Prostate derived factor in human prostate cancer cells: gene induction by vitamin D via a p53-dependent mechanism and inhibition of prostate cancer cell growth.

abstract：:The phytohemagglutinin (PHA)-stimulated human lymphocytes demonstrated trace or no activity (dihydro) folate acid reductase using three methods including a radioassay, but demonstrated ample activity of thymidylate synthetase. This was true regardless of the day of harvest, (first through seventh) of the stimulated ly...

journal_title：Journal of cellular physiology

authors： Haurani FI,Kardinal CG,Biermann WA

更新日期：1978-04-01 00:00:00

abstract：:COVID-19, a new disease caused by the 2019-novel coronavirus (SARS-CoV-2), has swept the world and challenged its culture, economy, and health infrastructure. Forced emergence to find an effective vaccine to immunize people has led scientists to design and examine vaccine candidates all over the world. Until a vaccine...

journal_title：Journal of cellular physiology

authors： Rezaei M,Ziai SA,Fakhri S,Pouriran R

更新日期：2020-09-09 00:00:00

abstract：:Recent studies have suggested that interferons (IFNs) have an antifibrotic effect in the liver independent of their antiviral effect although its detailed mechanism remains largely unknown. Some microRNAs have been reported to regulate pathophysiological activities of hepatic stellate cells (HSCs). We performed analys...

journal_title：Journal of cellular physiology

authors： Sekiya Y,Ogawa T,Iizuka M,Yoshizato K,Ikeda K,Kawada N

更新日期：2011-10-01 00:00:00

abstract：:Cultured bovine adrenocortical cells were previously shown to be functionally deficient in selenium and vitamin E when grown in medium supplemented with fetal bovine serum. In the present experiments, the lack of significant bioavailable amounts of selenium in the medium was demonstrated by the finding of only low lev...

journal_title：Journal of cellular physiology

authors： Hornsby PJ,Pearson DW,Autor AP,Aldern KA,Harris SE

更新日期：1985-04-01 00:00:00

abstract：:Osteosarcoma (OS) is a primary highly malignant tumor of bone, affecting predominately adolescents and young adults between 10 and 20 years of age. OS is characterized by an extremely aggressive clinical course, with a rapid development of metastasis to the lung and distant bones. ...

journal_title：Journal of cellular physiology

authors： Laschi M,Bernardini G,Geminiani M,Ghezzi L,Amato L,Braconi D,Millucci L,Frediani B,Spreafico A,Franchi A,Campanacci D,Capanna R,Santucci A

更新日期：2015-11-01 00:00:00

abstract：:We have studied the transcriptional activity, steady-state mRNA levels, and steady-state protein levels of the c-myc and transferrin receptor (TfR) genes in murine M1 myeloid leukemia cells arrested in G1 phase of the cell cycle by different methods. When cells are growth-arrested by density inhibition, a technique th...

journal_title：Journal of cellular physiology

authors： Neckers LM,Tsuda H,Weiss E,Pluznik DH

更新日期：1988-05-01 00:00:00

abstract：:A monoclonal antibody (mAb), 2E12, against the neural cell adhesion molecule L1 recognized the 200 kDa component of L1. The epitope of L1 reacting with mAb 2E12 was localized in its carbohydrate chain, judging from the results of experiments on glycopeptidase F treatment. The physiological effect of adding mAbL1 (2E12...

journal_title：Journal of cellular physiology

authors： Asou H

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND:Surgical stress has been suggested to facilitate colon cancer growth and metastasis. However, the precise mechanisms by which surgical trauma promotes colon cancer progression remain poorly understood. METHODS:To unravel the mechanisms underlying surgery-induced colon cancer progression, a syngenic transpla...

journal_title：Journal of cellular physiology

authors： Sun Z,Du C,Xu P,Miao C

更新日期：2019-04-01 00:00:00

abstract：OBJECTIVE:This study aims to investigate the effect of polo-like kinase 1 (PLK1) inhibition on cisplatin (DDP)-resistant gastric cancer (GC) cells. METHODS:The transcriptional level of PLK1 was measured by quantitative reverse-transcription polymerase chain reaction. Expressions of PLK1 and its downstream mediators as...

journal_title：Journal of cellular physiology

authors： Chen Z,Chai Y,Zhao T,Li P,Zhao L,He F,Lang Y,Qin J,Ju H

更新日期：2019-05-01 00:00:00

abstract：:Addition of ATP to cultures of transformed mouse fibroblasts, 3T6 cells, resulted in cell growth inhibition, whereas the growth of the non-transformed counterparts, 3T3 cells, was only slightly affected. The inhibition was found to be specific for adenine nucleotides, and concentration dependent. At relatively low con...

journal_title：Journal of cellular physiology

authors： Belzer I,Friedberg I

更新日期：1989-09-01 00:00:00

abstract：:Experiments were carried out to test the hypothesis that cell spreading and phagocytosis are similar cell responses to different-sized substrata. The following morphological and biochemical studies provided evidence for this supposition. Cells phagocytosed 1.09-micron and 5.7-micron latex beads, but were unable to com...

