Growth Parameters of Turkish Children With an Autoinflammatory Disease Before and After Canakinumab Treatment.

Abstract:

OBJECTIVE:To evaluate the effect of canakinumab on growth parameters of patients with autoinflammatory diseases. METHODS:This retrospective study included Colchicine resistant familial Mediterranean fever (FMF), Mevalonate kinase deficiency (MKD), Tumor necrosis factor receptor-associated periodic fever syndrome (TRAPS), Deficiency of adenosine deaminase 2 (DADA2) patients treated with canakinumab for at least six consecutive months. RESULTS:Eleven patients with FMF, 9 with MKD, 3 with TRAPS, and 1 with DADA2 were included. The median age (range) at diagnosis and drug initiation was 6.06 (1.45-16.06) years and 9.72 (1.82-19.11) years, respectively. The mean weight, height, and BMI SD scores significantly increased after canakinumab. There were significant improvements in laboratory parameters and disease activities. However, growth parameters after the drug did not differ according to gender, the duration of diagnostic delay, and age at the diagnosis. CONCLUSIONS:Canakinumab seems to have a positive effect on growth in patients with autoinflammatory diseases by controlling disease activity and inflammation.

journal_name

Indian Pediatr

journal_title

Indian pediatrics

authors

Balci S,Ekinci RMK,Dogruel D,Altintas DU,Yilmaz M

subject

Has Abstract

pub_date

2020-07-15 00:00:00

pages

637-640

issue

7

eissn

0019-6061

issn

0974-7559

journal_volume

57

pub_type

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