HHV-6, -7, -8). Lifelong latency may develop in the host with reactivation during periods of relative imm...

journal_title：Seminars in respiratory and critical care medicine

authors： Zamora MR

更新日期：2011-08-01 00:00:00

abstract：:Lung cancer in never smokers (LCINS) has lately been recognized as a unique disease based on rapidly gained knowledge from genomic changes to treatment responses. The focus of this article is on current knowledge and challenges with regard to LCINS expanded from recent reviews highlighting five areas: (1) distribution...

journal_title：Seminars in respiratory and critical care medicine

authors： Yang P

更新日期：2011-02-01 00:00:00

abstract：:Cystic fibrosis (CF) is a complicated disease involving many organ systems. Identification of the cystic fibrosis transmembrane regulator (CFTR) genetic code has not only enhanced our understanding of the mechanism of CF pathology but has also provided explanations for phenotypic variation. Additionally, genetic testi...

journal_title：Seminars in respiratory and critical care medicine

authors： Lommatzsch ST,Aris R

更新日期：2009-10-01 00:00:00

abstract：:Computed tomography (CT) is the core imaging modality for the evaluation of thoracic disorders. With the recently developed dual-energy CT (DECT) technique, the clinical utility of CT in the management of pulmonary diseases can be expanded. The most actively investigated principle of dual energy is material decomposit...

journal_title：Seminars in respiratory and critical care medicine

authors： Remy-Jardin M,Faivre JB,Pontana F,Molinari F,Tacelli N,Remy J

更新日期：2014-02-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) is the most common subtype of lung cancer and the leading cause of cancer-related death. Although durable local control rates are high after surgical resection or definitive radiotherapy for early-stage disease, a substantial proportion of these patients eventually experience regiona...

journal_title：Seminars in respiratory and critical care medicine

authors： Dams RV,Yuan Y,Robinson CG,Lee P

更新日期：2020-06-01 00:00:00

abstract：: ...

journal_title：Seminars in respiratory and critical care medicine

authors： Oh SS,Folch E

更新日期：2018-12-01 00:00:00

abstract：:In the past 5 years, there has arguably been a shift in the pathologic diagnosis of lung cancer, especially adenocarcinoma, moving toward a more patient-centered approach to reporting that works to incorporate information that may be clinically meaningful to prognosis and impactful to clinical management strategy. As ...

journal_title：Seminars in respiratory and critical care medicine

authors： Konopka KE

更新日期：2016-10-01 00:00:00

abstract：:Daily oral care with chlorhexidine for mechanically ventilated patients is ubiquitous in contemporary intensive care practice. The practice is predicated upon meta-analyses suggesting that adding chlorhexidine to daily oral care regimens can reduce ventilator-associated pneumonia (VAP) rates by up to 40%. Close analys...

journal_title：Seminars in respiratory and critical care medicine

authors： Klompas M

更新日期：2017-06-01 00:00:00

abstract：:The overarching goals of early sepsis management include early recognition, appropriate antibiotic therapy and source control, maintenance of hemodynamic stability, and supportive care of organ dysfunction. Despite increasing awareness of the global burden of sepsis, and general agreement on the goals of management, t...

journal_title：Seminars in respiratory and critical care medicine

authors： Moss SR,Prescott HC

更新日期：2019-10-01 00:00:00

abstract：:Catheters are the leading source of bloodstream infections in critically ill patients. Because the clinical signs of infection are nonspecific, such infections are overly suspected, which results in unnecessary removal of catheters. A conservative approach might be attempted in mild infections, whereas catheters shoul...

journal_title：Seminars in respiratory and critical care medicine

authors： Timsit JF,Dubois Y,Minet C,Bonadona A,Lugosi M,Ara-Somohano C,Hamidfar-Roy R,Schwebel C

更新日期：2011-04-01 00:00:00

abstract：:Respiratory samples obtained by bronchoalveolar lavage (BAL) in infectious processes provide important microbiological and cytological information to manage this type of patient. Most of the clinical and experimental BAL investigations have been done in ventilator-associated pneumonia (VAP) and in immunosuppressed con...

