当前位置： SCI文献检索 > GASTROINTESTINAL ENDOSCOPY期刊下所有文献 > p53 and K-ras mutations in pancreatic juice samples from patients with chronic pancreatitis.

p53 and K-ras mutations in pancreatic juice samples from patients with chronic pancreatitis.

Abstract：

BACKGROUND:Mutations in p53 and ras genes are frequent in pancreatic carcinoma. Several ras mutations are consistently detected in the pancreatic juice from patients with chronic pancreatitis. The p53 gene mutations have been detected occasionally in chronic pancreatitis tissue. It was the aim of this study to evaluate the presence and clinical significance of p53 and ras mutations in clinical pancreatic juice samples from patients with chronic pancreatitis. METHODS:Pancreatic juice was obtained from 66 patients with chronic pancreatitis and no evidence of pancreatic carcinoma (51 men, 15 women; age 17-86 years [mean 49.6 +/- 12.9]). Patients were followed prospectively for 26 +/- 3 (4-54) months. Detection of p53 gene mutations was by temperature gradient gel electrophoresis (TGGE) and single strand conformation polymorphism (SSCP) for exons 5-8. Analysis of ras mutations was performed by SSCP/polymerase chain reaction, restriction fragment length polymorphism/polymerase chain reaction. All mutations were confirmed by sequencing. RESULTS:Five of 66 (7.5%) pancreatic juice samples contained p53 mutations, and ras mutations were detected in 6 cases (9%). Cytology was negative in all cases. No pancreatic carcinoma developed during follow-up and neither cancer cells nor preneoplastic lesions could be detected histologically in resected specimens. Although no correlation between p53 mutations and duration of pancreatitis or drinking habits was found, K-ras mutations correlated with both heavy smoking and severity of the disease. CONCLUSION:p53 and ras mutations can be detected in a minority of pancreatic juice samples from patients with chronic pancreatitis in the absence of malignancy.

journal_name

Gastrointest Endosc

journal_title

Gastrointestinal endoscopy

authors

Löhr M,Müller P,Mora J,Brinkmann B,Ostwald C,Farré A,Lluis F,Adam U,Stubbe J,Plath F,Nizze H,Hopt UT,Barten M,Capellá G,Liebe S

doi

10.1067/mge.2001.112711

keywords:

subject

Has Abstract

pub_date

2001-06-01 00:00:00

pages

734-43

issue

7

eissn

0016-5107

issn

1097-6779

pii

S0016-5107(01)29815-0

journal_volume

53

pub_type

杂志文章

相关文献

GASTROINTESTINAL ENDOSCOPY文献大全
  • The Paddington International Virtual Chromoendoscopy Score in ulcerative colitis exhibits very good inter-rater agreement after computerized module training: a multicenter study across academic and community practice (with video).

    abstract：BACKGROUND AND AIMS:Electronic virtual chromoendoscopy (EVC) can demonstrate ongoing disease activity in ulcerative colitis (UC), even when Mayo subscores suggest healing. However, applicability of EVC technology outside the expert setting has yet to be determined. METHODS:Fifteen participants across 5 centers reviewe...

    journal_title：Gastrointestinal endoscopy

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.gie.2018.02.044

    authors： Trivedi PJ,Kiesslich R,Hodson J,Bhala N,Boulton RA,Cooney R,Gui X,Iqbal T,Li KK,Mumtaz S,Pathmakanthan S,Quraishi MN,Sagar VM,Shah A,Sharma N,Siau K,Smith S,Ward S,Widlak MM,Bisschops R,Ghosh S,Iacucci M

    更新日期：2018-07-01 00:00:00

  • Family history of colorectal cancer and prevalence of advanced colorectal neoplasia in asymptomatic screened populations in different age groups.

    abstract：BACKGROUND AND AIMS:The clinical significance of a family history (FH) of colorectal cancer (CRC) in first-degree relatives (FDRs) in CRC screening stratified by different age groups of screened individuals is not fully understood. We investigated the relationship between FH and the presence of advanced colorectal neop...

