Miltefosine: oral treatment of leishmaniasis.

abstract：:HBV infection remains a major global health problem and continues to be a common cause of liver-related morbidity and mortality in both immunocompetent and immunosuppressed individuals. Reactivation of HBV is a serious complication of chemotherapy/immunosuppressive therapy in patients with HBV infection. In this artic...

journal_title：Expert review of anti-infective therapy

authors： Idilman R,Arat M

更新日期：2011-08-01 00:00:00

abstract：:As the result of improved bacteriological techniques, Kingella kingae is emerging as an important cause of infections of the skeletal system in children younger than 2 years of age. This review details the bacteriological features and detection methods of this pathogen, as well as the epidemiology, clinical presentati...

journal_title：Expert review of anti-infective therapy

authors： Yagupsky P

更新日期：2004-10-01 00:00:00

abstract：:Inhaled antibiotics are not usually considered outside the setting of cystic fibrosis or Pneumocystis jiroveci prophylaxis. However, because they deliver high drug concentrations at the site of infection with negligible systemic absorption and toxicity, they are logical compliments to standard intravenous therapy for ...

journal_title：Expert review of anti-infective therapy

authors： Lesho E

更新日期：2005-06-01 00:00:00

abstract：:Pertussis is a serious respiratory disease in infants that can also affect children and adults. Vaccination against pertussis was introduced in the 1950s and in the 1990s a resurgence of pertussis was observed worldwide. The aim of this work is to summarize the recent data concerning pertussis disease in different cou...

journal_title：Expert review of anti-infective therapy

authors： Falleiros Arlant LH,de Colsa A,Flores D,Brea J,Avila Aguero ML,Hozbor DF

更新日期：2014-10-01 00:00:00

abstract：:The development of HIV-1 integrase strand transfer inhibitors (INSTIs) has been a major therapeutic breakthrough in the management of HIV-1 infection. The first HIV-1 integrase inhibitor, raltegravir, was licensed in 2007 and was subsequently approved for use in treatment-naive patients. Since then, newer members of t...

journal_title：Expert review of anti-infective therapy

authors： Lampiris HW

更新日期：2012-01-01 00:00:00

abstract：:In clinical practice, a significant proportion of HIV-infected patients receive lopinavir/ritonavir (LPV/r) as a component of highly active antiretroviral therapy (HAART). The study by Israr et al. was designed to evaluate the effects of the HIV protease inhibitor LPV/r on gingival epithelium growth and differentiatio...

journal_title：Expert review of anti-infective therapy

authors： Rivero A,Pérez-Camacho I

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Tocilizumab, an inhibitor of the interleukin-6 receptor, may decrease the inflammatory response and control the symptoms of severe coronavirus disease 2019 (COVID-19), but the evidence is scarce. METHODS:This retrospective study included patients with severe COVID-19 requiring oxygen therapy who received to...

journal_title：Expert review of anti-infective therapy

authors： Tomasiewicz K,Piekarska A,Stempkowska-Rejek J,Serafińska S,Gawkowska A,Parczewski M,Niścigorska-Olsen J,Łapiński TW,Zarębska-Michaluk D,Kowalska JD,Horban A,Flisiak R

更新日期：2021-01-01 00:00:00

abstract：:Healthy children are high transmitters of influenza and can experience poor influenza outcomes. Many questions remain about the efficacy and impect of preventive measures because most existing studies report imprecise proxies of influenza incidence, do not follow subjects throughout the entire influenza season and acr...

journal_title：Expert review of anti-infective therapy

authors： Lee BY,Shah M

更新日期：2012-10-01 00:00:00

abstract：:Late presentation of HIV is common and is associated with several adverse outcomes including an increased risk of clinical progression, blunted immune recovery on highly active antiretroviral therapy and a greater risk of drug toxicity. Late presenters may have higher rates of poor adherence, exacerbated by the same f...

journal_title：Expert review of anti-infective therapy

authors： Waters L,Sabin CA

更新日期：2011-10-01 00:00:00

abstract：INTRODUCTION:Influenza-Like Illness is a leading cause of hospitalization in children. Disease burden due to influenza and other respiratory viral infections is reported on a population level, but clinical scores measuring individual changes in disease severity are urgently needed. Areas covered: We present a composite...

journal_title：Expert review of anti-infective therapy

authors： Rath B,Conrad T,Myles P,Alchikh M,Ma X,Hoppe C,Tief F,Chen X,Obermeier P,Kisler B,Schweiger B

