EUS-guided photodynamic therapy of the pancreas: a pilot study.

Abstract:

BACKGROUND:Photodynamic therapy of pancreatic cancer by using percutaneously placed light catheters has been reported. The feasibility and safety of EUS-guided photodynamic therapy of the pancreas was studied in a porcine model. METHODS:After injection of porfimer sodium, a 19-gauge needle was inserted into the pancreas, the liver, the spleen, and the kidney under EUS guidance. A small diameter quartz optical fiber was passed through the EUS needle and used to illuminate the tissue with laser light. The tissue response to photodynamic therapy was examined. RESULTS:Localized tissue necrosis was achieved in all organs, without significant complication. There was no significant difference in inflammation induced by photodynamic therapy within the various organs. CONCLUSIONS:EUS-guided photodynamic therapy is a safe and simple technique that can induce small areas of focal tissue ablation within the liver, the pancreas, the kidney, and the spleen, and potentially could be used to treat a variety of benign and malignant conditions.

journal_name

Gastrointest Endosc

authors

Chan HH,Nishioka NS,Mino M,Lauwers GY,Puricelli WP,Collier KN,Brugge WR

doi

10.1016/s0016-5107(03)02361-7

keywords:

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

95-9

issue

1

eissn

0016-5107

issn

1097-6779

pii

S0016-5107(03)02361-7

journal_volume

59

pub_type

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