Abstract：
:Using data from Germany, we examine if month of birth influences survival up to age 105. Since age reporting at the highest ages is notoriously unreliable we draw on age-validated information from a huge age validation project of 1487 alleged German semi-supercentenarians aged 105+. We use month of birth as an exogenous indicator for seasonal changes in the environment around the time of birth. We find that the seasonal distribution of birth dates changes with age. For 925 age-validated semi-supercentenarians the seasonality is more pronounced than at the time of their birth (1880-1900). Among the December-born the relative risk of survival from birth to age 105+is 16% higher than the average, among the June-born, 23% lower. The month-of-birth pattern in the survival risk of the German semi-supercentenarians resembles closely the month-of-birth pattern in remaining life expectancy at age 50 in Denmark.
journal_name
Exp Gerontoljournal_title
Experimental gerontologyauthors
Doblhammer G,Scholz R,Maier Hdoi
10.1016/j.exger.2005.07.012keywords:
subject
Has Abstractpub_date
2005-10-01 00:00:00pages
829-35issue
10eissn
0531-5565issn
1873-6815pii
S0531-5565(05)00154-3journal_volume
40pub_type
杂志文章abstract：:We determined the contribution of body fat distribution, peak VO2, fat mass, and dietary intake to variation in plasma lipids in elderly individuals. Volunteers were a healthy cohort of older Caucasian women (n = 75, mean age +/- SD, 72 +/- 5 years) and older men (n = 101, 72 +/- 5 years). We determined fat mass from ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(97)00052-1
更新日期：1997-11-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:To explore the impact of diabetic peripheral neuropathy (DPN) on the recovery of older persons with diabetes mellitus (DM) after hip-fracture surgery. DESIGN, SETTING, PARTICIPANTS:Secondary data for this study came from a clinical trial on the effectiveness of a DM-specific care model for 176 ol...
journal_title：Experimental gerontology
pub_type： 临床试验,杂志文章
doi：10.1016/j.exger.2019.02.004
更新日期：2019-05-01 00:00:00
abstract：:Diseases of the elderly, including neurodegenerative and cardiovascular disorders and cancer, may develop through the accumulation of "hits" composed of genetic and epigenetic risk factors. The "iceberg" buildup of these hits over time may exceed the tolerance threshold of a particular tissue, thus precipitating disea...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/s0531-5565(96)00156-8
更新日期：1997-07-01 00:00:00
abstract：OBJECTIVE:Mitochondria produce cellular energy via oxidative phosphorylation (OXPHOS), mediated by respiratory chain complexes I to IV and ATP synthase (complex V). Mitochondrial respiratory complexes have been shown to decline with age in several tissues. As the intestinal epithelium is a tissue with a high energy dem...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2020.110924
更新日期：2020-07-01 00:00:00
abstract：:Physical activity has been associated with alterations in telomere length, a potential indicator of biological aging, but several inconsistencies exist. Our aim was to investigate the associations between physical activity in midlife and leukocyte telomere length (LTL) measured in old age in the Helsinki Businessmen S...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2012.02.003
更新日期：2013-01-01 00:00:00
abstract：:Aging is associated with diminished regenerative capacity and increased risk of chronic diseases. There is now compelling evidence suggests that aging process is reversible. Besides metabolic modification and systematic factors, both senescence elimination and cellular reprogramming showed beneficial effects on tissue...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2020.111005
更新日期：2020-09-01 00:00:00
abstract：:Increasing evidence suggests an important role of mitochondrial dysfunction in the pathogenesis of many common age-related neurodegenerative diseases, including Alzheimer's disease (AD). AD is the most common neurodegenerative disorder characterized by dementia, memory loss, neuronal apoptosis and eventually death of ...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2006.03.012
更新日期：2006-07-01 00:00:00
abstract：:Despite general belief that the mechanical properties of bone material contribute to whole bone strength, it is still obscure what the age effects are on mechanical behavior of the bone material, particularly in the case of the femoral neck trabeculae. In this study, atomic force microscopy was used for imaging and me...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2011.11.011
