Abstract：
OBJECTIVE:To document bone mineral density of children and adolescents with cystic fibrosis. DESIGN:Cross-sectional study. SETTING:Tertiary-care center of Northern India, July 2012 to August 2015. PARTICIPANTS:52 children aged 6-18 years with cystic fibrosis and 62 healthy controls of similar age and sex. METHODS:Both patients and controls were stratified into two groups, as pre-pubertal and peri-/post-pubertal, and compared for whole body bone mineral density, measured using dual energy X-ray absorptiometry. Serum levels of calcium, phosphate, alkaline phosphatase, 25-hydroxyvitamin D and parathyroid hormone were measured in children with cystic fibrosis. RESULTS:Compared with controls, the mean (SD) bone mineral density of children with cystic fibrosis was significantly lower in both the pre-pubertal (0.7 (0.1) g/cm2 vs 0.9 (0.1) g/cm2; P<0.001)) and peri-/post-pubertal groups (0.9 (0.1) g/cm2 vs 1.1 (0.1) g/cm2; P<0.001). Also, the mean (SD) bone mineral apparent density of pre-pubertal and peri-/post-pubertal cystic fibrosis patients was lower than the controls (P <0.001 and P= 0.01, respectively). Thirty-seven (71.2%) cystic fibrosis patients had serum 25-hydroxyvitamin D level below 15 ng/mL. CONCLUSION:Bone mineral density of children with cystic fibrosis was significantly lower than controls; majority of them were vitamin-D deficient. Intervening at an early stage of the disease and providing optimal therapy involving simultaneous management of the several factors affecting bone mineral accretion may be beneficial in improving bone health of these patients.
journal_name
Indian Pediatrjournal_title
Indian pediatricsauthors
Gupta S,Mukherjee A,Khadgawat R,Kabra M,Lodha R,Kabra SKdoi
10.1007/s13312-017-1065-7subject
Has Abstractpub_date
2017-07-15 00:00:00pages
545-549issue
7eissn
0019-6061issn
0974-7559journal_volume
54pub_type
杂志文章abstract：CONTEXT:Cryptosporidium spp. is a zoonotic infection, now being recognized as a significant cause of diarrhea in both immunocompetent and immunocompromised hosts. However, there still exist significant knowledge gaps in its estimated global burden, epidemiology, diagnosis and management. EVIDENCE ACQUISITION:A semi-sy...
journal_title：Indian pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s13312-017-1093-3
更新日期：2017-04-15 00:00:00
abstract：:Eighty one pregnant women (20 +/- 2 weeks of gestation) were assessed for their nutritional status. They were divided into three groups; Group I women (n = 30) were given 200 mg ferrous sulphate (FeSO4) tablet per day for 15 weeks, Group II women (n = 25) were given FeSO4 tablets along with 2,000,000 IU of vitamin A a...
journal_title：Indian pediatrics
pub_type： 临床试验,杂志文章
doi：
更新日期：1995-08-01 00:00:00
abstract：OBJECTIVE:To find the effects of inhaled corticosteroids and the impact of different doses of inhaled corticosteroids on the isolation of nasopharyngeal flora in asthmatic children aged 1-15 years. METHODS:The study included 75 children with asthma and 25 age-matched controls. Nasopharyngeal swabs were obtained. Bacte...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2019-11-15 00:00:00
abstract：:The study population included 110 term healthy small-for-gestational age (SGA) infants having a blood sugar of > 30 mg/dl at the age of < 30 minutes. They were randomized into two groups; (a) Group I (study group) received sugar-fortified milk formula and (b) Group II (control group) received standard milk formula. A ...
