Abstract:
:Tuberculosis is rising in the developing world due to poor health care, human immunodeficiency virus type 1 infection, and the low protective efficacy of the Mycobacterium bovis BCG vaccine. A new vaccination strategy that could protect adults in the developing world from tuberculosis could have a huge impact on public health. We show that BCG boosted by poxviruses expressing antigen 85A induced unprecedented 100% protection of guinea pigs from high-dose aerosol challenge with Mycobacterium tuberculosis, suggesting a strategy for enhancing and prolonging the efficacy of BCG.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Williams A,Goonetilleke NP,McShane H,Clark SO,Hatch G,Gilbert SC,Hill AVdoi
10.1128/IAI.73.6.3814-3816.2005keywords:
subject
Has Abstractpub_date
2005-06-01 00:00:00pages
3814-6issue
6eissn
0019-9567issn
1098-5522pii
73/6/3814journal_volume
73pub_type
杂志文章abstract::Carbon storage regulator A (CsrA) is an RNA binding protein that has been characterized in many bacterial species to play a central regulatory role by modulating several metabolic processes. We recently showed that a homolog of CsrA in Borrelia burgdorferi (CsrA(Bb), BB0184) was upregulated in response to propagation ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00882-10
更新日期:2011-02-01 00:00:00
abstract::Four mouse monoclonal antibodies have been developed which react with Mycobacterium tuberculosis antigen 5. Each of these monoclonal antibodies has been used to prepare immunoabsorbents, and antigen has been isolated from unheated M. tuberculosis H37Ra culture filtrate by affinity chromatography with these absorbents....
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.45.1.52-55.1984
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abstract::Strains of Bacteroides fragilis associated with diarrhea in children (termed enterotoxigenic B. fragilis, or ETBF) produce a heat-labile ca. 20-kDa protein toxin (BFT). The purpose of this study was to examine the activity of BFT on polarized monolayers of human intestinal epithelial cells (T84 cells). In Ussing chamb...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.65.9.3561-3570.1997
更新日期:1997-09-01 00:00:00
abstract::Neutrophil collagenase (matrix metalloproteinase 8 [MMP-8]) is an important mediator of tissue destruction in inflammatory diseases. Studies of anaerobic periodontal infections have shown that active MMP-8 in gingival crevicular fluid is associated with the degradation of periodontal tissues in progressive periodontit...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.67.5.2319-2326.1999
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abstract::Host control of Coxiella burnetii infections is believed to be mediated primarily by activated monocytes/macrophages. The activation of macrophages by cytokines leads to the production of reactive oxygen intermediates (ROI) and reactive nitrogen intermediates (RNI) that have potent antimicrobial activities. The contri...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.72.11.6666-6675.2004
更新日期:2004-11-01 00:00:00
abstract::Wild-type Bordetella bronchiseptica and a bvg mutant strain were used for invasion and survival experiments in human Caco-2 and A549 epithelial cells. Both bacterial strains were able to enter and persist within the host cells for at least a week. A significant proportion of the bacteria from both B. bronchiseptica st...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.62.7.3008-3011.1994
更新日期:1994-07-01 00:00:00
abstract::PspA is an antigenically variable surface protein of Streptococcus pneumoniae that appears to be essential for full pneumococcal virulence. In addition, monoclonal antibodies to PspA protect mice against infection with specific strains of pneumococci virulent for mice. In this study, we have isolated the 43-kDa N-term...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.59.4.1285-1289.1991
更新日期:1991-04-01 00:00:00
abstract::To explore the mechanisms underlying the eosinophil-mediated inflammation of tropical pulmonary eosinophilia (TPE), bronchoalveolar lavage (BAL) fluid, serum, and supernatants from pulmonary and blood leukocytes (WBC) from patients with acute TPE (n = 6) were compared with those obtained from healthy uninfected indivi...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.71.3.1337-1342.2003
更新日期:2003-03-01 00:00:00
