Antibody response to three doses of standard and double dose of trivalent oral polio vaccine.

Abstract:

:The study was undertaken to compare the antibody response of 6-12 weeks old infants after three doses of standard trivalent oral polio vaccine (TOPV) (Groups A; (n = 42) with three doses of double the amount of TOPV (Group B; n = 35). Seroconversions in Group A were 64.2, 80.9% and 57.1% for Types I, II and III polioviruses, respectively. The corresponding figures for Group B were 77.7, 80.0 and 60.6%, respectively, the differences being insignificant. Differences in feeding practices and presence of maternal antibodies did not affect seroconversion. This suggests that increasing the amount of vaccine virus in each dose is not an alternative to present strategy. Breast feeding and presence of maternal antibodies are not responsible for poor seroconversion.

journal_name

Indian Pediatr

journal_title

Indian pediatrics

authors

Agarwal A,Sharma D,Kumari S,Khare S

subject

Has Abstract

pub_date

1991-10-01 00:00:00

pages

1141-5

issue

10

eissn

0019-6061

issn

0974-7559

journal_volume

28

pub_type

杂志文章
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    pub_type: 杂志文章

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    更新日期:2004-11-01 00:00:00

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    pub_type: 杂志文章,随机对照试验

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