journal_title：Indian pediatrics
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1992-11-01 00:00:00
abstract：:In the newborn period, unconjugated hyperbilirubinemia (UHB) is common, multifactoral, and associated with a variety of physiologic and pathologic conditions. The most commonly identified pathologic cause leading to hyperbilirubinemia is hemolytic disease of the newborn. We report a five-days-old female infant with ne...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：OBJECTIVE:We examined associations of different adiposity measures with cortisol responses during the Trier Social Stress Test for children (TSST-C). DESIGN:Descriptive study. SETTING:Holdsworth Memorial Hospital, Mysore, India. PARTICIPANTS:Adolescents aged 13.5y from a birth cohort were recruited (N=269, 133 boys)...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2018-02-15 00:00:00
abstract：:A retrospective analysis was carried out to identify factors associated with delay in diagnosis of Kawasaki disease in a tertiary care pediatric hospital setting in Chennai, India. Over a period of 2 years, a total of 37 cases were studied. The cases were divided into Early Diagnosis Group (EDG) and Delayed Diagnosis ...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：10.1007/s13312-012-0130-5
更新日期：2012-08-01 00:00:00
abstract：OBJECTIVE:To determine the incidence, risk factors and outcome of acute kidney injury (AKI) in hospitalized children with nephrotic syndrome. METHODS:All consecutive hospitalized children (aged 1-14 years) with diagnosis of nephrotic syndrome between February 2016 and February 2017 were enrolled for the study. Childre...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2019-02-15 00:00:00
abstract：BACKGROUND:Human trypansomiasis due to infection by animal trypanosomes is rarely reported from India. CASE CHARACTERISTICS:We describe clinical presentation of a 2-month-old boyfrom a rat infested house in rural Gujarat who was diagnosed to be havinginfection with the rodent parasite Trypanosoma lewisi. OBSERVATION:...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2018-01-15 00:00:00
abstract：OBJECTIVES:To evaluate whether zinc supplements prevent mortality and morbidity in breastfed low birth weight infants. METHODS:All randomized or qausi-randomized trials with individual or cluster allocation and using concurrent controls were included. Study population included LBW infants irrespective of gestational s...
journal_title：Indian pediatrics
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s13312-011-0043-8
更新日期：2011-02-01 00:00:00
abstract：OBJECTIVE:To compare the short-term efficacy of room air versus 100% oxygen for resuscitation of asphyxic newborns at birth. DESIGN:Multicentric quasi randomized controlled trial. SETTING:Teaching hospitals. INCLUSION CRITERIA:Asphyxiated babies weighing greater than 1000 grams, with heart rate less than 100 per min...
journal_title：Indian pediatrics
pub_type： 临床试验,杂志文章,多中心研究
doi：
更新日期：2003-06-01 00:00:00
abstract：BACKGROUND:Antiphospholipid syndrome is a multisystem auto-immune disorder characterized by arterial or venous thrombosis in children. CASE CHARACTERISTICS:11-year-old child with pneumococcal meningitis also had cerebral sinus vein thrombosis and pulmonary artery segmental thrombosis. OBSERVATION:Pro-thrombotic evalu...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2018-05-15 00:00:00
abstract：:Berardinelli-Seip congenital lipodystrophy (BSCL) is a very rare genetic disorder characterized by lipoatrophy, hypertriglyceridemia, hepatomegaly and acromegaloid features. On the basis of mutational and haplotype analysis, BSCL families have been classified into three types BSCL 1, BSCL2 and BSCLX. We report Berardi...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2006-05-01 00:00:00
abstract：BACKGROUND:Lysinuric protein intolerance is an inherited disorder of transport of cationic amino acids, causing amino aciduria. CASE CHARACTERISTICS:A 3-year-old boy with 12 month history of episodic change in behavior (decreased sleep, poor interaction), stunted growth and hyperammonemia. OUTCOME:Genetic analysis re...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：10.1007/s13312-016-0920-2
更新日期：2016-08-08 00:00:00
abstract：:In the present study, brainstorm auditory evoked responses (BAER) were recorded in 68 at risk neonates discharged from the neonatal ICU of Safdarjung Hospital. The high risk group of 35 neonates included 13 neonates with multiple (3-4) risk factors and 22 neonates with single risk factors, viz., prematurity (less than...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：1991-10-01 00:00:00
abstract：UNLABELLED:Iron supplementation programs using pediatric tablets or drops have not been successful in the control of anemia amongst infants and children in India. Sprinkles is an innovative multi-micronutrient home fortification strategy to control iron deficiency and anemia. OBJECTIVE:We aimed to determine the hemato...