abstract::By subcutaneous treatment with an aqueous solution of 6-O-stearoyl-N-acetylmuramyl-L-alanyl-D-isoglutamine [6-O-CH3-(CH2)16-CO-MurNAc-L-Ala-D-isoGln] [referred to here as L18-MDP(Ala)], an augmentation of the resistance of mice to Escherichia coli, Pseudomonas aeruginosa. Staphylococcus aureus, and Candida albicans in...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.37.1.292-300.1982
更新日期:1982-07-01 00:00:00
abstract::In order to evaluate during experimental Trypanosoma brucei infections the potential role of tumor necrosis factor alpha (TNF-alpha) in the host-parasite interrelationship, C57BL/6 TNF-alpha knockout mice (TNF-alpha-/-) as well as C57BL/6 wild-type mice were infected with pleomorphic T. brucei AnTat 1.1 E parasites. I...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.67.6.3128-3132.1999
更新日期:1999-06-01 00:00:00
abstract::The extracellular cysteine protease from Streptococcus pyogenes is a virulence factor that plays a significant role in host-pathogen interaction. Streptococcal protease is expressed as an inactive 40-kDa precursor that is autocatalytically converted into a 28-kDa mature (active) enzyme. Replacement of the single cyste...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.67.9.4326-4333.1999
更新日期:1999-09-01 00:00:00
abstract::The indigenous microbial flora of the middle ear cavity of Mongolian gerbils, Meriones unguiculatus, was isolated, characterized, and identified, showing it to be sparse and transitory. Organisms, when found in the middle ear cavity, were most likely to be Staphylococcus epidermidis-like organisms. Cerumen from the ex...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.32.3.1113-1118.1981
更新日期:1981-06-01 00:00:00
abstract::Synthetic peptides and murine monoclonal antibodies were used to map cross-reactive chlamydial epitopes. A species-specific epitope in the central region of variable sequence region 4 abuts the amino-terminal end of a B-serogroup-specific or F/G-serogroup-specific epitope, which in turn abuts known serovar-specific ep...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.64.7.2839-2841.1996
更新日期:1996-07-01 00:00:00
abstract::Hypoferremia, the reduction of plasma transferrin iron levels during infection, has been shown to control Neisseria meningitidis infection in mice. The exact nature of the mechanism that regulates this response has been obscure. We have previously shown that hypoferremia does not result from an accelerated removal of ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.44.2.320-325.1984
更新日期:1984-05-01 00:00:00
abstract::Infection with Trypanosoma cruzi, the agent of Chagas' disease, may induce antibodies and T cells reactive with self antigens (autoimmunity). Because autoimmunity is generally thought to develop during the chronic phase of infection, one hypothesis is that autoimmunity develops only after long-term, low-level stimulat...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.69.9.5643-5649.2001
更新日期:2001-09-01 00:00:00
abstract::Tubercle bacilli failed to grow in iron-void media enriched with solutions of iron-containing transferrin (Tr) or ferritin (F) because these substances do not provide the bacilli with iron, which is essential for their growth. Animal serum and macrophages possessed no iron carrier with an ability to satisfy the need o...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.9.1.34-40.1974
更新日期:1974-01-01 00:00:00
abstract::Helicobacter pylori secretes a pore-forming VacA toxin that has structural features and activities substantially different from those of other known bacterial toxins. VacA can assemble into multiple types of water-soluble flower-shaped oligomeric structures, and most VacA activities are dependent on its capacity to ol...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00254-16
更新日期:2016-08-19 00:00:00
abstract::The chlamydial cryptic plasmid encodes eight putative open reading frames (ORFs), designated pORF1 to -8. Antibodies raised against these ORF proteins were used to localize the endogenous proteins during chlamydial infection. We found that the pORF5 protein (also known as pgp3) was detected mainly in the cytosol of Ch...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01377-07
更新日期:2008-08-01 00:00:00
abstract::CD8(+) T lymphocytes often play a primary role in adaptive immunity to cytosolic microbial pathogens. Surprisingly, CD8(+) T cells are not required for protective immunity to the enteric pathogen Shigella flexneri, despite the ability of Shigella to actively secrete proteins into the host cytoplasm, a location from wh...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00939-10
