A pilot model of vaccination against hepatitis B virus suitable for mass vaccination campaigns in hyperendemic areas.

Abstract:

:A hepatitis B vaccination campaign was carried out in a town of 60,000 inhabitants, Afragola, Campania, Italy, a hyperendemic area for hepatitis B where HBsAg prevalence was 13.4% and anti-HBc prevalence was 64.7%. This experimental pilot project aimed to reduce the incidence of both acute and asymptomatic viral hepatitis B and of related chronic liver complications. From 1983-1989, 8,400 subjects were vaccinated: 6,900 children up to 10 years of age and 1,500 subjects from 11-60 years of age. High seroconversion rates were observed: 99.0% in all children under one year of age, 96.0% in the older children, and 86.7% in adults. The rate of infection in Afragola has diminished from 63/100,000 in 1983 to 10/100,000 in 1989. Carriers of HBsAg decreased in the general population (7.3% compared to 13.4%), especially in children up to 10 years of age (1.0% compared to 9.0%). In babies who received hepatitis B vaccine at the same time as compulsory vaccinations compliance was 98% while it was 80% in babies who were vaccinated separately. In June 1991 the Italian Parliament promulgated a decree which imposes hepatitis B vaccination for all newborn babies at 3, 5, and 11 months of age, at the same times as the mandatory childhood vaccinations (diphtheria, tetanus, and polio) according to a new protocol (Piazza scheme) which has been in use since January 1987 in our pilot vaccination campaign in Afragola.

journal_name

J Med Virol

authors

Da Villa G,Piazza M,Iorio R,Picciotto L,Peluso P,De Luca G,Basile B

doi

10.1002/jmv.1890360408

keywords:

subject

Has Abstract

pub_date

1992-04-01 00:00:00

pages

274-8

issue

4

eissn

0146-6615

issn

1096-9071

journal_volume

36

pub_type

杂志文章
  • A case of Coxsackie A9 virus infection with orchitis.

    abstract::A thirteen-year-old boy with bilateral orchitis was diagnosed as being infected by Coxsackie A9 virus by isolation of the virus from a throat swab and a fecal specimen. Serologic investigations revealed the development of transitory specific neutralizing IgM antibodies against the isotate and of persistent antibodies ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890030207

    authors: Willems WR,Hornig C,Bauer H,Klingmüller V

    更新日期:1978-01-01 00:00:00

  • Hepatitis B virus markers in anti-HBc only positive individuals.

    abstract::Isolated reactivity to hepatitis B virus (HBV) core antigen (anti-HBc) is observed relatively frequently in immunocompromised individuals, intravenous drug abusers (IVDA), and in the presence of HCV infection. The reason for the lack of HBsAg is not clear. The aim of the present study was to investigate which factors ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1052

    authors: Weber B,Melchior W,Gehrke R,Doerr HW,Berger A,Rabenau H

    更新日期:2001-07-01 00:00:00

  • Genotypic and phenotypic analysis of the env gene from South African HIV-1 subtype B and C isolates.

    abstract::The objective of the study was to assess the genotypic and phenotypic properties of 18 viral strains from human immunodeficiency virus-1 (HIV-1) positive patients and to identify subtype C isolates for vaccine design strategies. All the isolates were non-syncytium-inducing (NSI) in both the primary and MT-2 cell cultu...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.10199

    authors: Treurnicht FK,Smith TL,Engelbrecht S,Claassen M,Robson BA,Zeier M,van Rensburg EJ

    更新日期:2002-10-01 00:00:00

  • Characterization of pandemic influenza A (H1N1) virus hemagglutinin specific polyclonal antibodies for biosensor applications.

    abstract::In this study, recombinant hemagglutinin protein (rH1N1HA) of Pandemic influenza virus and polyclonal antibodies against it for biosensor applications have been characterized. For rapid and high sensitive detection of H1N1 virus or its antibodies, PCR-free and label free detection method based on a surface plasmon res...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23753

    authors: Athmaram TN,Saraswat S,Sikarwar B,Verma SK,Singh AK,Boopathi M

    更新日期:2014-03-01 00:00:00

  • Two years outcome of women infected with high risk HPV having normal colposcopy following low-grade or equivocal cytological abnormalities: are HPV16 and 18 viral load clinically useful predictive markers?

