Abstract:
:ProtoNet is an automatic hierarchical classification of the protein sequence space. In 2004, the ProtoNet (version 4.0) presents the analysis of over one million proteins merged from SwissProt and TrEMBL databases. In addition to rich visualization and analysis tools to navigate the clustering hierarchy, we incorporated several improvements that allow a simplified view of the scaffold of the proteins. An unsupervised, biologically valid method that was developed resulted in a condensation of the ProtoNet hierarchy to only 12% of the clusters. A large portion of these clusters was automatically assigned high confidence biological names according to their correspondence with functional annotations. ProtoNet is available at: http://www.protonet.cs.huji.ac.il.
journal_name
Nucleic Acids Resjournal_title
Nucleic acids researchauthors
Kaplan N,Sasson O,Inbar U,Friedlich M,Fromer M,Fleischer H,Portugaly E,Linial N,Linial Mdoi
10.1093/nar/gki007keywords:
subject
Has Abstractpub_date
2005-01-01 00:00:00pages
D216-8issue
Database issueeissn
0305-1048issn
1362-4962pii
33/suppl_1/D216journal_volume
33pub_type
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