Molecular basis of listeriolysin O pH dependence.

abstract：:The use of molecular methods is altering our understanding of the microbial biosphere and the complexity of the tree of life. Here, we report a newly discovered uncultured plastid-bearing eukaryotic lineage named the rappemonads. Phylogenies using near-complete plastid ribosomal DNA (rDNA) operons demonstrate that thi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim E,Harrison JW,Sudek S,Jones MD,Wilcox HM,Richards TA,Worden AZ,Archibald JM

更新日期：2011-01-25 00:00:00

abstract：:Genetic deletion studies have shown that haploinsufficiency of Delta-like ligand (Dll) 4, a transmembrane ligand for the Notch family of receptors, results in major vascular defects and embryonic lethality. To better define the role of Dll4 during vascular growth and differentiation, we selected the postnatal retina a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lobov IB,Renard RA,Papadopoulos N,Gale NW,Thurston G,Yancopoulos GD,Wiegand SJ

更新日期：2007-02-27 00:00:00

abstract：:The Clausius-Mossotti function for the dielectric constant is expanded in terms of single atom and pair polarizabilities, leading to contributions that depend on both the trace and the anisotropy of the pair-polarizability tensor. The short-range contribution of the anisotropic part to the pair polarizabilities has pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alder BJ,Beers JC,Strauss HL,Weis JJ

更新日期：1980-06-01 00:00:00

abstract：:In choanoflagellates, the closest living relatives of animals, multicellular rosette development is regulated by environmental bacteria. The simplicity of this evolutionarily relevant interaction provides an opportunity to identify the molecules and regulatory logic underpinning bacterial regulation of development. We...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Woznica A,Cantley AM,Beemelmanns C,Freinkman E,Clardy J,King N

更新日期：2016-07-12 00:00:00

abstract：:Dendritic spines are of major importance in information processing and memory formation in central neurons. Estradiol has been shown to induce an increase of dendritic spine density on hippocampal neurons in vivo and in vitro. The neurotrophin brain-derived neurotrophic factor (BDNF) recently has been implicated in ne...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murphy DD,Cole NB,Segal M

更新日期：1998-09-15 00:00:00

abstract：:The present study examined the social skills of previously institutionalized, 8-y-old Romanian children from the Bucharest Early Intervention Project and the influence of attachment security and brain electrical activity (alpha power) on these skills. Participants included children randomized to an intervention involv...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Almas AN,Degnan KA,Radulescu A,Nelson CA 3rd,Zeanah CH,Fox NA

更新日期：2012-10-16 00:00:00

abstract：:Cadherin/catenin-based adhesions coordinate cellular growth, survival, migration, and differentiation within a tissue by mechanically anchoring cells to their neighbors. They also intersect with diverse signaling pathways in development and cancer. Although the adhesive functions of adherens junction proteins are well...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Livshits G,Kobielak A,Fuchs E

更新日期：2012-03-27 00:00:00

abstract：:The necroptosis cell death pathway has been implicated in host defense and in the pathology of inflammatory diseases. While phosphorylation of the necroptotic effector pseudokinase Mixed Lineage Kinase Domain-Like (MLKL) by the upstream protein kinase RIPK3 is a hallmark of pathway activation, the precise checkpoints ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Petrie EJ,Birkinshaw RW,Koide A,Denbaum E,Hildebrand JM,Garnish SE,Davies KA,Sandow JJ,Samson AL,Gavin X,Fitzgibbon C,Young SN,Hennessy PJ,Smith PPC,Webb AI,Czabotar PE,Koide S,Murphy JM

更新日期：2020-04-14 00:00:00

abstract：:In the vertebrate embryo, the cephalic neural crest cells (CNCCs) produce cells belonging to two main lineages: the neural [including neurons, glial cells of the peripheral nervous system (PNS), and melanocytes] and the mesenchymal (chondrocytes, osteoblasts, smooth muscle cells, and connective tissue cells), whereas ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Calloni GW,Glavieux-Pardanaud C,Le Douarin NM,Dupin E

更新日期：2007-12-11 00:00:00

abstract：:Mitochondrial membrane potentials and resistances have been determined under various metabolic conditions by the use of piezoelectric-driven microelectrodes. The mean state 3 potentials (about +19 mv) are higher than the potentials in state 4 (about +9 mv). DNP in uncoupling concentrations or KCN have no significant e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tupper JT,Tedeschi H