    abstract::Management of patients infected with high-risk HPV (hrHPV) despite normal colposcopy following abnormal cytology remains a clinical challenge. The aim of this study was to evaluate if, in that specific population, initial HPV 16 and HPV 18 viral loads are predictive of infection clearance over a 24-month follow-up. A ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23276

    authors: Carcopino X,Henry M,Mancini J,Giusiano S,Boubli L,Olive D,Tamalet C

    更新日期:2012-06-01 00:00:00

  • Localization of CD8+ cells specific for hepatitis B virus surface protein in the liver of immunized mice.

    abstract::DNA plasmids are potent inducers of long-lasting antigen-specific CTL responses. Little is known about the distribution of antigen-specific CD8+ T cells in the lymphoid tissue and the non-lymphoid tissue after DNA immunization. HBsAg-specific CD8+ T cells in peripheral blood mononuclear cells, spleen, lymph nodes, and...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21039

    authors: Qu D,Lanier G,Yuan ZH,Wen YM,Howard CR,Ahmed R

    更新日期:2008-02-01 00:00:00

  • Molecular epidemiology of astroviruses in Japan from 1995 to 1998 by reverse transcription-polymerase chain reaction with serotype-specific primers (1 to 8).

    abstract::In addition to the serotype-specific primers described previously (1 to 7), a new serotype 8-specific primer has been designed, allowing detection of all astrovirus serotypes. A total of 1,382 diarrheal stool samples in 5 regions in Japan were examined by reverse transcription-polymerase chain reaction (RT-PCR). The i...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:

    authors: Sakamoto T,Negishi H,Wang QH,Akihara S,Kim B,Nishimura S,Kaneshi K,Nakaya S,Ueda Y,Sugita K,Motohiro T,Nishimura T,Ushijima H

    更新日期:2000-07-01 00:00:00

  • Evaluation of LIAISON® XL system for HBsAg, and anti-HCV and anti-HIV/Ag p24.

    abstract::The aim of this study was to compare the data obtained using the new LIAISON® XL chemiluminescence system to search for HBsAg, anti-HCV, and anti-HIV1-2/p24 Ag with those obtained using the VITROS system currently adopted by the Microbiology Unit of the Hospital of Legnano. Routine samples of patients who were referre...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24648

    authors: De Paschale M,Manco MT,Belvisi L,Cagnin D,Cerulli T,Paganini A,Arpino O,Cianflone A,Agrappi C,Mirri P,Clerici P

    更新日期:2017-03-01 00:00:00

  • Inactivation of hepatitis A virus by heat treatment in aqueous solution.

    abstract::Hepatitis A virus infections have been reported recently among hemophilic patients in Italy and Germany, leading to speculation that infectious hepatitis A virus (HAV) might have been present in some factor VIII concentrates. In both cases, the implicated factor concentrates had been treated by a solvent/detergent met...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890410113

    authors: Murphy P,Nowak T,Lemon SM,Hilfenhaus J

    更新日期:1993-09-01 00:00:00

  • Brief report: parainfluenza virus type 3 infections: findings in Sydney and some observations on variations in seasonality world-wide.

    abstract::Parainfluenza virus type 3 (Para 3) is an important childhood pathogen causing a significant amount of bronchiolitis and pneumonia in infants. Virus data were analysed over a twelve-year period (1978-1989), and a peak incidence of infection was observed in spring as in Houston, USA, unlike in the United Kingdom where ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890350105

    authors: de Silva LM,Cloonan MJ

    更新日期:1991-09-01 00:00:00

  • Molecular detection and phylogenetic analysis of human parechovirus in individuals with acute diarrhea and healthy controls in Guangzhou, China.

