Abstract：
:In metazoans, cyclin-dependent kinase 7 (CDK7) has essential roles in both the cell-division cycle and transcription, as a CDK-activating kinase (CAK) and as a component of the general transcription factor TFIIH, respectively. Controversy over its double duty has been resolved, but questions remain. First, how does CDK7 achieve the dual substrate specificity necessary to perform both roles? Second, is there a deeper connection implied by the dichotomy of CDK7 function, for example similar mechanisms controlling cell division and gene expression, and/or actual coordination of the two processes? Enzymological studies have revealed solutions to the unusual substrate recognition problem, and there is evidence that the distinct functions of CDK7 can be regulated independently. Finally, despite divergence in their wiring, the CAK-CDK networks of budding yeast, fission yeast and metazoans all link transcriptional regulation with operation of the cell-cycle machinery. This connection might help to ensure that mRNAs encoding effectors of cell division are expressed at the right time in the cycle.
journal_name
J Cell Scijournal_title
Journal of cell scienceauthors
Fisher RPdoi
10.1242/jcs.02718keywords:
subject
Has Abstractpub_date
2005-11-15 00:00:00pages
5171-80issue
Pt 22eissn
0021-9533issn
1477-9137pii
118/22/5171journal_volume
118pub_type
杂志文章,评审abstract：:Chloroquine resistance in the human malaria parasite, Plasmodium falciparum, arises from decreased accumulation of the drug in the ;digestive vacuole' of the parasite, an acidic compartment in which chloroquine exerts its primary toxic effect. It has been proposed that changes in the pH of the digestive vacuole might ...
journal_title：Journal of cell science
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pub_type： 杂志文章
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journal_title：Journal of cell science
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更新日期：2009-02-15 00:00:00
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更新日期：2015-07-15 00:00:00
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journal_title：Journal of cell science
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doi：10.1242/jcs.149799
更新日期：2014-08-01 00:00:00
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更新日期：2004-12-15 00:00:00
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更新日期：2004-08-01 00:00:00
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更新日期：1987-05-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2014-09-01 00:00:00
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journal_title：Journal of cell science
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doi：10.1242/jcs.096610
更新日期：2012-01-15 00:00:00
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journal_title：Journal of cell science
pub_type： 杂志文章
doi：
更新日期：1996-03-01 00:00:00
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journal_title：Journal of cell science
pub_type： 杂志文章,评审
doi：10.1242/jcs.123612
更新日期：2013-08-15 00:00:00
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journal_title：Journal of cell science
pub_type： 杂志文章
doi：
更新日期：1999-09-01 00:00:00
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journal_title：Journal of cell science
pub_type： 杂志文章
doi：
更新日期：1998-03-01 00:00:00
abstract：:Regulation of cell-cell contacts is essential for integrity of the vascular endothelium. Here, a critical role of the F-actin-binding protein drebrin in maintaining endothelial integrity is revealed under conditions mimicking vascular flow. Drebrin knockdown leads to weakening of cell-cell contacts, characterized by l...
journal_title：Journal of cell science
pub_type： 杂志文章
doi：10.1242/jcs.129437
更新日期：2013-08-15 00:00:00
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journal_title：Journal of cell science
pub_type： 杂志文章
doi：10.1242/jcs.216630
更新日期：2018-09-03 00:00:00
abstract：:Polarization of the motile cell is associated with the formation of a distinct plasma membrane domain, the pseudopod, whose stabilization determines the directionality of cell movement. The rapid movement of cells over a substrate requires that an essential aspect of cell motility must be the supply of the necessary m...
journal_title：Journal of cell science
pub_type： 杂志文章,评审
doi：
更新日期：1999-06-01 00:00:00
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pub_type： 杂志文章
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更新日期：2013-12-01 00:00:00
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journal_title：Journal of cell science
pub_type： 杂志文章
doi：
更新日期：1998-08-01 00:00:00
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journal_title：Journal of cell science
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doi：
更新日期：2002-02-01 00:00:00
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journal_title：Journal of cell science
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更新日期：2002-05-01 00:00:00
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journal_title：Journal of cell science
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journal_title：Journal of cell science
pub_type： 杂志文章
doi：
更新日期：1980-04-01 00:00:00
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更新日期：2006-03-01 00:00:00
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journal_title：Journal of cell science
pub_type： 杂志文章
doi：
更新日期：2000-06-01 00:00:00
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