    journal_title：Gastrointestinal endoscopy

    pub_type： 杂志文章

    doi：10.1016/j.gie.2020.01.033

    authors： Sekiguchi M,Kakugawa Y,Nakamura K,Matsumoto M,Tomizawa Y,Murakami Y,Saito Y,Matsuda T

    更新日期：2020-06-01 00:00:00

  • Temporary placement of fully covered self-expandable metal stents in benign biliary strictures: midterm evaluation (with video).

    abstract：BACKGROUND:Benign biliary strictures (BBS) have been endoscopically managed with placement of multiple plastic stents. Uncovered metal stents have been associated with mucosal hyperplasia and partially covered self-expandable metal stents with migration. Recently, fully covered self-expandable metal stents (CSEMSs) wit...

    journal_title：Gastrointestinal endoscopy

    pub_type： 杂志文章

    doi：10.1016/j.gie.2008.11.029

    authors： Mahajan A,Ho H,Sauer B,Phillips MS,Shami VM,Ellen K,Rehan M,Schmitt TM,Kahaleh M

    更新日期：2009-08-01 00:00:00

  • Diagnosis of colorectal tumorous lesions by magnifying endoscopy.

    abstract：BACKGROUND:The magnifying colonoscope allows 100-fold magnified viewing of the colonic surface. METHODS:We examined 2050 colorectal tumorous lesions by magnifying endoscopy, stereomicroscopy, and histopathology and classified these lesions according to pit pattern. Based on stereomicroscopy, lesions with a type 1 or 2...

    journal_title：Gastrointestinal endoscopy

    pub_type： 杂志文章

    doi：10.1016/s0016-5107(96)70222-5

    authors： Kudo S,Tamura S,Nakajima T,Yamano H,Kusaka H,Watanabe H

    更新日期：1996-07-01 00:00:00

  • ERCP features in 27 patients with autoimmune pancreatitis.

    abstract：BACKGROUND:Autoimmune pancreatitis has been proposed as a new clinical entity. However, the ERCP features of this entity have not been well described. METHODS:Clinical and radiographic features in 27 patients with a diagnosis of autoimmune pancreatitis were evaluated. RESULTS:All 27 patients were at first suspected t...

    journal_title：Gastrointestinal endoscopy

    pub_type： 杂志文章

    doi：10.1067/mge.2002.122653

    authors： Horiuchi A,Kawa S,Hamano H,Hayama M,Ota H,Kiyosawa K

    更新日期：2002-04-01 00:00:00

  • Endoscopic prediction of tumor invasion depth in early gastric cancer.

    abstract：BACKGROUND:Although conventional endoscopy is a good diagnostic tool to evaluate tumor depth (T staging) in early gastric cancer (EGC), its accuracy has not been determined and no consensus has been reached regarding standard endoscopic criteria. OBJECTIVE:To evaluate the diagnostic accuracy of endoscopic T staging an...

    journal_title：Gastrointestinal endoscopy

    pub_type： 杂志文章

    doi：10.1016/j.gie.2010.11.053

    authors： Choi J,Kim SG,Im JP,Kim JS,Jung HC,Song IS

    更新日期：2011-05-01 00:00:00

  • EUS-guided trucut needle biopsies in patients with solid pancreatic masses: a prospective study.

    abstract：BACKGROUND:A trucut needle biopsy device that can be used to obtain specimens from the pancreas and other perigastric organs under EUS guidance has been developed and successfully tested in animals. Moreover, EUS-guided trucut needle biopsy has been used safely in humans and appears to provide more accurate results tha...

    journal_title：Gastrointestinal endoscopy

    pub_type： 杂志文章

    doi：10.1016/s0016-5107(03)02538-0

    authors： Larghi A,Verna EC,Stavropoulos SN,Rotterdam H,Lightdale CJ,Stevens PD

    更新日期：2004-02-01 00:00:00

  • Integrated diagnostic strategy for the invasion depth of early gastric cancer by conventional endoscopy and EUS.

    abstract：BACKGROUND:Although conventional endoscopy (CE) and EUS are considered useful for predicting the invasion depth (T-staging) in early gastric cancer (EGC), no effective diagnostic strategy has been established. OBJECTIVE:To produce simple CE criteria and to elucidate an efficient diagnostic method by combining CE and E...

