Abstract:
:Spider dragline silk with its superlative tensile properties provides an ideal system to study the relationship between morphology and mechanical properties of a structural protein. Accordingly, we synthesized two hybrid multiblock copolymers by condensing poly(alanine) [(Ala)(5)] blocks of the structural proteins (spidroin MaSp1 and MaSp2) of spider dragline silk with different oligomers of isoprene (2200 and 5000 Da) having reactive end groups. The synthetic multiblock polymer displayed similar secondary structure to that of natural spidroin, the peptide segment forming a beta-sheet structure. These multiblock polymers showed a significant solubility in the component solvents. Moreover, the copolymer which contains the short polyisoprene segment would aggregate into a micellar-like structure, as observed by TEM.
journal_name
Biomacromoleculesjournal_title
Biomacromoleculesauthors
Zhou C,Leng B,Yao J,Qian J,Chen X,Zhou P,Knight DP,Shao Zdoi
10.1021/bm060199tsubject
Has Abstractpub_date
2006-08-01 00:00:00pages
2415-9issue
8eissn
1525-7797issn
1526-4602journal_volume
7pub_type
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