    abstract::Human parechoviruses (HPeVs) are prevalent in young children; however, their effects are incompletely understood. We investigated the prevalence, genotype distribution, and phylogeny of HPeVs in individuals with diarrhea (n = 430) and healthy controls (n = 93) by the analysis of stool specimens collected from July 201...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.25222

    authors: Chen X,Shi T,Huang J,Xiao G,Huang J,Xiong Y,Li X,Chen H,Zheng X,Yu S,Chen Q

    更新日期:2018-09-01 00:00:00

  • Hepatitis C virus genotypes in hemodialysis patients in Angola.

    abstract::To our knowledge, there are no published data on hepatitis C virus (HCV) genotypes in Angola. This study aimed at assessing the distribution of HCV genotypes in seropositive hemodialysis patients in Luanda. Among 51 HCV-positive subjects included, viremia was detected in 27 (53%). HCV genotyping was performed by bidir...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.25354

    authors: da Costa Marques Borges LF,Zalis MG,Santoro-Lopes G,Varella RB

    更新日期:2019-03-01 00:00:00

  • Impact of HIV infection and highly active antiretroviral therapy (HAART) on B cell subpopulations in children.

    abstract::B-cells play an important role in defending children against various infections. In view of scare data, we undertook this prospective cohort study to describe B cell compartment in HIV infected children (<5 years of age) and the effect of HAART on B cell subpopulations. HIV infected children (<5 years) from Pediatric ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.25074

    authors: Singh R,Mukherjee A,Singla M,Vajpayee M,Negi N,Kabra SK,Lodha R,Das BK

    更新日期:2018-07-01 00:00:00

  • Analysis of virus and host factors in a study of A/Peking/2/79 (H3N2) cold-adapted vaccine recombinant in which vaccine-associated illness occurred in normal volunteers.

    abstract::Live attenuated cold-adapted influenza vaccine is undergoing evaluation in man. Several strains have proven to be safe, immunogenic, nontransmissible, and protective against experimental challenge. In this study of A/Peking/2/79(H3N2), with six internal genes from the cold-adapted (Ca) parent A/Ann Arbor/6/60(H2N2), w...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890260209

    authors: Betts RF,Douglas RG Jr,Maassab HF,DeBorde DC,Clements ML,Murphy BR

    更新日期:1988-10-01 00:00:00

  • Measles virus genotype B2 is not inactive: evidence of continued circulation in Africa.

    abstract::This study describes two measles outbreaks--one in Cape Town, South Africa in November 2002, and the other in Luanda, Angola in March 2003. The outbreaks were notable because they were caused by closely related genotype B2 viruses. This genotype was first described in an outbreak in Libreville, Gabon in the 1980s and ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20491

    authors: Smit SB,Hardie D,Tiemessen CT

    更新日期:2005-12-01 00:00:00

  • Minimal reactivation of Kaposi's sarcoma-associated herpesvirus by corticosteroids in latently infected B cell lines.

    abstract::Corticosteroid use in transplant recipients increases the incidence and severity of Kaposi's sarcoma (KS), a disease associated with KS-associated herpesvirus (KSHV) infection. Recently, the prototypic corticosteroid, hydrocortisone, was shown to directly induce lytic cycle reactivation of KSHV in latently-infected BC...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.2155

    authors: Zoeteweij JP,Rinderknecht AS,Davis DA,Yarchoan R,Blauvelt A

    更新日期:2002-03-01 00:00:00

  • Serum concentrations of ribavirin and pegylated interferon and viral responses in patients infected with HIV and HCV.

    abstract::The hepatitis C virus (HCV) infects a substantial proportion of patients infected with human immunodeficiency virus (HIV). Patients infected with both HCV and HIV respond poorly to anti-HCV treatment with pegylated interferon alpha and ribavirin. But few data are available on the influence of ribavirin and interferon ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21227

    authors: Nicot F,Legrand-Abravanel F,Lafont T,Dubois M,Sauné K,Pasquier C,Chatelut E,Izopet J

    更新日期:2008-09-01 00:00:00

  • Detection by PCR of human polyomaviruses BK and JC in immunocompromised individuals and partial sequencing of control regions.