journal_title：Indian pediatrics
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2007-02-01 00:00:00
abstract：:The International Classification of Functioning, Disability and Health (ICF) is a framework for describing health status; however, there is a gap in literature for supporting its use as a classification tool. The purpose of this paper is to provide a perspective on its use in describing children with cerebral palsy. T...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：10.1007/s13312-016-0935-8
更新日期：2016-09-08 00:00:00
abstract：:Serial ultrasound scans were done in 300 fetuses between 16 to 24 weeks of gestation to establish the normogram of fetal kidney circumference (FKC) and fetal abdominal circumference (FAC) ratio (FKC/FAC). Of 300 fetuses, 150 fetuses were in the high risk group for fetal malformation and 150 patients were in the contro...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：1994-09-01 00:00:00
abstract：:Cord problems at birth were prospectively studied in 12,000 singleton deliveries, of which 258 (2.15%) babies had cord abnormalities. Nearly 32% of these cases had fetal distress and 20.5% had 1 minute Apgar score less than 6. Of the various cord problems nuchal cord was noted in 79.1%, cord prolapse in 12.4% and true...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：1992-03-01 00:00:00
abstract：OBJECTIVE:To examine the association between hematological indices and serum uric acid in adolescents with hyperuricemia. METHODS:10-year retrospective cohort study of 607 patients with hyperuricemia registered with the Pediatric Nephrology Department. RESULTS:There was a statistically significant positive correlatio...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：10.1007/s13312-014-0547-0
更新日期：2014-12-01 00:00:00
abstract：BACKGROUND:Multiple pituitary hormone deficiency and Turner syndrome have overlapping features in peripubertal girls and is a diagnostic challenge. CASE CHARACTERISTICS:16-year-old girl having Turner phenotype undergoing evaluation for severe short stature and pubertal arrest. OBSERVATION:45,X karyotype, and multiple...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：10.1007/s13312-015-0721-z
更新日期：2015-09-01 00:00:00
abstract：:We report a 12-year-old child with pseudohypoparathyroidism (PHP) whose mother had pseudopseudohypoparathyroidism. The child had low serum calcium, high phosphorous and high parathormone (PTH) levels. PHP occurs due to a defect in the guanine nucleotide binding protein (G protein). She also had hypothyroidism which is...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：10.1007/s13312-012-0225-z
更新日期：2012-12-01 00:00:00
abstract：:Twenty five to thirty per cent of all patients admitted with head injuries to any large hospital are children. Head injuries in children differ in several ways from those seen in the adult population. A standard management protocol is used in a service hospital and CT and neurosurgical consultation/transfer is based o...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：1994-06-01 00:00:00
abstract：:Children with cow milk allergy are suspected to develop calcium metabolism disturbances. We observed increased markers of bone turnover in these children. Children with cow milk allergy are more prone to develop the disturbances of the bone mineralization even in the first year of life. ...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：10.1007/s13312-013-0194-x
更新日期：2013-07-01 00:00:00
abstract：:We enrolled 75 consecutive infants presenting with history of first seizure at a tertiary care hospital in New Delhi, India. Clinical and biochemical work-up for etiology, and electroencephalography were performed in all infants. Developmental assessment was done 3-month after discharge. 72% had generalized seizures, ...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2016-10-08 00:00:00
abstract：:Acute interstitial nephritis (AIN) should be ruled out in children with unexplained acute renal failure. We present a 4 1/2 year old girl who presented with oliguric acute renal failure preceded by a febrile illness. Renal histopathology revealed features of drug induced AIN. She recovered with dialysis, other support...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2003-04-01 00:00:00
abstract：OBJECTIVE:To compare the effect of withholding maintenance phenobarbitone on breakthrough seizures. DESIGN:A double blind randomized controlled trial. SETTING:Level II neonatal intensive care unit (NICU) of a teaching hospital in Northern India. PARTICIPANTS:152 term and near term neonates (34 weeks of gestation age...
journal_title：Indian pediatrics
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2016-12-15 00:00:00
abstract：OBJECTIVE:To identify the factors influencing brain injury in infants with congenital heart disease (CHD) after cardiac surgery. METHODS:This retrospective study investigated 103 infants with CHD undergoing cardiac surgery between January 2013 and February 2016. Pre- and postoperative amplitude-integrated electroencep...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2020-02-15 00:00:00
abstract：:Thirty six neonates with severe birth asphyxia (Apgar score less than or equal to 3 at 1 min), 32 with moderate birth asphyxia (Apgar score 4 to 6 at 1 min) and 35 controls (Apgar score greater than or equal to 7 at 1 min) matched for weight and gestation were followed up prospectively for neurodevelopmental outcome. ...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：1989-08-01 00:00:00
abstract：OBJECTIVE:To compare lipid parameters between diabetics and controls and to study association between metabolic control and lipid profile. METHODS:Lipid profile and HbA1c were measured (n=80, 39 boys) in diabetic children [age 10.7(3.4) y] and 54 controls, tests repeated after 1 year (in 45 diabetics). RESULTS:Diabet...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：10.1007/s13312-016-0787-2
更新日期：2016-01-01 00:00:00