    journal_title：Gastrointestinal endoscopy

    pub_type： 杂志文章

    doi：10.1016/j.gie.2015.01.022

    authors： Tsujii Y,Kato M,Inoue T,Yoshii S,Nagai K,Fujinaga T,Maekawa A,Hayashi Y,Akasaka T,Shinzaki S,Watabe K,Nishida T,Iijima H,Tsujii M,Takehara T

    更新日期：2015-09-01 00:00:00

  • Long-term outcomes of endoscopic treatment of aberrant hepatic duct injuries after cholecystectomy.

    abstract：BACKGROUND AND AIMS:Right aberrant hepatic ducts are an anatomic variant with clinical relevance because of the risk of injury during cholecystectomy. Treatment options for aberrant hepatic duct injuries are not standardized. This study aims to analyze the long-term results of endoscopic treatment of aberrant hepatic d...

    journal_title：Gastrointestinal endoscopy

    pub_type： 杂志文章

    doi：10.1016/j.gie.2019.09.043

    authors： Tringali A,Massinha P,Schepis T,Landi R,Boškoski I,Perri V,Bove V,Costamagna G

    更新日期：2020-03-01 00:00:00

  • Predicting mortality in patients with in-hospital nonvariceal upper GI bleeding: a prospective, multicenter database study.

    abstract：BACKGROUND:Nonvariceal upper GI bleeding (NVUGIB) that occurs in patients already hospitalized for another condition is associated with increased mortality, but outcome predictors have not been consistently identified. OBJECTIVE:To assess clinical outcomes of NVUGIB and identify predictors of mortality from NVUGIB in ...

    journal_title：Gastrointestinal endoscopy

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.gie.2013.10.009

    authors： Marmo R,Koch M,Cipolletta L,Bianco MA,Grossi E,Rotondano G,PNED 1 and PNED 2 Investigators.

    更新日期：2014-05-01 00:00:00

  • Albumin and C-reactive protein levels predict short-term mortality after percutaneous endoscopic gastrostomy in a prospective cohort study.

    abstract：BACKGROUND:Percutaneous endoscopic gastrostomy (PEG) is a procedure with many complications that sometimes can be devastating. To give better advice to patients referred for PEG regarding risk of complications, important risk factors should be known. OBJECTIVE:To evaluate whether age, body mass index, albumin levels, ...

    journal_title：Gastrointestinal endoscopy

    pub_type： 杂志文章

    doi：10.1016/j.gie.2010.09.012

    authors： Blomberg J,Lagergren P,Martin L,Mattsson F,Lagergren J

    更新日期：2011-01-01 00:00:00

  • The ASGE guidelines for the appropriate use of colonoscopy in an open access system.

    abstract：BACKGROUND:Appropriateness of indications is essential to the rational utilization of resources. The aim of this study was to evaluate the appropriate use of colonoscopy in an open access system and to assess whether the American Society for Gastrointestinal Endoscopy (ASGE) guidelines are useful in clinical practice. ...

    journal_title：Gastrointestinal endoscopy

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1067/mge.2000.106683

    authors： Minoli G,Meucci G,Bortoli A,Garripoli A,Gullotta R,Leo P,Pera A,Prada A,Rocca F,Zambelli A

    更新日期：2000-07-01 00:00:00

  • EUS-guided portal injection chemotherapy for treatment of hepatic metastases: feasibility in the acute porcine model.

    abstract：BACKGROUND AND AIMS:Direct injection of chemotherapy into the portal vein for treatment of liver metastases may increase hepatic tissue levels while decreasing systemic levels and toxicities. We aimed to evaluate EUS-guided portal injection chemotherapy (EPIC) by using drug-eluting microbeads or nanoparticles and compa...

    journal_title：Gastrointestinal endoscopy

    pub_type： 杂志文章

    doi：10.1016/j.gie.2015.08.064

    authors： Faigel DO,Lake DF,Landreth TL,Kelman CC,Marler RJ

    更新日期：2016-02-01 00:00:00

  • Does quantitative serologic testing for Helicobacter pylori predict peptic ulcer disease in cirrhosis?