    abstract::Immunocompromised individuals were tested for the presence of the human polyomaviruses JC (JCV) and BK (BKV) by the polymerase chain reaction (PCR). The use of appropriate primers in a nested PCR allowed the detection of both viruses simultaneously. Viruses were differentiated by restriction fragment length analysis o...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890420208

    authors: Schätzl HM,Sieger E,Jäger G,Nitschko H,Bader L,Ruckdeschel G,Jäger G

    更新日期:1994-02-01 00:00:00

  • Seroprevalence of hepatitis A virus antibodies in Turkish and Moroccan children in Rotterdam.

    abstract::Seasonal fluctuations in hepatitis A have been observed in the Netherlands related to Turkish and Moroccan children after visiting their home countries. This study determined the prevalence and associated factors of hepatitis A virus (HAV) antibodies in Turkish and Moroccan children in Rotterdam. A random sample was t...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.10576

    authors: Richardus JH,Vos D,Veldhuijzen IK,Groen J

    更新日期:2004-02-01 00:00:00

  • Immune memory response induced in vitro by recombinant hepatitis B surface antigen challenge 13-18 years after primary vaccination.

    abstract::The question of whether booster doses are required to maintain long-term protection against hepatitis B virus (HBV) after primary vaccination remains to be determined. Thus, the aim of this study was to evaluate the immune memory responses to hepatitis B surface antigen (HBsAg) challenge in vaccinated individuals thro...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24012

    authors: do Livramento A,Schultz J,Batista KZ,Treitinger A,de Cordova CM,Spada C

    更新日期:2014-10-01 00:00:00

  • Paper-based point-of-care testing for cost-effective diagnosis of acute flavivirus infections.

    abstract::Flavivirus infections are a serious healthcare concern in tropical and subtropical countries. Although well-established laboratory tests can provide early diagnosis of acute dengue or Zika infections, access to these tests is limited in developing countries, presenting an urgent need to develop simple, rapid, and robu...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24806

    authors: Bedin F,Boulet L,Voilin E,Theillet G,Rubens A,Rozand C

    更新日期:2017-09-01 00:00:00

  • Characterization of new epidemic strains of influenza B virus by using neutralizing monoclonal antibodies.

    abstract::During the 1998-1999 influenza season, two distinct influenza B virus Yamagata group strains were isolated from the patients of a private clinic. Each responded differently to monoclonal antibodies (Mabs) 5H4 and 8B3 on staining, and hemagglutination inhibition and neutralizing tests. When the analysis of nucleotide s...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.2099

    authors: Nakagawa N,Kubota R,Morikawa S,Nakagawa T,Baba K,Okuno Y

    更新日期:2001-12-01 00:00:00

  • Mix-breeding with HEV-infected swine induced inapparent HEV infection in SPF rabbits.

    abstract::Studies have shown that swine HEV (sHEV) and rabbit HEV (rHEV) can experimentally infect rabbits and swine, respectively. However, no published data have documented isolating sHEV strains from rabbits in natural environment so far. To clarify the possibility of natural cross-species transmission of sHEV to rabbits, th...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24374

    authors: Liu L,Wang L,Xia J,Zhang Y,Zeng H,Liu P,Zou Q,Wang L,Zhuang H

    更新日期:2016-04-01 00:00:00

  • Atypical presentation of human bocavirus: Severe respiratory tract infection complicated with encephalopathy.

    abstract::Human bocavirus (HBOV) has been reported as a worldwide distributed respiratory pathogen. It has also been associated with encephalitis recently by detection of the virus in cerebrospinal fluid (CSF) of patients presented with encephalitis. This retrospective study aimed to present clinical features of HBOV infections...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24263

    authors: Akturk H,Sık G,Salman N,Sutcu M,Tatli B,Ciblak MA,Erol OB,Torun SH,Citak A,Somer A

