Role of inhaled antibacterials in hospital-acquired and ventilator-associated pneumonia.

abstract：:The development of HIV-1 integrase strand transfer inhibitors (INSTIs) has been a major therapeutic breakthrough in the management of HIV-1 infection. The first HIV-1 integrase inhibitor, raltegravir, was licensed in 2007 and was subsequently approved for use in treatment-naive patients. Since then, newer members of t...

journal_title：Expert review of anti-infective therapy

authors： Lampiris HW

更新日期：2012-01-01 00:00:00

abstract：:Intracellular pathogens present a major health risk because of their innate ability to evade clearance. Their location within host cells and ability to react to the host environment by mutation or transcriptional changes often enables survival mechanisms to resist standard therapies. Host-directed drugs do not target ...

journal_title：Expert review of anti-infective therapy

authors： Collier MA,Gallovic MD,Peine KJ,Duong AD,Bachelder EM,Gunn JS,Schlesinger LS,Ainslie KM

更新日期：2013-11-01 00:00:00

abstract：:New respiratory fluoroquinolones (FQs), such as levofloxacin, offer many improved qualities over older agents, such as ciprofloxacin. These include retaining excellent Gram-negative bacilli activity, with improved Gram-positive activity. New FQ-like levofloxacin possesses greater bioavailabilty and a longer serum half...

journal_title：Expert review of anti-infective therapy

authors： Lynch JP 3rd,File TM Jr,Zhanel GG

更新日期：2006-10-01 00:00:00

abstract：:Preterm prelabor rupture of membranes (pPROM) is the precursor of up to 40% of preterm deliveries and an independent risk factor for neonatal disease, death and long-term pulmonary and neurodevelopmental deficits. A significant proportion of cases of pPROM are infection driven, although these are difficult to delineat...

journal_title：Expert review of anti-infective therapy

authors： Ugwumadu A

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND:Hospital antibiotic use is rising. We aimed to evaluate the antibiotic-use prevalence and length of stay. METHODS:We conducted a single-center retrospective study of patients < 18-years-old admitted to general pediatric services who received ≥ 1 antibiotic over six months. Demographics, culture results and ...

journal_title：Expert review of anti-infective therapy

authors： Gourishankar A,Agbasi A,Kain C,Lin E

更新日期：2020-11-01 00:00:00

abstract：:Despite many theoretical and in vitro advantages, clinical data comparing combination therapy with colistin + rifampicin to colistin alone for infection due to extremely-drug resistant (XDR) Acinetobacter baumanni are scarce and limited by small numbers and/or low quality evidence. This article represents the first la...

journal_title：Expert review of anti-infective therapy

authors： Pogue JM,Kaye KS

更新日期：2013-09-01 00:00:00

abstract：:Human rickettsioses caused by intracellular bacteria of the genus Rickettsia are distributed worldwide and are transmitted by arthropod vectors such as ticks, fleas, mites and lice. They have a wide range of manifestations from benign to life-threatening diseases. Mortality rates of up to 30% have been reported for so...

journal_title：Expert review of anti-infective therapy

authors： Botelho-Nevers E,Socolovschi C,Raoult D,Parola P

更新日期：2012-12-01 00:00:00

abstract：:Meningococcal disease is a life-threatening condition and a major cause of bacterial meningitis and sepsis worldwide. In many fatal cases, meningococcal disease is rapidly progressive and death occurs within hours of the initial symptoms. The early identification of patients at high risk of death would be useful in or...

journal_title：Expert review of anti-infective therapy

authors： Montero-Martín M,Inwald DP,Carrol ED,Martinón-Torres F

更新日期：2014-11-01 00:00:00

abstract：:Use of nonsystemic antimicrobials with activity against enteropathogens is a promising approach for treatment of infectious diarrhea and other nonsystemic gastrointestinal infections. Rifaximin is approved by the US FDA for the treatment of travelers' diarrhea caused by noninvasive strains of Escherichia coli in patie...

journal_title：Expert review of anti-infective therapy

authors： Cottreau J,Baker SF,DuPont HL,Garey KW

更新日期：2010-07-01 00:00:00

abstract：:Lymphatic filariasis (LF) is an important public health problem endemic in 73 countries, where it is a major cause of acute and chronic morbidity and a significant impediment to socioeconomic development. It is targeted for elimination by 2020, through preventive chemotherapy using albendazole in combination with eith...

