Inhibition of c-Jun N-terminal kinase limits lipopolysaccharide-induced pulmonary neutrophil influx.

abstract：:Leukotrienes have been implicated in the bronchoconstriction caused by indirect stimuli. In the present study we examined the effect of oral ABT-761, a novel 5-lipoxygenase (5-LO) inhibitor, on exercise- and adenosine (AMP)-induced bronchoconstriction in nine asthmatics. At the four 1-d, single-dose treatment periods,...

journal_title：American journal of respiratory and critical care medicine

authors： Van Schoor J,Joos GF,Kips JC,Drajesk JF,Carpentier PJ,Pauwels RA

更新日期：1997-03-01 00:00:00

abstract：:Burkholderia gladioli has been reported as colonizing the airways of patients with cystic fibrosis (CF) but has not previously been associated with adverse outcome. We describe six patients with CF in whom the same strain of B. gladioli, on the basis of ribotyping and biochemical characteristics, was grown in their sp...

journal_title：American journal of respiratory and critical care medicine

authors： Wilsher ML,Kolbe J,Morris AJ,Welch DF

更新日期：1997-04-01 00:00:00

abstract：:Arousal is believed to be needed for upper airway opening in obstructive hypopneas-apneas, without compelling evidence to support this notion. The association may be incidental. I studied the temporal relation between arousal and opening and impact of arousal on flow response at opening in 82 patients (apnea-hypopnea ...

journal_title：American journal of respiratory and critical care medicine

authors： Younes M

更新日期：2004-03-01 00:00:00

abstract：:Although hematopoietic stem cell transplantation (HSCT) can be curative in patients with certain malignancies, survival is poor if the recipient becomes critically ill. This prospective study examined the outcomes of 115 consecutive HSCT patients admitted to the medical intensive care unit (MICU) of a tertiary cancer ...

journal_title：American journal of respiratory and critical care medicine

authors： Price KJ,Thall PF,Kish SK,Shannon VR,Andersson BS

更新日期：1998-09-01 00:00:00

abstract：RATIONALE:The immune response in sepsis is characterized by overt immune dysfunction. Studies indicate immunostimulation represents a viable therapy for patients. One study suggests a potentially protective role for interleukin 5 (IL-5) in sepsis; however, the loss of eosinophils in this disease presents a paradox. OB...

journal_title：American journal of respiratory and critical care medicine

authors： Linch SN,Danielson ET,Kelly AM,Tamakawa RA,Lee JJ,Gold JA

更新日期：2012-08-01 00:00:00

abstract：:E-selectin, an early mediator of leukocyte-endothelial adhesion, is expressed on activated endothelium. Soluble E-selectin is present in the supernatant of cytokine-activated endothelial cells and elevated serum levels are found in a variety of inflammatory conditions. We documented elevated E-selectin serum levels in...

journal_title：American journal of respiratory and critical care medicine

authors： Cummings CJ,Sessler CN,Beall LD,Fisher BJ,Best AM,Fowler AA 3rd

更新日期：1997-08-01 00:00:00

abstract：:The effects of exposure to environmental tobacco smoke (ETS) on pulmonary function were investigated in a random sample of 1,033 adults aged 40 to 69 yr from a residential area in Beijing. Compared with those not exposed, those exposed to ETS either at home or at work were associated with a 102-ml (SE = 40 ml) reducti...

journal_title：American journal of respiratory and critical care medicine

authors： Xu X,Li B

更新日期：1995-01-01 00:00:00

abstract：:Many persons say that they "don't know" whether they snore. The purpose of this study was to investigate the prevalence and correlates of such responses in an elderly population. Subjects were 1715 members (1,155 men, 560 women) of a previously defined cohort (Western Group Collaborative Study) followed prospectively ...