更新日期：2017-06-01 00:00:00

abstract：:Telavancin is a parenteral lipoglycopeptide antibiotic with a dual mechanism of action contributing to bactericidal activity against multidrug-resistant Gram-positive pathogens. It has been approved for the treatment of complicated skin and skin structure infections due to susceptible Gram-positive bacteria and hospit...

journal_title：Expert review of anti-infective therapy

authors： Hegde SS,Janc JW

更新日期：2014-12-01 00:00:00

abstract：:Intracellular pathogens present a major health risk because of their innate ability to evade clearance. Their location within host cells and ability to react to the host environment by mutation or transcriptional changes often enables survival mechanisms to resist standard therapies. Host-directed drugs do not target ...

journal_title：Expert review of anti-infective therapy

authors： Collier MA,Gallovic MD,Peine KJ,Duong AD,Bachelder EM,Gunn JS,Schlesinger LS,Ainslie KM

更新日期：2013-11-01 00:00:00

abstract：:In 2013, an estimated 1.5 million HIV-positive pregnant women gave birth, with 240,000 children worldwide acquiring HIV. More than 90% of new pediatric infections occurred in Sub-Saharan Africa. The latest WHO guidelines recommended efavirenz (EFV)-based antiretroviral therapy as the first-line regimen for prevention ...

journal_title：Expert review of anti-infective therapy

authors： De Nardo P,Gentilotti E,Nguhuni B,Vairo F,Chaula Z,Nicastri E,Ippolito G

更新日期：2016-01-01 00:00:00

abstract：:Influenza has circulated among humans for centuries and kills more people than many newly emerging diseases. The present methods for control of influenza are not adequate, especially for dealing with a pandemic. In the face of a rapidly spreading outbreak, a race to isolate the virus and prepare a vaccine would probab...

journal_title：Expert review of anti-infective therapy

authors： Epstein SL

更新日期：2003-12-01 00:00:00

abstract：:During the 2010 HIV Diagnostics Conference, which took place in Orlando (FL, USA) between 24 and 26 March 2010, salient new data related to three aspects of HIV testing (rapid point-of-care testing, laboratory assays and new technologies) were presented and discussed. A conundrum central to HIV diagnostics in the USA ...

journal_title：Expert review of anti-infective therapy

authors： Pandori MW,Branson BM

更新日期：2010-06-01 00:00:00

abstract：:The advent of highly active antiretroviral therapy (HAART) has revolutionized the treatment of HIV. A wide variety of antiretroviral agents are now available, allowing patients and physicians a choice of effective therapy. However, drug resistance and toxicities are emerging as major treatment challenges in the HAART ...

journal_title：Expert review of anti-infective therapy

authors： Jones R,Gazzard B

更新日期：2006-04-01 00:00:00

abstract：:Use of nonsystemic antimicrobials with activity against enteropathogens is a promising approach for treatment of infectious diarrhea and other nonsystemic gastrointestinal infections. Rifaximin is approved by the US FDA for the treatment of travelers' diarrhea caused by noninvasive strains of Escherichia coli in patie...

journal_title：Expert review of anti-infective therapy

authors： Cottreau J,Baker SF,DuPont HL,Garey KW

更新日期：2010-07-01 00:00:00

abstract：:Bacillus anthracis is the causative agent of anthrax, a disease that plagues both humans and various animal species. Effective vaccines are available, but those approved for human use are crude culture supernatants that require multiple injections and a yearly boost. Many experts agree that it is now time for the next...

journal_title：Expert review of anti-infective therapy

authors： Tournier JN,Ulrich RG,Quesnel-Hellmann A,Mohamadzadeh M,Stiles BG

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND:The coronavirus disease 2019 (COVID-19) pandemic has affected almost 2.5 million people worldwide with almost 170,000 deaths reported to date. So far, there is scarce evidence for the current treatment options available for COVID-19. Vitamin C has previously been used for treatment of severe sepsis and septi...

journal_title：Expert review of anti-infective therapy

authors： Hiedra R,Lo KB,Elbashabsheh M,Gul F,Wright RM,Albano J,Azmaiparashvili Z,Patarroyo Aponte G

更新日期：2020-12-01 00:00:00

abstract：:Preterm prelabor rupture of membranes (pPROM) is the precursor of up to 40% of preterm deliveries and an independent risk factor for neonatal disease, death and long-term pulmonary and neurodevelopmental deficits. A significant proportion of cases of pPROM are infection driven, although these are difficult to delineat...