    更新日期:2015-11-01 00:00:00

  • Detection of a nuclear antigen 2 (EBNA2)-variant Epstein-Barr virus strain in two siblings with fatal lymphoproliferative disease.

    abstract::An EBV type 1 variant strain was detected in two Turkish siblings (boy and girl), who both suffered and died from similar progressive Epstein-Barr virus (EBV)-associated lymphoproliferative disease. Molecular characterisation of this EBV isolate revealed a 51bp-deletion and six nucleotide changes within the Epstein-Ba...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/(SICI)1096-9071(199601)48:1<114::AID-JMV18

    authors: Schuster V,Seidenspinner S,Kreth HW

    更新日期:1996-01-01 00:00:00

  • Emergence of uncommon HIV-1 non-B subtypes and circulating recombinant forms and trends in transmission of antiretroviral drug resistance in patients with primary infection during the 2013-2015 period in Marseille, Southeastern France.

    abstract::Primary HIV-1 infections (PHI) with non-B subtypes are increasing in developed countries while transmission of HIV-1 harboring antiretroviral resistance-associated mutations (RAMs) remains a concern. This study assessed non-B HIV-1 subtypes and RAMs prevalence among patients with PHI in university hospitals of Marseil...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.25228

    authors: Tamalet C,Tissot-Dupont H,Motte A,Tourrès C,Dhiver C,Ravaux I,Poizot-Martin I,Dieng T,Tomei C,Bregigeon S,Zaegel-Faucher O,Laroche H,Aherfi S,Mokhtari S,Chaudet H,Ménard A,Brouqui P,Stein A,Colson P

    更新日期:2018-10-01 00:00:00

  • HCV in peripheral blood mononuclear cells are predominantly carried on the surface of cells in HIV/HCV co-infected individuals.

    abstract::HCV replication in extra-hepatic reservoirs has been suggested to occur in many tissues including PBMCs. A recent study showed evidence for compartmentalization and evolution of HCV in PBMCs. However, the cells that support HCV replication in PBMCs have not been identified. In this study we have fractionated the PBMC ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21906

    authors: Natarajan V,Kottilil S,Hazen A,Adelsberger J,Murphy AA,Polis MA,Kovacs JA

    更新日期:2010-12-01 00:00:00

  • Detection of varicella-zoster virus DNA in 414 human trigeminal ganglia from cadavers by the polymerase chain reaction: a comparison of the detection rate of varicella-zoster virus and herpes simplex virus type 1.

    abstract::Investigation of varicella-zoster virus (VZV) is important epidemiologically, and determination of its prevalence rate in human trigeminal ganglia is important to provide surveillance data. To date, studies on VZV detection in trigeminal ganglia have used specimens obtained from a relatively limited number of cadavers...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21687

    authors: Inoue H,Motani-Saitoh H,Sakurada K,Ikegaya H,Yajima D,Hayakawa M,Sato Y,Otsuka K,Kobayashi K,Nagasawa S,Iwase H

    更新日期:2010-02-01 00:00:00

  • Isolation of saffold virus type 2 in green monkey kidney cells.

    abstract::Saffold viruses (SAFV) have been discovered recently and they are classified into Theilovirus species in genus Cardiovirus in the Picornaviridae family. SAFV, especially those belonging to the genotype 2, have been difficult to propagate in laboratory cell lines. This study describes the successful isolation of an eff...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23352

    authors: Blomqvist S,Lappalainen M,Paananen A,Ylipaasto P,Roivainen M

    更新日期:2012-09-01 00:00:00

  • Herpes simplex and human papilloma virus coinfections in oral mucosa of men-A 6-year follow-up study.

    abstract::Herpes simplex virus (HSV) establishes latency in neurons and recurrent infections in oral mucosa. This prospective study analyzes HSV prevalence in oral mucosal brush samples from men with known human papillomavirus (HPV) status. We hypothesized that HSV-1-infection could facilitate HPV persistence as a cofactor. Thi...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24965

    authors: Mäki J,Paavilainen H,Kero K,Hukkanen V,Syrjänen S

    更新日期:2018-03-01 00:00:00