    abstract：BACKGROUND:Helicobacter Pylori is strongly associated with peptic ulcer disease. A correlation between high IgG serum antibody concentrations and a clinical diagnosis has been reported. It has been recognized that peptic ulcer disease occurs with increased frequency in cirrhosis. In this study, we attempted to establis...

    journal_title：Gastrointestinal endoscopy

    pub_type： 临床试验,杂志文章

    doi：10.1053/ge.1999.v50.98595

    authors： Tsai CJ

    更新日期：1999-09-01 00:00:00

  • Endoscopic ultrasound-guided fine-needle aspiration biopsy using linear array and radial scanning endosonography.

    abstract：BACKGROUND:Endoscopic ultrasound (EUS) accurately stages gastrointestinal malignancies but is less able to differentiate between neoplastic and inflammatory processes. EUS-guided fine-needle aspiration (EUS FNA) has been reported useful for obtaining a diagnosis in suspected gastrointestinal lesions. We report our enti...

    journal_title：Gastrointestinal endoscopy

    pub_type： 杂志文章

    doi：10.1016/s0016-5107(97)70266-9

    authors： Gress FG,Hawes RH,Savides TJ,Ikenberry SO,Lehman GA

    更新日期：1997-03-01 00:00:00

  • A comparison of laser therapy, plastic stents, and expandable metal stents for palliation of malignant dysphagia in patients without a fistula.

    abstract：BACKGROUND:Many options are available for palliation of inoperable malignant stenoses of the esophagus. We report our experience with different modalities of endoscopic therapy. METHODS:From 1986 to 1996, we treated 125 patients with dysphagia caused by unresectable malignant tumors with endoscopic therapy. Seventy pa...

    journal_title：Gastrointestinal endoscopy

    pub_type： 杂志文章

    doi：10.1016/s0016-5107(98)70007-0

    authors： Gevers AM,Macken E,Hiele M,Rutgeerts P

    更新日期：1998-10-01 00:00:00

  • Impact of inpatient status and gender on small-bowel capsule endoscopy findings.

    abstract：BACKGROUND:Video capsule endoscopy (VCE) is most commonly performed in the outpatient setting to evaluate obscure GI bleeding. OBJECTIVE:To determine the impact of gender and inpatient status on VCE findings. DESIGN:Retrospective study. SETTING:Two tertiary medical centers and a VA medical center. PATIENTS:A total ...

    journal_title：Gastrointestinal endoscopy

    pub_type： 杂志文章

    doi：10.1016/j.gie.2011.07.019

    authors： Robinson CA,Jackson C,Condon D,Gerson LB

    更新日期：2011-11-01 00:00:00

  • Laparoscopy-assisted versus balloon enteroscopy-assisted ERCP in bariatric post-Roux-en-Y gastric bypass patients.

    abstract：BACKGROUND:Data on balloon enteroscopy-assisted ERCP (BEA-ERCP) versus laparoscopy-assisted ERCP (LA-ERCP) in post-Roux-en-Y gastric bypass (RYGB) patients are lacking. OBJECTIVES:To compare BEA-ERCP with LA-ERCP in post-RYGB patients and to identify factors that predict therapeutic success with BEA-ERCP. DESIGN:Retr...

    journal_title：Gastrointestinal endoscopy

    pub_type： 杂志文章

    doi：10.1016/j.gie.2011.11.019

    authors： Schreiner MA,Chang L,Gluck M,Irani S,Gan SI,Brandabur JJ,Thirlby R,Moonka R,Kozarek RA,Ross AS

    更新日期：2012-04-01 00:00:00

  • Endoscopic stenting in patients with recurrent malignant obstruction after gastric surgery: uncovered versus simultaneously deployed uncovered and covered (double) self-expandable metal stents.

    abstract：BACKGROUND:Uncovered, rather than covered, metal stents are commonly used for palliation of malignant gastric outlet obstruction because of the low risk of stent migration, but tumor ingrowth risk is a major drawback. Few reports address malignant obstruction after gastric surgery. OBJECTIVE:Our purpose was to compare...

    journal_title：Gastrointestinal endoscopy

    pub_type： 杂志文章

    doi：10.1016/j.gie.2006.08.030

    authors： Song GA,Kang DH,Kim TO,Heo J,Kim GH,Cho M,Heo JH,Kim JY,Lee JS,Jeoung YJ,Jeon TY,Kim DH,Sim MS