更新日期：2012-02-01 00:00:00
abstract：BACKGROUND:Low muscle strength (dynapenia) is a primary characteristic of sarcopenia, the age-related loss of muscle mass and strength or low walking speed. New evidence suggests that muscle strength positively affects blood pressure (BP) responses to exercise. As older adults with lowest handgrip strength also have lo...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2020.110984
更新日期：2020-09-01 00:00:00
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journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(93)90046-g
更新日期：1993-11-01 00:00:00
abstract：:The echidna Tachyglossus aculeatus is a monotreme mammal from Australia that is exceptionally long-living. Its documented maximum lifespan of 50 years is 3.7 times that predicted from its body mass. Other exceptionally long-living mammals (naked mole-rats and humans) are known to have peroxidation-resistant membrane c...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2008.05.015
更新日期：2008-08-01 00:00:00
abstract：:The maximal lifespan (MLS) of mammals is inversely correlated with the peroxidation index, a measure of the proportion and level of unsaturation of polyunsaturated fatty acids (PUFA) in membranes. This relationship is likely related to the fact that PUFA are highly susceptible to damage by peroxidation. Previous compa...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2015.08.011
更新日期：2015-10-01 00:00:00
abstract：:It is well established that the proliferative potential of the liver declines with aging. Epidermal growth factor (EGF)-stimulated DNA synthesis is reduced in hepatocytes from aged rats relative to young rats, and this reduction correlates with diminished activation of the extracellular signal-regulated kinase (ERK) p...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(02)00239-5
更新日期：2003-04-01 00:00:00
abstract：:Telomeres are specialised structures located at the end of eukaryotic chromosomes, that get short during progressive cell divisions. Therefore, telomere may be an indicator of the mitotic history of a cell and it is also a determining factor for the residual cell life span. One mechanism, compensating for the telomere...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(03)00058-5
更新日期：2003-06-01 00:00:00
abstract：:Collagens and elastin are 'building blocks' of tissues and extracellular matrix. Mutations in these proteins cause severe congenital syndromes. Adverse genetic variations may accelerate the aging process in adults contributing to premature morbidity, disability and/or mortality. Favorable variants may contribute to lo...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2019.110781
更新日期：2020-01-01 00:00:00
abstract：:Maintaining physical mobility is important for preventing age-related comorbidities in older adults. Endurance and resistance training prevent mobility loss in aging, but exercise alone does not always achieve the expected improvements in physical and cardiopulmonary function. Recent preclinical evidence suggests that...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2020.110972
更新日期：2020-08-01 00:00:00
abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder characterized by accumulation of aggregated forms of the 40- and 42-amino acid Abeta peptides (Abeta40 and Abeta42). Estrogen replacement therapy (ERT) in postmenopausal women is associated with decreased risk for AD and/or delay in disease onset. The mechanism ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/s0531-5565(00)00157-1
更新日期：2000-12-01 00:00:00
abstract：OBJECTIVES:We explored the male-female health-survival paradox in the context of health expectancy (HE) at age 65 and thereafter, using three different morbidity measures and different severity cut-offs with and without adjustments for the share of nursing home residents. METHODS:HE at ages 65, 70, 75, 80, and 85 was ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2020.111196
更新日期：2021-03-01 00:00:00
abstract：:Caloric restriction (CR) without malnutrition in mice and rats reduces the incidence of spontaneous tumors and delays their appearance while increasing maximum life span. These results depend largely on CR per se, and not on low intakes of fat or other nutrients. Although most studies have tested CR imposed early in l...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/0531-5565(92)90012-o
更新日期：1992-09-01 00:00:00
