Restricted replication of Listeria monocytogenes in a gamma interferon-activated murine hepatocyte line.

abstract：:Natural antibodies are those immunoglobulin molecules found in mammalian serum that arise in the absence of exposure to environmental pathogens and may comprise an early host defense against invading pathogens. The spirochete Borrelia burgdorferi first encounters natural antibodies when its arthropod vector, Ixodes sc...

journal_title：Infection and immunity

authors： Belperron AA,Bockenstedt LK

更新日期：2001-10-01 00:00:00

abstract：:Livers of normal mice trapped over 80% of intravenously injected 51Cr-labeled lipopolysaccharide after 1 h. Liver fractionation studies showed that nearly 45% of the labeled endotoxin was associated with cell nuclei, 20% with the mitochondrial-lysosomal fraction, and approximately 30% with the cell sap. Analysis of th...

journal_title：Infection and immunity

authors： Zlydaszyk JC,Moon RJ

更新日期：1976-07-01 00:00:00

abstract：:Penetration of the intestinal mucosa at areas of Peyer's patches is an important first step for Salmonella typhimurium to produce lethal systemic disease in mice. However, mutations in genes that are important for intestinal invasion result in only moderately decreased virulence of S. typhimurium for mice. Here we rep...

journal_title：Infection and immunity

authors： Bäumler AJ,Tsolis RM,Valentine PJ,Ficht TA,Heffron F

更新日期：1997-06-01 00:00:00

abstract：:The present study was performed to determine whether Histoplasma capsulatum (yeast phase) is able to activate the alternative complement pathway. H. capsulatum yeasts were shown to consume C3 in C4-deficient guinea pig serum. Immunoelectrophoretic conversion of alternative pathway component factor B confirmed that C3 ...

journal_title：Infection and immunity

authors： Ratnoff WD,Pepple JM,Winkelstein JA

更新日期：1980-10-01 00:00:00

abstract：:Saccharomyces boulardii is a nonpathogenic yeast used in the treatment of Clostridium difficile diarrhea and colitis. We have reported that S. boulardii inhibits C. difficile toxin A enteritis in rats by releasing a 54-kDa protease which digests the toxin A molecule and its brush border membrane (BBM) receptor (I. Cas...

journal_title：Infection and immunity

authors： Castagliuolo I,Riegler MF,Valenick L,LaMont JT,Pothoulakis C

更新日期：1999-01-01 00:00:00

abstract：:An antiserum, C16, was raised in cattle against freeze-thawed extracts of sporozoites of Theileria parva (Muguga). This antiserum, which neutralizes sporozoite infectivity in vitro, identified theileria-specific antigens having approximate molecular masses of 105, 90, 85, 69, 67, 52, 47, and 43 kilodaltons (kDa) on We...

journal_title：Infection and immunity

authors： Iams KP,Hall R,Webster P,Musoke AJ

更新日期：1990-06-01 00:00:00

abstract：:B-cell-deficient mice were prepared by administration of rabbit anti-mouse-mu antiserum to newborn animals within 12 h of birth onwards. Such immunodeficient animals, along with the normal controls, were infected intravenously with Cryptococcus neoformans. There was no difference in the mortality pattern, viable count...

journal_title：Infection and immunity

authors： Monga DP,Kumar R,Mohapatra LN,Malaviya AN

更新日期：1979-10-01 00:00:00

abstract：:The properties of two candidate Salmonella typhi-based live oral typhoid vaccine strains, BRD691 (S. typhi Ty2 harboring mutations in aroA and aroC) and BRD1116 (S. typhi Ty2 harboring mutations in aroA, aroC, and htrA), were compared in a number of in vitro and in vivo assays. BRD1116 exhibited an increased susceptib...

journal_title：Infection and immunity

authors： Lowe DC,Savidge TC,Pickard D,Eckmann L,Kagnoff MF,Dougan G,Chatfield SN

更新日期：1999-02-01 00:00:00

abstract：:The ability of the endospore-forming, gram-positive bacterium Bacillus anthracis to survive in activated macrophages is key to its germination and survival. In a previous publication, we discovered that exposure of primary murine macrophages to B. anthracis endospores upregulated NOS 2 concomitant with an .NO-dependen...

journal_title：Infection and immunity

authors： Weaver J,Kang TJ,Raines KW,Cao GL,Hibbs S,Tsai P,Baillie L,Rosen GM,Cross AS

更新日期：2007-08-01 00:00:00

abstract：:In this study, the efficacy of bactericidal/permeability-increasing protein (BPI) was assessed in a rat model of chronic otitis media with effusion. BPI injection prevented disturbance of the mucociliary clearance system of the middle ear. Hence, it is postulated that BPI can be a new therapy for chronic otitis media ...