    更新日期：2007-05-01 00:00:00

  • Introducer method of percutaneous endoscopic cecostomy and antegrade continence enema by use of the Chait Trapdoor cecostomy catheter in patients with adult neurogenic bowel.

    abstract：BACKGROUND:Previous reports on percutaneous endoscopic cecostomy (PEC) for the delivery of antegrade continence enema (ACE) in adults have been presented in the form of case reports. Heretofore the tubes used in the pull method of PEC have been thick bolster catheters. The author performed PEC by using the introducer m...

    journal_title：Gastrointestinal endoscopy

    pub_type： 杂志文章

    doi：10.1016/j.gie.2005.12.035

    authors： Uno Y

    更新日期：2006-04-01 00:00:00

  • Colonic concentrations of hydrogen and methane following colonoscopic preparation with an oral lavage solution.

    abstract：:Explosions are a rare complication of electrocautery in the colon. The cause of these explosions is ignition of gas containing hydrogen (greater than 4%) or methane (greater than 5%), and oxygen. Hydrogen and methane are products of colonic bacterial metabolism. Oral solutions used for colonoscopy preparation are desi...

    journal_title：Gastrointestinal endoscopy

    pub_type： 杂志文章

    doi：10.1016/s0016-5107(90)71168-6

    authors： Strocchi A,Bond JH,Ellis C,Levitt MD

    更新日期：1990-11-01 00:00:00

  • Endoscopic sclerotherapy for portal hypertension due to extrahepatic obstruction: long-term follow-up.

    abstract：:Between 1982 and 1987, 43 patients with variceal bleeding due to extrahepatic portal obstruction were treated by repeated endoscopic injection sclerotherapy using 1% polidocanol intravariceally. This decreased rebleeding, as evidenced by a decrease in bleeding risk factor (BRF), mean transfusion requirement, and mean ...

    journal_title：Gastrointestinal endoscopy

    pub_type： 杂志文章

    doi：10.1016/s0016-5107(89)72798-x

    authors： Bhargava DK,Dwivedi M,Dasarathy S,Arora A

    更新日期：1989-07-01 00:00:00

  • Use of video and magnetic endoscope imaging for rating competence at colonoscopy: validation of a measurement tool.

    abstract：BACKGROUND:Counting the number of procedures performed provides at best a crude measure of technical competence in colonoscopy. The aim of this study was to develop and validate a qualitative and a quantitative score for measuring technical competency in colonoscopy using videotape evaluation. METHODS:Eighteen endosco...

    journal_title：Gastrointestinal endoscopy

    pub_type： 杂志文章

    doi：10.1067/mge.2002.128133

    authors： Shah SG,Thomas-Gibson S,Brooker JC,Suzuki N,Williams CB,Thapar C,Saunders BP

    更新日期：2002-10-01 00:00:00

  • Prevalence and risk factors for musculoskeletal injuries related to endoscopy.

    abstract：BACKGROUND:There are limited data regarding work-related injury among endoscopists. OBJECTIVE:To define the prevalence of endoscopy-related musculoskeletal injuries and their impact on clinical practice and to identify physician and practice characteristics associated with their development. DESIGN:Survey. SETTING:E...

    journal_title：Gastrointestinal endoscopy

    pub_type： 杂志文章

    doi：10.1016/j.gie.2014.06.036

    authors： Ridtitid W,Coté GA,Leung W,Buschbacher R,Lynch S,Fogel EL,Watkins JL,Lehman GA,Sherman S,McHenry L

    更新日期：2015-02-01 00:00:00

  • Gastric residual volume after split-dose compared with evening-before polyethylene glycol bowel preparation.

    abstract：BACKGROUND AND AIMS:Split-dose bowel preparation for colonoscopy results in superior preparation quality. However, some endoscopy units remain hesitant to prescribe split-dose preparation given theoretical concerns about possible aspiration caused by gastric residual fluid when a second dose is given close to the time ...