journal_title：Expert review of anti-infective therapy

authors： Rebollo MP,Bockarie MJ

更新日期：2013-07-01 00:00:00

abstract：:Endobronchial tuberculosis is defined as tuberculous infection of the tracheobronchial tree. Although clinical features differ between various types and stages of endobronchial tuberculosis, common symptoms are cough, hemoptysis, sputum production, wheezing, chest pain, fever and dyspnea. Endobronchial tuberculosis is...

journal_title：Expert review of anti-infective therapy

authors： Rikimaru T

更新日期：2004-04-01 00:00:00

abstract：:Mycobacterium caprae, a member of the Mycobacterium tuberculosis complex, causes tuberculosis (TB) in man and animals. Some features distinguish M. caprae from its epidemiological twin, Mycobacterium bovis: M. caprae is evolutionarily older, accounts for a smaller burden of zoonotic TB and is not globally distributed,...

journal_title：Expert review of anti-infective therapy

authors： Prodinger WM,Indra A,Koksalan OK,Kilicaslan Z,Richter E

更新日期：2014-12-01 00:00:00

abstract：:Introduction: In light of the emergence of antibiotic-resistant bacteria, phage (bacteriophage) therapy has been recognized as a potential alternative or addition to antibiotics in Western medicine for use in humans.Areas covered: This review assessed the scientific literature on phage therapy published between 1 Janu...

journal_title：Expert review of anti-infective therapy

authors： Caflisch KM,Suh GA,Patel R

更新日期：2019-12-01 00:00:00

abstract：:Antifungal susceptibility testing should identify in vitro resistance among a normally susceptible population or should detect the development of resistance during therapy. The Clinical and Laboratory Standards Institute (CLSI; formerly the National Committee for Clinical Laboratory Standards [NCCLS]) has developed re...

journal_title：Expert review of anti-infective therapy

authors： Cantón E,Espinel-Ingroff A,Pemán J

更新日期：2009-02-01 00:00:00

abstract：:Although penicillin remains the first-choice treatment for Streptococcus pyogenes infection, macrolides are important alternatives for allergic patients and lincosamides are recommended together with β-lactams in invasive infections. S. pyogenes may exhibit macrolide resistance because of active efflux (mef genes) or ...

journal_title：Expert review of anti-infective therapy

authors： Silva-Costa C,Friães A,Ramirez M,Melo-Cristino J

更新日期：2015-05-01 00:00:00

abstract：:Fluoroquinolones are an important group of antibiotics that are used widely in the treatment of various infectious diseases in adults as a result of their excellent spectrum of activity, significant tissue penetration and convenient routes of administration. Their use in children, however, has been limited until recen...

journal_title：Expert review of anti-infective therapy

authors： Velissariou IM

更新日期：2006-10-01 00:00:00

abstract：INTRODUCTION:The identification of factors that can predispose to the development of severe influenza is essential to enable the implementation of optimal prevention and control measures for vulnerable populations. AREAS COVERED:Unfortunately, data in the pediatric age group remain difficult to interpret. However, epi...

journal_title：Expert review of anti-infective therapy

authors： Principi N,Esposito S

更新日期：2016-10-01 00:00:00

abstract：INTRODUCTION:Carbapenem-resistant Enterobacterales (CRE) represent a global public health problem. Precision medicine (PM) is a multicomponent medical approach that should be used to individualize the management of patients infected with CRE. AREAS COVERED:Here, we differentiate carbapenem-producing CRE (CP-CRE) from ...

journal_title：Expert review of anti-infective therapy

authors： Reyes S,Nicolau DP

更新日期：2020-08-01 00:00:00

abstract：:Itraconazole (Sporanox) is a triazole antifungal agent with a broad activity spectrum and favorable pharmacokinetic and safety profiles. Numerous clinical trials have established the efficacy and safety of itraconazole in the treatment of superficial fungal infections. In this field, full exploitation of its pharmacok...

journal_title：Expert review of anti-infective therapy

authors： Caputo R

更新日期：2003-12-01 00:00:00

abstract：:The 49th Annual Spring Meeting of the British Society of Parasitology was held at Nottingham University, UK, on 11-14 April 2011. Although a meeting of a national parasitological society, the meeting attracted approximately 375 delegates from 30 countries worldwide. Of the various themes at this meeting, two were focu...

journal_title：Expert review of anti-infective therapy

authors： Staines HM,Croft SL,Horrocks PD

更新日期：2011-07-01 00:00:00

abstract：:In Malaysia, various aspects of the epidemiology of pneumococcal carriage and disease remain largely unclear due to the lack of supporting data. Although a number of relevant studies have been documented, their individual discrete findings are not sufficient to inform experts on pneumococcal epidemiology at a national...