journal_title：Seminars in respiratory and critical care medicine

authors： Ramírez P,Valencia M,Torres A

更新日期：2007-10-01 00:00:00

abstract：:Aspirin-exacerbated respiratory disease (AERD) is a unique syndrome of airway inflammation that frequently occurs in patients with nasal polyposis, chronic sinusitis, and asthma. These patients tend to have progressive and recalcitrant sinus disease requiring frequent surgical intervention and in many cases systemic c...

journal_title：Seminars in respiratory and critical care medicine

authors： White AA,Stevenson DD

更新日期：2012-12-01 00:00:00

abstract：:Sarcoidosis is a granulomatous disease of unknown etiology that involves the lungs or intrathoracic lymph nodes in more than 90% of patients. The clinical spectrum of sarcoidosis is protean, but pulmonary manifestations often dominate. Chest radiographs are abnormal in 90 to 95% of patients with sarcoidosis; the most ...

journal_title：Seminars in respiratory and critical care medicine

authors： Lynch JP 3rd

更新日期：2003-08-01 00:00:00

abstract：:This article reviews recent developments in the selection, assessment, and management of the potential lung donor, which aim to increase donor organ use. The scarcity of suitable donor organs continues to limit lung transplantation, but the situation is changing. An expanded donor pool, including the now widespread us...

journal_title：Seminars in respiratory and critical care medicine

authors： Snell GI,Paraskeva M,Westall GP

更新日期：2013-06-01 00:00:00

abstract：:Intensive care unit (ICU) acquired pneumonia is one of the most common and morbid health care-associated infections. Despite decades of work developing and testing prevention strategies, ICU-acquired pneumonia remains stubbornly pervasive. Pneumonia prevention studies are difficult to interpret because all are at risk...

journal_title：Seminars in respiratory and critical care medicine

authors： Klompas M

更新日期：2019-08-01 00:00:00

abstract：:Pulmonary fibrosis is a devastating disease that occurs in association with environmental exposures, several inherited diseases, collagen vascular disease, as well as in an idiopathic form. Epithelial cell damage, excessive fibroblast proliferation, upregulation of extracellular matrix production, and attenuated matri...

journal_title：Seminars in respiratory and critical care medicine

authors： Wurfel MM,Raghu G

更新日期：2002-04-01 00:00:00

abstract：:Pandemics of influenza have been reported since the early sixteenth century. Recent pandemics include the Spanish flu (H1N1) from 1918 to 1920 (resulting in approximately 50 million deaths worldwide); the Asian flu (H2N2) from 1957 to 1958 (resulting in more than 1 million deaths); the Hong Kong flu (H3N2) from 1968 t...

journal_title：Seminars in respiratory and critical care medicine

authors： Rajagopal S,Treanor J

更新日期：2007-04-01 00:00:00

abstract：:Evaluation of a patient with hypoventilation requires a combination of clinical history, physical examination, pulmonary function testing, and chest radiography to help determine the cause. Specialized testing such as measurement of respiratory muscle strength and assessment of ventilatory control may also be needed. ...

journal_title：Seminars in respiratory and critical care medicine

authors： Berry RB,Sriram P

更新日期：2009-06-01 00:00:00

abstract：:Delivery of medication to sites of action through airways has been used for centuries but has gained momentum in recent decades. Currently available modes of aerosol delivery offer advantages but still there are shortcomings. Delivery of active agents to sites of action is affected by many factors beyond the character...

journal_title：Seminars in respiratory and critical care medicine

authors： Singh S,Kanbar-Agha F,Sharafkhaneh A

更新日期：2015-08-01 00:00:00

abstract：:Invasive fungal infections, especially candidemia and systemic candidiasis, have become a major cause of morbidity and mortality in the last few decades. This comes in parallel with the major advances made in intensive care. Patients who are critically ill, in medical or surgical ICUs are especially at risk for CANDID...

journal_title：Seminars in respiratory and critical care medicine

authors： Vazquez JA

更新日期：2010-02-01 00:00:00

abstract：:Nonspecific interstitial pneumonia (NSIP) represents one histologic subtype of idiopathic interstitial pneumonia (IIP). NSIP is typified by temporal homogeneity and less profusion of fibroblastic foci than is seen with usual interstitial pneumonia (UIP), the most common IIP. Clinically patients with NSIP present with ...

journal_title：Seminars in respiratory and critical care medicine

authors： Flaherty KR,Martinez FJ,Travis W,Lynch JP 3rd

更新日期：2001-08-01 00:00:00