journal_title：Infection and immunity

authors： Nell MJ,Koerten HK,Grote JJ

更新日期：2000-05-01 00:00:00

abstract：:Chromosomes from Cryptococcus neoformans, an encapsulated yeast pathogen, were separated by contour-clamped homogeneous field gel electrophoresis. Seven strains representing all four serotypes were studied. It was found that each strain had a unique, reproducible pattern of chromosome bands which could potentially be ...

journal_title：Infection and immunity

authors： Perfect JR,Magee BB,Magee PT

更新日期：1989-09-01 00:00:00

abstract：:We performed ex vivo experiments with Plasmodium falciparum-infected human placentas from primi- and multigravida women from Cameroon. All women, independent of their gravida status, had anti-chondroitin sulfate A (CSA) adhesion antibodies which cross-reacted with heterologous strains, such as FCR3 and Palo-Alto(FUP)1...

journal_title：Infection and immunity

authors： Gysin J,Pouvelle B,Fievet N,Scherf A,Lépolard C

更新日期：1999-12-01 00:00:00

abstract：:With large amounts of parasite gene sequence available, additional bioinformatic tools to screen these sequences for identifying genes encoding antigens are needed. Proteins containing tandem repeat (TR) domains are often B-cell antigens, and antibody responses toward TR domains of the proteins are dominant in human i...

journal_title：Infection and immunity

authors： Goto Y,Coler RN,Reed SG

更新日期：2007-02-01 00:00:00

abstract：:Cell-mediated immunity to herpes simplex virus type 1 (HSV-1) was assessed by a lymphocytotoxicity 51-Cr-release microassay procedure, using the MA-160 human prostatic adenoma cell line chronically infected with HSV-1 and its parent cell line as control. The specific immune release mean plus or minus standard deviatio...

journal_title：Infection and immunity

authors： Thong YH,Vincent MM,Hensen SA,Fuccillo DA,Rola-Pleszczynski M,Bellanti JA

更新日期：1975-07-01 00:00:00

abstract：:Yersinia pestis causes bubonic, pneumonic, and septicemic plague, diseases that are rapidly lethal to most mammals, including humans. Plague develops as a consequence of bacterial neutralization of the host's innate immune response, which permits uncontrolled growth and causes the systemic hyperactivation of the infla...

journal_title：Infection and immunity

authors： Dhariwala MO,Olson RM,Anderson DM

更新日期：2017-10-18 00:00:00

abstract：:The C-terminal 19-kDa domain of merozoite surface protein 1 (MSP1₁₉) is the target of protective antibodies but alone is poorly immunogenic. Previously, using the Plasmodium yoelii murine model, we fused P. yoelii MSP1₁₉ (PyMSP1₁₉) with full-length P. yoelii merozoite surface protein 8 (MSP8). Upon immunization, the M...

journal_title：Infection and immunity

authors： Alaro JR,Angov E,Lopez AM,Zhou H,Long CA,Burns JM Jr

更新日期：2012-07-01 00:00:00

abstract：:A toxin associated with Toxoplasma gondii infection was obtained from the trophozoites and culture medium used to propagate the parasite in cell cultures. The toxin, named Toxofactor (TF), administered parenterally or nonparenterally in adult mice, produces transient symptoms of lethargy, ruffled fur, and body weight ...

journal_title：Infection and immunity

authors： Grimwood B,O'Connor G,Gaafar HA

更新日期：1983-12-01 00:00:00

abstract：:In the present study, the role of virulence factors in and the effect of opsonization on the interactions between Bordetella pertussis and human monocytes were investigated. The methods used facilitated the distinction between attachment and ingestion of bacteria by monocytes. Nonopsonized virulent B. pertussis cells ...

journal_title：Infection and immunity

authors： Hazenbos WL,van den Berg BM,van't Wout JW,Mooi FR,van Furth R

更新日期：1994-11-01 00:00:00

abstract：:No studies to date clearly define the interactions between Porphyromonas gingivalis and human peripheral blood polymorphonuclear leukocytes (PMN), nor has a protective role for antibody to P. gingivalis been defined. Using a fluorochrome phagocytosis microassay, we investigated PMN phagocytosis and killing of P. gingi...

journal_title：Infection and immunity

authors： Cutler CW,Kalmar JR,Arnold RR

更新日期：1991-06-01 00:00:00

abstract：:The outer membrane proteins of Bordetella avium were examined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Sarkosyl-insoluble outer membrane protein-enriched profiles from 50 virulent B. avium isolates, containing major 21,000- and 37,000-molecular-weight proteins (21K and 37K proteins, respectively) ...