更新日期：1969-07-01 00:00:00

abstract：:The later stages of cochlear differentiation and the developmental onset of hearing require thyroid hormone. Although thyroid hormone receptors (TRs) are a prerequisite for this process, it is likely that other factors modify TR activity during cochlear development. The mouse cochlea expresses type 2 deiodinase (D2), ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ng L,Goodyear RJ,Woods CA,Schneider MJ,Diamond E,Richardson GP,Kelley MW,Germain DL,Galton VA,Forrest D

更新日期：2004-03-09 00:00:00

abstract：:Asian patients with chronic hepatitis C (CHC) are known to have better virological responses to pegylated (Peg) IFN-based therapy than Western patients. Although IL28B gene polymorphisms may contribute to this difference, whether favorable hepatitis C virus (HCV) kinetics during treatment plays a role remains unclear....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hsu CS,Hsu SJ,Chen HC,Tseng TC,Liu CH,Niu WF,Jeng J,Liu CJ,Lai MY,Chen PJ,Kao JH,Chen DS

更新日期：2011-03-01 00:00:00

abstract：:Bone morphogenetic protein (BMP) signaling plays a major role in dorsoventral patterning in vertebrates and in Drosophila. Remarkably, in Tribolium, a beetle with an ancestral type of insect development, early BMP/dpp exhibits differential expression along the anteroposterior axis. However, the BMP/Dpp inhibitor Sog/c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： van der Zee M,Stockhammer O,von Levetzow C,Nunes da Fonseca R,Roth S

更新日期：2006-10-31 00:00:00

abstract：:Previous studies have shown that the immunosuppressive and carcinogenic polycyclic aromatic hydrocarbon 7,12-dimethylbenz(a)anthracene (DMBA) impairs Ca(2+)-dependent transmembrane signaling in human and murine lymphocytes. The purpose of the present studies was to analyze potential mechanisms of immunosuppression by ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Archuleta MM,Schieven GL,Ledbetter JA,Deanin GG,Burchiel SW

更新日期：1993-07-01 00:00:00

abstract：:Characterizing the entropy of a system is a crucial, and often computationally costly, step in understanding its thermodynamics. It plays a key role in the study of phase transitions, pattern formation, protein folding, and more. Current methods for entropy estimation suffer from a high computational cost, lack of gen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nir A,Sela E,Beck R,Bar-Sinai Y

更新日期：2020-12-01 00:00:00

abstract：:Proteins internalized into the endocytic pathway are usually degraded. Efficient proteolysis requires denaturation, induced by acidic conditions within lysosomes, and reduction of inter- and intrachain disulfide bonds. Cytosolic reduction is mediated enzymatically by thioredoxin, but the mechanism of lysosomal reducti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arunachalam B,Phan UT,Geuze HJ,Cresswell P

更新日期：2000-01-18 00:00:00

abstract：:Spatial memory enhances an organism's navigational ability. Memory typically resides within the brain, but what if an organism has no brain? We show that the brainless slime mold Physarum polycephalum constructs a form of spatial memory by avoiding areas it has previously explored. This mechanism allows the slime mold...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reid CR,Latty T,Dussutour A,Beekman M

更新日期：2012-10-23 00:00:00

abstract：:Entropic effects have often been invoked to explain the extraordinary catalytic power of enzymes. In particular, the hypothesis that enzymes can use part of the substrate-binding free energy to reduce the entropic penalty associated with the subsequent chemical transformation has been very influential. The enzymatic r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kazemi M,Himo F,Åqvist J

更新日期：2016-03-01 00:00:00

abstract：:Despite an important role in vascular development and repair, the origin of endothelial progenitors remains unknown. Accumulating evidence indicates that cells derived from the hematopoietic system participate in angiogenesis. However, the identity and functional role of these cells remain controversial. Here we show ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bailey AS,Willenbring H,Jiang S,Anderson DA,Schroeder DA,Wong MH,Grompe M,Fleming WH

更新日期：2006-08-29 00:00:00

abstract：:Nicotiana tabacum cv. Turkish Samsun NN plants were transformed with a modified and truncated replicase gene encoded by RNA-2 of cucumber mosaic virus strain Fny. The replicase gene had been modified by deleting a 94-base-pair region spanning nucleotides 1857-1950; the deletion also caused a shift in the open reading ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Anderson JM,Palukaitis P,Zaitlin M