journal_title：American journal of respiratory and critical care medicine

authors： Bliwise DL,Swan GE,Carmelli D,La Rue A

更新日期：1999-12-01 00:00:00

abstract：RATIONALE:There is consensus on the need to address social determinants of tuberculosis (TB) to achieve TB control, but evidence based on interventions is lacking. OBJECTIVES:We reanalyzed data from the sociomedical experiment performed at the Papworth Village Settlement in England, where the impact of stable employme...

journal_title：American journal of respiratory and critical care medicine

authors： Bhargava A,Pai M,Bhargava M,Marais BJ,Menzies D

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Mild obstructive sleep apnea (OSA) is a highly prevalent disorder in adults; however, whether mild OSA has significant neurocognitive and cardiovascular complications is uncertain. OBJECTIVES:The specific goals of this Research Statement are to appraise the evidence regarding whether long-term adverse neuro...

journal_title：American journal of respiratory and critical care medicine

authors： Chowdhuri S,Quan SF,Almeida F,Ayappa I,Batool-Anwar S,Budhiraja R,Cruse PE,Drager LF,Griss B,Marshall N,Patel SR,Patil S,Knight SL,Rowley JA,Slyman A,ATS Ad Hoc Committee on Mild Obstructive Sleep Apnea.

更新日期：2016-05-01 00:00:00

abstract：RATIONALE:Diesel motor exhaust is classified by the International Agency for Research on Cancer as probably carcinogenic to humans. The epidemiologic evidence is evaluated as limited because most studies lack adequate control for potential confounders and only a few studies have reported on exposure-response relationsh...

journal_title：American journal of respiratory and critical care medicine

authors： Olsson AC,Gustavsson P,Kromhout H,Peters S,Vermeulen R,Brüske I,Pesch B,Siemiatycki J,Pintos J,Brüning T,Cassidy A,Wichmann HE,Consonni D,Landi MT,Caporaso N,Plato N,Merletti F,Mirabelli D,Richiardi L,Jöckel KH,Ah

更新日期：2011-04-01 00:00:00

abstract：:Induced sputum using hypertonic saline (HS) is a useful research tool to study airway inflammation (AI). HS provocation testing can also be used to measure airway hyperresponsiveness (AHR). A combined HS challenge and sputum induction procedure has been developed to permit assessment of AI and AHR in a single test. Th...

journal_title：American journal of respiratory and critical care medicine

authors： Jones PD,Hankin R,Simpson J,Gibson PG,Henry RL

更新日期：2001-10-01 00:00:00

abstract：:Patients in whom acid-fast bacilli smear-positive pulmonary tuberculosis was newly diagnosed were randomized to receive 400 mg moxifloxacin, 300 mg isonaizid, or 600 mg rifampin daily for 5 days. Sixteen-hour overnight sputa collections were made for the 2 days before and for 5 days of monotherapy. Bactericidal activi...

journal_title：American journal of respiratory and critical care medicine

authors： Gosling RD,Uiso LO,Sam NE,Bongard E,Kanduma EG,Nyindo M,Morris RW,Gillespie SH

更新日期：2003-12-01 00:00:00

abstract：RATIONALE:The effect of indoor air pollutants on respiratory morbidity among patients with chronic obstructive pulmonary disease (COPD) in developed countries is uncertain. OBJECTIVES:The first longitudinal study to investigate the independent effects of indoor particulate matter (PM) and nitrogen dioxide (NO(2)) conc...

journal_title：American journal of respiratory and critical care medicine

authors： Hansel NN,McCormack MC,Belli AJ,Matsui EC,Peng RD,Aloe C,Paulin L,Williams DL,Diette GB,Breysse PN

更新日期：2013-05-15 00:00:00

abstract：:The timing and magnitude of airway narrowing in central apneas is unknown. We have developed a method of apnea classification that relies on the transmission of cardiac airflow oscillation to indicate airway patency. Using a theoretical model, we showed that the amplitude of the cardiac airflow oscillation is proporti...

