Abstract:
OBJECTIVE:To evaluate the effect of canakinumab on growth parameters of patients with autoinflammatory diseases. METHODS:This retrospective study included Colchicine resistant familial Mediterranean fever (FMF), Mevalonate kinase deficiency (MKD), Tumor necrosis factor receptor-associated periodic fever syndrome (TRAPS), Deficiency of adenosine deaminase 2 (DADA2) patients treated with canakinumab for at least six consecutive months. RESULTS:Eleven patients with FMF, 9 with MKD, 3 with TRAPS, and 1 with DADA2 were included. The median age (range) at diagnosis and drug initiation was 6.06 (1.45-16.06) years and 9.72 (1.82-19.11) years, respectively. The mean weight, height, and BMI SD scores significantly increased after canakinumab. There were significant improvements in laboratory parameters and disease activities. However, growth parameters after the drug did not differ according to gender, the duration of diagnostic delay, and age at the diagnosis. CONCLUSIONS:Canakinumab seems to have a positive effect on growth in patients with autoinflammatory diseases by controlling disease activity and inflammation.
journal_name
Indian Pediatrjournal_title
Indian pediatricsauthors
Balci S,Ekinci RMK,Dogruel D,Altintas DU,Yilmaz Msubject
Has Abstractpub_date
2020-07-15 00:00:00pages
637-640issue
7eissn
0019-6061issn
0974-7559journal_volume
57pub_type
杂志文章abstract:BACKGROUND:Fetal growth restriction and abnormal Doppler flow studies are commonly associated. Neonatal outcomes are not well known particularly in developing countries, where the burden of the disease is the highest. OBJECTIVE:To determine outcomes of preterm infants with history of absent/reversed end-diastolic umbi...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:10.1007/s13312-013-0235-5
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVE:To document bone mineral density of children and adolescents with cystic fibrosis. DESIGN:Cross-sectional study. SETTING:Tertiary-care center of Northern India, July 2012 to August 2015. PARTICIPANTS:52 children aged 6-18 years with cystic fibrosis and 62 healthy controls of similar age and sex. METHODS:B...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:10.1007/s13312-017-1065-7
更新日期:2017-07-15 00:00:00
abstract::This study was conducted in 2006 to assess the current iodine nutriure of the population in Haryana by assessing the urinary iodine excretion levels amongst the school age children between 6-12 years. Altogether 3,019 urine samples were collected from all the 19 districts in Haryana. The urinary iodine was analyzed by...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2009-01-01 00:00:00
abstract::Patent ductus arteriosus (PDA) is a major morbidity in preterm infants, especially in extremely premature infants less than 28 weeks. The clinical signs and symptoms of PDA in preterm infants are non specific and insensitive for making an early diagnosis of significant ductal shunting. Functional echocardiography is e...
journal_title:Indian pediatrics
pub_type: 杂志文章,评审
doi:10.1007/s13312-011-0062-5
更新日期:2011-04-01 00:00:00
abstract::Sixty children with acute bacterial meningitis (ABM) were prospectively studied for their serum sodium values and cerebrospinal fluid (CSF), serum and urinary osmolality. The results have been compared with 20 age and nutritionally matched controls. Even though mean serum osmolality (283.2 +/- 13.84 mOsm/kg) and serum...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:1993-10-01 00:00:00
abstract::A prospective study was performed on 44 patients (newborn to one year old) with acute bacterial meningitis. Sonograms were obtained within 72 hours of diagnosis, and repeated on 7th, 14th or at an early date, if required. The spectrum of sonographic features of meningitis included normal scan (35.4%), echogenic sulci ...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:1994-11-01 00:00:00
abstract:BACKGROUND:Auxiliary partial orthotopic liver transplantation is a technique where part of diseased native liver is removed and replaced with healthy donor liver so that, the left behind native liver could later regenerate. CASE CHARACTERISTICS:2 year 6 month old girl with acute liver failure due to Hepatitis A. She u...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:10.1007/s13312-016-0795-2
更新日期:2016-01-01 00:00:00
abstract::The incidence and the factors that influence twinning were studied in six villages of Dholka Taluka, a rural field training centre. The twinning rate was 10.10 per 1000 maternities. The monozygotic and dizygotic twinning rates were 4.53 and 5.56, respectively by applying Weinberg's differential formula. In three fourt...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:1990-03-01 00:00:00
abstract::Cord problems at birth were prospectively studied in 12,000 singleton deliveries, of which 258 (2.15%) babies had cord abnormalities. Nearly 32% of these cases had fetal distress and 20.5% had 1 minute Apgar score less than 6. Of the various cord problems nuchal cord was noted in 79.1%, cord prolapse in 12.4% and true...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:1992-03-01 00:00:00
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journal_title:Indian pediatrics
pub_type: 杂志文章
doi:10.1007/s13312-013-0042-z
更新日期:2013-02-01 00:00:00
abstract:: ...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2018-12-15 00:00:00
abstract::Pulmonary manifestations of sarcoidosis are common and may be initially confused with other common diseases like tuberculosis. We report an 11 yr old girl who presented with chronic cough, low grade fever, recent exposure to tuberculosis and hilar lymphadenopathy. She was provisionally diagnosed as pulmonary tuberculo...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2007-08-01 00:00:00
abstract:OBJECTIVE:To compare the mycobacteriological yield from gastric lavage (GL) and bronchoalveolar lavage (BAL), in children with pulmonary tuberculosis. METHODS:58 consecutive children with chest radiograph suggestive of tuberculosis and positive Mantoux test or a positive history of family contact with a case of tuberc...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2000-09-01 00:00:00