    journal_title：Gastrointestinal endoscopy

    pub_type： 杂志文章

    doi：10.1016/j.gie.2015.08.081

    authors： Agrawal D,Elsbernd B,Singal AG,Rockey D

    更新日期：2016-03-01 00:00:00

  • Case series of intra-abdominal adhesions induced by artificial ulceration after endoscopic submucosal dissection before additional laparoscopic gastrectomy.

    abstract：BACKGROUND:As endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) increases, increasing numbers of patients require additional gastrectomy with lymph node dissection after noncurative ESD. ESD may cause intra-abdominal adhesions, making additional laparoscopic gastrectomy technically difficult. OBJEC...

    journal_title：Gastrointestinal endoscopy

    pub_type： 杂志文章

    doi：10.1016/j.gie.2010.03.1066

    authors： Akagi T,Shiraishi N,Hiroishi K,Etoh T,Yasuda K,Kitano S

    更新日期：2010-08-01 00:00:00

  • Transgastric natural-orifice transluminal endoscopic surgery peritoneoscopy in humans: a pilot study in efficacy and gastrotomy site selection by using a hybrid technique.

    abstract：BACKGROUND:Diagnostic natural-orifice transluminal endoscopic surgery (NOTES) peritoneoscopy can easily be performed with standard endoscopic equipment in animal studies. The efficacy and optimal transgastric site for NOTES access in humans, however, has not been determined. OBJECTIVE:To characterize the efficacy of v...

    journal_title：Gastrointestinal endoscopy

    pub_type： 杂志文章

    doi：10.1016/j.gie.2010.03.1070

    authors： Nikfarjam M,McGee MF,Trunzo JA,Onders RP,Pearl JP,Poulose BK,Chak A,Ponsky JL,Marks JM

    更新日期：2010-08-01 00:00:00

  • Prediction of drainage effectiveness during endoscopic stenting of malignant hilar strictures: the role of liver volume assessment.

    abstract：BACKGROUND:The optimal endoscopic approach to the drainage of malignant hilar strictures remains controversial, especially with regard to the extent of desirable drainage and unilateral or bilateral stenting. OBJECTIVE:To identify useful criteria for predicting successful endoscopic drainage. DESIGN AND SETTING:Retro...

    journal_title：Gastrointestinal endoscopy

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.gie.2010.06.040

    authors： Vienne A,Hobeika E,Gouya H,Lapidus N,Fritsch J,Choury AD,Chryssostalis A,Gaudric M,Pelletier G,Buffet C,Chaussade S,Prat F

    更新日期：2010-10-01 00:00:00

  • Preoperative indicators of failure of en bloc resection or perforation in colorectal endoscopic submucosal dissection: implications for lesion stratification by technical difficulties during stepwise training.

    abstract：BACKGROUND AND AIMS:The technical difficulties inherent in endoscopic submucosal dissection (ESD) for colorectal neoplasms may result in the failure of en bloc resection or perforation. The aim of this retrospective study was to assess the predictors of en bloc resection failure or perforation by using preoperatively a...

    journal_title：Gastrointestinal endoscopy

    pub_type： 杂志文章

    doi：10.1016/j.gie.2015.08.024

    authors： Imai K,Hotta K,Yamaguchi Y,Kakushima N,Tanaka M,Takizawa K,Kawata N,Matsubayashi H,Shimoda T,Mori K,Ono H

    更新日期：2016-05-01 00:00:00

  • EMR for early gastric cancer in Korea: a multicenter retrospective study.

    abstract：BACKGROUND:EMR has been accepted as a treatment modality for selected cases of early gastric cancer (EGC) in Japan. However, long-term outcomes after EMR for EGC have not been fully documented. OBJECTIVES:We reviewed the experiences of EMR for EGC in Korea, with emphasis on the long-term outcome. DESIGN:Multicenter, ...

    journal_title：Gastrointestinal endoscopy

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.gie.2007.04.013

    authors： Kim JJ,Lee JH,Jung HY,Lee GH,Cho JY,Ryu CB,Chun HJ,Park JJ,Lee WS,Kim HS,Chung MG,Moon JS,Choi SR,Song GA,Jeong HY,Jee SR,Seol SY,Yoon YB

    更新日期：2007-10-01 00:00:00