journal_title：American journal of respiratory and critical care medicine

authors： Lemke RP,Idiong N,Al-Saedi S,Kwiatkowski K,Cates DB,Rigatto H

更新日期：1998-02-01 00:00:00

abstract：:We evaluated positron emission tomographic imaging of pulmonary transgene expression, using an enhanced mutant herpes simplex virus-1 thymidine kinase as the reporter gene, in the lungs of normal rats. Sixteen rats were studied 3 days after an intratracheal administration of 5 x 10(9) to 1 x 10(11) viral particles of ...

journal_title：American journal of respiratory and critical care medicine

authors： Richard JC,Zhou Z,Ponde DE,Dence CS,Factor P,Reynolds PN,Luker GD,Sharma V,Ferkol T,Piwnica-Worms D,Schuster DP

更新日期：2003-05-01 00:00:00

abstract：RATIONALE:Although interferon (IFN)-gamma release assays are approved for the diagnosis of latent tuberculosis infection (LTBI), limited data exist regarding their performance in HIV infection. OBJECTIVES:To compare tuberculin skin test (TST) results to the commercial IFN-gamma release assay QuantiFERON-TB Gold In-Tub...

journal_title：American journal of respiratory and critical care medicine

authors： Luetkemeyer AF,Charlebois ED,Flores LL,Bangsberg DR,Deeks SG,Martin JN,Havlir DV

更新日期：2007-04-01 00:00:00

abstract：RATIONALE:The degree to which chronic respiratory health effects caused by exposures to cotton dust and endotoxin is reversible after cessation of textile work is unknown. OBJECTIVES:To investigate changes in lung function and respiratory symptoms after cessation of textile work and to determine whether past exposure ...

journal_title：American journal of respiratory and critical care medicine

authors： Shi J,Hang JQ,Mehta AJ,Zhang HX,Dai HL,Su L,Eisen EA,Christiani DC

更新日期：2010-07-15 00:00:00

abstract：:Dobutamine has been proposed as a means of disclosing a pathologic oxygen supply (DO2) dependency in critically ill patients. Like other catecholamines, however, dobutamine might increase cellular metabolism, so that oxygen consumption (VO2) would increase regardless of the presence or absence of a supply dependency. ...

journal_title：American journal of respiratory and critical care medicine

authors： De Backer D,Moraine JJ,Berre J,Kahn RJ,Vincent JL

更新日期：1994-07-01 00:00:00

abstract：:Most of the studies linking chronic obstructive pulmonary disease (COPD) with oxidative stress are in vitro, using invasive techniques, or measuring systemic oxidative stress. The aim of this study was to quantify oxidative stress in the lungs in patients with COPD and in healthy smokers, as reflected by 8-isoprostane...

journal_title：American journal of respiratory and critical care medicine

authors： Montuschi P,Collins JV,Ciabattoni G,Lazzeri N,Corradi M,Kharitonov SA,Barnes PJ

更新日期：2000-09-01 00:00:00

abstract：:If lipid peroxidation (LP) contributes to organ dysfunction in sepsis rather than simply reflecting established injury, it should occur soon after the onset of the septic insult, and it may not progress uniformly in all organs. We assessed whether LP occurs within 90 min after onset of continuous intravenous endotoxin...

journal_title：American journal of respiratory and critical care medicine

authors： Clements NC Jr,Habib MP

更新日期：1995-03-01 00:00:00

abstract：:Smoking is the major risk factor for chronic respiratory symptoms, but dietary factors may also play a role. Most studies of diet and lung disease have been cross-sectional and conducted in populations with a Western-style diet. We analyzed the relation between dietary intake at baseline and new onset of cough with ph...

journal_title：American journal of respiratory and critical care medicine

authors： Butler LM,Koh WP,Lee HP,Yu MC,London SJ

更新日期：2004-08-01 00:00:00

abstract：RATIONALE:S100A12 is overexpressed during inflammation and is a marker of inflammatory disease. Furthermore, it has been ascribed to the group of damage-associated molecular pattern molecules that promote inflammation. However, the exact role of human S100A12 during early steps of immune activation and sepsis is only p...