abstract：:Coronary heart disease is less prevalent in pre-menopausal women than in men, but increases at the onset of menopause. This delay is due to estrogen protective effects. The rise of cholesterolemia is one of the main risk factors for coronary disease. Since 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) is the ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2009.10.014
更新日期：2010-02-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to compare the effects of 12 weeks of traditional resistance training (TRT) or resistance training using Cluster-set (CS) on functional performance and physical fitness of postmenopausal and elderly women. METHODS:Participants (61.1 ± 4.9 years, body mass 64.5 ± 1.8 kg, height 155.7...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2020.111011
更新日期：2020-09-01 00:00:00
abstract：:The purpose of this study was to examine the relative contributions of changes in muscle quality and body composition to changes in lower-extremity physical function (LEPF) following a 6-month exercise and weight loss intervention in overweight and obese older women. Thirty-eight overweight and obese (BMI = 30.0 ± 4.4...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2018.04.011
更新日期：2018-07-15 00:00:00
abstract：:The balance between the activities of matrix metalloproteinases (MMPs) and the tissue inhibitors of metalloproteinases (TIMPs) is an important control point in tissue remodeling. Previous studies have demonstrated elevated expression of the MMPs collagenase and stromelysin-1 by aged human diploid fibroblasts compared ...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(95)02010-1
更新日期：1996-01-01 00:00:00
abstract：:The correlation between serum levels of pituitary and thyroid hormones and the activity of two antioxidant enzymes (AOE), catalase (CAT) and superoxide dismutase (SOD), in different immune and nonimmune organs of young and old rats was investigated. Serum levels of growth hormone (GH), prolactin (Prl), thyroid-stimula...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/0531-5565(94)00053-0
更新日期：1995-03-01 00:00:00
abstract：:Fragility fractures due to osteoporosis and its most dreaded complication - hip fractures - are the cause of disability, high mortality and place a considerable burden on global health economics. Although much work has been done to accurately predict mortality and find risk factors for poor health outcome, little atte...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2017.06.002
更新日期：2017-10-01 00:00:00
abstract：BACKGROUND:Fatigue resistance (FR) was here defined as the time during which grip strength (GS) drops to 50% of its maximum during sustained contraction. Since different GS systems exist, we compared FR obtained with Pneumatic (Pneu) and Hydraulic (Hydr) handgrip systems. Hand pain induced by both systems was also inve...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2020.110950
更新日期：2020-07-15 00:00:00
abstract：:Despite well-documented evidence for lifespan extension by methionine restriction (MR), underlying mechanisms remain unknown. As methionine can alter S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH), the substrate and product of DNA methyltransferase-1 (DNMT1), we hypothesized that MR diet alters DNA methyl...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2016.12.003
更新日期：2017-02-01 00:00:00
abstract：:Age-related behavioral declines are common manifestations of aging in animals. Negative geotaxis, an innate escape response during which flies ascend the wall of a cylinder after being tapped to its bottom, is one of the behaviors that senesces in Drosophila. Many laboratories, including ours, have used a variety of n...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2005.02.005
更新日期：2005-05-01 00:00:00
abstract：:Neural correlates of placebo analgesia (PA) in patients with neurocognitive disorders have not yet been elucidated. The present study aimed to evaluate how and to what extent executive (dys)functions of the medial prefrontal cortex (MPFC) may be related to PA. To this end, twenty-three subjects complaining of differen...
journal_title：Experimental gerontology
pub_type： 杂志文章
doi：10.1016/j.exger.2019.01.011
更新日期：2019-04-01 00:00:00
abstract：:As a major intracellular source of reactive oxygen species (ROS), mitochondria are involved in aging and lifespan regulation. Using the yeast chronological aging model, researchers have identified conserved signaling pathways that affect lifespan by modulating mitochondrial functions. Caloric restriction and a genetic...
journal_title：Experimental gerontology
pub_type： 杂志文章,评审
doi：10.1016/j.exger.2011.08.007
更新日期：2011-11-01 00:00:00