更新日期：1992-09-15 00:00:00

abstract：:Methods are described for the removal of the sporophytic pollen grain coating of Brassica oleracea and for the isolation of coat polypeptides. The coat contains a small number of proteins ranging from 6 to 45 kDa. Many of the larger proteins are glycosylated, while all carry high positive charges resulting in pI value...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Doughty J,Hedderson F,McCubbin A,Dickinson H

更新日期：1993-01-15 00:00:00

abstract：:Genetic recombination provides an important mechanism for the repair of DNA double-strand breaks. Homologous pairing and strand exchange lead to the formation of DNA intermediates, in which sister chromatids or homologous chromosomes are covalently linked by four-way Holliday junctions (HJs). Depending on the type of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shah Punatar R,Martin MJ,Wyatt HD,Chan YW,West SC

更新日期：2017-01-17 00:00:00

abstract：:A tremendous amount of radioactivity was discharged because of the damage to cooling systems of nuclear reactors in the Fukushima No. 1 nuclear power plant in March 2011. Fukushima and its adjacent prefectures were contaminated with fission products from the accident. Here, we show a geographical distribution of radio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kinoshita N,Sueki K,Sasa K,Kitagawa J,Ikarashi S,Nishimura T,Wong YS,Satou Y,Handa K,Takahashi T,Sato M,Yamagata T

更新日期：2011-12-06 00:00:00

abstract：:In earlier papers L.W. introduced two sequences of higher-rank zeta functions associated to a smooth projective curve over a finite field, both of them generalizing the Artin zeta function of the curve. One of these zeta functions is defined geometrically in terms of semistable vector bundles of rank n over the curve ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weng L,Zagier D

更新日期：2020-03-24 00:00:00

abstract：:The neuronal nucleus plays a vital role in information processing, but whether it supports computational functions such as paired-pulse facilitation, comparable to synapses, is unclear. Ca(2+)-dependent movement of calmodulin (CaM) to the nucleus is highly responsive to Ca(2+) entry through L-type channels and promote...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mermelstein PG,Deisseroth K,Dasgupta N,Isaksen AL,Tsien RW

更新日期：2001-12-18 00:00:00

abstract：:Cytochrome P450 enzymes are monooxygenases that contain a functional heme b group linked to a conserved cysteine with a thiolate bond. In the native state, the central iron atom is hexacoordinated with a covalently bound water molecule. The exclusion of solvent molecules from the active site is essential for efficient...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oprea TI,Hummer G,Garcia AE

更新日期：1997-03-18 00:00:00

abstract：:Paramyxoviruses are enveloped, nonsegmented, negative-strand RNA viruses that cause a wide spectrum of human and animal diseases. The viral genome, packaged by the nucleoprotein (N), serves as a template for the polymerase complex, composed of the large protein (L) and the homo-tetrameric phosphoprotein (P). The ∼250-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Abdella R,Aggarwal M,Okura T,Lamb RA,He Y

更新日期：2020-03-03 00:00:00

abstract：:The maspin protein has tumor suppressor activity in breast and prostate cancers. It inhibits cell motility and invasion in vitro and tumor growth and metastasis in nude mice. Maspin is structurally a member of the serpin (serine protease inhibitors) superfamily but deviates somewhat from classical serpins. We find tha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sheng S,Truong B,Fredrickson D,Wu R,Pardee AB,Sager R

更新日期：1998-01-20 00:00:00

abstract：:In response to vascular injury, vascular smooth muscle cells (VSMCs) may switch from a contractile to a proliferative phenotype thereby contributing to neointima formation. Previous studies showed that the long noncoding RNA (lncRNA) NEAT1 is critical for paraspeckle formation and tumorigenesis by promoting cell proli...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ahmed ASI,Dong K,Liu J,Wen T,Yu L,Xu F,Kang X,Osman I,Hu G,Bunting KM,Crethers D,Gao H,Zhang W,Liu Y,Wen K,Agarwal G,Hirose T,Nakagawa S,Vazdarjanova A,Zhou J

更新日期：2018-09-11 00:00:00

abstract：:Early conformational events during folding of acyl-CoA binding protein (ACBP), an 86-residue alpha-helical protein, were explored by using a continuous-flow mixing apparatus with a dead time of 70 micros to measure changes in intrinsic tryptophan fluorescence and tryptophan-dansyl fluorescence energy transfer. Althoug...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Teilum K,Maki K,Kragelund BB,Poulsen FM,Roder H

更新日期：2002-07-23 00:00:00