journal_title：American journal of respiratory and critical care medicine

authors： Foell D,Wittkowski H,Kessel C,Lüken A,Weinhage T,Varga G,Vogl T,Wirth T,Viemann D,Björk P,van Zoelen MA,Gohar F,Srikrishna G,Kraft M,Roth J

更新日期：2013-06-15 00:00:00

abstract：:Although the incidence of pulmonary hypertension is higher in female patients, numerous experimental studies have demonstrated better outcome in female animals, exacerbation of the disease after ovariectomy, and a strong protective effect of estrogen: a phenomenon known as the "estrogen paradox" of pulmonary hypertens...

journal_title：American journal of respiratory and critical care medicine

authors： Umar S,Rabinovitch M,Eghbali M

更新日期：2012-07-15 00:00:00

abstract：RATIONALE:Secondhand tobacco smoke (SHS) and traffic-related air pollutants are associated with asthma and allergy. Diesel exhaust particles (DEPs) and SHS can interact with allergens in exacerbating allergic airway diseases through generation of reactive oxygen species. Glutathione S-transferases (GSTs) metabolize rea...

journal_title：American journal of respiratory and critical care medicine

authors： Gilliland FD,Li YF,Gong H Jr,Diaz-Sanchez D

更新日期：2006-12-15 00:00:00

abstract：RATIONALE:The role of NADPH oxidase activation in pneumonia is complex because reactive oxygen species contribute to both microbial killing and regulation of the acute pulmonary infiltrate. The relative importance of each role remains poorly defined in community-acquired pneumonia. OBJECTIVES:We evaluated the contribu...

journal_title：American journal of respiratory and critical care medicine

authors： Marriott HM,Jackson LE,Wilkinson TS,Simpson AJ,Mitchell TJ,Buttle DJ,Cross SS,Ince PG,Hellewell PG,Whyte MK,Dockrell DH

更新日期：2008-04-15 00:00:00

abstract：:A number of new observations have added to our understanding of mast cell biology and the relevance of this cell to the genesis of asthma. The purpose of this review has been to highlight this new information and to refer the reader to extensive reviews where previously documented and well-known data are available. Of...

journal_title：American journal of respiratory and critical care medicine

authors： Wasserman SI

更新日期：1994-11-01 00:00:00

abstract：:In asthma, the acute increment of airway responsiveness caused by exposure to allergen is associated with influx of eosinophils into the airways. The relationship between chronic airway hyperresponsiveness and airway inflammation is unclear, as they do not change consistently following long-term anti-inflammatory trea...

journal_title：American journal of respiratory and critical care medicine

authors： Crimi E,Spanevello A,Neri M,Ind PW,Rossi GA,Brusasco V

更新日期：1998-01-01 00:00:00

abstract：:Sensitive measures of lung function applicable to young subjects are needed to detect early cystic fibrosis (CF) lung disease. Forty children with CF aged 2 to 5 years and 37 age-matched healthy control subjects performed multiple-breath inert gas washout, plethysmography, and spirometry. Thirty children in each group...

journal_title：American journal of respiratory and critical care medicine

authors： Aurora P,Bush A,Gustafsson P,Oliver C,Wallis C,Price J,Stroobant J,Carr S,Stocks J,London Cystic Fibrosis Collaboration.

更新日期：2005-02-01 00:00:00

abstract：:Salbutamol inhibits neutropenia, increased airway resistance, and gas exchange abnormalities provoked by platelet-activating factor (PAF) challenge in normal persons. To further explore the intriguing dissociation between spirometric abnormalities and gas exchange defects shown in patients with asthma, we investigated...

journal_title：American journal of respiratory and critical care medicine

authors： Díaz O,Barberà JA,Marrades R,Chung KF,Roca J,Rodriguez-Roisin R

更新日期：1997-07-01 00:00:00