journal_title：Expert review of anti-infective therapy

authors： Ugwumadu A

更新日期：2007-08-01 00:00:00

abstract：INTRODUCTION:Drug-resistant tuberculous meningitis has been reported worldwide. Isoniazid mono-resistance is the most frequent cause of drug-resistant tuberculous meningitis, a life-threatening disease. Extensive drug-resistant tuberculous meningitis has also been reported in some isolated case reports. Areas covered: ...

journal_title：Expert review of anti-infective therapy

authors： Garg RK,Rizvi I,Malhotra HS,Uniyal R,Kumar N

更新日期：2018-11-01 00:00:00

abstract：:Despite significant advances in the day-to-day management of patients receiving hematopoietic stem cell transplantations, including the introduction of new antiviral drugs, cytomegalovirus (CMV) infection continues to be a major cause of morbidity and mortality. The aim of this article is to undertake a literature-bas...

journal_title：Expert review of anti-infective therapy

authors： Bacigalupo A,Boyd A,Slipper J,Curtis J,Clissold S

更新日期：2012-11-01 00:00:00

abstract：:Tuberculosis (TB) is mainly an intracellular infection of the lung alveolar macrophages, and any anti-TB agent must therefore be active at the macrophage. Among the available therapies, isoniazid and rifampicin are the most effective drugs against susceptible Mycobacterium tuberculosis, but they are ineffective agains...

journal_title：Expert review of anti-infective therapy

authors： Viveiros M,Martins M,Couto I,Rodrigues L,Machado D,Portugal I,Amaral L

更新日期：2010-04-01 00:00:00

abstract：INTRODUCTION:The nervous system is involved in 10-15% of patients infected with B. burgdorferi, B. afzelii and B. garinii. This review will address widespread misconceptions about the clinical phenomenology, diagnostic approach and response to treatment of neuroborreliosis. Areas covered: Improvements in diagnostic tes...

journal_title：Expert review of anti-infective therapy

authors： Halperin JJ

更新日期：2018-01-01 00:00:00

abstract：INTRODUCTION:Onychomycosis is a chronic fungal infection of the nail bed, matrix or plate. It accounts for roughly 50% of all nail disease. As the prevalence of onychomycosis is increasing, a critical review of diagnostic techniques and treatment options is required. Areas covered: This review discusses the current dia...

journal_title：Expert review of anti-infective therapy

authors： Gupta AK,Mays RR,Versteeg SG,Shear NH,Piguet V

更新日期：2018-12-01 00:00:00

abstract：:Despite many theoretical and in vitro advantages, clinical data comparing combination therapy with colistin + rifampicin to colistin alone for infection due to extremely-drug resistant (XDR) Acinetobacter baumanni are scarce and limited by small numbers and/or low quality evidence. This article represents the first la...

journal_title：Expert review of anti-infective therapy

authors： Pogue JM,Kaye KS

更新日期：2013-09-01 00:00:00

abstract：INTRODUCTION:The pathogenic and highly transmissible etiological agent, SARS-CoV-2, has caused a serious threat COVID-19 pandemic. WHO has declared the epidemic a public health emergency of international concern owing to its high contagiosity, mortality rate, and morbidity. Till now, there is no approved vaccine or dru...

journal_title：Expert review of anti-infective therapy

authors： Hossain MJ,Rahman SMA

更新日期：2020-12-23 00:00:00

abstract：:Necrobacillosis, often used synonymously with Lemierre's syndrome, is a form of abscess infection in the peritonsillar area associated with a thrombophlebitis and caused by the strict anaerobic species Fusobacterium necrophorum. The thrombosis formed affects the internal jugular vein, from which the bacteria are seede...

journal_title：Expert review of anti-infective therapy

authors： Dahlén G,Ebenfelt A

更新日期：2011-02-01 00:00:00

abstract：:Endobronchial tuberculosis is defined as tuberculous infection of the tracheobronchial tree. Although clinical features differ between various types and stages of endobronchial tuberculosis, common symptoms are cough, hemoptysis, sputum production, wheezing, chest pain, fever and dyspnea. Endobronchial tuberculosis is...

journal_title：Expert review of anti-infective therapy

authors： Rikimaru T

更新日期：2004-04-01 00:00:00

abstract：:Invasive yeast infections are a significant cause of morbidity and mortality in patients with defective immune response, such as those with cancer-related immunosuppression, organ transplantation or other immunodeficiencies, and neonates. Hospitalization in the intensive care unit may increase the risk for such infect...

journal_title：Expert review of anti-infective therapy

authors： Garbino J,Katragkou A,Roilides E

更新日期：2007-02-01 00:00:00