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Neoplasms arising in large gastric hyperplastic polyps: endoscopic and pathologic features.

Abstract：

BACKGROUND:Little is known about gastric neoplasms arising from hyperplastic polyps (HPs). OBJECTIVE:To investigate the risk factors associated with neoplasms within HPs and to evaluate the role of alterations of the p16-cyclin D1-pRb pathway in the malignant transformation of HPs. DESIGN:Retrospective, case-control study. SETTING:Tertiary-care center. PATIENTS:Between May 1995 and January 2011, a total of 809 HPs >1 cm were investigated. Associated neoplasms were present in 30 HPs (case group); 30 HPs without neoplasms were selected as a control group. INTERVENTIONS:Gastric polypectomy. MAIN OUTCOME MEASUREMENTS:The risk factors associated with neoplasms within HPs and immunohistochemical expression of p16, cyclin D1, p53, and Ki-67 between case and control groups. RESULTS:Of the 809 HPs, 15 had associated dysplasia, and 15 had carcinoma. Multivariate analysis showed that neoplasm was associated with patient age (odds ratio [OR] 1.159; 95% confidence interval [CI], 1.243-2.044; P < .001), polyp size (OR 1.103; 95% CI, 1.055-1.152; P < .001), and polyp lobulation (OR 4.549; 95% CI, 1.759-11.0766; P < .001) but not with location, multiplicity, intestinal metaplasia, growth pattern, or Helicobacter pylori infection. Loss of p16 expression and high Ki-67 expression were observed in dysplastic areas of HPs compared with the control group (p16 = 14.3% vs 60%; P = .001, Ki-67 = 60.7% vs 36.7%; P < .001). However, no significant differences were found in nondysplastic areas in both groups. LIMITATIONS:Single-center, retrospective study. CONCLUSION:HPs >1 cm may indicate the presence of neoplasms. Loss of p16 and high Ki-67 expression may be markers of HP-associated dysplasia.

journal_name

Gastrointest Endosc

journal_title

Gastrointestinal endoscopy

authors

Ahn JY,Son DH,Choi KD,Roh J,Lim H,Choi KS,Lee JH,Kim DH,Song HJ,Lee GH,Jung HY,Kim JH,Han S,Park YS

doi

10.1016/j.gie.2014.04.020

subject

Has Abstract

pub_date

2014-12-01 00:00:00

pages

1005-13.e2

issue

6

eissn

0016-5107

issn

1097-6779

pii

S0016-5107(14)01356-X

journal_volume

80

pub_type

杂志文章

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