journal_title：Journal of cellular physiology

authors： Grinnell F

更新日期：1984-04-01 00:00:00

abstract：:Loss of TSC1 function, a crucial negative regulator of mTOR signaling, is a common alteration in bladder cancer. Mutations in other members of the PI3K pathway, leading to mTOR activation, are also found in bladder cancer. This provides rationale for targeting mTOR for treatment of bladder cancer characterized by TSC1...

journal_title：Journal of cellular physiology

authors： Alayev A,Salamon RS,Schwartz NS,Berman AY,Wiener SL,Holz MK

更新日期：2017-02-01 00:00:00

abstract：:Macrophages are central mediators of the immune, contributing both to the initiation and the resolution of inflammation. The concept of macrophage activation and program has stimulated interest in its definition, and functional significance in homeostasis and diseases. It has been known that macrophages could be diffe...

journal_title：Journal of cellular physiology

authors： Liu G,Yang H

更新日期：2013-03-01 00:00:00

abstract：:Fibroblast growth factors (FGFs) are soluble ligands important for embryonic patterning, limb and brain development, and stem cell proliferation. They activate specific receptors (FGFR) to elicit changes in gene expression and cellular responses such as proliferation, differentiation, and survival, but the extent to w...

journal_title：Journal of cellular physiology

authors： Garcia-Maya M,Anderson AA,Kendal CE,Kenny AV,Edwards-Ingram LC,Holladay A,Saffell JL

更新日期：2006-02-01 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) play pivotal roles in bone and cartilage growth and repair. Through phenotypes of short-ear (se) mice, which have BMP-5 mutations, a role for BMP-5 in some specific aspects of skeletogenesis and cartilage growth is known. This report examines BMP-5 expression in the growth plate and ...

journal_title：Journal of cellular physiology

authors： Mailhot G,Yang M,Mason-Savas A,Mackay CA,Leav I,Odgren PR

更新日期：2008-01-01 00:00:00

abstract：:Mesenchymal stem cells (MSC) represent emerging cell-based therapies for diabetes and associated complications. Ongoing clinical trials are using exogenous MSC to treat type 1 and 2 diabetes, cardiovascular disease and non-healing wounds due to diabetes. The majority of these trials are aimed at exploiting the ability...

journal_title：Journal of cellular physiology

authors： Smith AN,Muffley LA,Bell AN,Numhom S,Hocking AM

更新日期：2012-09-01 00:00:00

abstract：:Proteasome inhibitors represent a promising therapy for the treatment of relapsed and/or refractory multiple myeloma, a disease that is concomitant with osteolysis and enhanced osteoclast formation. While blockade of the proteosome pathway has been recently shown to influence osteoclast formation and function, the pre...

journal_title：Journal of cellular physiology

authors： Ang E,Pavlos NJ,Rea SL,Qi M,Chai T,Walsh JP,Ratajczak T,Zheng MH,Xu J

更新日期：2009-08-01 00:00:00

abstract：:Lipocalin-2 (Lcn2; also termed neutrophil gelatinase-associated lipocalin (NGAL)) levels correlate positively with heart failure (HF) yet mechanisms via which Lcn2 contributes to the pathogenesis of HF remain unclear. In this study, we used coronary artery ligation surgery to induce ischemia in wild-type (wt) mice and...

journal_title：Journal of cellular physiology

authors： Sung HK,Chan YK,Han M,Jahng JWS,Song E,Danielson E,Berger T,Mak TW,Sweeney G

更新日期：2017-08-01 00:00:00

abstract：:In previous studies on HeLa cells we demonstrated estrogen-responsiveness of the epidermal growth factor receptor (EGFR) gene, as 17beta-estradiol (E(2)) and selective estrogen receptor modulators (SERMs) genistein (G), daidzein (D), and 4-hydroxytamoxifen (4OH-T) modulated its transcription in a ligand- and estrogen ...

journal_title：Journal of cellular physiology

authors： Salvatori L,Caporuscio F,Coroniti G,Starace G,Frati L,Russo MA,Petrangeli E

更新日期：2009-07-01 00:00:00

abstract：:Alkaptonuria (AKU) is a rare disease correlated with deficiency of the enzyme homogentisate 1,2 dioxygenase, which causes homogentisic acid (HGA) accumulation. HGA is subjected to oxidation/polymerization reactions, leading to the production of a peculiar melanin-like pigmentation (ochronosis) after chronic inflammati...

journal_title：Journal of cellular physiology

authors： Schiavone ML,Millucci L,Bernardini G,Giustarini D,Rossi R,Marzocchi B,Santucci A

更新日期：2020-10-01 00:00:00

abstract：:Osteoclasts and macrophages share progenitors that must receive decisive lineage signals driving them into their respective differentiation routes. Macrophage colony stimulation factor M-CSF is a common factor; bone is likely the stimulus for osteoclast differentiation. To elucidate the effect of both, shared mouse bo...

