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Stochastic yet biased expression of multiple Dscam splice variants by individual cells.

Abstract：

:The Drosophila melanogaster gene Dscam is essential for axon guidance and has 38,016 possible alternative splice forms. This diversity can potentially be used to distinguish cells. We analyzed the Dscam mRNA isoforms expressed by different cell types and individual cells. The choice of splice variants expressed is regulated both spatially and temporally. Different subtypes of photoreceptors express broad yet distinctive spectra of Dscam isoforms. Single-cell RT-PCR documented that individual cells express several different Dscam isoforms and allowed an estimation of the diversity that is present. For example, we estimate that each R3/R4 photoreceptor cell expresses 14-50 distinct mRNAs chosen from the spectrum of thousands of splice variants distinctive of its cell type. Thus, the Dscam repertoire of each cell is different from those of its neighbors, providing a potential mechanism for generating unique cell identity in the nervous system and elsewhere.

journal_name

Nat Genet

journal_title

Nature genetics

authors

Neves G,Zucker J,Daly M,Chess A

doi

10.1038/ng1299

keywords:

subject

Has Abstract

pub_date

2004-03-01 00:00:00

pages

240-6

issue

3

eissn

1061-4036

issn

1546-1718

pii

ng1299

journal_volume

36

pub_type

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