abstract:OBJECTIVE:To evaluate recovery and survival of severely wasted children without community management of acute malnutrition programme. DESIGN:Single time point follow-up (24th December 2013 - 2nd April, 2014) of severely wasted children identified in a community-based cross-sectional survey (September 2012 - October 20...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:10.1007/s13312-017-1142-y
更新日期:2017-10-15 00:00:00
abstract::A case of idiopathic hypereosinophilic syndrome who had an unusual presentation in the form of pericardial effusion is being presented here. The child initially responded to corticosteroids but could not maintain normal eosinophil counts on tapering of steroids. Therefore he was put on hydroxyurea and low dose of ster...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVE:To describe the clinical spectrum and factors associated with poor short-term outcomes in children with interstitial lung disease (ILD). DESIGN:Retrospective chart review SETTING:Pediatric Chest Clinic of a tertiary care hospital METHODOLOGY:We retrieved information regarding clinical course and laborato...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:10.1007/s13312-013-0034-z
更新日期:2013-01-08 00:00:00
abstract::A 5 year old boy and a 10 year old girl presented with acute onset of psychotic disorder, which occurred one week after an upper respiratory infection. MRI images of brain were consistent with the diagnosis of acute disseminated encephalomyelitis (ADEM) in both cases. ADEM is one of the differential diagnoses to be co...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2008-12-01 00:00:00
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journal_title:Indian pediatrics
pub_type: 杂志文章,评审
doi:10.1007/s13312-015-0772-1
更新日期:2015-12-01 00:00:00
abstract:OBJECTIVE:To assess the effects of delayed cord clamping (DCC) on hemoglobin (Hb), mean corpuscular volume (MCV) and ferritin level in infants 2 months or older. EVIDENCE ACQUISITION:Meta-analysis of randomized control trials searched systematically from PubMed, Cochrane and Web of science. Trials published from Jan 1...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2020-09-15 00:00:00
abstract::Neural tube defects (NTD) comprise of a group of congenital malformations that include spina bifida, anencephaly and encephalocele. Reports have implicated zinc deficiency as one of the causative factors of NTDs. We compared the serum zinc level of 23 newborns having neural tube defects with 35 healthy controls by spe...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2006-09-01 00:00:00
abstract:OBJECTIVE:To examine the association between hematological indices and serum uric acid in adolescents with hyperuricemia. METHODS:10-year retrospective cohort study of 607 patients with hyperuricemia registered with the Pediatric Nephrology Department. RESULTS:There was a statistically significant positive correlatio...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:10.1007/s13312-014-0547-0
更新日期:2014-12-01 00:00:00
abstract::No clear operational definition of 'Community Participation' has emerged over the last decade of experimentation. One reason is the markedly contrasting perspectives that exist at different levels such as Aid Agencies, Ministry of Health, Government Health Programmes and Non-Government Organizations (NGOs). A more pra...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:1989-11-01 00:00:00
abstract:BACKGROUND:Antiphospholipid syndrome is a multisystem auto-immune disorder characterized by arterial or venous thrombosis in children. CASE CHARACTERISTICS:11-year-old child with pneumococcal meningitis also had cerebral sinus vein thrombosis and pulmonary artery segmental thrombosis. OBSERVATION:Pro-thrombotic evalu...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2018-05-15 00:00:00
abstract::The best known muscular dystrophies are X-linked dystrophinopathies. A clinically and genetically heterogeneous group presenting with weakness of the pelvic and shoulder girdles is that of the limb-girdle muscular dystrophies (LGMDs). Sarcoglycanopathies (SGPs) are autosomal recessive LGMDs. We report a rare case of p...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2003-11-01 00:00:00
abstract:BACKGROUND:Posterior reversible encephalopathy syndrome (PRES) is a benign disorder of reversible subcortical vasogenic cerebral edema. CASE CHARACTERISTICS:A 13-yr-old girl presented 4 days after complete recovery from diabetic ketoacidosis with symptoms of headache, altered sensorium, seizures, and visual loss. Ther...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2019-03-15 00:00:00
abstract::We prospectively studied the effect of oral paracetamol in closing hemodynamically significant Patent ductus arteriosus in preterm infants (gestational age <32 weeks) where Ibuprofen was contraindicated. 29 of 40 neonates (72.5%) showed successful response while 11 (29.5%) failed to show any response. No major complic...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2016-02-01 00:00:00
abstract::A retrospective analysis was carried out to identify factors associated with delay in diagnosis of Kawasaki disease in a tertiary care pediatric hospital setting in Chennai, India. Over a period of 2 years, a total of 37 cases were studied. The cases were divided into Early Diagnosis Group (EDG) and Delayed Diagnosis ...
journal_title:Indian pediatrics
pub_type: 杂志文章
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更新日期:2012-08-01 00:00:00
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journal_title:Indian pediatrics
pub_type: 杂志文章
doi:
更新日期:2018-04-15 00:00:00
abstract::Children with cow milk allergy are suspected to develop calcium metabolism disturbances. We observed increased markers of bone turnover in these children. Children with cow milk allergy are more prone to develop the disturbances of the bone mineralization even in the first year of life. ...
journal_title:Indian pediatrics
pub_type: 杂志文章
doi:10.1007/s13312-013-0194-x
更新日期:2013-07-01 00:00:00
abstract::We studied the ability of B-type natriuretic peptide (BNP) in predicting mortality among 86 in-patients with severe acute malnutrition presenting with co-morbidity, and found that cut-off level of BNP ≥201 pg/mL in Receiver operating characteristics curve [AU-ROC 0.96 (95% CI 0.92,1.003, P<0.0001)] had high discrimina...
journal_title:Indian pediatrics
pub_type: 信件
doi:
更新日期:2020-04-15 00:00:00