journal_title：Expert review of anti-infective therapy

authors： Le CF,Jefferies JM,Yusof MY,Sekaran SD,Clarke SC

更新日期：2012-06-01 00:00:00

abstract：:The well-known problems of classic treatment of the leishmaniases with pentavalent antimony (reduced efficacy), difficulties of administration and increasing frequency and severity of adverse events have stimulated the search for new drugs to treat these diseases. Other injectable, oral and topical drugs have not been...

journal_title：Expert review of anti-infective therapy

authors： Soto J,Soto P

更新日期：2006-04-01 00:00:00

abstract：:Despite the constantly increasing need for new antimicrobial agents, antibiotic drug discovery and development seem to have greatly decelerated in recent years. Presented with the significant problem of advancing antimicrobial resistance, the global scientific community has attempted to find alternative solutions; one...

journal_title：Expert review of anti-infective therapy

authors： Falagas ME,Grammatikos AP,Michalopoulos A

更新日期：2008-10-01 00:00:00

abstract：:Cationic antimicrobial peptides are a novel type of antibiotic offering much potential in the treatment of microbial-related diseases. They offer many advantages for commercial development, including a broad spectrum of action and modest size. However, despite the identification or synthetic production of thousands of...

journal_title：Expert review of anti-infective therapy

authors： Hale JD,Hancock RE

更新日期：2007-12-01 00:00:00

abstract：INTRODUCTION:Invasive fungal diseases (IFDs) have received attention as an emerging public health threat, are difficult to diagnose and to treat, and are associated with substantial morbidity and mortality. The standard of care in IFD management requires an early and targeted antifungal treatment, hence covers - amongs...

journal_title：Expert review of anti-infective therapy

authors： Knabl L,Lass-Flörl C

更新日期：2020-08-01 00:00:00

abstract：:Post-exposure prophylaxis (PEP) with antiretrovirals is now widely used worldwide after either occupational contact (with blood or another blood-containing fluid), or nonoccupational contact (mainly sexual or injection-drug use). It is assumed to reduce the risk of HIV transmission by at least 80%, although its effica...

journal_title：Expert review of anti-infective therapy

authors： Rey D

更新日期：2011-04-01 00:00:00

abstract：:West Nile virus (WNV) is a mosquito-borne enveloped positive-strand RNA virus that emerged in North America in 1999 in New York City. Over the past 15 years, WNV has become established throughout the USA and has spread into Canada, Mexico and the Caribbean. CDC reports indicate >41,000 clinical cases, including more t...

journal_title：Expert review of anti-infective therapy

authors： Montgomery RR,Murray KO

更新日期：2015-03-01 00:00:00

abstract：INTRODUCTION:Although evidence indicates that use of procalcitonin to guide antibiotic decisions for the treatment of acute respiratory infections (ARI) decreases antibiotic consumption and improves clinical outcomes, algorithms used within studies had differences in PCT cut-off points and frequency of testing. We ther...

journal_title：Expert review of anti-infective therapy

authors： Schuetz P,Bolliger R,Merker M,Christ-Crain M,Stolz D,Tamm M,Luyt CE,Wolff M,Schroeder S,Nobre V,Reinhart K,Branche A,Damas P,Nijsten M,Deliberato RO,Verduri A,Beghé B,Cao B,Shehabi Y,Jensen JS,Beishuizen A,de Jo

更新日期：2018-07-01 00:00:00

abstract：:Drug resistance in HIV-infected children is one of the main contributors to antiretroviral treatment (ART) failure, especially in developing countries. Sub-Saharan Africa has the largest burden of pediatric HIV infection in the world. Herein, we systematically review the current status of ART failure in HIV-infected A...

journal_title：Expert review of anti-infective therapy

authors： Jenabian MA,Costiniuk CT,Mboumba Bouassa RS,Chapdeleine Mekue Mouafo L,Brogan TV,Bélec L

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:Pneumocystis jirovecii is a ubiquitous fungus, which causes pneumonia in humans. Diagnosis was hampered by the inability to culture the organism, and based on microscopic examination of respiratory samples or clinical presentation. New assays can assist in the diagnosis and even aid with the emergence of r...

journal_title：Expert review of anti-infective therapy

authors： White PL,Backx M,Barnes RA

更新日期：2017-05-01 00:00:00