journal_title：Infection and immunity

authors： Leyh R,Griffith RW

更新日期：1992-03-01 00:00:00

abstract：:Toll-like receptors (TLRs) play a critical role in early immune recognition of Aspergillus, which can regulate host defense during invasive pulmonary Aspergillosis (IPA). However, the role of TLR7 in the pathogenesis of IPA remains unknown. In this study, an in vivo model of IPA was established to investigate the cont...

journal_title：Infection and immunity

authors： Xu B,Luo Q,Gong Y,Li J,Cao J

更新日期：2021-01-25 00:00:00

abstract：:Resurgence is a major concern after malaria elimination. After the initiation of the elimination program on Aneityum Island in 1991, microscopy showed that Plasmodium falciparum disappeared immediately, whereas P. vivax disappeared from 1996 onward, until P. vivax cases were reported in January 2002. By conducting mal...

journal_title：Infection and immunity

authors： Kaneko A,Chaves LF,Taleo G,Kalkoa M,Isozumi R,Wickremasinghe R,Perlmann H,Takeo S,Tsuboi T,Tachibana S,Kimura M,Björkman A,Troye-Blomberg M,Tanabe K,Drakeley C

更新日期：2014-01-01 00:00:00

abstract：:Species-specific antibody epitopes within several major immunoreactive protein orthologs of Ehrlichia species have recently been identified and molecularly characterized. In this study, dominant B-cell epitopes within the acidic (pI 5.35) ankyrin repeat-containing 200-kDa major immunoreactive protein (gp200) of Ehrlic...

journal_title：Infection and immunity

authors： Nethery KA,Doyle CK,Zhang X,McBride JW

更新日期：2007-10-01 00:00:00

abstract：:The opportunistic pathogen Pseudomonas aeruginosa is a major cause of sepsis in severely burned patients. If it is not eradicated from the wound, it translocates to the bloodstream, causing sepsis, multiorgan failure, and death. We recently described the P. aeruginosa heparinase-encoding gene, hepP, whose expression w...

journal_title：Infection and immunity

authors： Dzvova N,Colmer-Hamood JA,Griswold JA,Hamood AN

更新日期：2017-12-19 00:00:00

abstract：:We have mapped a group of virulence genes of Porphyromonas gingivalis to a single large fragment of the genome. These genes (rgpA, kgp, and hagA) all contain a consensus repeat sequence (HArep). rgpA and kgp encode cysteine proteases with Arg-X and Lys-X specificity, respectively, and hagA encodes a hemagglutinin. Gen...

journal_title：Infection and immunity

authors： Lewis JP,Macrina FL

更新日期：1999-05-01 00:00:00

abstract：:Levels of interferon in adult bovine serum and in fetal bovine serum and tissues were examined during the course of transplacental bovine viral diarrhea virus infection. The cows produced circulating interferon between 2 and 9 days after viral inoculation, with mean peak levels in the serum on day 4. Interferon could ...

journal_title：Infection and immunity

authors： Rinaldo CR Jr,Isackson DW,Overall JC Jr,Glasgow LA,Brown TT,Bistner SI,Gillespie JH,Scott FW

更新日期：1976-09-01 00:00:00

abstract：:The complement system plays a key role in resistance to cryptococcosis. In the present study, we examined several factors that influence the binding of C3 cleavage fragments to Cryptococcus neoformans. Binding of C3 was determined by using normal human serum supplemented with 125I-labeled C3. Incubation of encapsulate...

journal_title：Infection and immunity

authors： Kozel TR,Pfrommer GS

更新日期：1986-04-01 00:00:00

abstract：:The Lyme disease spirochete Borrelia burgdorferi reduces the expression of outer surface protein C (OspC) in response to the development of an anti-OspC humoral response, leading to the hypothesis that the ability to repress OspC expression is critical for the pathogen to proceed to chronic infection. B. burgdorferi w...

journal_title：Infection and immunity

authors： Xu Q,Seemanapalli SV,McShan K,Liang FT

更新日期：2006-09-01 00:00:00

abstract：:An anti-glucosyltransferase serum was prepared against a pure enzyme preparation from Streptococcus sanguis OMZ 9, which synthesized both soluble and insoluble dextran. Sera, crude gamma globulins, and antibody fractions obtained after gel filtration on a Bio-Gel P200 column were used to study enzyme-antibody interact...

journal_title：Infection and immunity

authors： Klein JP,Schöller M,Frank RM

更新日期：1978-06-01 00:00:00

abstract：:Protective immunity in mice to the infective third-stage larvae (L3) of Strongyloides stercoralis was shown to be dependent on immunoglobulin M (IgM), complement activation, and granulocytes. The objectives of the present study were to determine whether IgG was also a protective antibody isotype and to define the spec...

journal_title：Infection and immunity

authors： Ligas JA,Kerepesi LA,Galioto AM,Lustigman S,Nolan TJ,Schad GA,Abraham D

更新日期：2003-12-01 00:00:00