journal_title：Journal of cellular physiology

authors： De Vries TJ,Schoenmaker T,Aerts D,Grevers LC,Souza PP,Nazmi K,van de Wiel M,Ylstra B,Lent PL,Leenen PJ,Everts V

更新日期：2015-01-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor-γ coactivator-1 deficient (Pgc-1β-/- ) murine hearts model the increased, age-dependent, ventricular arrhythmic risks attributed to clinical conditions associated with mitochondrial energetic dysfunction. These were accompanied by compromised action potential (AP) upstroke ra...

journal_title：Journal of cellular physiology

authors： Ahmad S,Valli H,Smyth R,Jiang AY,Jeevaratnam K,Matthews HR,Huang CL

更新日期：2019-04-01 00:00:00

abstract：:In novel coronavirus disease 2019 (COVID-19), the increased frequency and overactivation of T helper (Th) 17 cells and subsequent production of large amounts of proinflammatory cytokines result in hyperinflammation and disease progression. The current study aimed to investigate the therapeutic effects of nanocurcumin ...

journal_title：Journal of cellular physiology

authors： Tahmasebi S,El-Esawi MA,Mahmoud ZH,Timoshin A,Valizadeh H,Roshangar L,Varshoch M,Vaez A,Aslani S,Navashenaq JG,Aghebati-Maleki L,Ahmadi M

更新日期：2020-12-28 00:00:00

abstract：:Numerous studies have suggested that urothelial cancer-associated 1 (UCA1) acts as a suppressor gene affecting cell proliferation and migration. However, the biological role and the potential mechanism of UCA1 in the progression of pre-eclampsia (PE) remains unclear. The UCA1 level was markedly upregulated in PE pregn...

journal_title：Journal of cellular physiology

authors： Liu J,Luo C,Zhang C,Cai Q,Lin J,Zhu T,Huang X

更新日期：2020-10-01 00:00:00

abstract：:Butyrate and acetate are bacterial metabolites present in the large intestine lumen. Although butyrate is well known to inhibit the in vitro proliferation of human colon carcinoma cells in a process involving the hyperacetylation of specific nuclear histones, little is known about the possible link between butyrate me...

journal_title：Journal of cellular physiology

authors： Andriamihaja M,Chaumontet C,Tome D,Blachier F

更新日期：2009-01-01 00:00:00

abstract：:BHK fibroblasts can be growth arrested by incubation in low serum (0.1%) medium. Growth is initiated by incubating cells in high serum (10%) medium. We have found that if the quiescent cells in low serum medium are incubated with insulin, the G0 to S transit time is decreased by two to six hours when serum (10%) is ad...

journal_title：Journal of cellular physiology

authors： Kletzien RF,Day P

更新日期：1980-12-01 00:00:00

abstract：:Ganoderma lucidum is used in traditional Chinese medicine to prevent or treat a variety of diseases, including cardiovascular disorders. We previously demonstrated that a glucan-containing extract of Reishi polysaccharides (EORP) has the potent anti-inflammatory action of reducing ICAM-1 expression in lipopolysacchari...

journal_title：Journal of cellular physiology

authors： Wang SH,Liang CJ,Weng YW,Chen YH,Hsu HY,Chien HF,Tsai JS,Tseng YC,Li CY,Chen YL

更新日期：2012-08-01 00:00:00

abstract：:Mouse heptoma cells that secrete large amounts of alpha-fetoprotein (AFP) and albumin have been crossed with rat hepatoma cells that secret only albumin, and in relatively small amounts, to investigate the influence of each parental genome upon the expression of serum proteins. All of the ten independent hybrid clones...

journal_title：Journal of cellular physiology

authors： Cassio D,Hassoux R,Dupiers M,Uriel J,Weiss MC

更新日期：1980-09-01 00:00:00

abstract：:32D cells are murine myeloid cells that grow indefinitely in Interleukin-3 (IL-3). In these cells, the type 1 insulin-like growth factor (IGF-I) and granulocytic-colony stimulating factor (G-CSF) induce differentiation to granulocytes. 32D cells do not express insulin receptor substrate-1 (IRS-1) or IRS-2, docking pro...

journal_title：Journal of cellular physiology

authors： Shi B,Prisco M,Calin G,Liu CG,Russo G,Giordano A,Baserga R

更新日期：2006-06-01 00:00:00

abstract：:The next-generation sequencing (NGS) based RNA sequencing (RNA-Seq) and transcriptome profiling offers an opportunity to unveil complex biological processes. Successful RNA-Seq and transcriptome profiling requires a large amount of high-quality RNA. However, NGS-quality RNA isolation is extremely difficult from recalc...

journal_title：Journal of cellular physiology

authors： Sharma D,Golla N,Singh D,Onteru SK

更新日期：2018-03-01 00:00:00