Major role of NAD-dependent lactate dehydrogenases in aerobic lactate utilization in Lactobacillus plantarum during early stationary phase.

Abstract:

:NAD-independent lactate dehydrogenases are commonly thought to be responsible for lactate utilization during the stationary phase of aerobic growth in Lactobacillus plantarum. To substantiate this view, we constructed single and double knockout mutants for the corresponding genes, loxD and loxL. Lactate-to-acetate conversion was not impaired in these strains, while it was completely blocked in mutants deficient in NAD-dependent lactate dehydrogenase activities, encoded by the ldhD and ldhL genes. We conclude that NAD-dependent but not NAD-independent lactate dehydrogenases are involved in this process.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Goffin P,Lorquet F,Kleerebezem M,Hols P

doi

10.1128/JB.186.19.6661-6666.2004

keywords:

subject

Has Abstract

pub_date

2004-10-01 00:00:00

pages

6661-6

issue

19

eissn

0021-9193

issn

1098-5530

pii

186/19/6661

journal_volume

186

pub_type

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