更新日期:2011-05-01 00:00:00
abstract::The intracellular pathogen Listeria monocytogenes replicates mainly in resting macrophages and hepatocytes residing in infected tissues. Both innate and acquired resistance strongly depend on activation of listericidal capacities of macrophages by gamma interferon (IFN-gamma) produced by natural killer cells and T lym...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.63.8.3187-3195.1995
更新日期:1995-08-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.16.3.885-890.1977
更新日期:1977-06-01 00:00:00
abstract::The effector mechanism, which operates against challenge parasites in the lungs of C57BL/6 mice vaccinated once with irradiated cercariae of Schistosoma mansoni, is mediated by CD4+ T helper lymphocytes. However, adoptive transfer of immunity from vaccinated donors to naive recipients by using sensitized T cells has n...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.65.1.42-48.1997
更新日期:1997-01-01 00:00:00
abstract::Borrelia burgdorferi, the causative agent of Lyme disease, loses its ability to infect and cause disease in mammalian hosts after repeated in vitro passage. To identify proteins preferentially expressed by the low-passage strain and thus representing potential virulence factors, the polypeptide profiles of virulent, l...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.60.11.4662-4672.1992
更新日期:1992-11-01 00:00:00
abstract::Human plasma was bactericidal for small numbers of Klebsiella pneumoniae, but larger numbers grew slowly over a period of 24 h. Human polymorphs in a clot of autologous plasma had a bacteriostatic effect on relatively large numbers of bacteria for up to 24 h and were much more effective than plasma alone. The bacteric...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.51.3.723-730.1986
更新日期:1986-03-01 00:00:00
abstract::Tuberculosis (TB) remains an enormous global health problem, and a new vaccine against TB more potent than the current inadequate vaccine, Mycobacterium bovis BCG, is urgently needed. We describe a recombinant BCG vaccine (rBCG30) expressing and secreting the 30-kDa major secretory protein of Mycobacterium tuberculosi...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.71.4.1672-1679.2003
更新日期:2003-04-01 00:00:00
abstract::Candida-associated denture stomatitis (DS) is a persistent and chronic oral infection of the denture-bearing palatal mucosa. DS stems from the ability of the fungal opportunistic pathogen Candida albicans to adhere to denture material and invade palatal tissue. Although DS is the most prevalent form of oral candidiasi...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00617-19
更新日期:2019-11-18 00:00:00
abstract::Heat-labile enterotoxins from Escherichia coli strains of porcine and human origin polymerize on heating to form high-molecular-weight aggregates, "procoligenoids," analogous to procholeragenoid derived from the cholera enterotoxin. This aggregation is accompanied by loss of biological activity (toxicity). Further hea...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.45.2.518-521.1984
更新日期:1984-08-01 00:00:00
abstract::In a previous study we showed that the involvement of EP4 subtype of the prostaglandin E (PGE) receptor is crucial for lipopolysaccharide (LPS)-induced osteoclast formation in vitro. The present study was undertaken to test whether EP4 is actually associated with LPS-induced bone resorption in vivo. In wild-type (WT) ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.68.12.6819-6825.2000
更新日期:2000-12-01 00:00:00
abstract::Active immunization with Porphyromonas gingivalis whole-cell preparations has been shown to prevent P. gingivalis infection and oral bone loss. Employing passive antibody transfer and opsonization, we demonstrate with this study that immunization-elicited P. gingivalis-specific immunoglobulin G facilitates clearance o...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.72.4.2408-2411.2004
更新日期:2004-04-01 00:00:00
abstract::Restoration of the ability of hypogammaglobulinemic serum to support opsonophagocytosis and intracellular killing of Bacteroides fragilis and Bacteroides thetaiotaomicron by human polymorphonuclear leukocytes was achieved by supplementation with normal human immunoglobulin M, but not with normal human immunoglobulin G...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:
更新日期:1980-05-01 00:00:00